# iS Clinical Brightening Serum for dry sensitive skin

**Lovi Fit: Low fit for dry sensitive skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: Concerning.

Page: https://lovi.care/skincare/it/p/is-clinical/brightening-serum/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [iS Clinical](https://lovi.care/skincare/it/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for dry sensitive skin; the serums alongside fit it better.

## Why this fit

- Offers moderate brightening for your dry and sensitive skin as alpha-arbutin and saccharum officinarum extract help to even skin tone, though the presence of alcohol denat and menthol may cause irritation.
- The formula provides mild resurfacing for dry or flaky skin with saccharum officinarum extract and vaccinium myrtillus leaf extract, but it lacks sufficient hydrating ingredients to fully address dryness.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/is-clinical/brightening-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/is-clinical/brightening-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/it/p/is-clinical/brightening-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/is-clinical/brightening-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/is-clinical/brightening-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/is-clinical/brightening-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/is-clinical/brightening-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/is-clinical/brightening-serum/for/dry-sensitive-skin): Low (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/is-clinical/brightening-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Alpha-Arbutin, Ascophyllum Nodosum Extract, Vaccinium Myrtillus Leaf Extract Fruit, Willow Bark Extract, Saccharum Officinarum Extract

## What the research says

- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- Polyvinyl pyrrolidone-K90/Eudragit RL100 dissolving microneedle patches loaded with alpha-arbutin and resveratrol enhanced intradermal delivery by approximately 2.6 times compared to cream and slightly decreased the melanin index in human participants without causing skin irritation. ([Biomaterials Science, 2023](https://pubmed.ncbi.nlm.nih.gov/37183632/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))
- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil. ([Nanomaterials, 2022](https://pubmed.ncbi.nlm.nih.gov/35889587/))
- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))

## Why other serums fit dry sensitive skin better

- Topical menthol induced significant pain, cold sensations, punctate and cold hyperalgesia, and increased cutaneous perfusion in 10 subjects compared to ethanol control, acting as a human model for cold pain by sensitizing peripheral cold C nociceptors and activating cold-specific A delta fibres. ([Brain, 2004](https://pubmed.ncbi.nlm.nih.gov/14985268/))
- Tocopherol succinate-loaded ethosomal gel increased skin deposition, stability, moisture, and mechanical properties in 13 human subjects compared to a control gel over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35274433/))
- In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle. ([Skin Pharmacology and Physiology, 2026](https://pubmed.ncbi.nlm.nih.gov/41758783/))

## What reviewers say

This review data is based on limited data. Users frequently report visible improvements in dark spots, skin radiance, and overall texture, noting that the formula is generally gentle enough for various skin types, including sensitive skin. Some users may find it less effective for stubborn conditions or notice potential irritation if used too frequently.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Evens skin tone (often mentioned)
- Liked: Gentle formula (sometimes noted)
- Liked: Improves texture (sometimes noted)
- Disliked: Slow/no results (sometimes noted)
- Disliked: Potential breakouts (rarely noted)
- Disliked: Price point (rarely noted)
- Disliked: Tingling sensation (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### Why is iS Clinical Brightening Serum a weak match for dry sensitive skin?

This serum is a weak match because it contains alcohol denat and menthol which may cause irritation, and it lacks sufficient hydrating ingredients to fully address dryness. A treatment for dry sensitive skin needs soothing moisturizers like ceramides and nourishing hydrators that protect the skin barrier without any risk of irritation.
Sources: [Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/)

### Which ingredients make this serum a poor fit for dry sensitive skin?

Alcohol denat and menthol make this serum a weak match for your dry and sensitive skin because they may cause irritation. A treatment of this type needs rich moisturizing and nourishing ingredients that provide excellent hydration and support the skin barrier without any risk of irritation.

### What does Alpha-Arbutin do for dry sensitive skin?

Alpha-arbutin helps fade dark spots and uneven skin tone while being gentle enough that it is unlikely to cause irritation on dry, sensitive skin. Advanced delivery formulas containing alpha-arbutin may also improve skin moisture content.
Sources: [Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39943675/)

### What does Ascophyllum Nodosum Extract do for dry sensitive skin?

Ascophyllum nodosum extract helps calm and nourish dry, sensitive skin by providing gentle plant-based hydration and antioxidant protection. It is unlikely to cause irritation and supports a smooth, comfortable feel.
Sources: [Marine Drugs, 2021](https://pubmed.ncbi.nlm.nih.gov/34436303/), [Marine Drugs, 2020](https://pubmed.ncbi.nlm.nih.gov/32575468/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine after toner and before moisturizer, starting just once a week. Because this product is a weak match for dry sensitive skin, a treatment of this type needs soothing plant extracts and plenty of gentle hydrating ingredients to keep dry skin calm and comfortable.

### Can I use this serum with retinol, and in what order?

It is best to avoid using this serum with retinol on dry and sensitive skin, because alcohol denat and menthol may cause irritation and the formula lacks sufficient hydrating ingredients. A treatment for this skin type needs soothing and hydrating ingredients to prevent dryness and discomfort.

### How often should I use this serum?

This treatment is best used once a week to start, as dry and sensitive skin needs careful care with active ingredients. A product of this type needs plenty of gentle hydrating ingredients and soothing agents to keep dry skin comfortable and prevent irritation.
Sources: [Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/)

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to clog pores or cause breakouts for dry sensitive skin, though alcohol denat and menthol may cause irritation. A product of this type needs rich hydrating and soothing ingredients to comfort dry skin while brightening.

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — €129.99 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin) — Superior fit — €57.00 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/it/p/augustinus-bader/the-serum/for/dry-sensitive-skin) — Superior fit — €380.10 at Amazon

## Routine for dry sensitive skin

### AM

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €9.19 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/dry-sensitive-skin) — Superior fit — €30.10 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/it/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — €20.40 at Amazon

### PM

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/it/p/missha/ultra-hyalon-cleansing-cream/for/dry-sensitive-skin) — Superior fit — €15.90 at Amazon
- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €9.19 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/dry-sensitive-skin) — Superior fit — €30.10 at Amazon
- Serum or Treatment: [Purito Centella Unscented Serum](https://lovi.care/skincare/it/p/purito/centella-unscented-serum/for/dry-sensitive-skin) — Superior fit — €17.60 at Amazon
- Moisturizer: [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/it/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin) — Superior fit — €92.92 at Amazon

### Weekly

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/it/p/missha/ultra-hyalon-cleansing-cream/for/dry-sensitive-skin) — Superior fit — €15.90 at Amazon
- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €9.19 at Amazon
- Enzyme Powder: [Fancl Facial Washing Powder](https://lovi.care/skincare/it/p/fancl/facial-washing-powder/for/dry-sensitive-skin) — Superior fit — €19.30 at Amazon
- Nourishing Mask: [MEDIHEAL Vita Essential Mask](https://lovi.care/skincare/it/p/mediheal/vita-essential-mask/for/dry-sensitive-skin) — Superior fit — €31.93 at Amazon
- Serum or Treatment: [Purito Centella Unscented Serum](https://lovi.care/skincare/it/p/purito/centella-unscented-serum/for/dry-sensitive-skin) — Superior fit — €17.60 at Amazon
- Moisturizer: [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/it/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin) — Superior fit — €92.92 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Butylene Glycol, Water, Glycerin, Alcohol Denat, Ascophyllum Nodosum Extract, Saccharum Officinarum Extract, Vaccinium Myrtillus Leaf Extract Fruit, Alpha-Arbutin, Glyceryl Polyacrylate, Polyporus Umbellatus Extract Mushroom Extract, Willow Bark Extract, Menthol, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/brightening-serum/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/brightening-serum/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/brightening-serum/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/brightening-serum/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/brightening-serum/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/brightening-serum/for/dry-sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/brightening-serum/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/brightening-serum/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/brightening-serum/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/brightening-serum/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/brightening-serum/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/brightening-serum/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/brightening-serum/for/dry-sensitive-skin