# iS Clinical Brightening Complex for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/is-clinical/brightening-complex/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [iS Clinical](https://lovi.care/skincare/it/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for dry skin due to the presence of Sodium Hyaluronate and Glycerin for humectant action, and Squalane for emollient action, which will help to hydrate and nourish your dry skin.
- The product offers excellent brightening and evening of skin tone due to the presence of alpha-arbutin and tetrahexyldecyl ascorbate in moderate concentrations.
- There are no risks of irritation for your dry and sensitive skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/is-clinical/brightening-complex/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/is-clinical/brightening-complex/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/is-clinical/brightening-complex/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/is-clinical/brightening-complex/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/is-clinical/brightening-complex/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/is-clinical/brightening-complex/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/is-clinical/brightening-complex/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/is-clinical/brightening-complex/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/is-clinical/brightening-complex/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Alpha-Arbutin, Licorice Root Extract, Tetrahexyldecyl Ascorbate, Willow Bark Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- Polyvinyl pyrrolidone-K90/Eudragit RL100 dissolving microneedle patches loaded with alpha-arbutin and resveratrol enhanced intradermal delivery by approximately 2.6 times compared to cream and slightly decreased the melanin index in human participants without causing skin irritation. ([Biomaterials Science, 2023](https://pubmed.ncbi.nlm.nih.gov/37183632/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil. ([Nanomaterials, 2022](https://pubmed.ncbi.nlm.nih.gov/35889587/))
- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))

## What reviewers say

Based on limited data, this product is highly praised for its ability to fade dark spots and hyperpigmentation, leading to a more even and radiant skin tone. Users with various skin types, including acne-prone and sensitive skin, find the formula to be gentle and non-irritating. A moderate number of users mention the high price point as a drawback, while a low frequency of reviews indicate no visible changes.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Evens skin tone (often mentioned)
- Liked: Gentle and non-irritating (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: No visible changes (rarely noted)
- Disliked: Unpleasant smell (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes iS Clinical Brightening Complex a great fit for dry sensitive skin?

iS Clinical Brightening Complex is a great fit for your dry sensitive skin because it uses sodium hyaluronate and glycerin to hydrate, and squalane to nourish, while avoiding harsh ingredients that may cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for dry sensitive skin?

Sodium hyaluronate and glycerin draw in moisture while squalane softens and nourishes your dry skin. These ingredients, along with alpha-arbutin and tetrahexyldecyl ascorbate, brighten and even your skin tone safely without any risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/)

### What does Hyaluronic Acid do for dry sensitive skin?

Hyaluronic acid is a great fit for dry, sensitive skin because it brings a large boost in hydration, making the skin feel soft and smooth while improving barrier function. It helps calm tightness and dryness, and is unlikely to cause irritation.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/)

### What does Alpha-Arbutin do for dry sensitive skin?

Alpha-arbutin helps fade dark spots and uneven skin tone while being gentle enough that it is unlikely to cause irritation on dry, sensitive skin. Advanced delivery formulas containing alpha-arbutin may also improve skin moisture content.
Sources: [Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39943675/)

### Where does it go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine after your toner and before your moisturizer. Putting it in the evening keeps things simple and is extra safe around sun exposure.

### Can I use this cream with retinol, and in what order?

You can use this treatment with retinol by applying your retinol first, letting it absorb, and then following with this cream to help nourish your dry skin. This product is unlikely to cause irritation for your sensitive skin because it avoids harsh ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/)

### How often should I use it?

You can use this treatment in your evening routine once a week to start, and then carefully use it more often if your dry sensitive skin tolerates it well and sees good results.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can it clog pores, cause breakouts or purging for dry sensitive skin?

This treatment is unlikely to clog pores or cause breakouts for dry sensitive skin because it is free of heavy, pore-clogging ingredients. It is formulated to hydrate and nourish your skin safely without triggering irritation.

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Stearyl alcohol and cetearyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — €129.99 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin) — Superior fit — €57.00 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/it/p/augustinus-bader/the-serum/for/dry-sensitive-skin) — Superior fit — €380.10 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €9.19 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/dry-sensitive-skin) — Superior fit — €30.10 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/it/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — €20.40 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Willow Bark Extract, Sodium Hyaluronate, Saccharum Officinarum Extract Extrait De Canne À Sucre Extract, Vaccinium Myrtillus Leaf Extract Fruit, Ascophyllum Nodosum Extract, Tetrahexyldecyl Ascorbate, Glycerin, Squalane, Imperata Cylindrica Root Extract, Glyceryl Stearate, Alpha-Arbutin, Peg-100 Stearate, Peg-8 Smdi Copolymer, Triethanolamine, Polyporus Umbellatus Extract Mushroom Extract, Stearyl Alcohol, Cetearyl Alcohol, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Dimethicone, 1,2-Hexanediol, Caprylyl Glycol, Citrus Aurantium Dulcis Oil, Xanthan Gum, Hydrogenated Lecithin, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/brightening-complex/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/brightening-complex/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/brightening-complex/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/brightening-complex/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/brightening-complex/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/brightening-complex/for/dry-sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/brightening-complex/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/brightening-complex/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/brightening-complex/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/brightening-complex/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/brightening-complex/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/brightening-complex/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/brightening-complex/for/dry-sensitive-skin