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HydroPeptide Power Serum for acne-prone skin

HydroPeptide Power Serum
  • Palmitoyl Tripeptide-5
  • Hexapeptide-11
  • Acetyl Hexapeptide-30
  • Sodium Hyaluronate
  • Lemon Peel Extract

High

  • HighCombination Skin Fit
  • HighEffectiveness
  • ExcellentSafety

A great choice for acne-prone skin; a few serums fit it even better.

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Excellent for your combination skin, this serum utilizes Hexapeptide-11 and Tetrahexyldecyl Ascorbate to effectively smooth texture and brighten your skin tone, addressing your concerns with acne and blemishes.
  • The inclusion of Glycerin and Sodium Hyaluronate provides essential hydration, supporting your skin's repair processes and reducing inflammation without causing irritation.
  • This formulation is safe for your acne-prone skin, containing soothing ingredients like Tocopherol and avoiding harsh components.

How to apply

  • Use your serum as part of your PM routine and start 3x/week before working up to daily use.
  • Apply this treatment after cleansing and toner, and before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
  • Apply the product on clean, dry skin to help manage your breakouts safely.
  • Avoid the eye area and do a patch test before your first use.

People Say

★4.8Overall rating based on 400+ reviews

Users consistently praise this serum as a lightweight, non-greasy anti-aging powerhouse that visibly plumps and smooths the skin. While it is highly effective for hydrating dry skin and softening fine lines without irritating sensitive complexions, the high price point and distinct scent are occasional points of contention.

Highlights

  • Lightweight texture Mostly Mentioned
    • “sinks right into skin”
    • “featherlight formula”
    • “perfect under makeup”
    • “no greasy residue”
  • Deep hydration Often Mentioned
    • “skin feels incredibly soft”
    • “visibly plumps”
    • “deeply hydrates without heaviness”
    • “glowing complexion”
  • Visible anti-aging Often Mentioned
    • “fine lines look reduced”
    • “skin feels firmer”
    • “years-younger appearance”
    • “unbelievable difference in 2 weeks”
  • High price point Often Mentioned
    • “a little pricey”
    • “worth the occasional splurge”
    • “wallet hurting”
  • Gentle on skin Sometimes Noted
    • “doesn't irritate my sensitive skin”
    • “calming peptides”
    • “no redness or breakouts”
    • “gentle formula”
  • Pleasant scent Sometimes Noted
    • “smells like heaven”
    • “hint of grapefruit”
    • “light and refreshing”
    • “smells like cucumbers”
  • Packaging size Rarely Noted
    • “1oz is too small”
    • “wish it was bigger”
    • “pump stopped working”
    • “expensive for the size”
  • Scent dislike Rarely Noted
    • “smell is a little off-putting”
    • “can't stand the scent”
    • “smells terrible”
    • “fragrance isn't for everyone”
  • Slow results Rarely Noted
    • “didn't see dramatic results”
    • “no huge difference”
    • “takes consistent use”
    • “wrinkles still there”

Sources: lovi.care, hydropeptide.com, dermstore.com, lovelyskin.com, youtube.com, wimj.com, and more

Questions and answers

What makes HydroPeptide Power Serum a great fit for acne-prone skin?

HydroPeptide Power Serum is a great fit for acne-prone skin because it uses gentle peptides and vitamin C to smooth texture and brighten tone while addressing blemishes. Ingredients like glycerin and sodium hyaluronate provide essential hydration to support skin repair and reduce inflammation without causing irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this serum a good fit for acne-prone skin?

This serum is a great fit for your acne-prone skin because it uses Hexapeptide-11 and Tetrahexyldecyl Ascorbate to smooth texture and brighten your tone, while Glycerin and Sodium Hyaluronate provide essential hydration to reduce inflammation without causing irritation. It also contains soothing ingredients like Tocopherol and avoids harsh components, making it safe and gentle for blemish-prone skin.

Clinical, Cosmetic and Investigational Dermatology, 2017

What does Palmitoyl Tripeptide-5 do for acne-prone skin?

Palmitoyl Tripeptide-5 helps improve skin texture and firmness, making it a supportive addition for acne-prone skin that needs smoothing without heavy oils.

Colloids and Surfaces. B, Biointerfaces, 2025

What does Hexapeptide-11 do for acne-prone skin?

Hexapeptide-11 is a peptide that may help improve skin elasticity and support overall skin health. For acne-prone skin, a product of this type needs soothing ingredients and lightweight hydrators that help calm redness and keep the skin barrier strong.

Redox Biology, 2015

Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in the evening routine after cleansing and before moisturizing, following Lovi's routine for acne-prone skin.

Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the treatment after your retinol to help calm the skin and provide hydration without causing irritation. Using soothing ingredients alongside active treatments is unlikely to cause issues and may reduce potential skin discomfort.

Journal of Cosmetic Dermatology, 2024Clinical, Cosmetic and Investigational Dermatology, 2017

How often should I use this serum?

This serum is a great fit for your acne-prone skin and is best used in your evening routine for simplicity and extra safety around sun exposure. It helps smooth texture and brighten skin tone while providing essential hydration and reducing inflammation without causing irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017

Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is a great fit for acne-prone skin because it relies on soothing ingredients and avoids harsh components that typically cause breakouts. It helps hydrate your skin and calm inflammation safely without clogging pores.

Clinical, Cosmetic and Investigational Dermatology, 2017Redox Biology, 2015

Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

What the research says

  • Hexapeptide-11 activated proteasome, autophagy, chaperones, and antioxidant response genes, protected fibroblasts against oxidative-stress-mediated premature cellular senescence, and improved skin elasticity in human subjects.

    Redox Biology, 2015
  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017
  • Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects.

    Colloids and Surfaces. B, Biointerfaces, 2025
  • Hexapeptide-11 reversibly downregulated ATM and p53 protein expression in intrinsically aged fibroblasts, extrinsically aged fibroblasts, and extrinsically aged dermal papillae cells at concentrations between 0.1% and 1.0% in vitro, thereby influencing the onset of cellular senescence.

    Journal of Cosmetic Science, 2013
  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011
  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022
  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

Ingredients

Water, Glycerin, Lactococcus Lysate Ferment, Butylene Glycol, Propanediol, Diethylhexyl Carbonate, Isopentyldiol, Pentylene Glycol, Diheptyl Succinate, Caprylyl Glycol, Hydroxyacetophenone, Olea Europaea Fruit Olive Fruit, Sodium Stearoyl Glutamate, Cetearyl Alcohol, Glyceryl Stearate, Potassium Olivoyl Hydrolyzed Oat Protein, Lysolecithin, Sclerotium Gum, Hexapeptide-11, Tetrahexyldecyl Ascorbate, 1,2-Hexanediol, Capryloyl Glycerin Sebacic Acid Copolymer, Phenylpropanol, Sorbitan Laurate, Pullulan, Xanthan Gum, Caprylic Capric Triglyceride, Glyceryl Oleate, Glycine Soja Seed Extract Soybean Seed Extract, Anogeissus Leiocarpus Bark Extract, Lemon Peel Extract, Palmitoyl Hexapeptide-19, Sodium Phytate, Hydroxyethylcellulose, Sodium Hyaluronate, Acetyl Dipeptide-1 Cetyl Ester, Citrus Aurantium Dulcis Peel Extract, Grapefruit Fruit Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Bergamot Fruit Extract, Citrus Aurantifolia Peel Extract, Citrus Nobilis Fruit Extract Mandarin Orange Fruit Extract, Tangerine Peel Extract, Acetyl Hexapeptide-30, Barosma Betulina Leaf Extract, Vanilla Planifolia Fruit Extract, Vitis Vinifera Fruit Extract Grape Fruit Extract, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-5, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Tocopherol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

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How does it fit your skin?

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