Eighth Day Regenerative Serum for acne-prone skin
Peptide-Rich Plasma
Sodium Hyaluronate
Niacinamide
Acetyl Glutamine
Manuka Honey
Average
- HighCombination Skin Fit
- AverageEffectiveness
- Low RiskSafety
Works for acne-prone skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your combination skin, as niacinamide helps regulate oil production and sodium hyaluronate provides hydration, though it does not directly target acne and blemishes.
- The serum's multiple peptides, such as Sh-Oligopeptide-2 and Palmitoyl Tripeptide-5, are excellent for skin regeneration and smoothing texture, which can indirectly support clearer skin.
- The product is generally safe for your combination skin, with a low risk of irritation from glycolic acid.
How to apply
- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.5Overall rating based on 300+ reviewsThis serum is highly praised for its "Peptide-Rich Plasma" technology, which users credit for rapidly improving skin texture, firmness, and radiance. While many describe it as a "holy grail" for anti-aging and hydration, a subset of users feel the high price tag is not justified by the results, which can be subtle for some.
Highlights
High price Mostly Mentioned
- “hefty price tag”
- “hard to justify”
- “investment skincare”
- “wallet-draining”
Fast absorption Often Mentioned
- “Lightweight, non-sticky, sinks in immediately, satin finish, layers well”
Visible anti-aging Often Mentioned
- “Smoother fine lines, plumper skin, increased firmness, brighter complexion, "instant glow."”
High-tech ingredients Sometimes Noted
- “Peptide-Rich Plasma, bio-identical actives, stem cell technology, clean formula, fragrance-free”
Hydration Sometimes Noted
- “Deeply hydrating, restores moisture barrier, skin feels bouncy, eliminates dryness”
Lack of results Sometimes Noted
- “No visible difference”
- “didn't work for me”
- “overhyped”
- “saw no change”
- “cheaper alternatives work better”
Packaging Rarely Noted
- “Sleek black bottle, airless pump, luxurious design, dispenses perfect amount”
Availability issues Rarely Noted
- “Frequently sold out”
- “hard to find”
- “waitlists”
- “stock issues”
No acne benefit Rarely Noted
- “Did not help breakouts”
- “didn't reduce acne”
- “neutral on blemishes”
Texture complaints Rarely Noted
- “Slightly tacky for some”
- “hard to spread (rare)”
- “leaves a film”
- “requires quick application”
Sources: lovi.care, nordstrom.com, violetgrey.com, editorialist.com, whowhatwear.com, reddit.com, and more
Questions and answers
How well does Eighth Day Regenerative Serum work for acne-prone skin?
Eighth Day Regenerative Serum works moderately well for acne-prone skin, as niacinamide helps control oil and peptides smooth texture, though it does not directly target breakouts. To work best for this skin, a treatment needs ingredients like niacinamide and zinc PCA to target blemishes while balancing hydration and oil without irritation.
Which ingredients make this serum a good fit for acne-prone skin?
Niacinamide helps regulate oil production, while multiple peptides smooth texture to support clearer skin, and sodium hyaluronate provides hydration. To best fit acne-prone skin, a treatment of this type needs targeted ingredients like propolis or zinc PCA for blemishes, along with balancing hydrators that control oil without causing dryness.
Scientific Reports, 2024Colloids and Surfaces. B, Biointerfaces, 2025
What does Peptide-Rich Plasma do for acne-prone skin?
Platelet-rich plasma helps calm inflamed acne lesions and improves the look of acne scars when used alongside in-office treatments like lasers or microneedling. Combining these methods is unlikely to cause extra downtime and may boost collagen production for smoother skin.
What does Hyaluronic Acid do for acne-prone skin?
Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Where does this serum go in a skincare routine for acne-prone skin?
This treatment goes in the evening routine, after cleansing and before moisturizing, to keep things simple and safe around sun use. For this skin, a product of this type needs soothing and oil-controlling ingredients like niacinamide and salicylic acid to help clear breakouts.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first and following with your retinol to help smooth texture while managing potential irritation. This combination is generally safe, though a product of this type for acne-prone skin also needs ingredients that directly target breakouts and blemishes.
How often should I use this serum?
Use this serum in the evening. Acne-prone skin needs a treatment that directly targets breakouts and blemishes with ingredients like salicylic acid or benzoyl peroxide.
Can this serum clog pores, cause breakouts or purging for acne-prone skin?
This serum is unlikely to cause breakouts on acne-prone skin, as niacinamide helps control oil and the overall formula is generally safe. However, because it does not directly target blemishes, acne-prone skin often needs products packed with clarifying ingredients like salicylic acid or benzoyl peroxide to truly keep pores clear.
Scientific Reports, 2024The British Journal of Dermatology, 2002
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.
The British Journal of Dermatology, 2002Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated.
Antioxidants, 2021Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects.
Colloids and Surfaces. B, Biointerfaces, 2025Topical insulin combined with fractional CO2 laser showed no significant difference in efficacy compared to topical PRP combined with fractional CO2 laser for atrophic acne scars in 30 patients.
Archives of Dermatological Research, 2025Subcision and microneedling combined with topical platelet-rich plasma resulted in significantly greater improvement in scar grading compared to subcision and microneedling alone in patients with atrophic scars.
Journal of Cutaneous and Aesthetic Surgery, 2024Platelets remain viable for up to 90 days in a refrigerated cosmetic vehicle with demonstrated topical clinical PRP facial benefits, and 20ml and 60ml PRP volumes are equally efficacious.
Journal of Drugs in Dermatology, 2020Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical overnight application of MGO Manuka Honey microemulsion eye cream significantly reduced symptomology, improved tear film stability and lipid layer thickness, and decreased lid margin staining, ocular Demodex, and bacterial load in patients with blepharitis compared to control eyes.
The Ocular Surface, 2020Optimel 16% manuka honey eye-drops significantly improved symptoms and objective signs in patients with meibomian gland dysfunction compared to baseline after 3 weeks.
The British Journal of Ophthalmology, 2022The application of Manuka honey and the GENADYNE A4 negative pressure wound therapy system in a 55-year-old woman with extensive phlegmonous and necrotic lesions following traumatic colonic rupture successfully enabled skin autografting and complete wound healing.
Medical Science Monitor, 2010
Why other serums fit acne-prone skin better
Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris.
The Journal of Clinical and Aesthetic Dermatology, 2020A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.
Clinical Pharmacology, 2018Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022
Ingredients
Water, Pentylene Glycol, Peptide-Rich Plasma, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Acetyl Hexapeptide-8, Sh-Oligopeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Acetyl Glutamine, Sodium Hyaluronate, Lysine Hcl, Alanine, Histidine Hcl, Arginine, Serine, Proline, Glutamic Acid, Threonine, Valine, Leucine, Glycine, Isoleucine, Phenylalanine, Taurine, Glycerin, Hedychium Coronarium Root Extract, Tripeptide-1, Polygonum Aviculare Extract, Honey, Nonapeptide-1, Acetyl Heptapeptide-4, Phytosphingosine, Sea Whip Extract, Niacinamide, Hydrolyzed Hyaluronic Acid, Aminobutyric Acid, Adenosine, Thioctic Acid, Glycolic Acid, Bacillus Soybean Folic Acid Extract Ferment, Polysorbate 20, Allantoin, Caprylyl Glycol, Lecithin, Butylene Glycol, 1,2-Hexanediol, Dextran, Phenoxyethanol, Ethylhexylglycerin, Xanthan Gum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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