# Dr. Althea 345 Relief Cream for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/dr-althea/345-relief-cream/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Dr. Althea](https://lovi.care/skincare/it/brands/dr-althea)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for skin with dark spots; a few moisturizers fit it even better.

## Why this fit

- This product offers excellent moisturizing and barrier support for your normal skin, with niacinamide and panthenol working to enhance resilience and provide mild brightening for pigmentation concerns.
- The inclusion of hyaluronic acid and various botanical extracts further contributes to hydration and soothing, complementing the primary ingredients.
- The formulation is safe for your skin, as it contains no harsh ingredients and includes soothing agents like Calendula Officinalis Flower Extract and Centella Asiatica Leaf Extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/dr-althea/345-relief-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/dr-althea/345-relief-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/dr-althea/345-relief-cream/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/dr-althea/345-relief-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/dr-althea/345-relief-cream/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/it/p/dr-althea/345-relief-cream/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/it/p/dr-althea/345-relief-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/dr-althea/345-relief-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/dr-althea/345-relief-cream/for/oily-acne-prone-skin): Superior

## Key ingredients

Niacinamide, Centella Asiatica, Hyaluronic Acid, Ceramide, Oenothera Biennis Oil

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport. ([Biomaterials Advances, 2022](https://pubmed.ncbi.nlm.nih.gov/35929319/))
- A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides. ([Medicina Cutanea Ibero-latino-americana, 1986](https://pubmed.ncbi.nlm.nih.gov/3528709/))
- Topical application of linseed, evening primrose, and olive oil emulsions accelerated wound closure in rats with excision wounds compared to untreated controls, though via different mechanisms. ([Drug Delivery and Translational Research, 2019](https://pubmed.ncbi.nlm.nih.gov/29667150/))

## What reviewers say

Based on a very large amount of data, this gel-cream is highly regarded by users with oily and acne-prone skin for its lightweight, fast-absorbing texture that effectively soothes redness and strengthens the skin barrier without causing pore congestion. Some users with dry skin find it insufficiently moisturizing, and a few report occasional breakouts or pilling when layered with other products.

- Liked: Hydrating for Oily Skin (often mentioned)
- Liked: Lightweight & Fast Absorbing (often mentioned)
- Liked: Soothing & Calming (often mentioned)
- Liked: Improves Skin Texture (sometimes noted)
- Disliked: Causes breakouts (sometimes noted)
- Disliked: Not moisturizing enough (sometimes noted)
- Disliked: Pilling issues (rarely noted)
- Disliked: Scent/Irritation (rarely noted)

## How to apply

- Could be used as part of your AM and PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it too hard so it absorbs nicely.
- For the best moisture, you can apply it when your skin is slightly damp. This helps your skin stay soft and happy.
- Remember to avoid the eye area when applying. Always do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Dr. Althea 345 Relief Cream a great fit for skin with dark spots?

This cream is a great fit because it contains niacinamide and panthenol, which help fade dark spots while keeping your skin calm and moisturized. These ingredients work to brighten uneven tone and support your skin barrier safely and effectively.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this cream a good fit for skin with dark spots?

This cream is a great fit for skin with dark spots because it contains niacinamide and panthenol, which help fade dark areas and brighten your complexion. Niacinamide works by reducing excess pigment, while panthenol provides deep moisture to keep your skin smooth and healthy.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Niacinamide do for skin with dark spots?

Niacinamide helps fade dark spots and uneven pigmentation by slowing down the transfer of pigment in the skin. It is generally well tolerated and may improve overall skin brightness with consistent use.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Centella Asiatica do for skin with dark spots?

Centella asiatica helps reduce dark spots by targeting the processes that cause excess pigment in the skin. Studies show that key compounds in this ingredient help calm the skin and manage melanin production.
Sources: [Molecular Medicine Reports, 2014](https://pubmed.ncbi.nlm.nih.gov/24756377/), [International Journal of Molecular Medicine, 2025](https://pubmed.ncbi.nlm.nih.gov/39513603/)

### Where does this cream go in a skincare routine for skin with dark spots?

This moisturizing treatment goes near the end of your morning routine before sunscreen, and as the final step in your evening routine. It provides great barrier support and hydration while helping to brighten dark spots.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use it with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying it either before or after your retinol to help keep your skin calm and hydrated. The formulation is very safe and well-suited to support your skin barrier while you use retinoids, which helps lower the likelihood of dryness and irritation.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/)

### How often should I use this cream?

You can use this moisturizing treatment twice daily as part of your morning and evening routine. Regular daily application helps keep skin hydrated and supports a brighter, more even look for dark spots.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can it clog pores, cause breakouts or purging for skin with dark spots?

This cream is a great fit for skin with dark spots, but some reviewers do report that it may cause breakouts. It helps brighten dark spots and hydrate your skin while keeping the formula gentle and safe.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use this cream around the eyes or on my body?

This moisturizing treatment is well-suited for the body and the thin skin around the eyes because its gentle formulation provides deep hydration and strong barrier support without harsh ingredients. Regular use helps smooth dry areas and keeps the skin calm and soft.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/dark-spots) — Superior fit — €18.06 at Amazon
- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/it/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/dark-spots) — High fit — €103.95 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/it/p/the-ordinary/natural-moisturizing-factors-ha/for/dark-spots) — High fit — €13.11 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/it/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €24.75 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €15.16 at Amazon
- SPF: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/it/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dark-spots) — Superior fit — €20.40 at Amazon

## Where to buy

- Amazon.it: €21.80 (https://www.amazon.it/dp/B07PK2P2XB?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Notino: €21.50 (https://www.notino.it/dr-althea/345-relief-cream-crema-lenitiva-e-rigenerante-per-pelli-sensibili/p-16315837/)
Prices checked 10 Oct – 2 Nov 2026.

## Ingredients

Water, Propanediol, Glycerin, Cyclohexasiloxane, 1,2-Hexanediol, Caprylic Capric Triglyceride, Niacinamide, Panthenol, Polyglycerin-3, Polyglyceryl-10 Stearate, Hydrogenated Poly C6-14 Olefin, Hydrogenated Polydecene, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Melia Azadirachta Flower Extract, Houttuynia Cordata Extract, Melia Azadirachta Leaf Extract, Oenothera Biennis Flower Extract, Curcuma Longa Root Extract, Ocimum Sanctum Leaf Extract, Calendula Officinalis Flower Extract, Agave Tequilana Leaf Extract, Sargassum Fulvellum Extract, Corallina Officinalis Extract, Lavandula Angustifolia Flower Extract, Centella Asiatica Leaf Extract, Opuntia Ficus-Indica Stem Extract, Gardenia Florida Fruit Extract, Perilla Ocymoides Leaf Extract, Hibiscus Sabdariffa Flower Extract, Hyaluronic Acid, Hydrogenated Lecithin, Empetrum Nigrum Fruit Juice, Dicaprylyl Carbonate, C14-22 Alcohols, Ammonium Acryloyldimethyltaurate Vp Copolymer, Polymethylsilsesquioxane, Dipropylene Glycol, Butylene Glycol, C12-20 Alkyl Glucoside, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Polyquaternium-51, Tromethamine, Fructooligosaccharides, Adenosine, Beta-Glucan, Glycine Soja Soybean Sterols, Peg-40 Castor Oil, Hydrolyzed Hyaluronic Acid, Resveratrol, Tocopherol, Ceramide Np, Oligopeptide-1, Phenoxyethanol, Potassium Sorbate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/dr-althea/345-relief-cream/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/dr-althea/345-relief-cream/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/dr-althea/345-relief-cream/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/dr-althea/345-relief-cream/for/dark-spots
- France: https://lovi.care/skincare/fr/p/dr-althea/345-relief-cream/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/dr-althea/345-relief-cream/for/dark-spots (this page)
- Netherlands: https://lovi.care/skincare/nl/p/dr-althea/345-relief-cream/for/dark-spots
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