Dermalogica Skin Smoothing Cream for mature skin

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Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

  Dermatologic Therapy, 2022

• Grape seed extract based emulgel and emulsion formulations reduced skin roughness, scaliness, wrinkles, and sebum content while enhancing elasticity and hydration.

  Pakistan Journal of Pharmaceutical Sciences, 2021

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.

  Clinical Pharmacology, 2018

• Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief.

  Plastic and Reconstructive Surgery, 2018

• Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo.

  Journal of Alternative and Complementary Medicine, 2010

• Topical CE Ferulic plus resveratrol BE serum following ablative fractional CO2 laser treatment reduced erythema index (308.9 vs. 325.3), shortened complete scabbing detachment time (6.0 vs. 6.5 days), decreased melanin index (-7.4% vs. +0.2%), and improved skin hydration compared to normal saline in 51 Chinese patients.

  Journal of the European Academy of Dermatology and Venereology, 2024

• Resveratrol cream improved skin hydration and tightening compared to cream without resveratrol in a group of probands.

  Acta Biochimica Polonica, 2019

• Topical application of a water-in-oil emulsion containing 2% Muscat hamburg grape seed extract significantly improved melanin, elasticity, and sebum content compared to a placebo in human volunteers over 8 weeks, with no reported skin hypersensitivity.

  International Journal of Cosmetic Science, 2015

• Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.

  Journal of Cosmetic Dermatology, 2025

• Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

  Contemporary Clinical Trials Communications, 2021

• Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.

  Journal of Cosmetic Dermatology, 2024

Ingredients

Water, Caprylic Capric Triglyceride, Ethylhexyl Hydroxystearate, Stearic Acid, Butylene Glycol, Glycerin, Aloe Barbadensis Leaf Juice, Dimethicone, Peg-8, Cetearyl Alcohol, Sodium Hyaluronate, Vitis Vinifera Seed Extract Grape Seed Extract, Saccharide Isomerate, Cucumis Sativus Fruit Extract, Arnica Montana Flower Extract, Hedera Helix Extract, Malva Sylvestris Flower Extract, Parietaria Officinalis Extract, Sambucus Nigra Flower Extract, Ascorbyl Palmitate, Trehalose, Algin, Hydrolyzed Sodium Hyaluronate, Serine, Linoleic Acid, Phytosterols, Cananga Odorata Oil Flower, Urea, Hydrogenated Lecithin, Pullulan, Caprylhydroxamic Acid, Citrus Aurantium Amara Flower Extract, Tocopheryl Acetate, Tetrasodium Glutamate Diacetate, Hexanediol, Pentylene Glycol, Glyceryl Polyacrylate, Sodium Citrate, Disodium Phosphate, Palmitoyl Hydroxypropyltrimonium, Amylopectin Glycerin Crosspolymer, Caprylyl Glycol, Potassium Phosphate, Citric Acid, Tocopherol, Methylpropanediol, Polysorbate 60, Panthenol, Polyquaternium-10, Cetyl Alcohol, Peg-100 Stearate, Glyceryl Stearate, Aminomethyl Propanol, Carbomer, Ethylhexylglycerin, Sodium Hydroxide, Hydroxystearic Acid, Bht, Benzyl Benzoate, Benzyl Salicylate, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.