🇮🇹Italy

Derma E Pure Biome Balancing Cleanser for acne-prone skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Derma E Pure Biome Balancing Cleanser

High

  • AverageCombination Skin Fit
  • HighEffectiveness
  • HighSafety

A great choice for acne-prone skin; a few cleansers fit it even better.

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • High suitability for your combination skin as decyl glucoside and glycerin offer moderate cleansing and hydration, while Centella Asiatica and Ganoderma Lucidum Extract provide anti-inflammatory benefits for acne and blemishes.
  • Panthenol and other humectants offer hydration, though stronger oil-controlling ingredients would further enhance its effectiveness for your combination skin.
  • The product is safe for your skin, with no harsh ingredients that could cause irritation.

How to apply

  • Could be used as part of your AM and PM routine. Start using it 3 times a week and build up to daily use if your skin tolerates it.
  • This cleanser is the first step in your morning routine and the second step after your pre-cleanser in the evening. Always follow up with a toner and moisturizer .
  • Gently massage a small amount of the cleanser onto your face in circular motions. Avoid harsh rubbing to keep your skin calm.
  • Apply the cleanser on slightly damp skin to help it work effectively against breakouts. Rinse thoroughly with lukewarm water .
  • Avoid the immediate eye area and do a patch test before your first use to check for any sensitivity.

People Say

★4.5Overall rating based on 600+ reviews

This sulfate-free gel cleanser is highly praised by users with sensitive and reactive skin for its ability to clean effectively without causing dryness or irritation. While it is celebrated for calming redness and maintaining skin balance, some users remain skeptical about the actual impact of its prebiotic/postbiotic ingredients given the short contact time during washing.

Highlights

  • Gentle on skin Often Mentioned
    • “Love it for my super sensitive skin.”
    • “Genuinely gentle, sulfate-free daily gel cleanser.”
    • “Gentle on sensitive skin.”
  • Non-stripping formula Often Mentioned
    • “Cleans without stripping and leaves skin soft.”
    • “Clears away dirt without stripping natural oils.”
    • “Cleanses without leaving your skin tight or dry.”
  • Calms redness/irritation Sometimes Noted
    • “Soothes redness and limits inflammation.”
    • “Calms the look of redness.”
  • Fragrance-free Sometimes Noted
    • “I loved the cleanser because it was fragrance-free.”
    • “Fragrance-free and safe for sensitive skin.”
    • “Free of artificial fragrances.”
  • Potential for sensitivity Rarely Noted
    • “Lemongrass extract that the most fragrance-reactive skin should patch test.”
    • “Should patch test first.”
  • Questionable biome claims Rarely Noted
    • “The prebiotic-postbiotic biome angle is more concept than payoff.”
    • “Prebiotics have little contact time.”
    • “Microbiome claim is hard to verify.”
  • Scent formula changes Rarely Noted
    • “What happened??? The scent...”
    • “Derma E reformulated their cleanser, so I need a replacement.”
    • “The scent is different now.”

Sources: lovi.care, walmart.com, lovelyskin.com, dermapproved.com, reddit.com, target.com, and more

Questions and answers

What makes DERMA E Pure Biome Balancing Cleanser a great fit for acne-prone skin?

DERMA E Pure Biome Balancing Cleanser is a great fit because gentle cleansers and hydrators clean without stripping, while Centella Asiatica helps calm red, angry blemishes. It has a very safe formula with no harsh ingredients, making it unlikely to cause irritation on sensitive skin.

Molecules, 2023Indian Journal of Pharmaceutical Sciences, 2016

Which ingredients make this cleanser a good fit for acne-prone skin?

This cleanser is a great fit for your acne-prone skin because decyl glucoside and glycerin clean gently while keeping skin hydrated, and Centella Asiatica and Ganoderma Lucidum Extract help calm blemishes and reduce inflammation. It is also safe and unlikely to cause irritation, though adding stronger oil-controlling ingredients would make it even more effective for your skin.

Molecules, 2023Indian Journal of Pharmaceutical Sciences, 2016

What does Centella Asiatica do for acne-prone skin?

Centella asiatica helps acne-prone skin by reducing redness, calming swelling, and supporting the skin barrier to keep it healthy. It is unlikely to cause irritation and may improve acne symptoms and overall skin appearance.

Molecules, 2023Indian Journal of Pharmaceutical Sciences, 2016

What does Lactobacillus Ferment do for acne-prone skin?

Lactobacillus Ferment helps calm acne-prone skin by supporting a balanced skin barrier and reducing irritation. Probiotics and ferments of this type are unlikely to cause issues and may help keep breakouts under control.

Journal of Experimental Pharmacology, 2025Journal of Cosmetic Dermatology, 2025

Where does this cleanser go in a skincare routine for acne-prone skin?

This cleanser is used as the first step in your morning routine and the second step in your evening routine after removing makeup. It gently cleanses your acne-prone skin with mild ingredients while providing soothing hydration and calming benefits.

Can I use this cleanser with retinol, and in what order?

You can use this cleanser with retinol by applying the cleanser first on your damp skin, rinsing it off, and then following with your retinol treatment once your face is completely dry. Gentle cleansers like this help keep your skin calm while you use strong treatments, and are unlikely to cause irritation.

Journal of Drugs in Dermatology, 2023American Journal of Clinical Dermatology, 2002

How often should I use this cleanser?

You can use this cleanser twice a day as part of your morning and evening routine. It has a great safety profile for acne-prone skin, with no harsh ingredients that may cause irritation.

The Journal of Dermatological Treatment, 2022

Can this cleanser clog pores, cause breakouts or purging for acne-prone skin?

This cleanser is unlikely to clog pores or cause breakouts on acne-prone skin because it avoids harsh ingredients that trigger irritation. Centella asiatica and other calming ingredients help keep blemishes in check while you wash.

Molecules, 2023Indian Journal of Pharmaceutical Sciences, 2016

Can I use this cleanser around the eyes or on my body?

You can use this cleanser on your body, but you should be careful around the thin skin of your eyes. Its gentle ingredients like panthenol help keep skin hydrated and are unlikely to cause irritation.

Surgical and Radiologic Anatomy, 2002American Journal of Clinical Dermatology, 2002

Is this cleanser fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Stearyl alcohol is a fatty alcohol, which soften the skin.

What the research says

  • Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

    Molecules, 2023

  • Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

    Indian Journal of Pharmaceutical Sciences, 2016

  • Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

    American Journal of Clinical Dermatology, 2002

  • A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

    The Journal of Dermatological Treatment, 2017

  • A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

    Journal of Cosmetic Dermatology, 2025

  • Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

    Journal of Alternative and Complementary Medicine, 2020

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

    Journal of Cosmetic Dermatology, 2019

  • Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects.

    Rejuvenation Research, 2015

  • A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects.

    Journal of Ginseng Research, 2022

  • A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline.

    Journal of Toxicology and Environmental Health. Part A, 2020

  • Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction.

    Journal of Clinical and Diagnostic Research, 2017

  • Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo.

    Experimental Dermatology, 2009

  • An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne.

    Clinical, Cosmetic and Investigational Dermatology, 2019

  • The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

    Journal of Cosmetic Dermatology, 2020

  • Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

    International Journal of Cosmetic Science, 2001

  • Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

    Journal of Drugs in Dermatology, 2012

  • Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.

    Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016

  • A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.

    Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

  • An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment.

    Aesthetic Plastic Surgery, 2018

Ingredients

Water, Glycerin, Decyl Glucoside, Stearyl Alcohol, Panthenol, Centella Asiatica Cell Culture Meristem Cell Culture, Inulin, Ganoderma Lucidum Extract Mushroom Extract, Lactobacillus Panax Ginseng Root Extract Ferment Filtrate, Xanthophyll Lutein, Cucumis Sativus Fruit Extract, Panax Quinquefolius Root Extract Panax Ginseng Root Extract, Camellia Sinensis Leaf Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Ombopogon Schoenanthus Extract, Allantoin, Aloe Barbadensis Leaf Juice, Pinus Pinaster Bark Extract, Glyceryl Stearate Citrate, Xanthan Gum, Sucrose, Tapioca Starch, Potassium Sorbate, Phenoxyethanol, Ethylhexylglycerin

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

Scan your face, then any product.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play

How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play