# Clinique Smart Clinical Repair Wrinkle Correcting Cream for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Clinique](https://lovi.care/skincare/it/brands/clinique)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as glycerin and sodium hyaluronate provide essential hydration, but the formula lacks sufficient ingredients for effective oil control to address your acne concerns.
- The presence of acetyl hexapeptide-8 and other peptides offers excellent moisturizing and wrinkle-correcting benefits, which are supportive but not targeted for your primary goal of managing acne, blemishes, and breakouts.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Cl1870 Peptide Complex, Sodium Hyaluronate, Acetyl Hexapeptide-8, Palmitoyl Tetrapeptide-7, Soybean Seed Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- ANT1 soybean extract cream ameliorated complications and enhanced skin recovery after Nd:YAG laser therapy in 45 Asian women, with higher concentrations significantly reducing wrinkles, spots, and pores compared to placebo. ([Annals of Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29369914/))
- Genistein and daidzein inhibited UVB-induced hydrogen peroxide production in keratinocytes acting as free radical scavengers with negligible skin disruption, whereas glycitein showed no protective activity. ([International Journal of Pharmaceutics, 2008](https://pubmed.ncbi.nlm.nih.gov/18761396/))
- A phytoestrogen-enriched cosmetic formulation containing biotransformed soybean extract increased collagen-I expression in fibroblast cells and skin explants in an estrogen receptor beta-dependent manner without harming skin microbiota. ([Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas E Biologicas, 2023](https://pubmed.ncbi.nlm.nih.gov/37878883/))

## Why other moisturizers fit acne-prone skin better

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35763437/))

## What reviewers say

Based on a very large amount of data, users find this cream to be deeply hydrating with a pleasant, lightweight texture that absorbs well and is suitable for sensitive skin due to its fragrance-free formula. Many report smoother, plumper skin and improved hydration. However, results for reducing deep wrinkles are inconsistent, with some users seeing significant improvement while others experience only basic moisturization.

- Liked: Deeply hydrating (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Fragrance-free, gentle (sometimes noted)
- Liked: Smoothes fine lines (sometimes noted)
- Disliked: Limited anti-aging (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Not rich enough (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Smart Clinical Repair Wrinkle Correcting Cream work for acne-prone skin?

This cream works for acne-prone skin with moderate suitability, providing essential hydration while lacking sufficient ingredients for effective oil control. A product of this type needs effective ingredients that provide excellent benefits for acne and blemishes, alongside soothing extracts and oil-controlling agents to manage breakouts.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for acne-prone skin?

Glycerin and sodium hyaluronate make this cream a moderate fit for your acne-prone skin by providing essential hydration, though other products fit it better. A product of this type needs targeted ingredients for oil control and soothing extracts to properly manage breakouts and blemishes.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Cl1870 Peptide Complex do for acne-prone skin?

Cl1870 Peptide Complex helps acne-prone skin by supporting the skin barrier and reducing breakouts without irritation. This type of ingredient works well for acne-prone skin when it contains soothing and barrier-strengthening additions like ceramides and niacinamide.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32697858/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this cream go in a skincare routine for acne-prone skin?

This moisturizing treatment goes near the end of your morning and evening routines, right before sunscreen in the morning. While it provides good hydration and smoothing benefits, acne-prone skin needs a product of this type that also includes oil-controlling ingredients to properly manage breakouts.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol, applying it after your retinol treatment to help keep your skin soft and reduce potential dryness or irritation. This type of product needs to also include ingredients that help balance oil and target breakouts to be a great fit for acne-prone skin.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22648223/)

### How often should I use this cream?

This cream works well when applied twice a day as part of your daily routine. Regular use helps keep your skin soft and hydrated while smoothing out wrinkles, though acne-prone skin also needs targeted oil-control ingredients to properly manage breakouts.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream works for acne-prone skin, but other products may fit it better because it lacks oil-control ingredients. It is unlikely to cause irritation or breakouts, but acne-prone skin needs lightweight, non-greasy moisturizers with blemish-fighting ingredients like salicylic acid or niacinamide to help keep pores clear.

### Can I use this cream around the eyes or on my body?

This moisturizing treatment is safe to use around the eyes, though the skin there is very thin and requires gentle care. An eye cream of this type needs lightweight hydrators and peptide ingredients to smooth and support this delicate area.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol and cetyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for acne-prone skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €18.06 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/it/p/cosrx/advanced-snail-96-mucin-power-essence/for/acne-prone-skin) — Superior fit — €12.09 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/it/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin) — Superior fit — €92.92 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/it/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.43 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/acne-prone-skin) — Superior fit — €103.91 at Amazon
- SPF: [SKIN1004 Madagascar Centella Air-Fit Suncream Plus](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/acne-prone-skin) — Superior fit — €16.03 at Amazon

## Where to buy

- Amazon.it: €66.49 (https://www.amazon.it/dp/B0B729HMJY?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Notino: €79.00 (https://www.notino.it/clinique/smart-clinical-repair-collagen-pdrn-cream-crema-leggera-antirughe/p-16402594/)
- Lookfantastic: €80.50 (https://www.lookfantastic.it/p/clinique-smart-clinical-repair-wrinkle-correcting-cream-all-skin-types-50ml/13760615/)
Prices checked 10 Oct – 23 Oct 2026.

## Ingredients

Water, Glycerin, Isostearyl Neopentanoate, Butylene Glycol, Glyceryl Stearate, Peg-100 Stearate, Dimethicone, Cetearyl Alcohol, Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Aminopropyl Ascorbyl Phosphate, Palmitoyl Tetrapeptide-7, Algae Extract, Sodium Hyaluronate, Palmitoyl Hexapeptide-12, Sigesbeckia Orientalis Extract, Whey Lactis Protéine Du Petit-Lait Protein, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetyl Glucosamine, Caffeine, Palmitoyl Tripeptide-1, Glycine Soja Seed Extract Soybean Seed Extract, Cetearyl Glucoside, Tocopheryl Acetate, Isohexadecane, Petrolatum, Caprylyl Glycol, Glycereth-26, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Glyceryl Polymethacrylate, Peg-8, Polysorbate 20, Hexylene Glycol, Polysorbate 80, Carbomer, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, Sorbitan Oleate, Cetyl Alcohol, Sodium Citrate, Disodium Edta, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/clinique/smart-clinical-repair-wrinkle-correcting-cream/for/acne-prone-skin