# CLEARSTEM CELLRENEW Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [CLEARSTEM](https://lovi.care/skincare/it/brands/clearstem)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your normal skin, as Camellia Sinensis and Sodium Hyaluronate provide antioxidant protection and hydration, which can help soothe redness and irritation.
- Aloe Barbadensis and Panthenol B5 further support calming effects and hydration, though the concentration of Ganoderma Lucidum and Curcuma Longa may offer limited additional benefits for your specific concerns.
- The product is safe for your sensitive skin, containing soothing ingredients like Camellia Sinensis and Aloe Barbadensis with no harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Ganoderma Lucidum, Bio-Available Collagen Cells Stem, Antioxidants, Curcuma Longa

## What the research says

- Topical application of (-)-epigallocatechin-3-gallate (EGCG) to human skin before UV irradiation decreases UV-induced production of hydrogen peroxide by 68-90% and nitric oxide by 30-100%, inhibits leukocyte infiltration and lipid peroxidation by 41-84%, and restores glutathione levels and glutathione peroxidase activity compared to UV exposure alone. ([Carcinogenesis, 2001](https://pubmed.ncbi.nlm.nih.gov/11181450/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of soap enriched with Ganoderma lucidum and goat's milk for 3 days resulted in almost complete regression of annular cutaneous sarcoidosis lesions in a 44-year-old male patient. ([Dermatology and Therapy, 2016](https://pubmed.ncbi.nlm.nih.gov/26868374/))
- Ganoderma lucidum polysaccharides at concentrations of 10, 20, and 40 ΓΖg/mL significantly increased fibroblast viability, migration, and CICP and TGF-Β1 expression compared to the control group, and external use in mice significantly increased wound healing rates and reduced healing time. ([Chinese Journal of Integrative Medicine, 2019](https://pubmed.ncbi.nlm.nih.gov/30552545/))
- Ethanolic extracts of Ganoderma lucidum rich in triterpenoids and phenolic acids exhibit antioxidant, anti-inflammatory, antityrosinase, antimicrobial, and cytotoxic effects, and can be successfully incorporated into topical cosmeceutical formulations while preserving their bioactivities. ([Food and Chemical Toxicology, 2017](https://pubmed.ncbi.nlm.nih.gov/28760544/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties. ([Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/38008088/))
- Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models. ([Drug Discovery Today, 2017](https://pubmed.ncbi.nlm.nih.gov/28711364/))
- A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation. ([Saudi Pharmaceutical Journal, 2024](https://pubmed.ncbi.nlm.nih.gov/38178851/))

## What reviewers say

Based on a very large amount of data, users with acne-prone, sensitive, and reactive skin highly praise this product for calming inflammation, improving hydration, and supporting skin barrier repair. Many report smoother texture and reduced redness. Some users note it is a gentle, long-term support product rather than an overnight solution for deep-seated skin concerns.

- Liked: Acne-safe formula (mostly mentioned)
- Liked: Calms inflammation (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Deeply hydrating (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Slow visible results (sometimes noted)
- Disliked: Insufficient for severe acne (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does CLEARstem CELLRENEW Serum work for sensitive skin?

This serum works moderately well for sensitive skin, offering hydration and calming redness through ingredients like Camellia Sinensis, sodium hyaluronate, and panthenol. It is safe to use, but to get a better fit, this skin needs a treatment that relies on ingredients like niacinamide and snail secretion filtrate to deeply soothe irritation and support skin health without risks.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Which ingredients make this serum a good fit for sensitive skin?

This serum fits sensitive skin because it contains soothing ingredients like green tea, aloe, and panthenol that help calm redness and irritation without harsh substances. To fit this skin even better, a treatment of this type needs highly compatible, potent antioxidants, hydrating components, and skin-repairing ingredients that target redness while completely avoiding any risk of irritation.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### What does Reishi Mushroom Extract do for sensitive skin?

Reishi Mushroom Extract helps calm sensitive skin by reducing irritation and soothing redness. It provides strong antioxidant support that protects stressed skin from daily damage.
Sources: [International Journal of Medicinal Mushrooms, 2022](https://pubmed.ncbi.nlm.nih.gov/35993963/), [Advances in Experimental Medicine and Biology, 2019](https://pubmed.ncbi.nlm.nih.gov/31777026/)

### Where does it go in a skincare routine for sensitive skin?

For sensitive skin, apply this treatment in the evening after cleansing and toning, and before moisturizing. To best care for sensitive skin, look for products of this type that feature gentle hydrators and soothing plant extracts like aloe and green tea to calm redness without harsh ingredients.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying the treatment after your soothing toner and before your moisturizer in your evening routine, while ensuring you also use a soothing regimen to help calm any sensitivity. This type of sensitive skin needs gentle, hydrating ingredients like panthenol and aloe vera to keep the skin calm and protected.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use it?

This treatment is applied in the evening as part of your routine for sensitive skin. While it is safe and provides gentle hydration, a product for this skin needs richer soothing ingredients and higher levels of calming plant extracts to work best.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin, as it contains soothing ingredients like green tea and aloe with no harsh substances. However, because it offers only an average fit, sensitive skin needs a treatment with higher concentrations of calming plant extracts and deeper hydration to truly prevent irritation.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €129.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €35.10 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €17.59 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €30.10 at Amazon
- Moisturizer with Sun Protection: [Clinique Mineral Sunscreen Fluid for Face SPF 50](https://lovi.care/skincare/it/p/clinique/broad-spectrum-spf-50-mineral-sunscreen-fluid-for-face/for/sensitive-skin) — Superior fit — €19.21 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Antioxidants, Camellia Sinensis, Sodium Hyaluronate, Ganoderma Lucidum, Curcuma Longa, Trifolium Pratense, Peppermint Essence, Curcuma Extract, Aloe Barbadensis, Panthenol B5, Bio-Available Collagen Cells Stem, Kunzea Pomifera Fruit Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/clearstem/cellrenew-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/clearstem/cellrenew-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/clearstem/cellrenew-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/clearstem/cellrenew-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/clearstem/cellrenew-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/clearstem/cellrenew-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/clearstem/cellrenew-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/clearstem/cellrenew-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/clearstem/cellrenew-serum/for/sensitive-skin