Clé de Peau Beauté La Crème for mature skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• A topical formulation containing panthenol, niacinamide, and dipotassium glycyrrhizate increased skin hydration by 74.1% and reduced transepidermal water loss by 13.5% at 28 days compared to baseline and untreated control in 35 individuals with xerosis.

  Journal of Cosmetic Dermatology, 2026

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism.

  Evidence-based Complementary and Alternative Medicine, 2015

• Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo.

  Experimental Dermatology, 2015

• Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide.

  Advanced Science, 2025

• Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question.

  The Journal of Clinical and Aesthetic Dermatology, 2021

• A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women.

  The British Journal of Dermatology, 2010

• A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation.

  International Journal of Cosmetic Science, 2024

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

Ingredients

Water, Pentaerythrityl Tetraethylhexanoate, Glycerin, Butylene Glycol, Triisostearin, Squalane, Behenyl Alcohol, Trehalose, Isodecyl Neopentanoate, Petrolatum, Dimethicone, Maltitol, Potassium Methoxysalicylate, Hydrogenated Polyisobutene, Stearyl Alcohol, Myristyl Myristate, Beheneth-20, Phenoxyethanol, Butyrospermum Parkii Butter Shea Butter, Silica, Theanine, Dimethylacrylamide Sodium Acryloyldimethyltaurate Crosspolymer, Microcrystalline Wax Cera Microcristallina Cire Microcristalline Wax Cera, Caprylic Capric Triglyceride, Phytosteryl Macadamiate, Trisodium Edta, Polyvinyl Alcohol, Peg Ppg-14 7 Dimethyl Ether, Peg Ppg-17 4 Dimethyl Ether, Tocopheryl Acetate, Retinyl Acetate, Parfum, Sodium Citrate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Alcohol, Bht, Hydrogenated Oil, Citric Acid, Sodium Metabisulfite, Sodium Metaphosphate, Ectoin, Dipotassium Glycyrrhizate, Iron Oxides Ci 77492, Hexyl Cinnamal, Citronellol, Alpha-Isomethyl Ionone, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Limonene, Linalool, Lilium Candidum Bulb Extract, Geraniol, Angelica Acutiloba Root Extract, Benzyl Benzoate, Hydrolyzed Silk, Olea Europaea Leaf Extract Olive Leaf Extract, Iris Florentina Root Extract, Paeonia Albiflora Root Extract, Sanguisorba Officinalis Root Extract, Crataegus Monogyna Flower Extract, Fagus Sylvatica Bud Extract, Panax Ginseng Root Extract, Glycine, Rubus Suavissimus Leaf Extract Raspberry Leaf Extract, Inositol, Tocopherol, Pinus Sylvestris Cone Extract, Camellia Sinensis Leaf Extract, Rosamarinus Officinalis Leaf Extract Rosemary Leaf Extract, Iron Oxides Ci 77491, Rosa Canina Fruit Extract, Perilla Ocymoides Leaf Extract, Serine, Zingiber Aromaticus Extract, Sodium Acetylated Hyaluronate, Isostearic Acid, Hydrolyzed Yeast, Benzoic Acid, Hydrolyzed Conchiolin Protein, Lauryl Betaine, Potentilla Erecta Root Extract, Polysorbate 20, Uncaria Gambir Extract, Sodium Carboxymethyl Beta-Glucan, Centaurea Cyanus Flower Extract, Bupleurum Falcatum Root Extract, Sodium Benzoate

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.