# Cetaphil Healthy Renew Face Serum for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/cetaphil/healthy-renew-face-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Cetaphil](https://lovi.care/skincare/it/brands/cetaphil)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your oily skin, this serum leverages niacinamide for effective oil control and inflammation reduction, addressing your concerns with acne, blemishes, and breakouts.
- The inclusion of panthenol and rice extract lees extract further supports skin barrier resilience and provides humectant action, enhancing overall skin health for your oily skin type.
- The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/cetaphil/healthy-renew-face-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/cetaphil/healthy-renew-face-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/cetaphil/healthy-renew-face-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/cetaphil/healthy-renew-face-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/cetaphil/healthy-renew-face-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/cetaphil/healthy-renew-face-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/cetaphil/healthy-renew-face-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/cetaphil/healthy-renew-face-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/cetaphil/healthy-renew-face-serum/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Peptides, Niacinamide, Panthenol, Rice Extract Lees Extract, Leontopodium Alpinum Extract

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Daily application of a cream containing niosomes loaded with purple glutinous rice extract in 20 human volunteers for 28 days resulted in a significant decrease in melanin index and skin roughness by -14.05% and -9.95%, and increases in skin hydration and elastic recovery by +48.73% and +35.98% compared to initial values. ([International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32812663/))
- The iontophoretic delivery of hyaluronic acid nanogel-loaded Saccharomyces/Rice Ferment Filtrate significantly reduced advanced glycation end products and mitigated skin stiffening in an ex vivo skin tissue glycation model. ([International Journal of Nanomedicine, 2025](https://pubmed.ncbi.nlm.nih.gov/40989892/))
- Red rice extract suppressed UVB-induced inflammation and skin aging in human skin fibroblasts by inhibiting the MAPK signaling pathway, leading to decreased NF-kappa B and AP-1 activation, reduced ECM degradation, and increased ECM synthesis compared to UVB-irradiated controls. ([Natural Product Communications, 2016](https://pubmed.ncbi.nlm.nih.gov/30508356/))
- Leontopodium alpinum callus culture extract improved anti-periorbital wrinkles, skin elasticity, dermal density, skin thickness, antioxidant activity, and moisturizing activity while suppressing inflammation and wrinkling compared to placebo and in response to UVB treatment. ([Genes, 2020](https://pubmed.ncbi.nlm.nih.gov/32098197/))
- Leontopodium alpinum callus culture extract at 10-15 mg/mL promoted COL-I production and inhibited MMP-1, OPN3, ROS, and calcium influx in a blue-light-induced human foreskin fibroblast damage model, indicating an anti-blue-light-damage effect through the OPN3-calcium pathway. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/36903418/))
- A concentrated ethanol extract of Edelweiss callus culture (ECC55) protected primary human keratinocytes and endotheliocytes against various inflammatory and oxidative stimuli by inhibiting chemokine release, restoring sirtuin-inhibited cellular markers, and suppressing inflammation-related gene expression. ([Mediators of Inflammation, 2012](https://pubmed.ncbi.nlm.nih.gov/23093820/))

## What reviewers say

Based on a very large amount of data, users with sensitive and aging skin frequently praise this serum as a gentle, effective alternative to retinol that improves skin texture without irritation. Many report a noticeable glow, increased hydration, and softer skin within weeks. Some users feel the anti-aging results are subtle compared to stronger treatments.

- Liked: Gentle on sensitive skin (mostly mentioned)
- Liked: Improves texture and glow (often mentioned)
- Liked: Lightweight and absorbent (often mentioned)
- Liked: Hydrating and softening (sometimes noted)
- Disliked: Packaging and pump issues (sometimes noted)
- Disliked: Small quantity / Low value (sometimes noted)
- Disliked: Lack of dramatic results (rarely noted)
- Disliked: Sticky or tacky finish (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Cetaphil Healthy Renew Face Serum a great fit for oily acne-prone skin?

This serum is a great fit because it uses niacinamide to help control oil and calm blemishes on oily skin. It also includes panthenol and rice extract lees extract to support a strong skin barrier and keep skin hydrated without clogging pores. The formula has an excellent safety profile, making it unlikely to cause irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

This serum is a great fit for your oily acne-prone skin because it contains niacinamide for oil control and inflammation reduction, alongside panthenol and rice extract lees extract to support your skin barrier. These ingredients help address breakouts while keeping your skin calm and healthy.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### What do Peptides do for oily acne-prone skin?

Peptides help calm oily, acne-prone skin by targeting acne-causing bacteria and reducing redness and swelling. Advanced delivery methods like nanomicelles may also improve how deeply these helpful ingredients sink into the skin.
Sources: [Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/), [Bioorganic Chemistry, 2025](https://pubmed.ncbi.nlm.nih.gov/40925226/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in the evening routine, placed after your cleansing toner and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to calm your skin and keep it hydrated. This approach helps reduce the irritation and dryness often caused by retinol while supporting your skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### How often should I use this serum?

You can use this serum in the evening as part of your routine. It is a great fit for your oily acne-prone skin, helping control oil and calm breakouts without causing irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause breakouts for oily acne-prone skin, as it uses niacinamide for oil control and inflammation reduction without harsh ingredients. It also has an excellent safety profile with no risks of irritation.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — €35.10 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — €34.95 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — €24.75 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/it/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — €29.00 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/it/p/dear-klairs/supple-preparation-unscented-toner/for/oily-acne-prone-skin) — Superior fit — €18.16 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — €18.47 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Butylene Glycol, Glycerin, Panthenol, 2-Hexanediol, Niacinamide, Cetyl Ethylhexanoate, Hydrogenated Polydecene, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Rice Extract Lees Extract, Leontopodium Alpinum Extract, Calcium Alginate, Propanediol, Hydrolyzed Soy Flour, Ethylhexylglycerin, Agar, Adenosine, Trisodium Ethylenediamine Disuccinate, Synthetic Fluorphlogopite, Caprylyl Glycol, Iron Oxides, Citric Acid, Sodium Benzoate, Potassium Sorbate, Buddleja Davidii Extract, Thymus Vulgaris Extract, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/cetaphil/healthy-renew-face-serum/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/cetaphil/healthy-renew-face-serum/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/cetaphil/healthy-renew-face-serum/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/cetaphil/healthy-renew-face-serum/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/cetaphil/healthy-renew-face-serum/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/cetaphil/healthy-renew-face-serum/for/oily-acne-prone-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/cetaphil/healthy-renew-face-serum/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/cetaphil/healthy-renew-face-serum/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/cetaphil/healthy-renew-face-serum/for/oily-acne-prone-skin
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