# Cetaphil Healthy Radiance Antioxidant-C Serum for oily acne-prone skin

**Lovi Fit: Superior fit for oily acne-prone skin.**
Oily Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/it/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Cetaphil](https://lovi.care/skincare/it/brands/cetaphil)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for oily acne-prone skin.

## Why this fit

- Excellent suitability for your oily skin and acne concerns is provided by the high concentrations of Sodium Ascorbyl Phosphate and Niacinamide, which effectively target oiliness and breakouts while offering antioxidant protection.
- The inclusion of Glycerin and various botanical extracts further supports skin hydration and soothes the skin, complementing the primary active ingredients.
- This formula is safe for your skin, with no risk of irritation due to the absence of harsh ingredients and the presence of beneficial soothing agents.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/it/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/it/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/cetaphil/healthy-radiance-antioxidant-c-serum/for/oily-acne-prone-skin): Superior (this page)

## Key ingredients

Niacinamide, Sodium Ascorbyl Phosphate Ascorbic Acid, Gentlebright Complex, Glycerin, Malva Sylvestris Flower Extract

## What the research says

- Topical combination of 5% sodium ascorbyl phosphate and 0.2% retinol reduced inflammatory acne lesions by 29.28% at 4 weeks and 63.10% at 8 weeks, outperforming either agent alone. ([International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19134126/))
- Combined ascorbyl palmitate and sodium ascorbyl phosphate treatment significantly reduced facial sebum secretions in healthy female volunteers compared to a placebo control over 90 days. ([Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Niacinamide treatment mitigated environmental stress-induced inflammatory mediators and restored Lamin B1 levels in human epidermal keratinocytes, and reduced erythema and inflammatory biomarkers in a UV challenge clinical study of 40 female panelists compared to vehicle control. ([International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32657437/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Lectins and niacinamide reversibly inhibit melanosome transfer to keratinocytes without affecting cell viability, and topical niacinamide reduces facial hyperpigmented spots in a dose-dependent and reversible manner. ([Experimental Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/15946237/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of Malva sylvestris hydroalcoholic extract and its constituent malvidin 3-glucoside reduced ear oedema, polymorphonuclear cell influx, and interleukin-1beta levels in mice with 12-O-tetradecanoylphorbol-acetate-induced ear inflammation. ([Food and Chemical Toxicology, 2013](https://pubmed.ncbi.nlm.nih.gov/23684757/))
- Topical application of hydroalcoholic extract of Malva sylvestris reduced oedema, leukocyte migration, and keratinocyte hyperproliferation in a mouse ear model of chronic skin inflammation induced by multiple applications of TPA, and caused low toxicity and reduced cell proliferation by apoptosis in HaCaT keratinocytes. ([Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2017](https://pubmed.ncbi.nlm.nih.gov/28711022/))
- Topical administration of Malva sylvestris 1% aqueous extract improved cutaneous wound healing with less fibrosis, less scar formation, and less hair follicle damage compared to control groups in male BALB/c mice. ([Iranian Journal of Basic Medical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/26221487/))

## What reviewers say

This serum is highly regarded for its gentle formulation, effectively addressing dullness, hyperpigmentation, and post-acne marks, making it suitable for sensitive and acne-prone skin. Most users appreciate its quick absorption and the resulting brighter, more radiant complexion. Some users, however, have noted an unpleasant scent and occasional issues with product oxidation or a sticky feel.

- Liked: Gentle on skin (often mentioned)
- Liked: Absorbs quickly (sometimes noted)
- Liked: Fades dark spots (sometimes noted)
- Liked: Improves radiance (sometimes noted)
- Disliked: Unpleasant smell (sometimes noted)
- Disliked: Arrives oxidized (rarely noted)
- Disliked: Can feel sticky (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Cetaphil Antioxidant-C Serum one of the best fits for oily acne-prone skin?

This serum is a great fit because high concentrations of Sodium Ascorbyl Phosphate and Niacinamide help target oiliness and breakouts while protecting your skin. Glycerin and botanical extracts add hydration and keep your skin calm with very little risk of irritation.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19134126/), [Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Sodium Ascorbyl Phosphate and Niacinamide make this serum an excellent fit because they help control oiliness and breakouts while keeping your skin calm. Glycerin and soothing plant extracts add light hydration, and the formula is very unlikely to cause irritation.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19134126/), [Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### What does Sodium Ascorbyl Phosphate do for oily acne-prone skin?

Sodium ascorbyl phosphate helps oily acne-prone skin by providing antimicrobial action and preventing sebum oxidation. It may also significantly reduce acne breakouts and improve skin clarity.
Sources: [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492184/), [Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20367669/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in your evening routine, applied after cleansing and before moisturizing. While this routine placement is chosen for simplicity and extra safety around sun exposure, this formula is unlikely to cause irritation and may also be used in the morning.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this treatment in your morning routine and your retinol at night. Using them at different times of day helps keep your oily skin clear and protects against irritation from harsh active ingredients.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19134126/)

### How often should I use this serum?

You can use this serum in your evening routine, and some people may also use it in the morning or twice a day. It is unlikely to cause irritation on oily acne-prone skin.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19134126/), [Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause breakouts on oily, acne-prone skin because it contains ingredients like niacinamide and sodium ascorbyl phosphate that help control oil and target breakouts safely without harshness.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19134126/), [Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for oily acne-prone skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — €35.10 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — €34.95 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/it/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — €24.75 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/it/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — €29.00 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/it/p/dear-klairs/supple-preparation-unscented-toner/for/oily-acne-prone-skin) — Superior fit — €18.16 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — €18.47 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Sodium Ascorbyl Phosphate, Methyl Gluceth-20, Butylene Glycol, Bis-Peg-18 Methyl Ether Dimethyl Silane, Niacinamide, Glycerin, Citric Acid, Xanthan Gum, Phenoxyethanol, Sorbitan Oleate Decylglucoside Crosspolymer, Hydroxyacetophenone, Alcohol, Disodium Edta, Sodium Pca, Caprylyl Glycol, Malva Sylvestris Stem Extract Flower Leaf, Peppermint Leaf Extract, Primula Veris Flower Extract, Alchemilla Vulgaris Stem Extract Flower Leaf, Veronica Officinalis Stem Extract Flower Leaf, Melissa Officinalis Leaf Extract, Achillea Millefolium Stem Extract Flower Leaf, Erythritol, Chondrus Crispus, Grapefruit Peel Extract, Citrus Aurantium Dulcis Peel Extract, Benzoic Acid, Sodium Hydroxide, Sorbic Acid, Lemon Peel Extract, Bht
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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