Cetaphil Healthy Radiance Antioxidant-C Serum for skin with dark spots

How to apply

Questions and answers

What the research says

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• The tetrapeptide PKEK exerts skin whitening effects by reducing UVB-stimulated mRNA expression of pigmentation-inducing mediators like POMC and tyrosinase, and significantly fades facial pigment spots when combined with sodium ascorbyl phosphate.

  Experimental Dermatology, 2012

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening.

  Dermatologic Therapy, 2022

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

  Journal of Cosmetic and Laser Therapy, 2006

• A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability.

  Journal of Cosmetic Science, 2020

• Lectins and niacinamide reversibly inhibit melanosome transfer to keratinocytes without affecting cell viability, and topical niacinamide reduces facial hyperpigmented spots in a dose-dependent and reversible manner.

  Experimental Dermatology, 2005

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Topical application of Malva sylvestris hydroalcoholic extract and its constituent malvidin 3-glucoside reduced ear oedema, polymorphonuclear cell influx, and interleukin-1beta levels in mice with 12-O-tetradecanoylphorbol-acetate-induced ear inflammation.

  Food and Chemical Toxicology, 2013

• Topical application of hydroalcoholic extract of Malva sylvestris reduced oedema, leukocyte migration, and keratinocyte hyperproliferation in a mouse ear model of chronic skin inflammation induced by multiple applications of TPA, and caused low toxicity and reduced cell proliferation by apoptosis in HaCaT keratinocytes.

  Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2017

• Topical administration of Malva sylvestris 1% aqueous extract improved cutaneous wound healing with less fibrosis, less scar formation, and less hair follicle damage compared to control groups in male BALB/c mice.

  Iranian Journal of Basic Medical Sciences, 2015

Ingredients

Water, Sodium Ascorbyl Phosphate, Methyl Gluceth-20, Butylene Glycol, Bis-Peg-18 Methyl Ether Dimethyl Silane, Niacinamide, Glycerin, Citric Acid, Xanthan Gum, Phenoxyethanol, Sorbitan Oleate Decylglucoside Crosspolymer, Hydroxyacetophenone, Alcohol, Disodium Edta, Sodium Pca, Caprylyl Glycol, Malva Sylvestris Stem Extract Flower Leaf, Peppermint Leaf Extract, Primula Veris Flower Extract, Alchemilla Vulgaris Stem Extract Flower Leaf, Veronica Officinalis Stem Extract Flower Leaf, Melissa Officinalis Leaf Extract, Achillea Millefolium Stem Extract Flower Leaf, Erythritol, Chondrus Crispus, Grapefruit Peel Extract, Citrus Aurantium Dulcis Peel Extract, Benzoic Acid, Sodium Hydroxide, Sorbic Acid, Lemon Peel Extract, Bht

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.