Centellian24 Madeca Cream for acne-prone skin

How to apply

Questions and answers

What the research says

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• Chitosan-based hydrogels loaded with asiaticoside-rich Centella asiatica extract achieved controlled drug release, skin permeability, antimicrobial activity, and synergistic wound healing effects in an in vitro model.

  International Journal of Molecular Sciences, 2023

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• Treatment with an asiaticoside-containing cream applied twice daily for 12 weeks significantly improved periorbital wrinkles in 65% of 27 female volunteers compared to a vehicle control cream.

  International Journal of Cosmetic Science, 2008

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

Ingredients

Centella Asiatica Extract, Cyclohexasiloxane, Niacinamide, Dicaprylyl Ether, 1,2-Hexanediol, C14-22 Alcohols, Dipropylene Glycol, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Ficus Carica Fruit Extract, Monarda Didyma Leaf Extract, Chrysanthemum Parthenium Extract Feverview Extract, Salvia Officinalis Leaf Water, Water-Soluble Collagen, Citrus Aurantium Dulcis Peel Oil, Hydrogenated Lecithin, Olea Europaea Oil Fruit Olive Oil Fruit, Centella Asiatica Oil, Polyglyceryl-10 Laurate, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Water, Dimethicone Vinyl Dimethicone Crosspolymer, Polyisobutene, C12-20 Alkyl Glucoside, Glyceryl Stearate Se, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Beta-Glucan, Sorbitan Oleate, Caprylyl Capryl Glucoside, Adenosine, Fructooligosaccharides, Sodium Stearoyl Glutamate, Disodium Edta, Glycerin, Sodium Laurate, Allantoin, Hydrolyzed Hyaluronic Acid, Lauric Acid, Madecassic Acid, Asiaticoside, Glucose, Asiatic Acid, Ceramide Np, Soluble Proteoglycan, Elastin, Sodium Hyaluronate, Polysorbate 60, Ethylhexylglycerin, Limonene

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.