# BY ECOM Heartleaf Ampoule for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/by-ecom/heartleaf-ampoule/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: BY ECOM
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin, this ampoule leverages Glycerin and Sodium Hyaluronate to provide essential hydration and support your skin barrier. The inclusion of Centella Asiatica Extract and Willow Bark Extract effectively addresses your concerns with redness and irritation by calming inflammation and decongesting pores.
- The formulation also contains Glycyrrhiza Glabra Root Extract, which further aids in soothing your sensitive skin and reducing inflammation.
- This product is safe for your sensitive skin as it avoids harsh ingredients and includes beneficial soothing agents like Centella Asiatica Extract and Anthemis Nobilis Flower Extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/by-ecom/heartleaf-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/by-ecom/heartleaf-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/by-ecom/heartleaf-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/by-ecom/heartleaf-ampoule/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/it/p/by-ecom/heartleaf-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/by-ecom/heartleaf-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/by-ecom/heartleaf-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/by-ecom/heartleaf-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/by-ecom/heartleaf-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Heartleaf Extract, Sodium Hyaluronate, Glycerin, Centella Asiatica Extract, Curcuma Longa Root Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream. ([Clinical, Cosmetic and Investigational Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27013898/))
- Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution. ([Molecules, 2019](https://pubmed.ncbi.nlm.nih.gov/31238562/))
- Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration. ([Gels, 2023](https://pubmed.ncbi.nlm.nih.gov/37754433/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties. ([Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/38008088/))
- Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models. ([Drug Discovery Today, 2017](https://pubmed.ncbi.nlm.nih.gov/28711364/))
- A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation. ([Saudi Pharmaceutical Journal, 2024](https://pubmed.ncbi.nlm.nih.gov/38178851/))

## What reviewers say

Users with oily and acne-prone skin frequently report that this ampoule effectively soothes inflammation and provides a cooling sensation. A moderate number of users also find it hydrating and notice some pore refining effects. A significant minority of reviewers mention a sticky finish and a strong alcohol scent, with some experiencing irritation or breakouts. Results for pore shrinking are mixed.

- Liked: Hydrating texture (often mentioned)
- Liked: Soothing and calming (often mentioned)
- Liked: Aesthetic packaging (sometimes noted)
- Liked: Pore refining (sometimes noted)
- Disliked: Alcohol scent (sometimes noted)
- Disliked: Pore claims weak (sometimes noted)
- Disliked: Sticky finish (sometimes noted)
- Disliked: Caused irritation (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes BY ECOM Heartleaf Ampoule a great fit for sensitive skin?

This ampoule is a great fit because it uses gentle ingredients like Glycerin and Sodium Hyaluronate to keep your skin hydrated while strengthening its barrier. It also helps calm redness and irritation using Centella Asiatica Extract and Willow Bark Extract.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for sensitive skin?

This serum is a great fit for sensitive skin because it uses glycerin and sodium hyaluronate to bring in moisture and support your skin barrier, while centella asiatica extract and willow bark extract help calm redness and irritation. It also includes licorice root extract and chamomile flower extract, which are soothing ingredients that are safe and gentle for easily upset skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Heartleaf Extract do for sensitive skin?

Heartleaf Extract helps calm sensitive, easily irritated skin by soothing redness and lowering inflammation. It also protects skin cells from everyday damage and oxidative stress.
Sources: [Antioxidants, 2022](https://pubmed.ncbi.nlm.nih.gov/35204104/), [Plants, 2021](https://pubmed.ncbi.nlm.nih.gov/34961096/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### Where does this serum go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Putting it in the evening helps keep things simple and safe around sun exposure, though some treatments can also be used in the morning.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this soothing treatment after your retinol to help calm any dryness or redness. This product is very suitable for sensitive skin because it avoids harsh ingredients and uses calming components like Centella Asiatica Extract and Glycerin to support the skin barrier.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### How often should I use this serum?

This ampoule is a great fit for your sensitive skin and is designed to be used in the evening during your routine. Using it daily helps deliver soothing hydration while keeping your skin calm and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This ampoule is unlikely to clog pores or cause breakouts for sensitive skin, as it avoids harsh ingredients and features soothing extracts like Centella Asiatica that help calm redness and irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €129.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €35.10 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €17.59 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/it/p/pixi/milky-tonic/for/sensitive-skin) — Superior fit — €30.10 at Amazon
- Moisturizer with Sun Protection: [Clinique Mineral Sunscreen Fluid for Face SPF 50](https://lovi.care/skincare/it/p/clinique/broad-spectrum-spf-50-mineral-sunscreen-fluid-for-face/for/sensitive-skin) — Superior fit — €19.21 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Houttuynia Cordata Extract, Methylpropanediol, Butylene Glycol, Glycerin, 2-Hexanediol, Cyclohexasiloxane, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Camellia Sinensis Leaf Extract, Centella Asiatica Extract, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Lemon Fruit Extract, Monarda Didyma Leaf Extract, Citrus Aurantium Dulcis Fruit Extract, Anthemis Nobilis Flower Extract, Avena Sativa Kernel Extract Oat Kernel Extract, Pteris Multifida Extract, Cynara Scolymus Leaf Extract, Curcuma Longa Root Extract, Ocimum Sanctum Leaf Extract, Chestnut Shell Extract, Piper Methysticum Stem Extract Root Leaf, Panax Ginseng Extract Berry, Corallina Officinalis Extract, Willow Bark Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Paeonia Albiflora Root Extract, Cnidium Officinale Root Extract, Pueraria Thunbergiana Root Extract, Portulaca Oleracea Extract, Enantia Chlorantha Bark Extract, Persea Gratissima Fruit Extract Avocado Fruit Extract, Hydrogenated Lecithin, Sodium Hyaluronate, Water-Soluble Collagen, Aloe Barbadensis Leaf Juice, Sh-Polypeptide-19, Ammonium Acryloyldimethyltaurate Vp Copolymer, Xanthan Gum, Water, Carbomer, Fructooligosaccharides, Beta-Glucan, Disodium Edta, Tromethamine, Polyquaternium-51, Hydrolyzed Hyaluronic Acid, Alcohol, Lecithin, Pistacia Lentiscus Gum, Maltodextrin, Sodium Phosphate, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Oleanolic Acid, Ethylhexylglycerin, Caprylyl Glycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/by-ecom/heartleaf-ampoule/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/by-ecom/heartleaf-ampoule/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/by-ecom/heartleaf-ampoule/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/by-ecom/heartleaf-ampoule/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/by-ecom/heartleaf-ampoule/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/by-ecom/heartleaf-ampoule/for/sensitive-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/by-ecom/heartleaf-ampoule/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/by-ecom/heartleaf-ampoule/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/by-ecom/heartleaf-ampoule/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/by-ecom/heartleaf-ampoule/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/by-ecom/heartleaf-ampoule/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/by-ecom/heartleaf-ampoule/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/by-ecom/heartleaf-ampoule/for/sensitive-skin