# Biotulin Supreme Skin Gel for oily skin

**Lovi Fit: Average fit for oily skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Biotulin](https://lovi.care/skincare/it/brands/biotulin)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily skin; other serums fit it better.

## Why this fit

- Offers moderate plumping and hydration for your oily skin due to glycerin and sodium hyaluronate, which help improve elasticity and manage oiliness.
- While providing general skincare benefits, the formula lacks specific ingredients to directly target oily shine.
- The product is safe for your oily skin, with no risks of irritation from harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/oily-skin): Average (this page)
- [Dry skin](https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/oily-acne-prone-skin): Average

## Key ingredients

Acmella Oleracea Extract, Imperata Cylindrica Root Extract, Sodium Hyaluronate, Vitis Vinifera Leaf Extract Grape Leaf Extract, Spilanthol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- An all-natural anti-wrinkle emulsion serum containing Acmella oleracea extract demonstrated safe skin tolerability and reduced facial wrinkles in human volunteers after 2 weeks of application. ([International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/))
- An Acmella oleracea extract-loaded glycolipid emulsion serum applied topically demonstrated safety with no ocular irritation or systemic dermal absorption, alongside significant improvements in facial skin hydration, smoothness, and reductions in roughness, scaliness, and wrinkles. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/))
- A novel formulation containing supramolecular retinol plus acmella oleracea extract significantly reduced dark circles by 13.8% in melanin index, decreased fine wrinkles, and increased skin firmness by 13.0% in 33 Chinese urban women after 6 weeks of use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34806292/))
- The optimized squalane-based spilanthol emulsion achieved a maximum skin retention of 118.71 μg/g and restored skin hydroxyproline content to 23.99 μg/g, outperforming positive and negative groups due to high drug release and miscibility driven by weak Van der Waals interactions. ([AAPS PharmSciTech, 2019](https://pubmed.ncbi.nlm.nih.gov/31222590/))
- Treatment with methanolic extract of Acmella oleracea leaves exerted potent antioxidant, anti-inflammatory, antimicrobial, and wound healing effects in vitro by reducing inflammatory mediators, scavenging free radicals, inhibiting bacterial growth, and enhancing fibroblast migration without inducing cytotoxicity. ([Journal of Ethnopharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/39357584/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A combination of Vitis vinifera shoot extract and a biotechnological extract demonstrated significant in vitro and in vivo antioxidant effects and improved clinical signs of photoaged skin in female subjects after a 4-week application. ([Journal of Drugs in Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17691204/))
- Pre-treatment with Vitis vinifera L. water extract (100 ΓΙg/mL) demonstrated antioxidant and scavenger activity against UV-A radiation and exerted an anti-mutagenic effect by maintaining apoptosis in UV-A and UV-B irradiated human keratinocytes (HaCaT). ([Journal of Photochemistry and Photobiology. B, Biology, 2020](https://pubmed.ncbi.nlm.nih.gov/32028189/))
- A water extract from grapevine leaves inhibited proinflammatory-induced interleukin-8 and vascular endothelial growth factor secretion in human keratinocytes compared to untreated challenged cells. ([Antioxidants, 2019](https://pubmed.ncbi.nlm.nih.gov/31100904/))

## Why other serums fit oily skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- An O/W cosmetic formula containing 2% Orthosiphon stamineus leaf extract reduced the oily appearance of skin, pore size, and improved complexion evenness and radiance in Caucasian and Asian volunteers compared to a formula with 1% zinc gluconate. ([International Journal of Cosmetic Science, 2011](https://pubmed.ncbi.nlm.nih.gov/20807263/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Biotulin Supreme Skin Gel work for oily skin?

Biotulin Supreme Skin Gel works for your oily skin by offering moderate plumping and hydration, but it lacks specific ingredients to directly target oily shine. To better manage oily skin, a product needs effective ingredients like niacinamide, ferulic acid, zinc PCA, or tea tree extract to control oil and balance the skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/)

### Which ingredients make this gel a good fit for oily skin?

Glycerin and sodium hyaluronate make this gel a reasonable fit for oily skin by offering moderate plumping and hydration that help manage oiliness. However, because it lacks ingredients to directly target oily shine, an oily skin type needs a product containing niacinamide, ferulic acid, zinc PCA, or tea tree extract to control sebum, reduce pores, and purify the skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Acmella Oleracea Extract do for oily skin?

Acmella oleracea extract helps improve skin smoothness and firmness, but because this ingredient is typically found in richer anti-wrinkle serums, oily skin needs a lightweight, oil-free formula that hydrates without clogging pores.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/), [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/)

### What does Imperata Cylindrica Root Extract do for oily skin?

Imperata cylindrica root extract helps keep skin feeling soft and comfortable. This type of extract provides lasting hydration, which oily skin needs to stay balanced without feeling heavy or greasy.

### Where does it go in a skincare routine for oily skin?

This treatment goes in your evening routine, as treatments with active ingredients are placed in the PM for simplicity and safety around sun exposure. While it provides moderate plumping and hydration for your oily skin, an average fit product for this skin type needs ingredients to directly target oily shine.

### Can I use this gel with retinol, and in what order?

You can use this gel in the same routine with retinol by applying the retinol first and following with this treatment to lock in moisture. The formula is safe and unlikely to cause irritation on oily skin.

### How often should I use it?

You can use this treatment in your evening routine, applying it after cleansing and before your moisturizer. It is safe for oily skin and helps provide moderate hydration, though an oily skin type also needs ingredients that directly target shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/)

### Can this gel clog pores, cause breakouts or purging for oily skin?

This gel is safe and unlikely to cause breakouts or clog pores on oily skin because it avoids harsh or irritating ingredients. However, a product for oily skin also needs specific ingredients to directly target and manage oily shine.

### Is it fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for oily skin

- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/oily-skin) — Superior fit — €37.99 at Amazon
- [Dr. Ceuracle Tea Tree Purifine 95 Essence](https://lovi.care/skincare/it/p/dr-ceuracle/tea-tree-purifine-95-essence/for/oily-skin) — Superior fit — €39.99 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/oily-skin) — High fit — €129.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/it/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — €24.75 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/oily-skin) — Superior fit — €103.91 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — €18.47 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Butylene Glycol, Alcohol, Imperata Cylindrica Root Extract, Acmella Oleracea Extract, Xanthan Gum, Chondrus Crispus, Benzoic Acid, Phenoxyethanol, Vitis Vinifera Leaf Extract Grape Leaf Extract, Sodium Hyaluronate, Sodium Hydroxide, Carbomer, Caprylyl Glycol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Dehydroacetic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biotulin/supreme-skin-gel/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biotulin/supreme-skin-gel/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/biotulin/supreme-skin-gel/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/biotulin/supreme-skin-gel/for/oily-skin
- France: https://lovi.care/skincare/fr/p/biotulin/supreme-skin-gel/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/biotulin/supreme-skin-gel/for/oily-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/biotulin/supreme-skin-gel/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/biotulin/supreme-skin-gel/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/biotulin/supreme-skin-gel/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/biotulin/supreme-skin-gel/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/biotulin/supreme-skin-gel/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biotulin/supreme-skin-gel/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biotulin/supreme-skin-gel/for/oily-skin