# Biossance Squalane + Probiotic Gel Moisturizer for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/biossance/squalane-probiotic-gel-moisturizer/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Biossance](https://lovi.care/skincare/it/brands/biossance)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- Offers excellent moisturizing for your combination skin, as squalane and glycerin provide balanced hydration without overwhelming oily areas. Lactic acid and Lepidium Sativum Sprout Extract offer mild exfoliation and antioxidant support, providing moderate benefits for your acne, blemishes, and breakouts.
- The formulation is highly suitable for your combination skin, with squalane and glycerin offering emollient and humectant actions respectively.
- The safety profile is excellent, with no risks of irritation for your acne-prone skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/biossance/squalane-probiotic-gel-moisturizer/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/biossance/squalane-probiotic-gel-moisturizer/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/biossance/squalane-probiotic-gel-moisturizer/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/biossance/squalane-probiotic-gel-moisturizer/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/biossance/squalane-probiotic-gel-moisturizer/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/it/p/biossance/squalane-probiotic-gel-moisturizer/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/biossance/squalane-probiotic-gel-moisturizer/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/biossance/squalane-probiotic-gel-moisturizer/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/biossance/squalane-probiotic-gel-moisturizer/for/oily-acne-prone-skin): High

## Key ingredients

Squalane, Probiotics, Glycerin, Lactococcus Lysate Ferment, Zingiber Officinale Root Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- A 1-year clinical study on human facial skin demonstrated that Zingiber officinale (L.) Rose extract inhibits the UV-induced decrease in skin elasticity and prevents or improves wrinkle formation around the eye. ([Archives of Dermatological Research, 2008](https://pubmed.ncbi.nlm.nih.gov/17968573/))
- Ginger extract transethosomal hydrogel improved skin permeability, sustained drug release, and exhibited significant inhibition of edema swelling along with reduced reactive oxygen species and prostaglandin E2 compared to free ginger extract hydrogel and ketoprofen gel in a rat-paw edema model. ([International Journal of Nanomedicine, 2023](https://pubmed.ncbi.nlm.nih.gov/36945254/))
- Topical delivery of ginger extract-loaded nanoemulsions significantly reduced arthritic symptoms, paw edema inhibition by 27.7%, and inflammatory cytokines in RA-induced rats compared to the negative control. ([Journal of Pharmaceutical Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/36773928/))

## What reviewers say

Based on a very large amount of data, this lightweight gel moisturizer is highly recommended for oily, combination, and sensitive skin types, effectively hydrating without pore clogging and visibly reducing redness. However, a significant number of recent reviews indicate dissatisfaction with a formula change, noting a stickier texture and less pleasant scent compared to the original. Dry skin types may find it insufficient for hydration, and some users express concerns about the price point. A small number of users have reported irritation or breakouts.

- Liked: Lightweight & fast absorbing (mostly mentioned)
- Liked: Balances oily skin (often mentioned)
- Liked: Calms redness & irritation (often mentioned)
- Disliked: Reformulation complaints (often mentioned)
- Liked: Excellent makeup base (sometimes noted)
- Disliked: Not hydrating enough (sometimes noted)
- Disliked: Price point (sometimes noted)
- Disliked: Irritation and breakouts (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Biossance Squalane + Probiotic Gel Moisturizer a great fit for acne-prone skin?

This moisturizer is a great fit because squalane and glycerin provide balanced hydration without overwhelming oily areas, while mild exfoliants help keep breakouts calm. It has a very safe formula with no harsh ingredients, so it is unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this moisturizer a good fit for acne-prone skin?

Squalane and glycerin make this moisturizer a great fit for your acne-prone skin by providing balanced hydration without overwhelming oily areas. Additionally, lactic acid and ginger root extract offer gentle support to help calm breakouts and keep your skin smooth.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Squalane do for acne-prone skin?

Squalane may help keep acne-prone skin soft and smooth, but peroxidated forms can trigger inflammation in skin cells. For a better fit on acne-prone skin, products need non-clogging, soothing ingredients that balance oil without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2006](https://pubmed.ncbi.nlm.nih.gov/16778793/)

### What do Probiotics do for acne-prone skin?

For acne-prone skin, probiotics help reduce breakouts, soothe redness, and calm inflammation while balancing the skin microbiome. They also help improve skin barrier function and decrease inflammatory markers with fewer side effects than conventional treatments.
Sources: [Journal of Experimental Pharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/39810881/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35384257/)

### Where does this cream go in a skincare routine for acne-prone skin?

This moisturizing treatment goes near the end of your evening routine, right after your treatment step. It helps keep your skin balanced and soft without any risk of irritation.

### Can I use this moisturizer with retinol, and in what order?

You can use this moisturizer with retinol by applying your retinol treatment first and following it with the moisturizer to keep your skin calm and hydrated. Using a supportive moisturizer alongside strong treatments helps reduce irritation and keeps your skin barrier comfortable.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatological Treatment, 2016](https://pubmed.ncbi.nlm.nih.gov/26293170/)

### How often should I use this cream?

You can use this moisturizing treatment twice a day as part of your morning and evening routine to keep your skin hydrated and balanced. Regular daily application helps improve overall skin moisture and comfort while being gentle enough for acne-prone skin.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this moisturizer clog pores, cause breakouts or purging for acne-prone skin?

This moisturizer is a great fit for your acne-prone skin because it provides balanced hydration without overwhelming oily areas and has an excellent safety profile with no risk of irritation from harsh ingredients. It helps keep your skin soft and calm while being unlikely to cause breakouts.

### Can I use this cream around the eyes or on my body?

This moisturizing treatment is well-suited for the body, but because the skin around the eyes is much thinner, you should use it carefully there to check how your skin responds. The safety profile is excellent, meaning it is unlikely to cause irritation when applied to these areas.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this moisturizer fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €18.06 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/it/p/cosrx/advanced-snail-96-mucin-power-essence/for/acne-prone-skin) — Superior fit — €12.09 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/it/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin) — Superior fit — €92.92 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/it/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.43 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/acne-prone-skin) — Superior fit — €103.91 at Amazon
- SPF: [SKIN1004 Madagascar Centella Air-Fit Suncream Plus](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/acne-prone-skin) — Superior fit — €16.03 at Amazon

## Where to buy

- Lookfantastic: €31.05 (https://www.lookfantastic.it/p/biossance-probiotic-bottle-pump-50ml-fs-fg/17625977/)
Prices checked 17 Oct 2026.

## Ingredients

Water, Squalane, Glycerin, Dimethicone, Pentylene Glycol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Lactococcus Lysate Ferment, Caprylic Capric Triglyceride, Phenoxyethanol, Caprylyl Glycol, Dimethiconol, Chondrus Crispus Extract, Allantoin, Bisabolol, Glycine Soja Soybean Sterols, Linoleic Acid, Sodium Phytate, Lecithin, Sodium Hydroxide, Sodium Hyaluronate, Lactic Acid, Lepidium Sativum Extract Sprout, Sodium Chloride, Sodium Benzoate, Citric Acid, Zingiber Officinale Root Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-probiotic-gel-moisturizer/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-probiotic-gel-moisturizer/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-probiotic-gel-moisturizer/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-probiotic-gel-moisturizer/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-probiotic-gel-moisturizer/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-probiotic-gel-moisturizer/for/acne-prone-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-probiotic-gel-moisturizer/for/acne-prone-skin
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