Biossance Squalane + Ectoin Overnight Rescue for oily acne-prone skin
Squalane
Ectoin
Glycerin
Shorea Stenoptera Seed Butter
Acetyl Hexapeptide-8
Average
- AverageOily Skin Fit
- AverageEffectiveness
- ExcellentSafety
Works for oily acne-prone skin; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate moisturizing for your oily skin, as squalane and glycerin hydrate and enhance barrier resilience without exacerbating oiliness.
- While beneficial for general skincare, the formula lacks targeted ingredients to address your primary concerns of acne, blemishes, and breakouts.
- The product is safe for your oily skin, with Ectoin and Squalane providing soothing benefits and no harsh ingredients present.
How to apply
- Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
- Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
- Gently press a small amount into your skin and avoid rubbing to keep pores clear.
- Apply on clean, slightly damp skin to help the product absorb better and control oil.
- Avoid the sensitive eye area and do a simple patch test before your first use.
People Say
★4.6Overall rating based on 2.0k+ reviewsMost users report waking up to soft, plump, and soothed skin without irritation. Those with oily or acne-prone skin occasionally find the formula too rich. This summary is based on a very large amount of data and should definitely be taken into account.
Highlights
Deeply hydrating Mostly Mentioned
- “My skin loves and drinks this right up.”
- “It keeps my face hydrated until morning.”
- “This is the first cream that has helped with my dry skin.”
- “Hydrates me very well overnight.”
Absorbs well Often Mentioned
- “Absorbs right in without the need to overly blend it in.”
- “It is not greasy at all like serums can be.”
- “Melts into your skin so easily and effortlessly.”
- “Absorbs quickly and leaves no greasy residue or film.”
Plumps and softens Often Mentioned
- “Wake up with plump, moisturized, healthy-looking skin.”
- “Makes my skin look super plump, glowing, and helps it to feel very soft.”
- “I wake up in the morning to baby smooth skin.”
- “Always makes my skin feeling so soft as soon as I put it on.”
Soothes sensitive skin Often Mentioned
- “There is no stinging, irritation or redness when using this product.”
- “I have very sensitive skin and this has been great for my skin.”
High price point Sometimes Noted
- “Seventy dollars for one small jar is a steep ask.”
- “Seventy dollars buys a single fifty-milliliter jar.”
- “Asks you to pay a premium.”
Heavy or greasy Rarely Noted
- “Consistency leaves a greasy feel to the skin.”
- “The overnight rescue is by far one of the thickest creams I have ever used.”
- “Heaviness, or a greasy feel may occur for some users.”
- “Oily and breakout-prone complexions will likely find it too rich.”
Jar packaging Rarely Noted
- “As always, a jar means scooping.”
- “Which is a small hygiene knock.”
- “The frosted glass jar is attractive but... a jar means scooping.”
May cause breakouts Rarely Noted
- “A few reviews mention that breakouts... may occur for some users.”
- “Not formulated to be fungal-acne safe.”
- “Oily and breakout-prone complexions will likely find it too rich.”
Sources: lovi.care, sephora.com, biossance.com, influenster.com, dermapproved.com, cultbeauty.co.uk, and more
Questions and answers
How well does Biossance Squalane + Ectoin Overnight Rescue work for oily acne-prone skin?
Biossance Squalane + Ectoin Overnight Rescue works reasonably well for oily acne-prone skin, as squalane and glycerin hydrate without making you oily, but it lacks targeted ingredients for breakouts. For a better fit, oily acne-prone skin needs lightweight, non-clogging treatments with active ingredients that specifically clear blemishes while keeping the skin balanced.
Which ingredients make this cream a good fit for oily acne-prone skin?
Squalane, glycerin, and ectoin make this cream a good fit because they hydrate and calm your skin without making it oily. Oily acne-prone skin needs a moisturizing treatment that clears breakouts and blemishes while keeping pores clear.
What does Squalane do for oily acne-prone skin?
Squalane may help keep oily skin soft and smooth, but oxidized squalene can trigger inflammation in acne-prone skin. Because of this, oily acne-prone skin needs lightweight, non-greasy ingredients that balance moisture without clogging pores.
What does Ectoin do for oily acne-prone skin?
Ectoin helps protect oily acne-prone skin from sun damage and premature aging caused by UV rays. It is lightweight and unlikely to clog pores, making it a comfortable addition to your daily routine.
Journal of Cosmetic Dermatology, 2024Skin Pharmacology and Physiology, 2004
Where does this cream go in a skincare routine for oily acne-prone skin?
This moisturizing treatment goes at the end of your evening routine, after cleansing and any serums. It hydrates your oily skin without making it greasy, though an acne-prone skin type needs added blemish-fighting ingredients to see the best results.
Can I use this cream with retinol, and in what order?
You can use this cream alongside retinol by applying it after your retinol treatment to help soothe your skin and keep it soft and comfortable. Using a gentle moisturizer with barrier-supporting ingredients is unlikely to interfere with your routine and may help reduce dryness and irritation while using retinoids.
How often should I use this cream?
You can use this moisturizing treatment daily to keep your oily skin hydrated and calm. For this skin type, a product of this type needs acne-fighting ingredients like salicylic acid or benzoyl peroxide to help clear breakouts and blemishes.
Can this cream clog pores, cause breakouts or purging for oily acne-prone skin?
This cream is unlikely to cause breakouts or clog pores on oily skin because reviewers rarely report heavy or greasy feelings, and it contains no harsh ingredients. However, it lacks targeted ingredients to actively address blemishes and breakouts, which an oily, acne-prone skin type needs.
Can I use this cream around the eyes or on my body?
This cream is safe to use around the eyes or on the body, though it is primarily designed as an all-over facial treatment. Its moisturizing ingredients help hydrate delicate or dry areas, while Ectoin and squalane provide a safe and soothing experience for thin skin.
Is this cream fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Combining ectoine and mannitol with UV filters significantly improved protection of squalene oxidation, catalase activity, and trans-UCA compared to UV filters alone in 10 subjects on irradiated areas.
Journal of Cosmetic Dermatology, 2024Topical 7% ectoine during serial 1064-nm Nd:YAG laser therapy produced a greater reduction in skin erythema, improved stratum corneum hydration, reduced transepidermal water loss, and decreased low-echogenic pixels in thirty participants compared to a vehicle control.
Biomedicines, 2026Regular application of a novel anti-ageing cream containing hyaluronic acid, ectoin, and botanical actives significantly reduced wrinkle depth and length in the periorbital area while demonstrating very good skin tolerance.
Polymers, 2023The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017
Why other moisturizers fit oily acne-prone skin better
Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.
Molecules, 2023A peel-off facial mask containing myoinositol and trehalose-loaded liposomes improved adult female acne by decreasing lesion counts, sebum production, GAGS scores, and local androgen levels while increasing beclin-1 levels.
Journal of Cosmetic Dermatology, 2017A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024
Ingredients
Water, Glycerin, Squalane, Shorea Stenoptera Seed Butter, Caprylic Capric Triglyceride, C12-16 Alcohols, Sodium Acrylates Copolymer, Ectoin, Jojoba Esters, Acetyl Hexapeptide-8, Magnesium Chloride, Palmitic Acid, Hydrogenated Lecithin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Lecithin, Sorbitan Isostearate, Tocopherol, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Sodium Gluconate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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