Biossance Squalane + Ectoin Overnight Rescue for combination skin
Squalane
Ectoin
Glycerin
Shorea Stenoptera Seed Butter
Acetyl Hexapeptide-8
Average
- AverageCombination Skin Fit
- AverageEffectiveness
- ExcellentSafety
Works for combination skin; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for your combination skin, as squalane provides emollient action and ectoine offers humectant benefits, though stronger oil-control ingredients would enhance results for your oily shine.
- The formula provides excellent moisturizing and barrier resilience due to squalane and ectoin, which hydrate and support your skin's natural defenses.
- The product is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing agents like ectoin and glycerin.
How to apply
- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
People Say
★4.6Overall rating based on 2.0k+ reviewsMost users report waking up to soft, plump, and soothed skin without irritation. Those with oily or acne-prone skin occasionally find the formula too rich. This summary is based on a very large amount of data and should definitely be taken into account.
Highlights
Deeply hydrating Mostly Mentioned
- “My skin loves and drinks this right up.”
- “It keeps my face hydrated until morning.”
- “This is the first cream that has helped with my dry skin.”
- “Hydrates me very well overnight.”
Absorbs well Often Mentioned
- “Absorbs right in without the need to overly blend it in.”
- “It is not greasy at all like serums can be.”
- “Melts into your skin so easily and effortlessly.”
- “Absorbs quickly and leaves no greasy residue or film.”
Plumps and softens Often Mentioned
- “Wake up with plump, moisturized, healthy-looking skin.”
- “Makes my skin look super plump, glowing, and helps it to feel very soft.”
- “I wake up in the morning to baby smooth skin.”
- “Always makes my skin feeling so soft as soon as I put it on.”
Soothes sensitive skin Often Mentioned
- “There is no stinging, irritation or redness when using this product.”
- “I have very sensitive skin and this has been great for my skin.”
High price point Sometimes Noted
- “Seventy dollars for one small jar is a steep ask.”
- “Seventy dollars buys a single fifty-milliliter jar.”
- “Asks you to pay a premium.”
Heavy or greasy Rarely Noted
- “Consistency leaves a greasy feel to the skin.”
- “The overnight rescue is by far one of the thickest creams I have ever used.”
- “Heaviness, or a greasy feel may occur for some users.”
- “Oily and breakout-prone complexions will likely find it too rich.”
Jar packaging Rarely Noted
- “As always, a jar means scooping.”
- “Which is a small hygiene knock.”
- “The frosted glass jar is attractive but... a jar means scooping.”
May cause breakouts Rarely Noted
- “A few reviews mention that breakouts... may occur for some users.”
- “Not formulated to be fungal-acne safe.”
- “Oily and breakout-prone complexions will likely find it too rich.”
Sources: lovi.care, sephora.com, biossance.com, influenster.com, dermapproved.com, cultbeauty.co.uk, and more
Questions and answers
How well does Biossance Squalane + Ectoin Overnight Rescue work for combination skin?
Biossance Squalane + Ectoin Overnight Rescue works reasonably well for combination skin, offering moderate suitability by keeping the skin soft while supporting its natural defenses without irritation. However, because it lacks oil-control ingredients, combination skin needs a product with added brightening and oil-balancing ingredients to better manage shine.
Clinical, Cosmetic and Investigational Dermatology, 2017Journal of Cosmetic Dermatology, 2024
Which ingredients make this cream a good fit for combination skin?
Squalane and ectoin make this cream a good fit for combination skin by softening dry patches and holding in moisture without causing irritation. However, a product of this type needs stronger oil-control ingredients and brightening agents to better handle oily shine.
Clinical, Cosmetic and Investigational Dermatology, 2017Journal of Cosmetic Dermatology, 2024
What does Squalane do for combination skin?
Squalane helps keep combination skin soft and smooth by locking in moisture without feeling heavy or greasy. It supports the skin barrier and provides lightweight hydration that works well for both dry and oily areas.
Skin Health and Disease, 2024Journal of Nanobiotechnology, 2025
What does Ectoin do for combination skin?
Ectoin helps keep combination skin balanced by holding onto moisture and strengthening the skin barrier without feeling heavy. It is unlikely to irritate dry or oily patches and may help calm redness while protecting skin cells from everyday damage.
Clinics in Dermatology, 2008Arhiv Za Higijenu Rada I Toksikologiju, 2016
Where does this cream go in a skincare routine for combination skin?
This moisturizing treatment goes in the evening routine after cleansing and before moisturizing, or as part of a weekly evening routine. It hydrates and protects your skin without irritation, though a product of this type needs stronger oil-control ingredients to better manage oily shine on combination skin.
Can I use this cream with retinol, and in what order?
You can use this moisturizing treatment with retinol by applying the cream after your retinol step in your evening routine. This helps keep your skin soft and smooth while reducing the dryness often caused by retinol.
How often should I use this cream?
You can use this treatment cream in your evening routine as part of your nightly skin care steps. Daily application helps improve skin moisture and barrier strength while keeping the routine simple and safe around sun exposure.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this cream clog pores, cause breakouts or purging for combination skin?
This cream is unlikely to clog pores or cause breakouts for your combination skin, as the risk is low and it contains gentle, soothing ingredients that are safe for your skin type. However, because it is an average fit, combination skin works best with products that also include strong oil-control ingredients to help balance out oily shine.
Can I use this cream around the eyes or on my body?
You can use this moisturizing treatment safely around your eyes and on your body because its gentle formula is free from harsh ingredients. It helps hydrate and protect delicate areas like the thin skin of the eyelids without causing irritation.
Is this cream fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Combining ectoine and mannitol with UV filters significantly improved protection of squalene oxidation, catalase activity, and trans-UCA compared to UV filters alone in 10 subjects on irradiated areas.
Journal of Cosmetic Dermatology, 2024Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Topical 7% ectoine during serial 1064-nm Nd:YAG laser therapy produced a greater reduction in skin erythema, improved stratum corneum hydration, reduced transepidermal water loss, and decreased low-echogenic pixels in thirty participants compared to a vehicle control.
Biomedicines, 2026Regular application of a novel anti-ageing cream containing hyaluronic acid, ectoin, and botanical actives significantly reduced wrinkle depth and length in the periorbital area while demonstrating very good skin tolerance.
Polymers, 2023Ectoine improves keratin dispersity and hydration, decreases drying stress development rates by approximately 30%, and improves stress reduction during rehydration by approximately 20% in stratum corneum compared to untreated controls.
Biochemistry and Biophysics Reports, 2021The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017
Ingredients
Water, Glycerin, Squalane, Shorea Stenoptera Seed Butter, Caprylic Capric Triglyceride, C12-16 Alcohols, Sodium Acrylates Copolymer, Ectoin, Jojoba Esters, Acetyl Hexapeptide-8, Magnesium Chloride, Palmitic Acid, Hydrogenated Lecithin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Lecithin, Sorbitan Isostearate, Tocopherol, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Sodium Gluconate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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