# Biossance Squalane + Copper Peptide Rapid Plumping Serum for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/it/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Biossance](https://lovi.care/skincare/it/brands/biossance)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for combination skin.

## Why this fit

- Highly suitable for your combination skin, this serum effectively addresses oily shine with squalane and sodium hyaluronate, which provide balanced hydration without exacerbating oiliness.
- The inclusion of glycerin and aloe barbadensis flower extract further supports skin hydration and soothes the skin, complementing the plumping effects of copper peptides.
- The product is safe for your skin, containing no harsh ingredients and featuring a blend of soothing agents that minimize irritation risk.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/it/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/it/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/mature-skin): Low
- [Dry sensitive skin](https://lovi.care/skincare/it/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin): High

## Key ingredients

Squalane, Copper Peptides, Sodium Hyaluronate, Acmella Oleracea Extract, Panthenol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- An all-natural anti-wrinkle emulsion serum containing Acmella oleracea extract demonstrated safe skin tolerability and reduced facial wrinkles in human volunteers after 2 weeks of application. ([International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- An Acmella oleracea extract-loaded glycolipid emulsion serum applied topically demonstrated safety with no ocular irritation or systemic dermal absorption, alongside significant improvements in facial skin hydration, smoothness, and reductions in roughness, scaliness, and wrinkles. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/))
- A novel formulation containing supramolecular retinol plus acmella oleracea extract significantly reduced dark circles by 13.8% in melanin index, decreased fine wrinkles, and increased skin firmness by 13.0% in 33 Chinese urban women after 6 weeks of use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34806292/))
- The optimized squalane-based spilanthol emulsion achieved a maximum skin retention of 118.71 μg/g and restored skin hydroxyproline content to 23.99 μg/g, outperforming positive and negative groups due to high drug release and miscibility driven by weak Van der Waals interactions. ([AAPS PharmSciTech, 2019](https://pubmed.ncbi.nlm.nih.gov/31222590/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))

## What reviewers say

Based on a very large amount of data, this serum is widely praised for its ability to deliver instant hydration and a visible plumping effect, making it a favorite for users with dry, dehydrated, or aging skin. The majority of users report a lightweight texture that absorbs well and improves skin bounce. A minority experience stickiness or find the high price point unjustifiable for the results achieved.

- Liked: Intense hydration (mostly mentioned)
- Liked: Elegant texture (often mentioned)
- Liked: Visible plumping (often mentioned)
- Liked: Improved texture (sometimes noted)
- Liked: Soothing properties (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Breakouts/Irritation (rarely noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Paradoxical drying (rarely noted)
- Disliked: Sticky after-feel (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Biossance Squalane + Copper Peptide Rapid Plumping Serum a great fit for combination skin?

This serum is a great fit for your combination skin because it gives you balanced hydration without adding oily shine, using squalane and sodium hyaluronate. Glycerin and aloe vera extract help keep your skin feeling soft while soothing it, and the formula is unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/)

### Which ingredients make this serum a good fit for combination skin?

This serum is a great fit for combination skin because squalane and sodium hyaluronate provide balanced hydration that helps control oily shine without feeling heavy. Glycerin and aloe barbadensis flower extract further support hydration and soothe the skin while complementing the plumping effects of copper peptides.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/)

### What does Squalane do for combination skin?

Squalane helps keep combination skin soft and smooth by locking in moisture without feeling heavy or greasy. It supports the skin barrier and provides lightweight hydration that works well for both dry and oily areas.
Sources: [Skin Health and Disease, 2024](https://pubmed.ncbi.nlm.nih.gov/39355739/), [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/)

### What do Copper Peptides do for combination skin?

Copper peptides help keep combination skin looking firm and smooth by supporting skin regeneration and improving elasticity. They may also help calm the skin and reduce fine lines while keeping your routine gentle.
Sources: [BioMed Research International, 2015](https://pubmed.ncbi.nlm.nih.gov/26236730/), [International Journal of Molecular Sciences, 2018](https://pubmed.ncbi.nlm.nih.gov/29986520/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and before moisturizing, as Lovi routines place treatments in the evening for simplicity and extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying it before your retinol at night to help keep your skin calm and hydrated. This type of routine layering is unlikely to cause irritation when the serum uses soothing agents to support your skin barrier.

### How often should I use this serum?

You can use this serum in your evening routine. Daily application helps keep your combination skin hydrated and smooth while minimizing irritation risk.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause breakouts or clog pores on combination skin, as it features balanced hydrators and a safe formula that minimizes irritation. Reviewers rarely report breakouts or irritation.

### Can I use this serum around the eyes or on my body?

Yes, you can use this serum around the eyes and on your body because its gentle formulation has a very good safety profile for delicate areas. It is unlikely to cause irritation while helping to smooth and hydrate thin skin.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/it/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/combination-skin) — High fit — €21.00 at Amazon
- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/combination-skin) — High fit — €29.69 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/it/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/combination-skin) — High fit — €17.99 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/it/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €13.50 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/combination-skin) — Superior fit — €103.91 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/it/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/combination-skin) — Superior fit — €40.49 at Amazon

## Where to buy

- Lookfantastic: €47.44 (https://www.lookfantastic.it/p/biossance-squalane-and-copper-peptide-rapid-plumping-serum-50ml/13643574/)
Prices checked 15 Oct 2026.

## Ingredients

Water, Glycerin, Propanediol, Squalane, Sodium Hyaluronate, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Copper Tripeptide-1, Acmella Oleracea Extract, Ectoin, Tetrapeptide-30, Palmitoyl Hexapeptide-52, Copper Pca, Panthenol, Sodium Polyglutamate, Camellia Sinensis Leaf Extract, Aloe Barbadensis Flower Extract, Passiflora Incarnata Flower Extract, Melia Azadirachta Leaf Extract, Solanum Melongena Fruit Extract, Curcuma Longa Root Extract, Ocimum Basilicum Leaf Extract Flower, Coccinia Indica Fruit Extract, Melia Azadirachta Flower Extract, Ocimum Sanctum Leaf Extract, Corallina Officinalis Extract, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Xanthan Gum, Phenoxyethanol, Ethylhexylglycerin, Citric Acid, Caprylyl Glycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin