# Avène Cleanance Comedoned Peeling for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/avene/cleanance-comedoned-peeling/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Avène](https://lovi.care/skincare/it/brands/avene)
Category: [Exfoliants](https://lovi.care/skincare/it/best/exfoliators)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other products fit it better.

## Why this fit

- Offers moderate exfoliation for your combination skin, as glycolic acid and salicylic acid work to address oily shine and provide general skincare benefits.
- The keratolytic action and seboregulation from these acids make it highly suitable for your skin type, though the concentrations offer general benefits rather than targeted treatment.
- The formulation is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/avene/cleanance-comedoned-peeling/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/avene/cleanance-comedoned-peeling/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/it/p/avene/cleanance-comedoned-peeling/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/it/p/avene/cleanance-comedoned-peeling/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/it/p/avene/cleanance-comedoned-peeling/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/avene/cleanance-comedoned-peeling/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/it/p/avene/cleanance-comedoned-peeling/for/mature-skin): Caution
- [Dry sensitive skin](https://lovi.care/skincare/it/p/avene/cleanance-comedoned-peeling/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/avene/cleanance-comedoned-peeling/for/oily-acne-prone-skin): Average

## Key ingredients

Glycolic Acid, Salicylic Acid, Zinc Gluconate

## What the research says

- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/))
- Daily use of a deep cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% significantly reduced total lesion count by 56.3% after 84 days in 35 subjects with mild to moderate truncal acne. ([Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36698447/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical 5% benzoyl peroxide plus salicylic acid achieved the greatest lesion reduction at early 2 to 4 week time points compared to benzoyl peroxide, clindamycin, and combination benzoyl peroxide/clindamycin, while 5% benzoyl peroxide plus salicylic acid and combination benzoyl peroxide/clindamycin showed similar efficacy at 10 to 12 weeks in acne patients. ([Journal of the American Academy of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20488582/))
- A dermocosmetic cream containing Punica granatum Pericarp extract, Salicylic acid, Niacinamide, Zinc gluconate, and Aqua Posae Filiformis significantly decreased inflammatory, non-inflammatory, and total lesion counts in subjects with mild to moderate acne compared to untreated hemi-faces after 15 days. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41487026/))
- Different strains of Propionibacterium acnes modulate cutaneous innate immunity with varying pro-inflammatory potentials, with P. acnes type III showing the highest and P. avidum the weakest, and zinc gluconate down-regulates the expression of most induced immune markers. ([Experimental Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23947673/))
- Zinc gluconate induced alpha2, alpha3, alphaV, and alpha6 integrins, copper gluconate induced alpha2, alpha6, and beta1, and manganese gluconate induced most studied integrins in cultured keratinocytes. ([The British Journal of Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10215764/))

## What reviewers say

This spot treatment is highly effective for reducing active breakouts and improving skin texture on acne-prone skin, with many users reporting rapid results. While generally well-tolerated, a strong alcohol scent is frequently noted, and some users experience mild irritation or find the usage instructions confusing. The product is praised for its lightweight, fast-absorbing texture.

- Liked: Rapid effectiveness (mostly mentioned)
- Liked: Excellent texture (often mentioned)
- Disliked: Strong alcohol scent (often mentioned)
- Liked: Good tolerance (sometimes noted)
- Liked: Smoother skin texture (sometimes noted)
- Disliked: Confusing usage limits (sometimes noted)
- Disliked: Potential irritation (rarely noted)
- Disliked: Price vs. size (rarely noted)

## How to apply

- Use this exfoliant product in your PM routine starting once a week, then increase frequency carefully if your skin feels fine.
- Apply this exfoliant step after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the exfoliant into your skin and wait a minute before layering.
- Apply the exfoliant to clean, dry skin to help control your oily shine comfortably.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/028e5e793422a3b665c02ff502cf5a68.mp4

## Questions and answers

### How well does Avène Cleanance Comedoned Peeling work for combination skin?

Avène Cleanance Comedoned Peeling works moderately well for your combination skin, using glycolic acid and salicylic acid to help address oily shine and provide general care safely. To achieve a better fit, a product of this type needs effective ingredients like niacinamide, propolis, or zinc PCA to provide optimal hydration, balance oiliness without dryness, and enhance radiance.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36698447/)

### Which ingredients make this exfoliant a good fit for combination skin?

Glycolic acid, salicylic acid, and zinc gluconate make this exfoliant a good fit for your combination skin by addressing oily shine and providing gentle exfoliation. To achieve an even better fit, combination skin needs products with effective ingredients like niacinamide, propolis, or zinc PCA that balance oiliness and maintain proper hydration without any risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36698447/)

### What does Glycolic Acid do for combination skin?

Glycolic acid helps smooth and brighten combination skin by gently loosening dead surface cells to speed up skin renewal. This ingredient is unlikely to cause irritation when used properly, but it needs a reliable sunscreen during the day since it makes skin more sensitive to the sun.
Sources: [Acta Dermato-venereologica, 1995](https://pubmed.ncbi.nlm.nih.gov/8651024/), [Archives of Dermatological Research, 1997](https://pubmed.ncbi.nlm.nih.gov/9248619/)

### What does Salicylic Acid do for combination skin?

Salicylic acid helps clear clogged pores and balance oily areas while remaining gentle enough for dry spots on combination skin. It reduces breakouts and oiliness effectively with a low likelihood of irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051857/)

### Where does it go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and before moisturizing, starting once a week and using it more often if your skin tolerates it well. To work best for your combination skin, this type of product needs ingredients that gently clear away dead skin cells and control oil, like glycolic and salicylic acids.

### Can I use this exfoliant with retinol, and in what order?

You can use this exfoliant with retinol by using them on different nights or spacing them out to keep your skin calm and smooth, since using both together may lead to dryness or irritation. To combine them safely, apply your retinol on certain nights and this treatment on others, always following up with a gentle moisturizer.

### How often should I use it?

Start by using this exfoliant treatment once a week in your evening routine, and if your skin feels comfortable and you see good results, you may carefully use it more often. This product helps address oily shine on combination skin, though an ideal fit for this skin type would include targeted active ingredients and balanced concentrations for more personalized benefits.
Sources: [Dermatologic Surgery, 2003](https://pubmed.ncbi.nlm.nih.gov/14725662/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32356917/)

### Can this exfoliant clog pores, cause breakouts or purging for combination skin?

This exfoliant is unlikely to cause breakouts or clog pores on combination skin, as its ingredients help clear away dead skin and balance oil. A product for this skin needs gentle exfoliating acids and oil-balancing ingredients like salicylic acid and zinc gluconate to keep pores clear without causing irritation.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/)

### Is it fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €37.99 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/it/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €380.10 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — €129.99 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/it/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €13.50 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/combination-skin) — Superior fit — €103.91 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €18.47 at Amazon

## Where to buy

- Amazon.it: €23.45 (https://www.amazon.it/dp/B0CH9FNGCN?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Notino: €23.50 (https://www.notino.it/avene/cleanance-comedomed-crema-intensa-contro-le-imperfezioni-della-pelle-acneica/p-16274731/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Glycolic Acid, Glycerin, Cetearyl Alcohol, Sodium Hydroxide, Cetearyl Glucoside, Salicylic Acid, Zinc Gluconate, Pumpkin Seed Oil, Caprylic Capric Triglyceride, Benzoic Acid, Caprylyl Glycol, Parfum, Xanthan Gum, Disodium Edta, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/avene/cleanance-comedoned-peeling/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/avene/cleanance-comedoned-peeling/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/avene/cleanance-comedoned-peeling/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/avene/cleanance-comedoned-peeling/for/combination-skin
- France: https://lovi.care/skincare/fr/p/avene/cleanance-comedoned-peeling/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/avene/cleanance-comedoned-peeling/for/combination-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/avene/cleanance-comedoned-peeling/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/avene/cleanance-comedoned-peeling/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/avene/cleanance-comedoned-peeling/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/avene/cleanance-comedoned-peeling/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/avene/cleanance-comedoned-peeling/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/avene/cleanance-comedoned-peeling/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/avene/cleanance-comedoned-peeling/for/combination-skin