# Avène Cleanance Comedomed for dry skin

**Lovi Fit: Caution fit for dry skin.**
Dry Skin Fit: Caution · Effectiveness: High · Safety: Concerning.

Page: https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Avène](https://lovi.care/skincare/it/brands/avene)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A poor match for dry skin; the serums alongside fit it better.

## Why this fit

- Offers moderate exfoliation for your dry skin due to the presence of glycolic acid and salicylic acid, which can cause excessive dryness and irritation, rather than providing the emollient and humectant actions needed for dry skin.
- While the product contains soothing ingredients like Dipotassium Glycyrrhizate and Tocopherol, the exfoliating acids are not ideal for your dry skin type.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/dry-skin): Caution (this page)
- [Combination skin](https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/oily-acne-prone-skin): High

## Key ingredients

Salicylic Acid, Glycolic Acid, Zinc Gluconate, Silybum Marianum Fruit Extract, Pumpkin Seed Oil

## What the research says

- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))
- A dermocosmetic cream containing Punica granatum Pericarp extract, Salicylic acid, Niacinamide, Zinc gluconate, and Aqua Posae Filiformis significantly decreased inflammatory, non-inflammatory, and total lesion counts in subjects with mild to moderate acne compared to untreated hemi-faces after 15 days. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41487026/))
- Daily use of a deep cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% significantly reduced total lesion count by 56.3% after 84 days in 35 subjects with mild to moderate truncal acne. ([Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36698447/))
- Different strains of Propionibacterium acnes modulate cutaneous innate immunity with varying pro-inflammatory potentials, with P. acnes type III showing the highest and P. avidum the weakest, and zinc gluconate down-regulates the expression of most induced immune markers. ([Experimental Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23947673/))
- Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37675655/))
- Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36204969/))
- Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris. ([Journal of Cutaneous Medicine and Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/37942562/))
- Topical treatment with pumpkin seed oil healed uniform wounds in rats, achieving full re-epithelialization, reappearance of skin appendages, and well-organized collagen fibers compared to untreated controls. ([Lipids in Health and Disease, 2016](https://pubmed.ncbi.nlm.nih.gov/27068642/))
- A combinational sunscreen formulation of UV filters, melatonin, and pumpkin seed oil ameliorated UV radiation-induced photoaging in adult Wistar albino rats by increasing SOD, GSH-Px, CAT, and collagen levels, while decreasing skin edema, skin thickness, and inflammatory cytokines compared to UV-exposed controls. ([European Journal of Pharmaceutical Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/30414837/))
- Topical pumpkin seed oil increased hair follicle proliferation in mice without causing liver toxicity, oxidative stress, or genotoxicity. ([Acta Histochemica, 2022](https://pubmed.ncbi.nlm.nih.gov/35447441/))

## What reviewers say

This treatment is frequently praised for its effectiveness on oily, blemish-prone, and sensitive skin, particularly in managing blackheads and closed comedones, with many users reporting clearer skin and fewer breakouts. A significant number of users also appreciate its lightweight texture and matte finish. Some users note a strong chemical scent and a drying effect, with a few experiencing irritation or a sticky consistency.

- Liked: Reduces blemishes (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: Strong chemical scent (often mentioned)
- Liked: Matte finish (sometimes noted)
- Liked: Prevents recurrence (sometimes noted)
- Disliked: Drying effect (sometimes noted)
- Disliked: Can cause irritation (rarely noted)
- Disliked: Sticky consistency (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### Why does Lovi advise caution with Avene Cleanance Comedomed for dry skin?

Lovi advises caution because this treatment offers moderate exfoliation from glycolic acid and salicylic acid, which can cause excessive dryness and irritation on dry skin. Instead of these acids, a product for dry skin needs nourishing and soothing ingredients that provide rich hydration, ceramides, niacinamide, or peptides to support the skin barrier.

### Which ingredients make this treatment a poor fit for dry skin?

Glycolic acid and salicylic acid make this treatment a poor fit because they offer moderate exfoliation that may cause excessive dryness and irritation on dry skin. Dry skin needs products with nourishing, barrier-supporting ingredients and moisture-binding agents to provide deep hydration and soothing relief.

### What does Salicylic Acid do for dry skin?

Salicylic acid is generally not a good fit for dry skin, as it is meant to clear out pores and remove dead skin rather than hydrate. Because dry skin needs soothing and moisture rather than exfoliation, a product for dry skin needs nourishing ingredients like urea to lock in moisture and keep the skin soft.

### What does Glycolic Acid do for dry skin?

Glycolic acid helps smooth and soften dry skin by speeding up the shedding of older surface cells. Because it can also cause the skin to lose more moisture, dry skin needs extra hydrating ingredients like glycerin or hyaluronic acid alongside it to keep the skin comfortable.
Sources: [Acta Dermato-venereologica, 1995](https://pubmed.ncbi.nlm.nih.gov/8651024/)

### Where does this treatment go in a skincare routine for dry skin?

This treatment goes in the evening routine for dry skin, but because exfoliating acids can cause dryness and irritation, a product for this skin needs rich hydrating and softening ingredients instead. Lovi routines start exfoliating steps just once a week, increasing frequency only if well tolerated.

### Can I use this treatment with retinol, and in what order?

Using this treatment with retinol is a poor match for your dry skin because the exfoliating acids can cause excessive dryness and irritation. Instead, dry skin needs gentle ingredients that add moisture and hold water in, rather than strong exfoliating acids.

### How often should I use this treatment?

This treatment is a poor fit for dry skin, so use it carefully just once a week to check for irritation, as the exfoliating acids may cause excessive dryness. Dry skin needs products that provide heavy moisture and hydration to keep it soft and smooth.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/)

### Can this treatment clog pores, cause breakouts or purging for dry skin?

This treatment is unlikely to clog pores on dry skin, but its exfoliating acids may cause excessive dryness and irritation. A product for this skin type needs rich moisturizing ingredients and soothing agents to lock in hydration and keep the skin soft and smooth.

### Is this treatment fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/it/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €20.29 at Amazon
- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/it/p/kravebeauty/great-barrier-relief/for/dry-skin) — Superior fit — €48.70 at Amazon

## Routine for dry skin

### AM

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €9.19 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — €15.16 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-skin) — Superior fit — €53.50 at Amazon
- SPF: [Thinkbaby Safe Sunscreen SPF 50+](https://lovi.care/skincare/it/p/thinkbaby/safe-sunscreen-spf-50/for/dry-skin) — Superior fit — €37.19 at Amazon

### PM

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/it/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — €15.90 at Amazon
- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €9.19 at Amazon
- Serum or Treatment: [SKIN1004 Madagascar Centella Poremizing Fresh Ampoule](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-poremizing-fresh-ampoule/for/dry-skin) — Superior fit — €16.60 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-skin) — Superior fit — €53.50 at Amazon

### Weekly

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/it/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — €15.90 at Amazon
- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €9.19 at Amazon
- Nourishing Mask: [MEDIHEAL Vita Essential Mask](https://lovi.care/skincare/it/p/mediheal/vita-essential-mask/for/dry-skin) — Superior fit — €31.93 at Amazon
- Serum or Treatment: [SKIN1004 Madagascar Centella Poremizing Fresh Ampoule](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-poremizing-fresh-ampoule/for/dry-skin) — Superior fit — €16.60 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-skin) — Superior fit — €53.50 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Proylene Glycol, Glycerin, Cetearyl Alcohol, Cetearyl Glucoside, Glyceryl Stearate, Peg-100 Stearate, Silica, Dimethicone, Bht, Caprylic Capric Triglyceride, Pumpkin Seed Oil, Sodium Hydroxide, Sodium Polyacrylate, Sodium Stearoyl Glutamate, Zinc Gluconate, Capryloyl Glycine, Citric Acid, Parfum, Disodium Edta, Sodium Benzoate, Potassium Sorbate, Glyceryl Laurate, Monolaurin, Silybum Marianum Fruit Extract, Butylene Glycol, Silymarin, Dipotassium Glycyrrhizate, Tocopherol, Glycolic Acid, Salicylic Acid, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/avene/cleanance-comedomed/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/avene/cleanance-comedomed/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/avene/cleanance-comedomed/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/avene/cleanance-comedomed/for/dry-skin
- France: https://lovi.care/skincare/fr/p/avene/cleanance-comedomed/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/dry-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/avene/cleanance-comedomed/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/avene/cleanance-comedomed/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/avene/cleanance-comedomed/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/avene/cleanance-comedomed/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/avene/cleanance-comedomed/for/dry-skin