# Anua Heartleaf 80 Moisture Soothing Ampoule for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [Anua](https://lovi.care/skincare/it/brands/anua)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/it/best/moisturizers)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for skin with dark spots.

## Why this fit

- Excellent suitability for your normal skin is provided by glycerin and hyaluronic acid for humectant action and panthenol for barrier repair, indirectly supporting skin health and recovery for pigmentation.
- The high concentration of Houttuynia Cordata Extract and Panthenol offers excellent moisturizing and soothing benefits, which are relevant for your skin.
- The safety profile is excellent due to the absence of harsh ingredients and the presence of soothing components like Houttuynia Cordata Extract, Allantoin, and Panthenol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-acne-prone-skin): Superior

## Key ingredients

Heartleaf Extract, Hyaluronic Acid, Glycerin, Allantoin, Panthenol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream. ([Clinical, Cosmetic and Investigational Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27013898/))
- Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution. ([Molecules, 2019](https://pubmed.ncbi.nlm.nih.gov/31238562/))
- Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration. ([Gels, 2023](https://pubmed.ncbi.nlm.nih.gov/37754433/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Prophylactic application of a topical scar gel containing Allium cepae extract, allantoin, and heparin significantly improves patient-assessed scar color, stiffness, and irregularity compared to no treatment in women following a cesarean section. ([Journal of Drugs in Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24509969/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))

## What reviewers say

Based on a very large amount of data, this ampoule is widely praised by users with sensitive and acne-prone skin for its ability to rapidly soothe redness and provide deep hydration without clogging pores. While most users achieve a "glass skin" glow and reduced inflammation, a minority experience a tacky finish or find it ineffective for severe breakouts.

- Liked: Soothing redness (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Acne care (sometimes noted)
- Liked: Lightweight texture (sometimes noted)
- Disliked: Small quantity (sometimes noted)
- Disliked: Sticky finish (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Lack of results (rarely noted)

## How to apply

- Could be used as part of your AM and PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it too hard so it absorbs nicely.
- For the best moisture, you can apply it when your skin is slightly damp. This helps your skin stay soft and happy.
- Remember to avoid the eye area when applying. Always do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Anua Heartleaf 80 Moisture Soothing Ampoule a great fit for skin with dark spots?

This ampoule is a great fit because glycerin and hyaluronic acid draw in moisture while panthenol repairs the skin barrier, which supports overall skin recovery for pigmentation. Additionally, high levels of heartleaf extract and panthenol provide soothing and moisturizing benefits with a very safe profile.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for skin with dark spots?

Glycerin and hyaluronic acid help keep normal skin hydrated, while panthenol repairs the skin barrier to support recovery for pigmentation. Additionally, a high concentration of heartleaf extract and panthenol provides great moisturizing and soothing benefits.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Heartleaf Extract do for skin with dark spots?

Heartleaf Extract helps calm skin and may reduce redness and irritation that often lead to dark spots. It is often included in products designed to soothe stressed skin and even out skin tone.

### What does Hyaluronic Acid do for skin with dark spots?

Hyaluronic acid is unlikely to directly fade dark spots, but it helps keep dry and uneven skin plump and deeply hydrated. To effectively target dark spots, this type of skin needs brightening ingredients like vitamin C or niacinamide alongside your hydrator.

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps the routine simple and safe around sun exposure. Using it at night helps calm the skin and supports recovery from dark spots with soothing ingredients like heartleaf extract and panthenol.

### Can I use this serum with retinol, and in what order?

You can use this moisturizing treatment alongside retinol by applying the serum first to calm and hydrate your skin before layering your retinol product on top. Using a soothing, barrier-repairing product like this helps keep skin comfortable and is unlikely to cause irritation when combined with active treatments.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How often should I use this serum?

This treatment is used in the evening as part of your routine. Daily application helps keep your skin hydrated and supported while managing dark spots.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to cause breakouts because it has a very low rate of complaints for causing them and an excellent safety profile with soothing ingredients like heartleaf extract, allantoin, and panthenol. Panthenol helps support barrier recovery and skin health.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use this serum around the eyes or on my body?

This moisturizing treatment is well-suited for the body and the thin skin around the eyes because its gentle ingredients safely hydrate and calm the area. Hyaluronic acid and glycerin draw in moisture, while panthenol helps repair the skin barrier without irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/it/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/dark-spots) — High fit — €21.00 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/it/p/missha/super-aqua-ultra-hyalron-ampoule/for/dark-spots) — Average fit — €27.55 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/it/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €24.75 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €15.16 at Amazon
- SPF: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/it/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dark-spots) — Superior fit — €20.40 at Amazon

## Where to buy

- Amazon.it: €22.05 (https://www.amazon.it/dp/B08CMVXQ9W?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Notino: €33.90 (https://www.notino.it/anua/heartleaf-80-moisture-ampoule-fiale-rigeneranti-intensive-per-la-pelle-con-effetto-lenitivo/p-16242798/)
Prices checked 17 Oct – 6 Nov 2026.

## Ingredients

Water, Houttuynia Cordata Extract, Glycerin, Butylene Glycol, 1,2-Hexanediol, Hyaluronic Acid, Betaine, Allantoin, Panthenol, Ethylhexylglycerin, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots
- France: https://lovi.care/skincare/fr/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots (this page)
- Netherlands: https://lovi.care/skincare/nl/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots