# Phytosphingosine and hexapeptide-9 Page: https://lovi.care/skincare/it/ingredients/phytosphingosine-and-hexapeptide-9 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy. Work well together Use them together in the same routine, applying the peptide first and following with the [phytosphingosine](https://lovi.care/skincare/it/ingredients/phytosphingosine). Phytosphingosine helps the skin absorb [hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9) better while strengthening the skin barrier for smoother results. If your skin feels sensitive, you can apply them on alternate nights or use a lower concentration. - [All about phytosphingosine](https://lovi.care/skincare/it/ingredients/phytosphingosine) - [All about hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9) ### [Phytosphingosine](https://lovi.care/skincare/it/ingredients/phytosphingosine) products - [CeraVe Hydrating Facial Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — [€9.19 at Amazon](https://www.amazon.it/dp/B07C5R51Q9?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/it/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — [€14.20 at Amazon](https://www.amazon.it/dp/B07C5XYT19?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [Aestura Atobarrier 365 Cream](https://lovi.care/skincare/it/p/aestura/atobarrier-365-cream/for/dry-skin) — High fit — [€31.00 at Amazon](https://www.amazon.it/dp/B09YDCCJBJ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [Cetaphil Ceramide Serum](https://lovi.care/skincare/it/p/cetaphil/ceramide-serum/for/acne-prone-skin) — Superior fit — [€35.67 at Amazon](https://www.amazon.it/dp/B0CZD72G5W?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [Bioderma Atoderm Intensive Eye](https://lovi.care/skincare/it/p/bioderma/atoderm-intensive-eye/for/acne-prone-skin) — High fit — [€16.60 at Notino](https://www.notino.it/bioderma/atoderm-intensive-eye-trattamento-lenitivo-per-palpebre-irritate/p-16026800/) - [Obagi Rebalance Skin Barrier Recovery Cream](https://lovi.care/skincare/it/p/obagi/rebalance-skin-barrier-recovery-cream/for/dry-sensitive-skin) — High fit - [Elizabeth Arden Advanced Ceramide Capsules Daily Youth Restoring Serum](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-capsules-daily-youth-restoring-serum/for/oily-skin) — High fit — [€34.90 at Amazon](https://www.amazon.it/dp/B06WLQWXY6?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) ### [Hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9) products - [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/it/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€82.90 at Notino](https://www.notino.it/elemis/pro-collagen-oxygenating-night-cream-crema-notte-rassodante-antirughe/p-16125564/) - [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/it/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit - [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/it/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€13.08 at Amazon](https://www.amazon.it/dp/B095YHYF33?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use phytosphingosine and hexapeptide-9 together? Yes, [phytosphingosine](https://lovi.care/skincare/it/ingredients/phytosphingosine) and [hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9) work well together to enhance skin barrier repair and support overall structure. Combining these ingredients helps improve absorption and reinforces the skin barrier. [Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/) [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/) ### Which goes first, phytosphingosine or hexapeptide-9? There is no specific rule on which ingredient goes first, but you can easily combine phytosphingosine and hexapeptide-9 in your routine for enhanced barrier repair and support. ### Are phytosphingosine and hexapeptide-9 good for sensitive skin? Phytosphingosine and hexapeptide-9 work well together to benefit dry, mature, and barrier-impaired skin. Combining them helps enhance skin repair and barrier support, as lipids improve peptide absorption and reinforce skin structure. [Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/) [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/) ## Research on phytosphingosine and hexapeptide-9 - [Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/18489348/) Phytosphingosine · International Journal of Cosmetic Science, 2007 - [Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids](https://pubmed.ncbi.nlm.nih.gov/12482041/) Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002 - [Salicyloyl-phytosphingosine: a novel agent for the repair of photoaged skin](https://pubmed.ncbi.nlm.nih.gov/18489360/) Phytosphingosine · International Journal of Cosmetic Science, 2007 - [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025 ## Other combinations - Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide-9) - Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/granactive-retinoid-and-hexapeptide-9) - Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9) - Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/pro-retinol-and-hexapeptide-9) - Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/it/ingredients/retinal-and-hexapeptide-9) - Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/it/ingredients/retinoid-blend-and-hexapeptide-9) - Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/retinol-and-hexapeptide-9) - Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/it/ingredients/tretinoin-and-hexapeptide-9) - Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/it/ingredients/vitamin-a-and-hexapeptide-9) - Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/it/ingredients/liposome-and-hexapeptide-9) - Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/it/ingredients/microcapsule-and-hexapeptide-9) - Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/it/ingredients/vitamin-c-and-hexapeptide-9) - Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/it/ingredients/betaine-and-hexapeptide-9) - Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/it/ingredients/glycerin-and-hexapeptide-9) - Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/hyaluronic-acid-and-hexapeptide-9) - Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/it/ingredients/niacinamide-and-hexapeptide-9) - Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/panthenol-and-hexapeptide-9) - Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/bakuchiol-and-hexapeptide-9) - Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/it/ingredients/arginine-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-gaba) - Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/it/ingredients/silk-amino-acids-and-hexapeptide-9) - Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/it/ingredients/taurine-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/it/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9) - Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/citric-acid-and-hexapeptide-9) - Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/glycolic-acid-and-hexapeptide-9) - Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/lactic-acid-and-hexapeptide-9) - Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/mandelic-acid-and-hexapeptide-9) - Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/it/ingredients/coenzyme-q10-and-hexapeptide-9) - Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/it/ingredients/green-tea-and-hexapeptide-9) - Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/it/ingredients/vitamin-e-and-hexapeptide-9) - Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-phytosphingosine) - Work well together: [Bio-placenta peptides and phytosphingosine](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-phytosphingosine) - Work well together: [Collagen peptide and phytosphingosine](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-phytosphingosine) - Work well together: [Phytosphingosine and copper peptide](https://lovi.care/skincare/it/ingredients/phytosphingosine-and-copper-peptide) - Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-phytosphingosine) - Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/it/ingredients/ceramide-building-complex-and-hexapeptide-9) - Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/cholesterol-and-hexapeptide-9) - Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/phytosterol-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-squalene) - Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-tri-ceramide-complex) - Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/it/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4) - Work well together: [Phytosphingosine and palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1) - Work well together: [Phytosphingosine and peptide-rich plasma](https://lovi.care/skincare/it/ingredients/phytosphingosine-and-peptide-rich-plasma) - Work well together: [Phytosphingosine and triple peptide blend](https://lovi.care/skincare/it/ingredients/phytosphingosine-and-triple-peptide-blend) - Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/salicylic-acid-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-baking-soda) - Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/it/ingredients/bleach-and-hexapeptide-9) - Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/it/ingredients/potassium-hydroxide-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-behenyl-alcohol) - Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-isopropyl-alcohol) - Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/polyvinyl-alcohol-and-hexapeptide-9) - Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/it/ingredients/copper-and-hexapeptide-9) - Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide-and-hexapeptide-9) - Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/it/ingredients/magnesium-and-hexapeptide-9) - Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/it/ingredients/zinc-and-hexapeptide-9) - Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/it/ingredients/zinc-sulfate-and-hexapeptide-9) - Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/azelaic-acid-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-protease) - Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/it/ingredients/superoxide-dismutase-and-hexapeptide-9) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/phytosphingosine-and-hexapeptide-9 - United Kingdom: https://lovi.care/skincare/uk/ingredients/phytosphingosine-and-hexapeptide-9 - Ireland: https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-hexapeptide-9 - Germany: https://lovi.care/skincare/de/ingredients/phytosphingosine-and-hexapeptide-9 - France: https://lovi.care/skincare/fr/ingredients/phytosphingosine-and-hexapeptide-9 - Italy: https://lovi.care/skincare/it/ingredients/phytosphingosine-and-hexapeptide-9 (this page) - Netherlands: https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-hexapeptide-9 - Spain: https://lovi.care/skincare/es/ingredients/phytosphingosine-and-hexapeptide-9 - Canada: https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-hexapeptide-9 - Australia: https://lovi.care/skincare/au/ingredients/phytosphingosine-and-hexapeptide-9 - Singapore: https://lovi.care/skincare/sg/ingredients/phytosphingosine-and-hexapeptide-9 - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/phytosphingosine-and-hexapeptide-9 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/phytosphingosine-and-hexapeptide-9