# Panthenol and hexapeptide Page: https://lovi.care/skincare/it/ingredients/panthenol-and-hexapeptide The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy. Work well together Use them together in the same routine, applying [panthenol](https://lovi.care/skincare/it/ingredients/panthenol) first to calm the skin and [hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide) second to firm it. Panthenol soothes the skin while hexapeptide helps smooth out fine lines, making them a great team for your daily routine. You can use them together normally, but if your skin feels sensitive, you can apply them on alternate days. - [All about panthenol](https://lovi.care/skincare/it/ingredients/panthenol) - [All about hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide) ### [Panthenol](https://lovi.care/skincare/it/ingredients/panthenol) products - [Cetaphil Gentle Skin Cleanser](https://lovi.care/skincare/it/p/cetaphil/gentle-skin-cleanser/for/dry-skin) — Superior fit — [€12.34 at Amazon](https://www.amazon.it/dp/B0CDXXGBK4?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [La Roche-Posay Toleriane Hydrating Gentle Cleanser](https://lovi.care/skincare/it/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — [€17.59 at Amazon](https://www.amazon.it/dp/B01N7T7JKJ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/it/p/cosrx/advanced-snail-96-mucin-power-essence/for/dry-skin) — Superior fit — [€12.09 at Amazon](https://www.amazon.it/dp/B00PBX3L7K?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [CeraVe Healing Ointment](https://lovi.care/skincare/it/p/cerave/healing-ointment/for/dry-skin) — High fit - [La Roche-Posay Cicaplast Baume B5+](https://lovi.care/skincare/it/p/la-roche-posay/cicaplast-baume-b5/for/sensitive-skin) — Superior fit — [€10.39 at Amazon](https://www.amazon.it/dp/B00ST2GSRK?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [Mederma Advanced Scar Gel](https://lovi.care/skincare/it/p/mederma/advanced-scar-gel/for/sensitive-skin) — High fit - [The Ordinary Hyaluronic Acid 2% + B5](https://lovi.care/skincare/it/p/the-ordinary/hyaluronic-acid-2-b5/for/acne-prone-skin) — High fit — [€9.80 at Amazon](https://www.amazon.it/dp/B01MYEZPC8?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [NIVEA Creme](https://lovi.care/skincare/it/p/nivea/creme/for/dry-skin) — High fit — [€5.28 at Amazon](https://www.amazon.it/dp/B00DT3QNKQ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [Aquaphor Lip Repair](https://lovi.care/skincare/it/p/aquaphor/lip-repair/for/dry-skin) — Superior fit - [Torriden Dive In Serum](https://lovi.care/skincare/it/p/torriden/dive-in-serum/for/acne-prone-skin) — Superior fit — [€31.37 at Amazon](https://www.amazon.it/dp/B07WZ2YTDP?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [RoC Retinol Correxion Line Smoothing Eye Cream](https://lovi.care/skincare/it/p/roc/retinol-correxion-line-smoothing-eye-cream/for/mature-skin) — High fit — [€20.99 at Amazon](https://www.amazon.it/dp/B08GGD7NRN?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [Cetaphil Daily Facial Cleanser](https://lovi.care/skincare/it/p/cetaphil/daily-facial-cleanser/for/oily-skin) — Superior fit — [€12.34 at Amazon](https://www.amazon.it/dp/B0CDXXGBK4?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) ### [Hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide) products - [SkinCeuticals P-TOX](https://lovi.care/skincare/it/p/skinceuticals/p-tox/for/mature-skin) — High fit — [€155.25 at Lookfantastic](https://www.lookfantastic.it/p/skinceuticals-p-tiox-neuro-peptide-serum-30ml/15456548/) ## Questions and answers ### Can you use panthenol and hexapeptide together? Yes, you can use [panthenol](https://lovi.care/skincare/it/ingredients/panthenol) and [hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide) together because they work well to strengthen your skin barrier and support skin regeneration. Panthenol helps reduce irritation, while hexapeptide may provide a significant anti-wrinkle effect. [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/) [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) ### Which goes first, panthenol or hexapeptide? Panthenol and hexapeptide work well together, so neither needs to go first when you use them. You can easily layer them or find them in a combined anti-aging routine to help strengthen your skin barrier and smooth out wrinkles. [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/) [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) ### Are panthenol and hexapeptide good for sensitive skin? Panthenol and hexapeptide work well together, making them ideal for sensitive, mature, or reactive skin. Panthenol helps reduce irritation and supports skin healing, while hexapeptide may provide anti-wrinkle benefits. [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/) [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) ## Research on panthenol and hexapeptide - [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002 - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013 - [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017 - [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017 - [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Panthenol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019 - [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025 ## Other combinations - Work well together: [Panthenol and salicylic acid](https://lovi.care/skincare/it/ingredients/panthenol-and-salicylic-acid) - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-granactive-retinoid) - Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/hexapeptide-and-hydroxypinacolone-retinoate) - Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-pro-retinol) - Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/it/ingredients/hexapeptide-and-retinal) - Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/it/ingredients/hexapeptide-and-retinoid-blend) - Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/it/ingredients/retinol-and-hexapeptide) - Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/it/ingredients/tretinoin-and-hexapeptide) - Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/it/ingredients/hexapeptide-and-vitamin-a) - Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/it/ingredients/hexapeptide-and-liposome) - Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/it/ingredients/hexapeptide-and-microcapsule) - Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/it/ingredients/vitamin-c-and-hexapeptide) - Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-betaine) - Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/it/ingredients/glycerin-and-hexapeptide) - Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-hyaluronic-acid) - Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/it/ingredients/panthenol-and-acetyl-hexapeptide-3) - Work well together: [Panthenol and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/panthenol-and-bio-placenta-peptides) - Work well together: [Panthenol and collagen peptide](https://lovi.care/skincare/it/ingredients/panthenol-and-collagen-peptide) - Work well together: [Panthenol and copper peptide](https://lovi.care/skincare/it/ingredients/panthenol-and-copper-peptide) - Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/it/ingredients/niacinamide-and-hexapeptide) - Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/panthenol-and-hexapeptide-9) - Work well together: [Panthenol and palmitoyl pentapeptide-4](https://lovi.care/skincare/it/ingredients/panthenol-and-palmitoyl-pentapeptide-4) - Work well together: [Panthenol and palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/panthenol-and-palmitoyl-tripeptide-1) - Work well together: [Panthenol and peptide-rich plasma](https://lovi.care/skincare/it/ingredients/panthenol-and-peptide-rich-plasma) - Work well together: [Panthenol and triple peptide blend](https://lovi.care/skincare/it/ingredients/panthenol-and-triple-peptide-blend) - Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/it/ingredients/bakuchiol-and-hexapeptide) - Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-arginine) - Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/it/ingredients/hexapeptide-and-gaba) - Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/it/ingredients/hexapeptide-and-silk-amino-acids) - Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-taurine) - Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/it/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide) - Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-citric-acid) - Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/it/ingredients/glycolic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-lactic-acid) - Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-mandelic-acid) - Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/it/ingredients/coenzyme-q10-and-hexapeptide) - Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/it/ingredients/green-tea-and-hexapeptide) - Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/it/ingredients/vitamin-e-and-hexapeptide) - Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/it/ingredients/ceramide-building-complex-and-hexapeptide) - Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-cholesterol) - Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-phytosphingosine) - Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-phytosterol) - Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/it/ingredients/hexapeptide-and-squalene) - Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/it/ingredients/hexapeptide-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/it/ingredients/salicylic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/it/ingredients/hexapeptide-and-baking-soda) - Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/it/ingredients/hexapeptide-and-bleach) - Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/it/ingredients/hexapeptide-and-potassium-hydroxide) - Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-behenyl-alcohol) - Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-isopropyl-alcohol) - Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-polyvinyl-alcohol) - Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/it/ingredients/hexapeptide-and-copper) - Work well together: [Panthenol and aha blend glycolic and citric acids](https://lovi.care/skincare/it/ingredients/panthenol-and-aha-blend-glycolic-and-citric-acids) - Work well together: [Panthenol and citric acid](https://lovi.care/skincare/it/ingredients/panthenol-and-citric-acid) - Work well together: [Glycolic acid and panthenol](https://lovi.care/skincare/it/ingredients/glycolic-acid-and-panthenol) - Work well together: [Panthenol and lactic acid](https://lovi.care/skincare/it/ingredients/panthenol-and-lactic-acid) - Work well together: [Panthenol and mandelic acid](https://lovi.care/skincare/it/ingredients/panthenol-and-mandelic-acid) - Work well together: [Panthenol and hyaluronic acid](https://lovi.care/skincare/it/ingredients/panthenol-and-hyaluronic-acid) - Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/it/ingredients/hexapeptide-and-magnesium) - Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/it/ingredients/hexapeptide-and-zinc) - Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/it/ingredients/hexapeptide-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide-and-hexapeptide) - Work well together: [Panthenol and tri-ceramide complex](https://lovi.care/skincare/it/ingredients/panthenol-and-tri-ceramide-complex) - Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/it/ingredients/azelaic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/it/ingredients/hexapeptide-and-protease) - Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/it/ingredients/hexapeptide-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/panthenol-and-hexapeptide - United Kingdom: https://lovi.care/skincare/uk/ingredients/panthenol-and-hexapeptide - Ireland: https://lovi.care/skincare/ie/ingredients/panthenol-and-hexapeptide - Germany: https://lovi.care/skincare/de/ingredients/panthenol-and-hexapeptide - France: https://lovi.care/skincare/fr/ingredients/panthenol-and-hexapeptide - Italy: https://lovi.care/skincare/it/ingredients/panthenol-and-hexapeptide (this page) - Netherlands: https://lovi.care/skincare/nl/ingredients/panthenol-and-hexapeptide - Spain: https://lovi.care/skincare/es/ingredients/panthenol-and-hexapeptide - Canada: https://lovi.care/skincare/ca/ingredients/panthenol-and-hexapeptide - Australia: https://lovi.care/skincare/au/ingredients/panthenol-and-hexapeptide - Singapore: https://lovi.care/skincare/sg/ingredients/panthenol-and-hexapeptide - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/panthenol-and-hexapeptide - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/panthenol-and-hexapeptide