# Hexapeptide and lactic acid Page: https://lovi.care/skincare/it/ingredients/hexapeptide-and-lactic-acid The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy. Keep them apart Apply [lactic acid](https://lovi.care/skincare/it/ingredients/lactic-acid) and [hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide) at different times of day because acids break down peptides and ruin their anti-aging power. The acidic lactic acid destroys the delicate structure of the hexapeptide, stopping it from smoothing your skin. You can use one in the morning and the other at night, or use milder formulas. - [All about hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide) - [All about lactic acid](https://lovi.care/skincare/it/ingredients/lactic-acid) ### [Hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide) products - [SkinCeuticals P-TOX](https://lovi.care/skincare/it/p/skinceuticals/p-tox/for/mature-skin) — High fit — [€155.25 at Lookfantastic](https://www.lookfantastic.it/p/skinceuticals-p-tiox-neuro-peptide-serum-30ml/15456548/) ### [Lactic acid](https://lovi.care/skincare/it/ingredients/lactic-acid) products - [Medicube Zero Pore Pad](https://lovi.care/skincare/it/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [€17.15 at Amazon](https://www.amazon.it/dp/B09V7Z4TJG?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [First Aid Beauty KP Bump Eraser Body Scrub](https://lovi.care/skincare/it/p/first-aid-beauty/kp-bump-eraser-body-scrub/for/dark-spots) — Average fit — [€29.60 at Amazon](https://www.amazon.it/dp/B08GNS58PQ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [EltaMD UV Clear Broad-Spectrum SPF 46](https://lovi.care/skincare/it/p/eltamd/uv-clear-broad-spectrum-spf-46/for/oily-acne-prone-skin) — Superior fit — [€73.90 at Amazon](https://www.amazon.it/dp/B00ZPWR0N8?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [First Aid Beauty Facial Radiance Pads](https://lovi.care/skincare/it/p/first-aid-beauty/facial-radiance-pads/for/sensitive-skin) — Superior fit — [€17.25 at Lookfantastic](https://www.lookfantastic.it/p/first-aid-beauty-brighten-glow-pads-28-ct./17716506/) - [CeraVe SA Lotion for Rough & Bumpy Skin](https://lovi.care/skincare/it/p/cerave/sa-lotion-for-rough-and-bumpy-skin/for/oily-skin) — Average fit — [€13.29 at Amazon](https://www.amazon.it/dp/B07WL7WV52?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [CeraVe Renewing SA Cream](https://lovi.care/skincare/it/p/cerave/renewing-sa-cream/for/oily-acne-prone-skin) — High fit - [The Ordinary Alpha Arbutin 2% + HA](https://lovi.care/skincare/it/p/the-ordinary/alpha-arbutin-2-ha/for/dark-spots) — Superior fit — [€12.08 at Amazon](https://www.amazon.it/dp/B06XCZFCFZ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [The Ordinary Retinal 0.2% Emulsion](https://lovi.care/skincare/it/p/the-ordinary/retinal-0-2-emulsion/for/oily-acne-prone-skin) — High fit — [€17.48 at Amazon](https://www.amazon.it/dp/B0CZ5VG3L1?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [Kate Somerville ExfoliKate Intensive Exfoliating Treatment](https://lovi.care/skincare/it/p/kate-somerville/exfolikate-intensive-exfoliating-treatment/for/mature-skin) — Superior fit — [€56.90 at Amazon](https://www.amazon.it/dp/B0753531MB?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [Dr. Dennis Gross Alpha Beta Universal Daily Peel](https://lovi.care/skincare/it/p/dr-dennis-gross/alpha-beta-universal-daily-peel/for/acne-prone-skin) — Superior fit — [€122.45 at Amazon](https://www.amazon.it/dp/B009QZ595Q?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [The Ordinary Lactic Acid 5% + HA](https://lovi.care/skincare/it/p/the-ordinary/lactic-acid-5-ha/for/dry-skin) — Superior fit - [Good Molecules Overnight Exfoliating Treatment](https://lovi.care/skincare/it/p/good-molecules/overnight-exfoliating-treatment/for/oily-skin) — Superior fit — [€22.99 at Amazon](https://www.amazon.it/dp/B08TMDRF1L?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use hexapeptide and lactic acid together? No, keep [hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide) and [lactic acid](https://lovi.care/skincare/it/ingredients/lactic-acid) apart in your routine because the low pH of lactic acid may break down the peptide bonds and reduce its effectiveness. Instead, use them in separate steps or routines, such as applying one in the morning and the other at night. ### Which goes first, hexapeptide or lactic acid? Keep hexapeptide and lactic acid apart by using them in separate steps or routines, such as AM and PM separation. The low pH of lactic acid may destabilize the peptide bonds and reduce the bioactivity of hexapeptide. ### Are hexapeptide and lactic acid good for sensitive skin? Hexapeptide and lactic acid should be separated into different routines to protect sensitive skin because the low pH of lactic acid may destabilize peptides and reduce their effectiveness. ## Research on hexapeptide and lactic acid - [Lactate triggers KAT8-mediated LTBP1 lactylation at lysine 752 to promote skin rejuvenation by inducing collagen synthesis in fibroblasts](https://pubmed.ncbi.nlm.nih.gov/39102921/) Lactic acid · International Journal of Biological Macromolecules, 2024 - [Poly-L-Lactic acid increases collagen gene expression and synthesis in cultured dermal fibroblast (Hs68) through the TGF-β/Smad pathway](https://pubmed.ncbi.nlm.nih.gov/36575891/) Lactic acid · Journal of Cosmetic Dermatology, 2023 - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013 - [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019 - [Do urea/ammonium lactate combinations achieve better skin protection and hydration than either component alone?](https://pubmed.ncbi.nlm.nih.gov/11803256/) Lactic acid · Skin Pharmacology and Applied Skin Physiology, 2002 ## Other combinations - Keep them apart: [Benzoyl peroxide and lactic acid](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide-and-lactic-acid) - Keep them apart: [Retinol and lactic acid](https://lovi.care/skincare/it/ingredients/retinol-and-lactic-acid) - Depends on the strength: [Niacinamide and lactic acid](https://lovi.care/skincare/it/ingredients/niacinamide-and-lactic-acid) - Work well together: [Lactic acid and sodium lactate](https://lovi.care/skincare/it/ingredients/lactic-acid-and-sodium-lactate) - Work well together: [Lactic acid and tromethamine](https://lovi.care/skincare/it/ingredients/lactic-acid-and-tromethamine) - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-granactive-retinoid) - Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/hexapeptide-and-hydroxypinacolone-retinoate) - Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-pro-retinol) - Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/it/ingredients/hexapeptide-and-retinal) - Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/it/ingredients/hexapeptide-and-retinoid-blend) - Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/it/ingredients/retinol-and-hexapeptide) - Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/it/ingredients/tretinoin-and-hexapeptide) - Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/it/ingredients/hexapeptide-and-vitamin-a) - Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/it/ingredients/hexapeptide-and-liposome) - Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/it/ingredients/hexapeptide-and-microcapsule) - Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/it/ingredients/vitamin-c-and-hexapeptide) - Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-betaine) - Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/it/ingredients/glycerin-and-hexapeptide) - Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-hyaluronic-acid) - Work well together: [Lactic acid and betaine](https://lovi.care/skincare/it/ingredients/lactic-acid-and-betaine) - Work well together: [Glycerin and lactic acid](https://lovi.care/skincare/it/ingredients/glycerin-and-lactic-acid) - Depends on the strength: [Lactic acid and hyaluronic acid](https://lovi.care/skincare/it/ingredients/lactic-acid-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/it/ingredients/niacinamide-and-hexapeptide) - Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/it/ingredients/panthenol-and-hexapeptide) - Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/it/ingredients/bakuchiol-and-hexapeptide) - Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-arginine) - Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/it/ingredients/hexapeptide-and-gaba) - Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/it/ingredients/hexapeptide-and-silk-amino-acids) - Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-taurine) - Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/it/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide) - Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-citric-acid) - Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/it/ingredients/glycolic-acid-and-hexapeptide) - Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/it/ingredients/lactic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Bio-placenta peptides and lactic acid](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-lactic-acid) - Keep them apart: [Carnosine and lactic acid](https://lovi.care/skincare/it/ingredients/carnosine-and-lactic-acid) - Keep them apart: [Lactic acid and collagen peptide](https://lovi.care/skincare/it/ingredients/lactic-acid-and-collagen-peptide) - Keep them apart: [Lactic acid and copper peptide](https://lovi.care/skincare/it/ingredients/lactic-acid-and-copper-peptide) - Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/lactic-acid-and-hexapeptide-9) - Keep them apart: [Lactic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/it/ingredients/lactic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Lactic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/lactic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Lactic acid and peptide-rich plasma](https://lovi.care/skincare/it/ingredients/lactic-acid-and-peptide-rich-plasma) - Keep them apart: [Lactic acid and triple peptide blend](https://lovi.care/skincare/it/ingredients/lactic-acid-and-triple-peptide-blend) - Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-mandelic-acid) - Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/it/ingredients/coenzyme-q10-and-hexapeptide) - Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/it/ingredients/green-tea-and-hexapeptide) - Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/it/ingredients/vitamin-e-and-hexapeptide) - Keep them apart: [Adapalene and lactic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-lactic-acid) - Keep them apart: [Lactic acid and granactive retinoid](https://lovi.care/skincare/it/ingredients/lactic-acid-and-granactive-retinoid) - Keep them apart: [Lactic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/lactic-acid-and-hydroxypinacolone-retinoate) - Keep them apart: [Pro-retinol and lactic acid](https://lovi.care/skincare/it/ingredients/pro-retinol-and-lactic-acid) - Keep them apart: [Retinal and lactic acid](https://lovi.care/skincare/it/ingredients/retinal-and-lactic-acid) - Keep them apart: [Lactic acid and retinoid blend](https://lovi.care/skincare/it/ingredients/lactic-acid-and-retinoid-blend) - Keep them apart: [Tretinoin and lactic acid](https://lovi.care/skincare/it/ingredients/tretinoin-and-lactic-acid) - Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/it/ingredients/ceramide-building-complex-and-hexapeptide) - Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-cholesterol) - Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-phytosphingosine) - Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-phytosterol) - Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/it/ingredients/hexapeptide-and-squalene) - Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/it/ingredients/hexapeptide-and-tri-ceramide-complex) - Work well together: [Lactic acid and gluconolactone](https://lovi.care/skincare/it/ingredients/lactic-acid-and-gluconolactone) - Work well together: [Lactic acid and lactobionic acid](https://lovi.care/skincare/it/ingredients/lactic-acid-and-lactobionic-acid) - Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/it/ingredients/salicylic-acid-and-hexapeptide) - Work well together: [Lactic acid and cholesterol](https://lovi.care/skincare/it/ingredients/lactic-acid-and-cholesterol) - Work well together: [Lactic acid and lauric acid](https://lovi.care/skincare/it/ingredients/lactic-acid-and-lauric-acid) - Work well together: [Linoleic acid and lactic acid](https://lovi.care/skincare/it/ingredients/linoleic-acid-and-lactic-acid) - Keep them apart: [Lactic acid and tri-ceramide complex](https://lovi.care/skincare/it/ingredients/lactic-acid-and-tri-ceramide-complex) - Work well together: [Arginine and lactic acid](https://lovi.care/skincare/it/ingredients/arginine-and-lactic-acid) - Work well together: [Lactic acid and GABA](https://lovi.care/skincare/it/ingredients/lactic-acid-and-gaba) - Work well together: [Silk amino acids and lactic acid](https://lovi.care/skincare/it/ingredients/silk-amino-acids-and-lactic-acid) - Work well together: [Lactic acid and taurine](https://lovi.care/skincare/it/ingredients/lactic-acid-and-taurine) - Work well together: [Lactic acid and theanine](https://lovi.care/skincare/it/ingredients/lactic-acid-and-theanine) - Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/it/ingredients/hexapeptide-and-baking-soda) - Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/it/ingredients/hexapeptide-and-bleach) - Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/it/ingredients/hexapeptide-and-potassium-hydroxide) - Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-behenyl-alcohol) - Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-isopropyl-alcohol) - Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-polyvinyl-alcohol) - Work well together: [Ferulic acid and lactic acid](https://lovi.care/skincare/it/ingredients/ferulic-acid-and-lactic-acid) - Work well together: [Vitamin E and lactic acid](https://lovi.care/skincare/it/ingredients/vitamin-e-and-lactic-acid) - Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/it/ingredients/hexapeptide-and-copper) - Keep them apart: [Azelaic acid and lactic acid](https://lovi.care/skincare/it/ingredients/azelaic-acid-and-lactic-acid) - Keep them apart: [Salicylic acid and lactic acid](https://lovi.care/skincare/it/ingredients/salicylic-acid-and-lactic-acid) - Work well together: [Allantoin and lactic acid](https://lovi.care/skincare/it/ingredients/allantoin-and-lactic-acid) - Work well together: [Lactic acid and bisabolol](https://lovi.care/skincare/it/ingredients/lactic-acid-and-bisabolol) - Work well together: [Panthenol and lactic acid](https://lovi.care/skincare/it/ingredients/panthenol-and-lactic-acid) - Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/it/ingredients/hexapeptide-and-magnesium) - Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/it/ingredients/hexapeptide-and-zinc) - Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/it/ingredients/hexapeptide-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide-and-hexapeptide) - Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/it/ingredients/azelaic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/it/ingredients/hexapeptide-and-protease) - Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/it/ingredients/hexapeptide-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/hexapeptide-and-lactic-acid - United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-lactic-acid - Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-lactic-acid - Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-lactic-acid - France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-lactic-acid - Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-lactic-acid (this page) - Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-lactic-acid - Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-lactic-acid - Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-lactic-acid - Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-lactic-acid - Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-lactic-acid - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-lactic-acid - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-lactic-acid