# Hexapeptide and betaine Page: https://lovi.care/skincare/it/ingredients/hexapeptide-and-betaine The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy. Work well together Use them together by applying the [betaine](https://lovi.care/skincare/it/ingredients/betaine) hydrating [serum](https://lovi.care/skincare/it/ingredients/serum) first, followed by the [hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide), because moisture helps peptides work better. Betaine draws in moisture that helps the hexapeptide sink in deep and keep your skin barrier strong. You can use your usual amounts since these two ingredients work together safely. [Effects of water activity and low molecular weight humectants on skin permeability and hydration dynamics - a double-blind, randomized and controlled study](https://pubmed.ncbi.nlm.nih.gov/24786192/) [The efficiency of humectants as skin moisturizers in the presence of oil](https://pubmed.ncbi.nlm.nih.gov/11301638/) - [All about hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide) - [All about betaine](https://lovi.care/skincare/it/ingredients/betaine) ### [Hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide) products - [SkinCeuticals P-TOX](https://lovi.care/skincare/it/p/skinceuticals/p-tox/for/mature-skin) — High fit — [€155.25 at Lookfantastic](https://www.lookfantastic.it/p/skinceuticals-p-tiox-neuro-peptide-serum-30ml/15456548/) ### [Betaine](https://lovi.care/skincare/it/ingredients/betaine) products - [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/it/p/cosrx/advanced-snail-96-mucin-power-essence/for/dry-skin) — Superior fit — [€12.09 at Amazon](https://www.amazon.it/dp/B00PBX3L7K?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [COSRX The Hyaluronic Acid 3 Serum](https://lovi.care/skincare/it/p/cosrx/the-hyaluronic-acid-3-serum/for/combination-skin) — High fit — [€24.50 at Notino](https://www.notino.it/cosrx/hyaluronic-acid-3-siero-idratante-intenso/p-16172039/) - [Good Molecules Niacinamide Serum](https://lovi.care/skincare/it/p/good-molecules/niacinamide-serum/for/oily-skin) — Average fit — [€18.00 at Amazon](https://www.amazon.it/dp/B08R994Q1L?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [COSRX Advanced Snail 92 All in One Cream](https://lovi.care/skincare/it/p/cosrx/advanced-snail-92-all-in-one-cream/for/sensitive-skin) — Superior fit — [€16.22 at Amazon](https://www.amazon.it/dp/B01LEJ5MSK?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [MEDIHEAL Collagen Ampoule Pad](https://lovi.care/skincare/it/p/mediheal/collagen-ampoule-pad/for/mature-skin) — High fit — [€33.00 at Amazon](https://www.amazon.it/dp/B0CBTRKLNZ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [PanOxyl Clarifying Exfoliant](https://lovi.care/skincare/it/p/panoxyl/clarifying-exfoliant/for/combination-skin) — High fit - [Anua Heartleaf 77% Clear Pad](https://lovi.care/skincare/it/p/anua/heartleaf-77-clear-pad/for/sensitive-skin) — High fit — [€23.99 at Amazon](https://www.amazon.it/dp/B08JLMRTZS?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [innisfree Cherry Blossom Glow Jelly Cream](https://lovi.care/skincare/it/p/innisfree/cherry-blossom-glow-jelly-cream/for/dry-skin) — Average fit — [€28.75 at Lookfantastic](https://www.lookfantastic.it/p/innisfree-cherry-blossom-glow-jelly-cream-50ml/15228003/) - [The INKEY List Omega Water Cream](https://lovi.care/skincare/it/p/the-inkey-list/omega-water-cream/for/dry-skin) — High fit — [€11.89 at Amazon](https://www.amazon.it/dp/B09XY514HX?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [Illiyoon Ceramide Ato Soothing Gel](https://lovi.care/skincare/it/p/illiyoon/ceramide-ato-soothing-gel/for/acne-prone-skin) — High fit - [COSRX Advanced Snail Mucin Power Sheet Mask](https://lovi.care/skincare/it/p/cosrx/advanced-snail-mucin-power-sheet-mask/for/dry-skin) — Superior fit — [€3.95 at Amazon](https://www.amazon.it/dp/B096XVVWG7?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) - [AMOREPACIFIC Treatment Enzyme Peel](https://lovi.care/skincare/it/p/amorepacific/treatment-enzyme-peel/for/dark-spots) — Superior fit ## Questions and answers ### Can you use hexapeptide and betaine together? Yes, you can use [hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide) and [betaine](https://lovi.care/skincare/it/ingredients/betaine) together because combining humectants like betaine with peptides helps enhance hydration and peptide delivery. For the best results, you can layer a hydrating [serum](https://lovi.care/skincare/it/ingredients/serum) containing betaine beneath your hexapeptide product. [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/) ### Which goes first, hexapeptide or betaine? You can layer a betaine hydrating serum beneath your hexapeptide product to enhance hydration and peptide delivery. Combining them helps support your skin barrier. ### Are hexapeptide and betaine good for sensitive skin? Hexapeptide and betaine work well together to enhance hydration and support the skin barrier, making them suitable for all skin types, including sensitive skin. Combining them helps improve moisture levels and supports overall skin health. [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28371204/) ## Research on hexapeptide and betaine - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013 - [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019 - [Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration](https://pubmed.ncbi.nlm.nih.gov/38611819/) Betaine · Molecules, 2024 - [Formulation of Ascorbic Acid and Betaine-based Therapeutic Deep Eutectic System for Enhanced Transdermal Delivery of Ascorbic Acid](https://pubmed.ncbi.nlm.nih.gov/38794349/) Betaine · Pharmaceutics, 2024 - [The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively](https://pubmed.ncbi.nlm.nih.gov/12535284/) Betaine · Skin Research and Technology, 2003 ## Other combinations - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-granactive-retinoid) - Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/hexapeptide-and-hydroxypinacolone-retinoate) - Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-pro-retinol) - Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/it/ingredients/hexapeptide-and-retinal) - Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/it/ingredients/hexapeptide-and-retinoid-blend) - Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/it/ingredients/retinol-and-hexapeptide) - Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/it/ingredients/tretinoin-and-hexapeptide) - Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/it/ingredients/hexapeptide-and-vitamin-a) - Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/it/ingredients/hexapeptide-and-liposome) - Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/it/ingredients/hexapeptide-and-microcapsule) - Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/it/ingredients/vitamin-c-and-hexapeptide) - Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-betaine) - Work well together: [Bio-placenta peptides and betaine](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-betaine) - Work well together: [Collagen peptide and betaine](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-betaine) - Work well together: [Betaine and copper peptide](https://lovi.care/skincare/it/ingredients/betaine-and-copper-peptide) - Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/it/ingredients/glycerin-and-hexapeptide) - Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-hyaluronic-acid) - Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/it/ingredients/betaine-and-hexapeptide-9) - Work well together: [Betaine and palmitoyl pentapeptide-4](https://lovi.care/skincare/it/ingredients/betaine-and-palmitoyl-pentapeptide-4) - Work well together: [Betaine and palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/betaine-and-palmitoyl-tripeptide-1) - Work well together: [Betaine and peptide-rich plasma](https://lovi.care/skincare/it/ingredients/betaine-and-peptide-rich-plasma) - Work well together: [Betaine and triple peptide blend](https://lovi.care/skincare/it/ingredients/betaine-and-triple-peptide-blend) - Work well together: [AHA blend glycolic and citric acids and betaine](https://lovi.care/skincare/it/ingredients/aha-blend-glycolic-and-citric-acids-and-betaine) - Work well together: [Betaine and citric acid](https://lovi.care/skincare/it/ingredients/betaine-and-citric-acid) - Work well together: [Glycolic acid and betaine](https://lovi.care/skincare/it/ingredients/glycolic-acid-and-betaine) - Work well together: [Lactic acid and betaine](https://lovi.care/skincare/it/ingredients/lactic-acid-and-betaine) - Work well together: [Mandelic acid and betaine](https://lovi.care/skincare/it/ingredients/mandelic-acid-and-betaine) - Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/it/ingredients/niacinamide-and-hexapeptide) - Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/it/ingredients/panthenol-and-hexapeptide) - Work well together: [Betaine and tri-ceramide complex](https://lovi.care/skincare/it/ingredients/betaine-and-tri-ceramide-complex) - Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/it/ingredients/bakuchiol-and-hexapeptide) - Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-arginine) - Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/it/ingredients/hexapeptide-and-gaba) - Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/it/ingredients/hexapeptide-and-silk-amino-acids) - Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-taurine) - Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/it/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide) - Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-citric-acid) - Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/it/ingredients/glycolic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-lactic-acid) - Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/it/ingredients/hexapeptide-and-mandelic-acid) - Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/it/ingredients/coenzyme-q10-and-hexapeptide) - Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/it/ingredients/green-tea-and-hexapeptide) - Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/it/ingredients/vitamin-e-and-hexapeptide) - Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/it/ingredients/ceramide-building-complex-and-hexapeptide) - Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-cholesterol) - Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/it/ingredients/hexapeptide-and-phytosphingosine) - Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-phytosterol) - Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/it/ingredients/hexapeptide-and-squalene) - Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/it/ingredients/hexapeptide-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/it/ingredients/salicylic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/it/ingredients/hexapeptide-and-baking-soda) - Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/it/ingredients/hexapeptide-and-bleach) - Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/it/ingredients/hexapeptide-and-potassium-hydroxide) - Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-behenyl-alcohol) - Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-isopropyl-alcohol) - Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-and-polyvinyl-alcohol) - Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/it/ingredients/hexapeptide-and-copper) - Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/it/ingredients/hexapeptide-and-magnesium) - Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/it/ingredients/hexapeptide-and-zinc) - Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/it/ingredients/hexapeptide-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide-and-hexapeptide) - Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/it/ingredients/azelaic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/it/ingredients/hexapeptide-and-protease) - Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/it/ingredients/hexapeptide-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/hexapeptide-and-betaine - United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-betaine - Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-betaine - Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-betaine - France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-betaine - Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-betaine (this page) - Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-betaine - Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-betaine - Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-betaine - Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-betaine - Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-betaine - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-betaine - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-betaine