# Hexapeptide-9 and squalene

Page: https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-squalene

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Work well together

Use them together in the same routine, applying the [squalene](https://lovi.care/skincare/it/ingredients/squalene) after the [hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9), because the oil helps the peptide sink in better. The squalene helps the hexapeptide-9 absorb more easily so your skin feels stronger and smoother. You do not need to change anything since this combination is very gentle.

- [All about hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9)
- [All about squalene](https://lovi.care/skincare/it/ingredients/squalene)

### [Hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9) products

- [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/it/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€82.90 at Notino](https://www.notino.it/elemis/pro-collagen-oxygenating-night-cream-crema-notte-rassodante-antirughe/p-16125564/)
- [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/it/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit
- [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/it/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€13.08 at Amazon](https://www.amazon.it/dp/B095YHYF33?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)

### [Squalene](https://lovi.care/skincare/it/ingredients/squalene) products

- [Clinique Even Better Clinical Dark Spot Corrector](https://lovi.care/skincare/it/p/clinique/even-better-clinical-dark-spot-corrector/for/oily-skin) — High fit
- [Elizabeth Arden Advanced Ceramide Capsules Daily Youth Restoring Serum](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-capsules-daily-youth-restoring-serum/for/oily-skin) — High fit — [€34.90 at Amazon](https://www.amazon.it/dp/B06WLQWXY6?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Perricone MD Vitamin C Ester CCC+ Ferulic Brightening Under-Eye Cream](https://lovi.care/skincare/it/p/perricone-md/vitamin-c-ester-ccc-ferulic-brightening-under-eye-cream/for/dark-spots) — High fit — [€81.00 at Amazon](https://www.amazon.it/dp/B0CP6FJ2P1?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Aestura A-Cica 365 Blemish Calming Serum](https://lovi.care/skincare/it/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin) — High fit

## Questions and answers

### Can you use hexapeptide-9 and squalene together?

Yes, [hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9) and [squalene](https://lovi.care/skincare/it/ingredients/squalene) work well together to enhance barrier support and skin repair. Squalene acts as an emollient and hydrating agent that improves peptide absorption and reinforces skin structure.

[Molecules, 2009](https://pubmed.ncbi.nlm.nih.gov/19169201/) [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/)

### Which goes first, hexapeptide-9 or squalene?

Hexapeptide-9 and squalene work well together to repair and support the skin barrier, with squalene's lipids helping improve peptide absorption.

[Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/)

### Are hexapeptide-9 and squalene good for sensitive skin?

Hexapeptide-9 and squalene work well together because lipid components like squalene help improve peptide absorption and reinforce skin structure. Lovi rates this combination as having a High fit for dry, mature, and barrier-impaired skin.

[Molecules, 2009](https://pubmed.ncbi.nlm.nih.gov/19169201/) [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/)

## Research on hexapeptide-9 and squalene

- [Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology](https://pubmed.ncbi.nlm.nih.gov/19169201/) Squalene · Molecules, 2009
- [Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin](https://pubmed.ncbi.nlm.nih.gov/33037252/) Squalene · Scientific Reports, 2020
- [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/granactive-retinoid-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/it/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/it/ingredients/retinoid-blend-and-hexapeptide-9)
- Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/retinol-and-hexapeptide-9)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/it/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/it/ingredients/vitamin-a-and-hexapeptide-9)
- Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/it/ingredients/liposome-and-hexapeptide-9)
- Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/it/ingredients/microcapsule-and-hexapeptide-9)
- Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/it/ingredients/vitamin-c-and-hexapeptide-9)
- Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/it/ingredients/betaine-and-hexapeptide-9)
- Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/it/ingredients/glycerin-and-hexapeptide-9)
- Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/hyaluronic-acid-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/it/ingredients/niacinamide-and-hexapeptide-9)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/panthenol-and-hexapeptide-9)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/it/ingredients/arginine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-gaba)
- Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/it/ingredients/silk-amino-acids-and-hexapeptide-9)
- Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/it/ingredients/taurine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/it/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9)
- Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/citric-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/mandelic-acid-and-hexapeptide-9)
- Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/it/ingredients/coenzyme-q10-and-hexapeptide-9)
- Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/it/ingredients/green-tea-and-hexapeptide-9)
- Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/it/ingredients/vitamin-e-and-hexapeptide-9)
- Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-squalene)
- Work well together: [Bio-placenta peptides and squalene](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-squalene)
- Work well together: [Collagen peptide and squalene](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-squalene)
- Work well together: [Copper peptide and squalene](https://lovi.care/skincare/it/ingredients/copper-peptide-and-squalene)
- Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/it/ingredients/hexapeptide-and-squalene)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/it/ingredients/ceramide-building-complex-and-hexapeptide-9)
- Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/cholesterol-and-hexapeptide-9)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/it/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/phytosterol-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-tri-ceramide-complex)
- Work well together: [Squalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/it/ingredients/squalene-and-palmitoyl-pentapeptide-4)
- Work well together: [Squalene and palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/squalene-and-palmitoyl-tripeptide-1)
- Work well together: [Peptide-rich plasma and squalene](https://lovi.care/skincare/it/ingredients/peptide-rich-plasma-and-squalene)
- Work well together: [Squalene and triple peptide blend](https://lovi.care/skincare/it/ingredients/squalene-and-triple-peptide-blend)
- Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/salicylic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-baking-soda)
- Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/it/ingredients/bleach-and-hexapeptide-9)
- Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/it/ingredients/potassium-hydroxide-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/polyvinyl-alcohol-and-hexapeptide-9)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/it/ingredients/copper-and-hexapeptide-9)
- Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide-and-hexapeptide-9)
- Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/it/ingredients/magnesium-and-hexapeptide-9)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/it/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/it/ingredients/zinc-sulfate-and-hexapeptide-9)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/azelaic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/it/ingredients/superoxide-dismutase-and-hexapeptide-9)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/hexapeptide-9-and-squalene
- United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-squalene
- Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-squalene
- Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-squalene
- France: https://lovi.care/skincare/fr/ingredients/hexapeptide-9-and-squalene
- Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-squalene (this page)
- Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-squalene
- Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-9-and-squalene
- Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-squalene
- Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-9-and-squalene
- Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-9-and-squalene
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-9-and-squalene
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-9-and-squalene