# Collagen peptide and protease

Page: https://lovi.care/skincare/it/ingredients/collagen-peptide-and-protease

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Keep them apart

Use them at different times of day, applying the [protease](https://lovi.care/skincare/it/ingredients/protease) first and the peptide second, because they cancel each other out. The protease breaks down the peptide, stopping it from firming the skin. You can separate them by using one in the morning and the other at night.

- [All about collagen peptide](https://lovi.care/skincare/it/ingredients/collagen-peptide)
- [All about protease](https://lovi.care/skincare/it/ingredients/protease)

### [Collagen peptide](https://lovi.care/skincare/it/ingredients/collagen-peptide) products

- [SkinMedica TNS Advanced+ Serum](https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/mature-skin) — High fit
- [Hero Mighty Patch](https://lovi.care/skincare/it/p/hero/mighty-patch/for/sensitive-skin) — High fit
- [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/it/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit
- [Olay Regenerist Collagen Peptide 24 Serum](https://lovi.care/skincare/it/p/olay-regenerist/collagen-peptide-24-serum/for/dry-skin) — High fit
- [No7 Pure Retinol 1% Night Concentrate](https://lovi.care/skincare/it/p/no7/pure-retinol-1-night-concentrate/for/combination-skin) — High fit
- [No7 Protect & Perfect Intense Advanced Night Cream](https://lovi.care/skincare/it/p/no7/protect-and-perfect-intense-advanced-night-cream/for/mature-skin) — Superior fit — [€30.71 at Amazon](https://www.amazon.it/dp/B09NQCNPJT?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Olay Regenerist Collagen Peptide 24 MAX Face Moisturizer](https://lovi.care/skincare/it/p/olay/regenerist-collagen-peptide-24-max-face-moisturizer/for/dry-skin) — High fit
- [No.7 Pure Retinol 0.3% Night Concentrate](https://lovi.care/skincare/it/p/no-7/pure-retinol-0-3-night-concentrate/for/dark-spots) — High fit
- [Olay Collagen Peptide 24 Eye Cream](https://lovi.care/skincare/it/p/olay/collagen-peptide-24-eye-cream/for/mature-skin) — Superior fit

### [Protease](https://lovi.care/skincare/it/ingredients/protease) products

- [COSRX Centella Cleansing Powder](https://lovi.care/skincare/it/p/cosrx/centella-cleansing-powder/for/combination-skin) — Superior fit
- [FANCL Deep Clear Washing Powder](https://lovi.care/skincare/it/p/fancl/deep-clear-washing-powder/for/oily-skin) — High fit — [€16.84 at Amazon](https://www.amazon.it/dp/B01KTJXVI4?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use collagen peptide and protease together?

No, you should keep [collagen peptide](https://lovi.care/skincare/it/ingredients/collagen-peptide) and [protease](https://lovi.care/skincare/it/ingredients/protease) apart because proteases degrade peptide bonds and render the active ingredients inactive. Avoid using them together in the same routine.

### Which goes first, collagen peptide or protease?

Keep collagen peptide and protease apart because the protease degrades the peptide bonds and renders the active ingredient inactive.

### Are collagen peptide and protease good for sensitive skin?

Collagen peptide and protease should be kept apart in your routine because the protease degrades the peptide bonds and renders the active ingredients inactive. While collagen peptides generally help support skin health, you should avoid combining enzymatic ingredients with peptides to ensure they remain effective.

## Research on collagen peptide and protease

- [Preparation and functional evaluation of collagen oligopeptide-rich hydrolysate from fish skin with the serine collagenolytic protease from Pseudoalteromonas sp. SM9913](https://pubmed.ncbi.nlm.nih.gov/29146927/) Protease · Scientific Reports, 2017
- [Collagen peptides affect collagen synthesis and the expression of collagen, elastin, and versican genes in cultured human dermal fibroblasts](https://pubmed.ncbi.nlm.nih.gov/38751975/) Collagen peptide · Frontiers in Medicine, 2024
- [Hydrolyzed Collagen Induces an Anti-Inflammatory Response That Induces Proliferation of Skin Fibroblast and Keratinocytes](https://pubmed.ncbi.nlm.nih.gov/36501011/) Collagen peptide · Nutrients, 2022

## Other combinations

- Keep them apart: [Adapalene and collagen peptide](https://lovi.care/skincare/it/ingredients/adapalene-and-collagen-peptide)
- Keep them apart: [Granactive retinoid and collagen peptide](https://lovi.care/skincare/it/ingredients/granactive-retinoid-and-collagen-peptide)
- Keep them apart: [Hydroxypinacolone retinoate and collagen peptide](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate-and-collagen-peptide)
- Keep them apart: [Pro-retinol and collagen peptide](https://lovi.care/skincare/it/ingredients/pro-retinol-and-collagen-peptide)
- Keep them apart: [Retinal and collagen peptide](https://lovi.care/skincare/it/ingredients/retinal-and-collagen-peptide)
- Keep them apart: [Retinoid blend and collagen peptide](https://lovi.care/skincare/it/ingredients/retinoid-blend-and-collagen-peptide)
- Depends on the strength: [Retinol and collagen peptide](https://lovi.care/skincare/it/ingredients/retinol-and-collagen-peptide)
- Keep them apart: [Tretinoin and collagen peptide](https://lovi.care/skincare/it/ingredients/tretinoin-and-collagen-peptide)
- Keep them apart: [Vitamin A and collagen peptide](https://lovi.care/skincare/it/ingredients/vitamin-a-and-collagen-peptide)
- Work well together: [Liposome and collagen peptide](https://lovi.care/skincare/it/ingredients/liposome-and-collagen-peptide)
- Work well together: [Microcapsule and collagen peptide](https://lovi.care/skincare/it/ingredients/microcapsule-and-collagen-peptide)
- Keep them apart: [Vitamin C and collagen peptide](https://lovi.care/skincare/it/ingredients/vitamin-c-and-collagen-peptide)
- Work well together: [Collagen peptide and betaine](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-betaine)
- Work well together: [Glycerin and collagen peptide](https://lovi.care/skincare/it/ingredients/glycerin-and-collagen-peptide)
- Work well together: [Hyaluronic acid and collagen peptide](https://lovi.care/skincare/it/ingredients/hyaluronic-acid-and-collagen-peptide)
- Depends on the strength: [Niacinamide and collagen peptide](https://lovi.care/skincare/it/ingredients/niacinamide-and-collagen-peptide)
- Work well together: [Panthenol and collagen peptide](https://lovi.care/skincare/it/ingredients/panthenol-and-collagen-peptide)
- Work well together: [Bakuchiol and collagen peptide](https://lovi.care/skincare/it/ingredients/bakuchiol-and-collagen-peptide)
- Work well together: [Arginine and collagen peptide](https://lovi.care/skincare/it/ingredients/arginine-and-collagen-peptide)
- Work well together: [Collagen peptide and GABA](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-gaba)
- Work well together: [Silk amino acids and collagen peptide](https://lovi.care/skincare/it/ingredients/silk-amino-acids-and-collagen-peptide)
- Work well together: [Taurine and collagen peptide](https://lovi.care/skincare/it/ingredients/taurine-and-collagen-peptide)
- Work well together: [Collagen peptide and theanine](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and collagen peptide](https://lovi.care/skincare/it/ingredients/aha-blend-glycolic-and-citric-acids-and-collagen-peptide)
- Keep them apart: [Collagen peptide and citric acid](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-citric-acid)
- Keep them apart: [Glycolic acid and collagen peptide](https://lovi.care/skincare/it/ingredients/glycolic-acid-and-collagen-peptide)
- Keep them apart: [Lactic acid and collagen peptide](https://lovi.care/skincare/it/ingredients/lactic-acid-and-collagen-peptide)
- Keep them apart: [Mandelic acid and collagen peptide](https://lovi.care/skincare/it/ingredients/mandelic-acid-and-collagen-peptide)
- Work well together: [Coenzyme Q10 and collagen peptide](https://lovi.care/skincare/it/ingredients/coenzyme-q10-and-collagen-peptide)
- Work well together: [Green tea and collagen peptide](https://lovi.care/skincare/it/ingredients/green-tea-and-collagen-peptide)
- Work well together: [Vitamin E and collagen peptide](https://lovi.care/skincare/it/ingredients/vitamin-e-and-collagen-peptide)
- Work well together: [Collagen peptide and beta-sitosterol](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and collagen peptide](https://lovi.care/skincare/it/ingredients/ceramide-building-complex-and-collagen-peptide)
- Work well together: [Cholesterol and collagen peptide](https://lovi.care/skincare/it/ingredients/cholesterol-and-collagen-peptide)
- Work well together: [Collagen peptide and phytosphingosine](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-phytosphingosine)
- Work well together: [Collagen peptide and phytosterol](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-phytosterol)
- Work well together: [Collagen peptide and squalene](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-squalene)
- Work well together: [Collagen peptide and tri-ceramide complex](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and collagen peptide](https://lovi.care/skincare/it/ingredients/salicylic-acid-and-collagen-peptide)
- Keep them apart: [Collagen peptide and baking soda](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-baking-soda)
- Keep them apart: [Bleach and collagen peptide](https://lovi.care/skincare/it/ingredients/bleach-and-collagen-peptide)
- Keep them apart: [Potassium hydroxide and collagen peptide](https://lovi.care/skincare/it/ingredients/potassium-hydroxide-and-collagen-peptide)
- Keep them apart: [Collagen peptide and behenyl alcohol](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-behenyl-alcohol)
- Keep them apart: [Collagen peptide and isopropyl alcohol](https://lovi.care/skincare/it/ingredients/collagen-peptide-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and collagen peptide](https://lovi.care/skincare/it/ingredients/polyvinyl-alcohol-and-collagen-peptide)
- Keep them apart: [Copper and collagen peptide](https://lovi.care/skincare/it/ingredients/copper-and-collagen-peptide)
- Keep them apart: [Magnesium and collagen peptide](https://lovi.care/skincare/it/ingredients/magnesium-and-collagen-peptide)
- Keep them apart: [Zinc and collagen peptide](https://lovi.care/skincare/it/ingredients/zinc-and-collagen-peptide)
- Keep them apart: [Zinc sulfate and collagen peptide](https://lovi.care/skincare/it/ingredients/zinc-sulfate-and-collagen-peptide)
- Keep them apart: [Benzoyl peroxide and collagen peptide](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide-and-collagen-peptide)
- Keep them apart: [Azelaic acid and collagen peptide](https://lovi.care/skincare/it/ingredients/azelaic-acid-and-collagen-peptide)
- Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-protease)
- Keep them apart: [Bio-placenta peptides and protease](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-protease)
- Keep them apart: [Superoxide dismutase and collagen peptide](https://lovi.care/skincare/it/ingredients/superoxide-dismutase-and-collagen-peptide)
- Keep them apart: [Copper peptide and protease](https://lovi.care/skincare/it/ingredients/copper-peptide-and-protease)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/it/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/it/ingredients/protease-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Protease and palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/protease-and-palmitoyl-tripeptide-1)
- Keep them apart: [Peptide-rich plasma and protease](https://lovi.care/skincare/it/ingredients/peptide-rich-plasma-and-protease)
- Keep them apart: [Protease and triple peptide blend](https://lovi.care/skincare/it/ingredients/protease-and-triple-peptide-blend)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/collagen-peptide-and-protease
- United Kingdom: https://lovi.care/skincare/uk/ingredients/collagen-peptide-and-protease
- Ireland: https://lovi.care/skincare/ie/ingredients/collagen-peptide-and-protease
- Germany: https://lovi.care/skincare/de/ingredients/collagen-peptide-and-protease
- France: https://lovi.care/skincare/fr/ingredients/collagen-peptide-and-protease
- Italy: https://lovi.care/skincare/it/ingredients/collagen-peptide-and-protease (this page)
- Netherlands: https://lovi.care/skincare/nl/ingredients/collagen-peptide-and-protease
- Spain: https://lovi.care/skincare/es/ingredients/collagen-peptide-and-protease
- Canada: https://lovi.care/skincare/ca/ingredients/collagen-peptide-and-protease
- Australia: https://lovi.care/skincare/au/ingredients/collagen-peptide-and-protease
- Singapore: https://lovi.care/skincare/sg/ingredients/collagen-peptide-and-protease
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/collagen-peptide-and-protease
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/collagen-peptide-and-protease