# Bio-placenta peptides and hydroxypinacolone retinoate

Page: https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Keep them apart

Use them at different times of day by applying [bio-placenta peptides](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides) in the morning and [hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate) at night, to avoid extra skin irritation. Both ingredients work hard to renew your skin, so using them together can cause redness and irritation. You can easily fix this by switching to a gentler strength or waiting longer between applications.

- [All about bio-placenta peptides](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides)
- [All about hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate)

### [Bio-placenta peptides](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides) products

- [LION POSE PEP TALK](https://lovi.care/skincare/it/p/lion-pose/pep-talk/for/dry-skin) — Average fit

### [Hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate) products

- [The Ordinary Granactive Retinoid 2% Emulsion](https://lovi.care/skincare/it/p/the-ordinary/granactive-retinoid-2-emulsion/for/oily-skin) — High fit — [€13.30 at Amazon](https://www.amazon.it/dp/B071HHSMTT?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [IOPE Retinol Super Bounce Serum](https://lovi.care/skincare/it/p/iope/retinol-super-bounce-serum/for/dark-spots) — Average fit
- [BYOMA Sensitive Retinol Oil](https://lovi.care/skincare/it/p/byoma/sensitive-retinol-oil/for/dry-skin) — Average fit
- [Medicube Deep Vita A Retinol Serum](https://lovi.care/skincare/it/p/medicube/deep-vita-a-retinol-serum/for/acne-prone-skin) — Average fit — [€18.89 at Amazon](https://www.amazon.it/dp/B0H7JHK95G?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Sunday Riley A+ High-Dose Retinoid Serum](https://lovi.care/skincare/it/p/sunday-riley/a-high-dose-retinoid-serum/for/oily-acne-prone-skin) — High fit

## Questions and answers

### Can you use bio-placenta peptides and hydroxypinacolone retinoate together?

Keep [bio-placenta peptides](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides) and [hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate) apart in your routine because combined stimulation may increase irritation. Alternate their usage by applying hydroxypinacolone retinoate in the evening and peptides in the morning.

### Which goes first, bio-placenta peptides or hydroxypinacolone retinoate?

Keep bio-placenta peptides and hydroxypinacolone retinoate apart in the same routine, using peptides in the morning and hydroxypinacolone retinoate at night. Combined stimulation from both may increase irritation since they both activate dermal remodeling pathways.

### Are bio-placenta peptides and hydroxypinacolone retinoate good for sensitive skin?

Bio-placenta peptides and hydroxypinacolone retinoate should be kept apart in your routine because combining them may increase irritation, especially on sensitive skin. Instead, you can alternate usage by applying your retinoid in the evening and peptides in the morning.

[Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39394831/)

## Research on bio-placenta peptides and hydroxypinacolone retinoate

- [Characterization of Acne-Prone Skin with Reflectance Confocal Microscopy and Optical Coherence Tomography and Modifications Induced by Topical Treatment and Probiotic Supplementation](https://pubmed.ncbi.nlm.nih.gov/37510902/) Hydroxypinacolone retinoate · Journal of Clinical Medicine, 2023
- [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023
- [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate)
- Keep them apart: [Adapalene and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/adapalene-and-bio-placenta-peptides)
- Keep them apart: [Bio-placenta peptides and granactive retinoid](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-granactive-retinoid)
- Keep them apart: [Bio-placenta peptides and pro-retinol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-pro-retinol)
- Keep them apart: [Bio-placenta peptides and retinal](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-retinal)
- Keep them apart: [Bio-placenta peptides and retinoid blend](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-retinoid-blend)
- Depends on the strength: [Retinol and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/retinol-and-bio-placenta-peptides)
- Keep them apart: [Tretinoin and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/tretinoin-and-bio-placenta-peptides)
- Keep them apart: [Bio-placenta peptides and vitamin A](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-vitamin-a)
- Keep them apart: [Hydroxypinacolone retinoate and collagen peptide](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate-and-collagen-peptide)
- Keep them apart: [Hydroxypinacolone retinoate and copper peptide](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate-and-copper-peptide)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Hydroxypinacolone retinoate and palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-tripeptide-1)
- Keep them apart: [Hydroxypinacolone retinoate and peptide-rich plasma](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate-and-peptide-rich-plasma)
- Keep them apart: [Hydroxypinacolone retinoate and triple peptide blend](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate-and-triple-peptide-blend)
- Work well together: [Bio-placenta peptides and liposome](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-liposome)
- Work well together: [Bio-placenta peptides and microcapsule](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-microcapsule)
- Keep them apart: [Vitamin C and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/vitamin-c-and-bio-placenta-peptides)
- Depends on the strength: [Niacinamide and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/niacinamide-and-hydroxypinacolone-retinoate)
- Work well together: [Bio-placenta peptides and betaine](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-betaine)
- Work well together: [Glycerin and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/glycerin-and-bio-placenta-peptides)
- Work well together: [Bio-placenta peptides and hyaluronic acid](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/niacinamide-and-bio-placenta-peptides)
- Work well together: [Panthenol and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/panthenol-and-bio-placenta-peptides)
- Work well together: [Bio-placenta peptides and bakuchiol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-bakuchiol)
- Work well together: [Bio-placenta peptides and arginine](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-arginine)
- Work well together: [Bio-placenta peptides and GABA](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-gaba)
- Work well together: [Bio-placenta peptides and silk amino acids](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-silk-amino-acids)
- Work well together: [Bio-placenta peptides and taurine](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-taurine)
- Work well together: [Bio-placenta peptides and theanine](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/aha-blend-glycolic-and-citric-acids-and-bio-placenta-peptides)
- Keep them apart: [Bio-placenta peptides and citric acid](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-citric-acid)
- Keep them apart: [Glycolic acid and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/glycolic-acid-and-bio-placenta-peptides)
- Keep them apart: [Bio-placenta peptides and lactic acid](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-lactic-acid)
- Keep them apart: [Bio-placenta peptides and mandelic acid](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-mandelic-acid)
- Work well together: [Bio-placenta peptides and coenzyme q10](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-coenzyme-q10)
- Work well together: [Green tea and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/green-tea-and-bio-placenta-peptides)
- Work well together: [Bio-placenta peptides and vitamin E](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-vitamin-e)
- Keep them apart: [AHA blend glycolic and citric acids and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/aha-blend-glycolic-and-citric-acids-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hydroxypinacolone retinoate and citric acid](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate-and-citric-acid)
- Keep them apart: [Glycolic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Lactic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/lactic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Mandelic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/mandelic-acid-and-hydroxypinacolone-retinoate)
- Work well together: [Bio-placenta peptides and beta-sitosterol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/ceramide-building-complex-and-bio-placenta-peptides)
- Work well together: [Bio-placenta peptides and cholesterol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-cholesterol)
- Work well together: [Bio-placenta peptides and phytosphingosine](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-phytosphingosine)
- Work well together: [Bio-placenta peptides and phytosterol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-phytosterol)
- Work well together: [Bio-placenta peptides and squalene](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-squalene)
- Work well together: [Bio-placenta peptides and tri-ceramide complex](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/salicylic-acid-and-bio-placenta-peptides)
- Keep them apart: [Salicylic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/salicylic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Vitamin C and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/vitamin-c-and-hydroxypinacolone-retinoate)
- Keep them apart: [Bio-placenta peptides and baking soda](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-baking-soda)
- Keep them apart: [Bio-placenta peptides and bleach](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-bleach)
- Keep them apart: [Bio-placenta peptides and potassium hydroxide](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-potassium-hydroxide)
- Keep them apart: [Bio-placenta peptides and behenyl alcohol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-behenyl-alcohol)
- Keep them apart: [Bio-placenta peptides and isopropyl alcohol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-isopropyl-alcohol)
- Keep them apart: [Bio-placenta peptides and polyvinyl alcohol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-polyvinyl-alcohol)
- Keep them apart: [Bio-placenta peptides and copper](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-copper)
- Keep them apart: [Benzoyl peroxide and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Bio-placenta peptides and magnesium](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-magnesium)
- Keep them apart: [Bio-placenta peptides and zinc](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-zinc)
- Keep them apart: [Bio-placenta peptides and zinc sulfate](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide-and-bio-placenta-peptides)
- Keep them apart: [Azelaic acid and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/azelaic-acid-and-bio-placenta-peptides)
- Keep them apart: [Bio-placenta peptides and protease](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-protease)
- Keep them apart: [Bio-placenta peptides and superoxide dismutase](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate
- United Kingdom: https://lovi.care/skincare/uk/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate
- Ireland: https://lovi.care/skincare/ie/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate
- Germany: https://lovi.care/skincare/de/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate
- France: https://lovi.care/skincare/fr/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate
- Italy: https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate (this page)
- Netherlands: https://lovi.care/skincare/nl/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate
- Spain: https://lovi.care/skincare/es/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate
- Canada: https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate
- Australia: https://lovi.care/skincare/au/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate
- Singapore: https://lovi.care/skincare/sg/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate