# Adapalene

Page: https://lovi.care/skincare/it/ingredients/adapalene

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Daily application of adapalene reduces and prevents atrophic acne scars while achieving superior treatment success, greater reductions in inflammatory and noninflammatory lesions, and lower acne severity indices. This treatment suits most skin types best and comes in [serums](https://lovi.care/skincare/it/ingredients/serum). It fits into a routine by keeping it apart from [glycolic acid](https://lovi.care/skincare/it/ingredients/glycolic-acid), [benzoyl peroxide](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide), and [vitamin C](https://lovi.care/skincare/it/ingredients/vitamin-c).

[American Journal of Clinical Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29549588/) [American Journal of Clinical Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34674160/) [Archives of Dermatological Research, 2022](https://pubmed.ncbi.nlm.nih.gov/34251536/)

This page shows adapalene products with a Lovi page. For every product, and a routine built for your skin, use the Lovi app.

### Popular adapalene products

- [Differin Gel](https://lovi.care/skincare/it/p/differin/gel/for/oily-acne-prone-skin) — High fit
- [Galderma Epiduo Gel](https://lovi.care/skincare/it/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit

### Other adapalene products

- [Differin Gel](https://lovi.care/skincare/it/p/differin/gel/for/oily-acne-prone-skin) — High fit
- [Galderma Epiduo Gel](https://lovi.care/skincare/it/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit
- [La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment](https://lovi.care/skincare/it/p/la-roche-posay/effaclar-adapalene-gel-0-1-acne-treatment/for/oily-skin) — Superior fit

## What to combine adapalene with

Ingredient Together How to use them

[Niacinamide](https://lovi.care/skincare/it/ingredients/niacinamide) Depends Use them at different times of day, applying [niacinamide](https://lovi.care/skincare/it/ingredients/niacinamide) in the morning and adapalene at night, because low-strength retinoids pair well with niacinamide. [Adapalene and niacinamide](https://lovi.care/skincare/it/ingredients/adapalene-and-niacinamide) [Glycolic acid](https://lovi.care/skincare/it/ingredients/glycolic-acid) Keep apart Use them on alternate nights, with [glycolic acid](https://lovi.care/skincare/it/ingredients/glycolic-acid) on one evening and adapalene the next, because combining them causes skin irritation. [Adapalene and glycolic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-glycolic-acid) [Benzoyl peroxide](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide) Keep apart Use them at different times of day, applying [benzoyl peroxide](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide) in the morning and adapalene at night, because they cancel each other out. [Adapalene and benzoyl peroxide](https://lovi.care/skincare/it/ingredients/adapalene-and-benzoyl-peroxide) [Vitamin C](https://lovi.care/skincare/it/ingredients/vitamin-c) Keep apart Use them at different times of day with [vitamin C](https://lovi.care/skincare/it/ingredients/vitamin-c) in the morning and adapalene at night, because combining them causes skin irritation. [Adapalene and vitamin C](https://lovi.care/skincare/it/ingredients/adapalene-and-vitamin-c) [AHA blend glycolic and citric acids](https://lovi.care/skincare/it/ingredients/aha-blend-glycolic-and-citric-acids) Keep apart Use them on alternate nights because they are both strong and can irritate skin when combined. [Adapalene and aha blend glycolic and citric acids](https://lovi.care/skincare/it/ingredients/adapalene-and-aha-blend-glycolic-and-citric-acids) [Salicylic acid](https://lovi.care/skincare/it/ingredients/salicylic-acid) Keep apart Use adapalene and [salicylic acid](https://lovi.care/skincare/it/ingredients/salicylic-acid) on alternate nights, applying salicylic acid one night and adapalene the next, because combining them causes irritation. [Adapalene and salicylic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-salicylic-acid) [Bio-placenta peptides](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides) Keep apart Use them at different times of day by applying your peptides in the morning and adapalene at night, to prevent skin irritation. [Adapalene and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/adapalene-and-bio-placenta-peptides) [Hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide) Keep apart Use them at different times of day by applying your peptide product in the morning and adapalene at night to avoid skin irritation. [Adapalene and hexapeptide](https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide) [Lactic acid](https://lovi.care/skincare/it/ingredients/lactic-acid) Keep apart Use them on alternate nights because they are both strong and can irritate your skin when mixed. [Adapalene and lactic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-lactic-acid) [Acetyl hexapeptide-3](https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3) Keep apart Use them at different times of day by applying [acetyl hexapeptide-3](https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3) in the morning and adapalene at night, because strong retinoids should not be mixed with peptides in the same routine. [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/it/ingredients/adapalene-and-acetyl-hexapeptide-3) [Mandelic acid](https://lovi.care/skincare/it/ingredients/mandelic-acid) Keep apart Use them on alternate nights because they are both strong and can irritate your skin when used together. [Adapalene and mandelic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-mandelic-acid) [Collagen peptide](https://lovi.care/skincare/it/ingredients/collagen-peptide) Keep apart Use them at different times of day, applying [collagen peptides](https://lovi.care/skincare/it/ingredients/collagen-peptide) in the morning and adapalene at night, to prevent skin irritation. [Adapalene and collagen peptide](https://lovi.care/skincare/it/ingredients/adapalene-and-collagen-peptide) [Copper peptide](https://lovi.care/skincare/it/ingredients/copper-peptide) Keep apart Use them at different times of day, applying [copper peptides](https://lovi.care/skincare/it/ingredients/copper-peptide) in the morning and adapalene at night, to prevent skin irritation. [Adapalene and copper peptide](https://lovi.care/skincare/it/ingredients/adapalene-and-copper-peptide) [Citric acid](https://lovi.care/skincare/it/ingredients/citric-acid) Keep apart Use them on alternate nights because combining them can cause skin irritation. [Adapalene and citric acid](https://lovi.care/skincare/it/ingredients/adapalene-and-citric-acid) [Hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9) Keep apart Use them at different times of day by applying [hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9) in the morning and adapalene at night, because combining them in the same routine causes skin irritation. [Adapalene and hexapeptide-9](https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide-9) [Peptide-rich plasma](https://lovi.care/skincare/it/ingredients/peptide-rich-plasma) Keep apart Use them at different times of day by applying peptides in the morning and adapalene at night, because combining them in the same routine causes irritation. [Adapalene and peptide-rich plasma](https://lovi.care/skincare/it/ingredients/adapalene-and-peptide-rich-plasma) [Triple peptide blend](https://lovi.care/skincare/it/ingredients/triple-peptide-blend) Keep apart Use them at different times of day by applying your peptide product in the morning and your adapalene at night to prevent irritation. [Adapalene and triple peptide blend](https://lovi.care/skincare/it/ingredients/adapalene-and-triple-peptide-blend) [Palmitoyl pentapeptide-4](https://lovi.care/skincare/it/ingredients/palmitoyl-pentapeptide-4) Keep apart Use them at different times of day, applying the peptide product in the morning and adapalene at night, to avoid extra skin irritation. [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/it/ingredients/adapalene-and-palmitoyl-pentapeptide-4) [Palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/palmitoyl-tripeptide-1) Keep apart Use them at different times of day by applying [palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/palmitoyl-tripeptide-1) in the morning and adapalene at night. [Adapalene and palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/adapalene-and-palmitoyl-tripeptide-1)

From the ingredient rules behind the "Works well with" and "Don't mix with" notes on every product in the Lovi app.

## Questions and answers

### What does adapalene do for the skin?

Adapalene helps reduce and prevent atrophic acne scars and decreases inflammatory and noninflammatory lesions. Daily application may also improve overall acne severity.

[American Journal of Clinical Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29549588/) [American Journal of Clinical Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34674160/)

### How do you use adapalene?

Use adapalene at night because strong retinoids should not be used during the day or combined with certain actives.

### Should you use adapalene in the morning or at night?

You should use adapalene at night, because many active ingredients and retinoids are best applied then or kept separate to avoid skin irritation.

### Can you use adapalene every day?

Yes, you can use adapalene daily to help treat acne. Daily application helps reduce both inflammatory and non-inflammatory lesions.

[American Journal of Clinical Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34674160/)

### Does adapalene cause purging or irritation?

Yes, adapalene may cause skin irritation. Using it alongside certain strong ingredients like acids or peptides can lead to increased irritation if not separated properly in your routine.

### Which skin types is adapalene best for?

Adapalene is best for skin types prone to moderate or severe facial acne.

[American Journal of Clinical Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29549588/)

### Can you use adapalene with glycolic acid?

No, you should keep adapalene and [glycolic acid](https://lovi.care/skincare/it/ingredients/glycolic-acid) apart by using them on alternate nights, with glycolic acid on one evening and adapalene the next, because combining them causes skin irritation.

## Research on adapalene

- [Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison](https://pubmed.ncbi.nlm.nih.gov/29549588/) Adapalene · American Journal of Clinical Dermatology, 2018
- [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Adapalene · American Journal of Clinical Dermatology, 2022
- [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Adapalene · Archives of Dermatological Research, 2022
- [Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials](https://pubmed.ncbi.nlm.nih.gov/37656094/) Adapalene · Journal of the American Academy of Dermatology, 2023

## Combining adapalene

- Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/it/ingredients/adapalene-and-acetyl-hexapeptide-3)
- Keep them apart: [Adapalene and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/adapalene-and-bio-placenta-peptides)
- Keep them apart: [Adapalene and collagen peptide](https://lovi.care/skincare/it/ingredients/adapalene-and-collagen-peptide)
- Keep them apart: [Adapalene and copper peptide](https://lovi.care/skincare/it/ingredients/adapalene-and-copper-peptide)
- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/it/ingredients/adapalene-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Adapalene and palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/adapalene-and-palmitoyl-tripeptide-1)
- Keep them apart: [Adapalene and peptide-rich plasma](https://lovi.care/skincare/it/ingredients/adapalene-and-peptide-rich-plasma)
- Keep them apart: [Adapalene and triple peptide blend](https://lovi.care/skincare/it/ingredients/adapalene-and-triple-peptide-blend)
- Depends on the strength: [Adapalene and niacinamide](https://lovi.care/skincare/it/ingredients/adapalene-and-niacinamide)
- Keep them apart: [Adapalene and aha blend glycolic and citric acids](https://lovi.care/skincare/it/ingredients/adapalene-and-aha-blend-glycolic-and-citric-acids)
- Keep them apart: [Adapalene and citric acid](https://lovi.care/skincare/it/ingredients/adapalene-and-citric-acid)
- Keep them apart: [Adapalene and glycolic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-glycolic-acid)
- Keep them apart: [Adapalene and lactic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-lactic-acid)
- Keep them apart: [Adapalene and mandelic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-mandelic-acid)
- Keep them apart: [Adapalene and salicylic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-salicylic-acid)
- Keep them apart: [Adapalene and vitamin C](https://lovi.care/skincare/it/ingredients/adapalene-and-vitamin-c)
- Keep them apart: [Adapalene and benzoyl peroxide](https://lovi.care/skincare/it/ingredients/adapalene-and-benzoyl-peroxide)

## Brands with adapalene

- French skincare: [Differin](https://lovi.care/skincare/it/brands/differin)
- Swiss skincare: [Galderma](https://lovi.care/skincare/it/brands/galderma)
- French skincare: [La Roche-Posay](https://lovi.care/skincare/it/brands/la-roche-posay)

## Related ingredients

- [Glycolic acid](https://lovi.care/skincare/it/ingredients/glycolic-acid)
- [Benzoyl peroxide](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide)
- [Vitamin C](https://lovi.care/skincare/it/ingredients/vitamin-c)
- [AHA blend glycolic and citric acids](https://lovi.care/skincare/it/ingredients/aha-blend-glycolic-and-citric-acids)
- [Niacinamide](https://lovi.care/skincare/it/ingredients/niacinamide)
- [Salicylic acid](https://lovi.care/skincare/it/ingredients/salicylic-acid)
- [Bio-placenta peptides](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides)
- [Hexapeptide](https://lovi.care/skincare/it/ingredients/hexapeptide)
- [Lactic acid](https://lovi.care/skincare/it/ingredients/lactic-acid)
- [Acetyl hexapeptide-3](https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3)
- [Mandelic acid](https://lovi.care/skincare/it/ingredients/mandelic-acid)
- [Collagen peptide](https://lovi.care/skincare/it/ingredients/collagen-peptide)
- [Copper peptide](https://lovi.care/skincare/it/ingredients/copper-peptide)
- [Citric acid](https://lovi.care/skincare/it/ingredients/citric-acid)
- [Hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9)
- [Peptide-rich plasma](https://lovi.care/skincare/it/ingredients/peptide-rich-plasma)
- [Triple peptide blend](https://lovi.care/skincare/it/ingredients/triple-peptide-blend)
- [Palmitoyl pentapeptide-4](https://lovi.care/skincare/it/ingredients/palmitoyl-pentapeptide-4)
- [Palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/palmitoyl-tripeptide-1)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every ingredient with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this ingredient guide: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/adapalene
- United Kingdom: https://lovi.care/skincare/uk/ingredients/adapalene
- Ireland: https://lovi.care/skincare/ie/ingredients/adapalene
- Germany: https://lovi.care/skincare/de/ingredients/adapalene
- France: https://lovi.care/skincare/fr/ingredients/adapalene
- Italy: https://lovi.care/skincare/it/ingredients/adapalene (this page)
- Netherlands: https://lovi.care/skincare/nl/ingredients/adapalene
- Spain: https://lovi.care/skincare/es/ingredients/adapalene
- Canada: https://lovi.care/skincare/ca/ingredients/adapalene
- Australia: https://lovi.care/skincare/au/ingredients/adapalene
- Singapore: https://lovi.care/skincare/sg/ingredients/adapalene
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/adapalene
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/adapalene