# Adapalene and hexapeptide-9 Page: https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide-9 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy. Keep them apart Use them at different times of day by applying [hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9) in the morning and [adapalene](https://lovi.care/skincare/it/ingredients/adapalene) at night, because combining them in the same routine causes skin irritation. Both ingredients work hard to smooth the skin, so putting them together overwhelms your face and causes redness. You can fix this by using a gentler strength, or by giving your skin more time between the two applications. - [All about adapalene](https://lovi.care/skincare/it/ingredients/adapalene) - [All about hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9) ### [Adapalene](https://lovi.care/skincare/it/ingredients/adapalene) products - [Differin Gel](https://lovi.care/skincare/it/p/differin/gel/for/oily-acne-prone-skin) — High fit - [Galderma Epiduo Gel](https://lovi.care/skincare/it/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit - [La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment](https://lovi.care/skincare/it/p/la-roche-posay/effaclar-adapalene-gel-0-1-acne-treatment/for/oily-skin) — Superior fit ### [Hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9) products - [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/it/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€82.90 at Notino](https://www.notino.it/elemis/pro-collagen-oxygenating-night-cream-crema-notte-rassodante-antirughe/p-16125564/) - [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/it/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit - [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/it/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€13.08 at Amazon](https://www.amazon.it/dp/B095YHYF33?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use adapalene and hexapeptide-9 together? No, you should keep [adapalene](https://lovi.care/skincare/it/ingredients/adapalene) and [hexapeptide-9](https://lovi.care/skincare/it/ingredients/hexapeptide-9) apart in your routine because combining them may increase skin irritation. Instead, alternate their usage by applying your retinoid in the evening and peptides in the morning. ### Which goes first, adapalene or hexapeptide-9? Keep adapalene and hexapeptide-9 apart because combining them may increase irritation. You can alternate usage by applying your retinoid in the evening and peptides in the morning. ### Are adapalene and hexapeptide-9 good for sensitive skin? Adapalene and hexapeptide-9 should be kept apart in your routine because combining them may increase irritation. Alternate their usage by applying your retinoid in the evening and peptides in the morning. ## Research on adapalene and hexapeptide-9 - [Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison](https://pubmed.ncbi.nlm.nih.gov/29549588/) Adapalene · American Journal of Clinical Dermatology, 2018 - [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Adapalene · American Journal of Clinical Dermatology, 2022 - [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Adapalene · Archives of Dermatological Research, 2022 - [Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials](https://pubmed.ncbi.nlm.nih.gov/37656094/) Adapalene · Journal of the American Academy of Dermatology, 2023 - [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025 ## Other combinations - Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/it/ingredients/adapalene-and-acetyl-hexapeptide-3) - Keep them apart: [Adapalene and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/adapalene-and-bio-placenta-peptides) - Keep them apart: [Adapalene and collagen peptide](https://lovi.care/skincare/it/ingredients/adapalene-and-collagen-peptide) - Keep them apart: [Adapalene and copper peptide](https://lovi.care/skincare/it/ingredients/adapalene-and-copper-peptide) - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/granactive-retinoid-and-hexapeptide-9) - Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/it/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9) - Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/pro-retinol-and-hexapeptide-9) - Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/it/ingredients/retinal-and-hexapeptide-9) - Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/it/ingredients/retinoid-blend-and-hexapeptide-9) - Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/retinol-and-hexapeptide-9) - Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/it/ingredients/tretinoin-and-hexapeptide-9) - Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/it/ingredients/vitamin-a-and-hexapeptide-9) - Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/it/ingredients/adapalene-and-palmitoyl-pentapeptide-4) - Keep them apart: [Adapalene and palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/adapalene-and-palmitoyl-tripeptide-1) - Keep them apart: [Adapalene and peptide-rich plasma](https://lovi.care/skincare/it/ingredients/adapalene-and-peptide-rich-plasma) - Keep them apart: [Adapalene and triple peptide blend](https://lovi.care/skincare/it/ingredients/adapalene-and-triple-peptide-blend) - Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/it/ingredients/liposome-and-hexapeptide-9) - Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/it/ingredients/microcapsule-and-hexapeptide-9) - Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/it/ingredients/vitamin-c-and-hexapeptide-9) - Depends on the strength: [Adapalene and niacinamide](https://lovi.care/skincare/it/ingredients/adapalene-and-niacinamide) - Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/it/ingredients/betaine-and-hexapeptide-9) - Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/it/ingredients/glycerin-and-hexapeptide-9) - Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/hyaluronic-acid-and-hexapeptide-9) - Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/it/ingredients/niacinamide-and-hexapeptide-9) - Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/panthenol-and-hexapeptide-9) - Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/bakuchiol-and-hexapeptide-9) - Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/it/ingredients/arginine-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-gaba) - Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/it/ingredients/silk-amino-acids-and-hexapeptide-9) - Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/it/ingredients/taurine-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/it/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9) - Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/citric-acid-and-hexapeptide-9) - Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/glycolic-acid-and-hexapeptide-9) - Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/lactic-acid-and-hexapeptide-9) - Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/mandelic-acid-and-hexapeptide-9) - Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/it/ingredients/coenzyme-q10-and-hexapeptide-9) - Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/it/ingredients/green-tea-and-hexapeptide-9) - Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/it/ingredients/vitamin-e-and-hexapeptide-9) - Keep them apart: [Adapalene and aha blend glycolic and citric acids](https://lovi.care/skincare/it/ingredients/adapalene-and-aha-blend-glycolic-and-citric-acids) - Keep them apart: [Adapalene and citric acid](https://lovi.care/skincare/it/ingredients/adapalene-and-citric-acid) - Keep them apart: [Adapalene and glycolic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-glycolic-acid) - Keep them apart: [Adapalene and lactic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-lactic-acid) - Keep them apart: [Adapalene and mandelic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-mandelic-acid) - Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/it/ingredients/ceramide-building-complex-and-hexapeptide-9) - Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/cholesterol-and-hexapeptide-9) - Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/it/ingredients/phytosphingosine-and-hexapeptide-9) - Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/phytosterol-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-squalene) - Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/salicylic-acid-and-hexapeptide-9) - Keep them apart: [Adapalene and salicylic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-salicylic-acid) - Keep them apart: [Adapalene and vitamin C](https://lovi.care/skincare/it/ingredients/adapalene-and-vitamin-c) - Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-baking-soda) - Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/it/ingredients/bleach-and-hexapeptide-9) - Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/it/ingredients/potassium-hydroxide-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-behenyl-alcohol) - Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-isopropyl-alcohol) - Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/it/ingredients/polyvinyl-alcohol-and-hexapeptide-9) - Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/it/ingredients/copper-and-hexapeptide-9) - Keep them apart: [Adapalene and benzoyl peroxide](https://lovi.care/skincare/it/ingredients/adapalene-and-benzoyl-peroxide) - Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide-and-hexapeptide-9) - Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/it/ingredients/magnesium-and-hexapeptide-9) - Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/it/ingredients/zinc-and-hexapeptide-9) - Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/it/ingredients/zinc-sulfate-and-hexapeptide-9) - Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/it/ingredients/azelaic-acid-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-protease) - Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/it/ingredients/superoxide-dismutase-and-hexapeptide-9) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/adapalene-and-hexapeptide-9 - United Kingdom: https://lovi.care/skincare/uk/ingredients/adapalene-and-hexapeptide-9 - Ireland: https://lovi.care/skincare/ie/ingredients/adapalene-and-hexapeptide-9 - Germany: https://lovi.care/skincare/de/ingredients/adapalene-and-hexapeptide-9 - France: https://lovi.care/skincare/fr/ingredients/adapalene-and-hexapeptide-9 - Italy: https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide-9 (this page) - Netherlands: https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide-9 - Spain: https://lovi.care/skincare/es/ingredients/adapalene-and-hexapeptide-9 - Canada: https://lovi.care/skincare/ca/ingredients/adapalene-and-hexapeptide-9 - Australia: https://lovi.care/skincare/au/ingredients/adapalene-and-hexapeptide-9 - Singapore: https://lovi.care/skincare/sg/ingredients/adapalene-and-hexapeptide-9 - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/adapalene-and-hexapeptide-9 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/adapalene-and-hexapeptide-9