# Adapalene and bio-placenta peptides Page: https://lovi.care/skincare/it/ingredients/adapalene-and-bio-placenta-peptides The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy. Keep them apart Use them at different times of day by applying your peptides in the morning and [adapalene](https://lovi.care/skincare/it/ingredients/adapalene) at night, to prevent skin irritation. Using both active ingredients at the same time can overload your skin and cause extra redness and irritation. To make this work safely, you can keep both in your routine by simply separating the times of day you apply them. - [All about adapalene](https://lovi.care/skincare/it/ingredients/adapalene) - [All about bio-placenta peptides](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides) ### [Adapalene](https://lovi.care/skincare/it/ingredients/adapalene) products - [Differin Gel](https://lovi.care/skincare/it/p/differin/gel/for/oily-acne-prone-skin) — High fit - [Galderma Epiduo Gel](https://lovi.care/skincare/it/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit - [La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment](https://lovi.care/skincare/it/p/la-roche-posay/effaclar-adapalene-gel-0-1-acne-treatment/for/oily-skin) — Superior fit ### [Bio-placenta peptides](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides) products - [LION POSE PEP TALK](https://lovi.care/skincare/it/p/lion-pose/pep-talk/for/dry-skin) — Average fit ## Questions and answers ### Can you use adapalene and bio-placenta peptides together? No, you should keep [adapalene](https://lovi.care/skincare/it/ingredients/adapalene) and [bio-placenta peptides](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides) apart because combining them may increase irritation. Instead, alternate their usage by applying adapalene in the evening and peptides in the morning. ### Which goes first, adapalene or bio-placenta peptides? Keep adapalene and bio-placenta peptides apart in your routine because combining them may increase irritation. Instead, alternate their usage by applying adapalene in the evening and peptides in the morning. ### Are adapalene and bio-placenta peptides good for sensitive skin? Keep adapalene and bio-placenta peptides apart in your routine because combined stimulation may increase irritation on sensitive skin. Instead, you can alternate usage by applying your retinoid in the evening and peptides in the morning. ## Research on adapalene and bio-placenta peptides - [Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison](https://pubmed.ncbi.nlm.nih.gov/29549588/) Adapalene · American Journal of Clinical Dermatology, 2018 - [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Adapalene · American Journal of Clinical Dermatology, 2022 - [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Adapalene · Archives of Dermatological Research, 2022 - [Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials](https://pubmed.ncbi.nlm.nih.gov/37656094/) Adapalene · Journal of the American Academy of Dermatology, 2023 ## Other combinations - Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/it/ingredients/adapalene-and-acetyl-hexapeptide-3) - Keep them apart: [Bio-placenta peptides and granactive retinoid](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-granactive-retinoid) - Keep them apart: [Bio-placenta peptides and hydroxypinacolone retinoate](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate) - Keep them apart: [Bio-placenta peptides and pro-retinol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-pro-retinol) - Keep them apart: [Bio-placenta peptides and retinal](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-retinal) - Keep them apart: [Bio-placenta peptides and retinoid blend](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-retinoid-blend) - Depends on the strength: [Retinol and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/retinol-and-bio-placenta-peptides) - Keep them apart: [Tretinoin and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/tretinoin-and-bio-placenta-peptides) - Keep them apart: [Bio-placenta peptides and vitamin A](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-vitamin-a) - Keep them apart: [Adapalene and collagen peptide](https://lovi.care/skincare/it/ingredients/adapalene-and-collagen-peptide) - Keep them apart: [Adapalene and copper peptide](https://lovi.care/skincare/it/ingredients/adapalene-and-copper-peptide) - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/it/ingredients/adapalene-and-hexapeptide-9) - Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/it/ingredients/adapalene-and-palmitoyl-pentapeptide-4) - Keep them apart: [Adapalene and palmitoyl tripeptide-1](https://lovi.care/skincare/it/ingredients/adapalene-and-palmitoyl-tripeptide-1) - Keep them apart: [Adapalene and peptide-rich plasma](https://lovi.care/skincare/it/ingredients/adapalene-and-peptide-rich-plasma) - Keep them apart: [Adapalene and triple peptide blend](https://lovi.care/skincare/it/ingredients/adapalene-and-triple-peptide-blend) - Work well together: [Bio-placenta peptides and liposome](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-liposome) - Work well together: [Bio-placenta peptides and microcapsule](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-microcapsule) - Keep them apart: [Vitamin C and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/vitamin-c-and-bio-placenta-peptides) - Depends on the strength: [Adapalene and niacinamide](https://lovi.care/skincare/it/ingredients/adapalene-and-niacinamide) - Work well together: [Bio-placenta peptides and betaine](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-betaine) - Work well together: [Glycerin and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/glycerin-and-bio-placenta-peptides) - Work well together: [Bio-placenta peptides and hyaluronic acid](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/niacinamide-and-bio-placenta-peptides) - Work well together: [Panthenol and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/panthenol-and-bio-placenta-peptides) - Work well together: [Bio-placenta peptides and bakuchiol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-bakuchiol) - Work well together: [Bio-placenta peptides and arginine](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-arginine) - Work well together: [Bio-placenta peptides and GABA](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-gaba) - Work well together: [Bio-placenta peptides and silk amino acids](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-silk-amino-acids) - Work well together: [Bio-placenta peptides and taurine](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-taurine) - Work well together: [Bio-placenta peptides and theanine](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/aha-blend-glycolic-and-citric-acids-and-bio-placenta-peptides) - Keep them apart: [Bio-placenta peptides and citric acid](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-citric-acid) - Keep them apart: [Glycolic acid and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/glycolic-acid-and-bio-placenta-peptides) - Keep them apart: [Bio-placenta peptides and lactic acid](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-lactic-acid) - Keep them apart: [Bio-placenta peptides and mandelic acid](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-mandelic-acid) - Work well together: [Bio-placenta peptides and coenzyme q10](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-coenzyme-q10) - Work well together: [Green tea and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/green-tea-and-bio-placenta-peptides) - Work well together: [Bio-placenta peptides and vitamin E](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-vitamin-e) - Keep them apart: [Adapalene and aha blend glycolic and citric acids](https://lovi.care/skincare/it/ingredients/adapalene-and-aha-blend-glycolic-and-citric-acids) - Keep them apart: [Adapalene and citric acid](https://lovi.care/skincare/it/ingredients/adapalene-and-citric-acid) - Keep them apart: [Adapalene and glycolic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-glycolic-acid) - Keep them apart: [Adapalene and lactic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-lactic-acid) - Keep them apart: [Adapalene and mandelic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-mandelic-acid) - Work well together: [Bio-placenta peptides and beta-sitosterol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-beta-sitosterol) - Work well together: [Ceramide-building complex and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/ceramide-building-complex-and-bio-placenta-peptides) - Work well together: [Bio-placenta peptides and cholesterol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-cholesterol) - Work well together: [Bio-placenta peptides and phytosphingosine](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-phytosphingosine) - Work well together: [Bio-placenta peptides and phytosterol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-phytosterol) - Work well together: [Bio-placenta peptides and squalene](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-squalene) - Work well together: [Bio-placenta peptides and tri-ceramide complex](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/salicylic-acid-and-bio-placenta-peptides) - Keep them apart: [Adapalene and salicylic acid](https://lovi.care/skincare/it/ingredients/adapalene-and-salicylic-acid) - Keep them apart: [Adapalene and vitamin C](https://lovi.care/skincare/it/ingredients/adapalene-and-vitamin-c) - Keep them apart: [Bio-placenta peptides and baking soda](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-baking-soda) - Keep them apart: [Bio-placenta peptides and bleach](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-bleach) - Keep them apart: [Bio-placenta peptides and potassium hydroxide](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-potassium-hydroxide) - Keep them apart: [Bio-placenta peptides and behenyl alcohol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-behenyl-alcohol) - Keep them apart: [Bio-placenta peptides and isopropyl alcohol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-isopropyl-alcohol) - Keep them apart: [Bio-placenta peptides and polyvinyl alcohol](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-polyvinyl-alcohol) - Keep them apart: [Bio-placenta peptides and copper](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-copper) - Keep them apart: [Adapalene and benzoyl peroxide](https://lovi.care/skincare/it/ingredients/adapalene-and-benzoyl-peroxide) - Keep them apart: [Bio-placenta peptides and magnesium](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-magnesium) - Keep them apart: [Bio-placenta peptides and zinc](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-zinc) - Keep them apart: [Bio-placenta peptides and zinc sulfate](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/benzoyl-peroxide-and-bio-placenta-peptides) - Keep them apart: [Azelaic acid and bio-placenta peptides](https://lovi.care/skincare/it/ingredients/azelaic-acid-and-bio-placenta-peptides) - Keep them apart: [Bio-placenta peptides and protease](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-protease) - Keep them apart: [Bio-placenta peptides and superoxide dismutase](https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/adapalene-and-bio-placenta-peptides - United Kingdom: https://lovi.care/skincare/uk/ingredients/adapalene-and-bio-placenta-peptides - Ireland: https://lovi.care/skincare/ie/ingredients/adapalene-and-bio-placenta-peptides - Germany: https://lovi.care/skincare/de/ingredients/adapalene-and-bio-placenta-peptides - France: https://lovi.care/skincare/fr/ingredients/adapalene-and-bio-placenta-peptides - Italy: https://lovi.care/skincare/it/ingredients/adapalene-and-bio-placenta-peptides (this page) - Netherlands: https://lovi.care/skincare/nl/ingredients/adapalene-and-bio-placenta-peptides - Spain: https://lovi.care/skincare/es/ingredients/adapalene-and-bio-placenta-peptides - Canada: https://lovi.care/skincare/ca/ingredients/adapalene-and-bio-placenta-peptides - Australia: https://lovi.care/skincare/au/ingredients/adapalene-and-bio-placenta-peptides - Singapore: https://lovi.care/skincare/sg/ingredients/adapalene-and-bio-placenta-peptides - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/adapalene-and-bio-placenta-peptides - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/adapalene-and-bio-placenta-peptides