# VR vs ISDIN Isdinceutics

Page: https://lovi.care/skincare/it/compare/vr-vs-isdin-isdinceutics

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

VR and ISDIN Isdinceutics are distinct skincare options designed to meet various daily needs. VR is known for the sensory pleasure of its moisturizers and considered formulas, suiting combination, sensitive, and dry skin best, with a standout [PDRN](https://lovi.care/skincare/it/ingredients/pdrn) CREAM for acne-prone skin. Meanwhile, the Spanish brand ISDIN Isdinceutics, founded in 1975, is revered for targeted eye products and advanced formulas that suit mature, dry, and sensitive skin, featuring the standout K-Ox Eyes for dark circles and puffiness. While both offer gentle and effective compositions, they differ primarily in their core strengths and targeted concerns, allowing each to support a smooth and balanced complexion.

ISDIN Isdinceutics is a Spanish skincare brand founded in 1975 and owned by Puig since 2027.

[puig.com](https://www.puig.com/en/newsroom/new-chapter-for-Isdin-Puig-to-assume-full-ownership/)

This page compares some of the most popular VR and ISDIN Isdinceutics products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg80c56b9248).

### Popular VR vs ISDIN Isdinceutics products

#### ISDIN Isdinceutics

- [K-Ox Eyes](https://lovi.care/skincare/it/p/isdin-isdinceutics/k-ox-eyes/for/dry-skin) — High fit

#### VR

- [PDRN CREAM](https://lovi.care/skincare/it/p/vr/pdrn-cream/for/sensitive-skin) — High fit

## Questions and answers

### VR or ISDIN Isdinceutics: which is better?

Both brands have strong options depending on your skin type, with ISDIN Isdinceutics K-Ox Eyes achieving a High Lovi fit for dry and sensitive skin. Meanwhile, VR [PDRN](https://lovi.care/skincare/it/ingredients/pdrn) CREAM earns a High Lovi fit for sensitive skin, and every product on this page from VR lists no fragrance.

### What is the difference between VR and ISDIN Isdinceutics?

VR and ISDIN Isdinceutics differ in fragrance and skin fit, as every VR product on this page has no fragrance and PDRN CREAM achieves a High fit for sensitive skin, while ISDIN Isdinceutics features fragrance in K-Ox Eyes, which achieves a High fit for dry, sensitive, and mature skin.

### Which is more affordable, VR or ISDIN Isdinceutics?

The provided page facts do not contain pricing information, so neither VR nor ISDIN Isdinceutics can be identified as more affordable.

### Which causes fewer breakouts, VR or ISDIN Isdinceutics?

Both VR and ISDIN Isdinceutics have average fits for acne-prone skin on Lovi. Every product on the VR page lists no fragrance, whereas the ISDIN Isdinceutics product on this page includes fragrance.

### How do the founding years and company ownership of VR and ISDIN Isdinceutics compare?

VR was founded in 2018 and is owned by an independent company. In contrast, ISDIN Isdinceutics was founded in 1975 in Spain and is owned by Puig since 2027.

### Which brand offers a fragrance-free option between VR and ISDIN Isdinceutics?

VR offers a fragrance-free option among the products on this page, as every item from the brand lists no fragrance in its ingredients. In contrast, ISDIN Isdinceutics includes fragrance in its eye product.

### How does the Lovi fit level for dry skin compare between VR's PDRN CREAM and ISDIN Isdinceutics' K-Ox Eyes?

For dry skin, Lovi rates VR's PDRN CREAM as Average fit, whereas ISDIN Isdinceutics' K-Ox Eyes achieves a High fit.

## Research behind their key ingredients

- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Chrysin protects epidermal keratinocytes from UVA- and UVB-induced damage](https://pubmed.ncbi.nlm.nih.gov/21699266/) Chrysin · Journal of Agricultural and Food Chemistry, 2011
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) 5-ceramide complex · Skin Pharmacology and Physiology, 2022
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Effects of Moringa oleifera Seed Oil on Cultured Human Sebocytes In Vitro and Comparison with Other Oil Types](https://pubmed.ncbi.nlm.nih.gov/37373478/) Moringa oleifera seed oil · International Journal of Molecular Sciences, 2023
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Chitosan derivative nanocarrier: safety evaluation,antibacterial property and ascorbyl palmitate encapsulation](https://pubmed.ncbi.nlm.nih.gov/19566395/) Ascorbyl palmitate · Journal of Microencapsulation, 2010
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin](https://pubmed.ncbi.nlm.nih.gov/41758783/) 5-ceramide complex · Skin Pharmacology and Physiology, 2026
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026

## The brands

- Skincare: [VR](https://lovi.care/skincare/it/brands/vr)
- Spanish skincare: [ISDIN Isdinceutics](https://lovi.care/skincare/it/brands/isdin-isdinceutics)

## More comparisons

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- [SKIN1004 vs ISDIN Isdinceutics](https://lovi.care/skincare/it/compare/skin1004-vs-isdin-isdinceutics)
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- [Anua vs ISDIN Isdinceutics](https://lovi.care/skincare/it/compare/anua-vs-isdin-isdinceutics)
- [Medicube vs VR](https://lovi.care/skincare/it/compare/medicube-vs-vr)
- [Medicube vs ISDIN Isdinceutics](https://lovi.care/skincare/it/compare/medicube-vs-isdin-isdinceutics)
- [The Ordinary vs VR](https://lovi.care/skincare/it/compare/the-ordinary-vs-vr)
- [The Ordinary vs ISDIN Isdinceutics](https://lovi.care/skincare/it/compare/the-ordinary-vs-isdin-isdinceutics)
- [Beauty of Joseon vs VR](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-vr)
- [Beauty of Joseon vs ISDIN Isdinceutics](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-isdin-isdinceutics)
- [COSRX vs VR](https://lovi.care/skincare/it/compare/cosrx-vs-vr)
- [COSRX vs ISDIN Isdinceutics](https://lovi.care/skincare/it/compare/cosrx-vs-isdin-isdinceutics)
- [CeraVe vs VR](https://lovi.care/skincare/it/compare/cerave-vs-vr)
- [CeraVe vs ISDIN Isdinceutics](https://lovi.care/skincare/it/compare/cerave-vs-isdin-isdinceutics)
- [La Roche-Posay vs VR](https://lovi.care/skincare/it/compare/la-roche-posay-vs-vr)
- [La Roche-Posay vs ISDIN Isdinceutics](https://lovi.care/skincare/it/compare/la-roche-posay-vs-isdin-isdinceutics)
- [Dr. Althea vs VR](https://lovi.care/skincare/it/compare/dr-althea-vs-vr)
- [Dr. Althea vs ISDIN Isdinceutics](https://lovi.care/skincare/it/compare/dr-althea-vs-isdin-isdinceutics)
- [Some By Mi vs VR](https://lovi.care/skincare/it/compare/some-by-mi-vs-vr)
- [Some By Mi vs ISDIN Isdinceutics](https://lovi.care/skincare/it/compare/some-by-mi-vs-isdin-isdinceutics)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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