# Trilogy vs Natura Bissé

Page: https://lovi.care/skincare/it/compare/trilogy-vs-natura-bisse

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Trilogy and Natura Bissé are distinct skincare lines recognized for their thoughtfully formulated products. The former is celebrated for its gentle cleansers and high-performing moisturizers that suit dry, balanced, and sensitive skin types best, featuring standouts like the [Rosehip](https://lovi.care/skincare/it/ingredients/rosehip-oil) Cream Cleanser and [Vitamin C](https://lovi.care/skincare/it/ingredients/vitamin-c) Ceramide Night Cream. In contrast, the Spanish brand is known for its luxurious moisturizers and advanced formulas that cater ideally to mature, dry, and sensitive skin with rich, nourishing properties, exemplified by the Diamond Extreme treatment. Ultimately, both offer carefully crafted treatments designed to restore balance and vitality to the complexion, differing primarily in their specific targeted ingredients and overall formulation approaches.

Natura Bissé is a Spanish skincare brand founded in 1979 and owned by Natura Bissé International, S.A..

[naturabisse.com](https://www.naturabisse.com/int/en/our-story.html) [tracxn.com](https://tracxn.com/d/accelerator-incubator/ushopal/__yjGH7DKhQGNWnINKarEuFce6tilrPzGJv0PnASFLfpg)

This page compares some of the most popular Trilogy and Natura Bissé products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg7cdefc47af).

### Popular Trilogy vs Natura Bissé products

#### Natura Bissé

- [Diamond Extreme](https://lovi.care/skincare/it/p/natura-bisse/diamond-extreme/for/mature-skin) — Superior fit — [€266.80 at Amazon](https://www.amazon.it/dp/B0BKLRMKZV?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)

#### Trilogy

- [Rosehip Cream Cleanser](https://lovi.care/skincare/it/p/trilogy/rosehip-cream-cleanser/for/sensitive-skin) — High fit
- [Line Smoothing Day Cream](https://lovi.care/skincare/it/p/trilogy/line-smoothing-day-cream/for/dry-skin) — High fit
- [Vitamin C Ceramide Night Cream](https://lovi.care/skincare/it/p/trilogy/vitamin-c-ceramide-night-cream/for/mature-skin) — High fit

## Questions and answers

### Trilogy or Natura Bissé: which is better?

Natura Bissé is better for mature skin where Lovi rates it as Superior, whereas Trilogy products on this page get High ratings for dry, sensitive, and dark spot skin types. Reviewers often mention Trilogy for hydrating and brightening moisturizers, though some report product performance and formulation complaints.

### What is the difference between Trilogy and Natura Bissé?

Trilogy offers three products on this page with varying fit levels across skin types, while Natura Bissé features just one moisturizer, Diamond Extreme, which has a Superior fit for mature skin.

### Trilogy or Natura Bissé: which moisturizer is better?

For mature skin, Natura Bissé Diamond Extreme moisturizer has a Superior Lovi fit, whereas the moisturizers from Trilogy, such as the [Vitamin C](https://lovi.care/skincare/it/ingredients/vitamin-c) Ceramide Night Cream and Line Smoothing Day Cream, have High and Average fits. Reviewers mostly mention that Trilogy offers hydrating and brightening moisturizers, but also note performance and formulation complaints.

### Which is more affordable, Trilogy or Natura Bissé?

This page does not contain pricing information, so we cannot tell whether Trilogy or Natura Bissé is more affordable.

### Which causes fewer breakouts, Trilogy or Natura Bissé?

Natura Bissé is unlikely to cause breakouts for most people, earning an average fit on this page for acne-prone skin, while Trilogy's products on this page have mixed fits ranging from average to low for acne-prone skin.

### Between Trilogy and Natura Bissé, which brand was founded earlier?

Natura Bissé was founded earlier, in 1979 in Spain, while Trilogy was founded later in 2002.

### How many products from Trilogy list no fragrance compared to Natura Bissé?

Trilogy has 1 out of 3 products on this page that list no fragrance, while Natura Bissé has 0 out of 1 products listing no fragrance.

### Which Trilogy moisturizer is recommended with a high fit level for mature skin?

Trilogy's Vitamin C Ceramide Night Cream is recommended with a high fit level for mature skin, while its Line Smoothing Day Cream has an average fit for that skin type.

## Research behind their key ingredients

- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling](https://pubmed.ncbi.nlm.nih.gov/32098197/) Leontopodium alpinum leaf extract flower · Genes, 2020
- [Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells](https://pubmed.ncbi.nlm.nih.gov/23093820/) Leontopodium alpinum leaf extract flower · Mediators of Inflammation, 2012
- [Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function](https://pubmed.ncbi.nlm.nih.gov/35409270/) Rosamarinus officinalis leaf extract rosemary leaf extract · International Journal of Molecular Sciences, 2022
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Topical Almond Oil for Prevention of Pressure Injuries: A Single-Blinded Comparison Study](https://pubmed.ncbi.nlm.nih.gov/32379165/) Prunus amygdalus dulcis oil · Journal of Wound, Ostomy, and Continence Nursing, 2020
- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) Shea butter · Journal of Cosmetic Dermatology, 2022
- [Formulation and evaluation of exotic fat based cosmeceuticals for skin repair](https://pubmed.ncbi.nlm.nih.gov/20046792/) Mangifera indica seed butter · Indian Journal of Pharmaceutical Sciences, 2008
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025
- [Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin](https://pubmed.ncbi.nlm.nih.gov/41758783/) Ceramide iii · Skin Pharmacology and Physiology, 2026
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026

## The brands

- Skincare: [Trilogy](https://lovi.care/skincare/it/brands/trilogy)
- Spanish skincare: [Natura Bissé](https://lovi.care/skincare/it/brands/natura-bisse)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/trilogy-vs-natura-bisse
- United Kingdom: https://lovi.care/skincare/uk/compare/trilogy-vs-natura-bisse
- Ireland: https://lovi.care/skincare/ie/compare/trilogy-vs-natura-bisse
- Germany: https://lovi.care/skincare/de/compare/trilogy-vs-natura-bisse
- France: https://lovi.care/skincare/fr/compare/trilogy-vs-natura-bisse
- Italy: https://lovi.care/skincare/it/compare/trilogy-vs-natura-bisse (this page)
- Netherlands: https://lovi.care/skincare/nl/compare/trilogy-vs-natura-bisse
- Spain: https://lovi.care/skincare/es/compare/trilogy-vs-natura-bisse
- Canada: https://lovi.care/skincare/ca/compare/trilogy-vs-natura-bisse
- Australia: https://lovi.care/skincare/au/compare/trilogy-vs-natura-bisse
- Singapore: https://lovi.care/skincare/sg/compare/trilogy-vs-natura-bisse
- Saudi Arabia: https://lovi.care/skincare/sa/compare/trilogy-vs-natura-bisse
- United Arab Emirates: https://lovi.care/skincare/ae/compare/trilogy-vs-natura-bisse