# Shiseido Senka vs Sesderma

Page: https://lovi.care/skincare/it/compare/shiseido-senka-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Shiseido Senka and Sesderma are well-regarded skincare brands originating from Japan and Spain, respectively. The Japanese brand is celebrated for its dependable cleansers and gentle formulas that suit normal, dry, oily, and combination skin, with the Perfect Whip standing out for acne-prone skin. Meanwhile, the Spanish brand is known for its advanced [serums](https://lovi.care/skincare/it/ingredients/serum) and meticulously engineered formulas tailored to sensitive, hyperpigmented, and aging skin, featuring the Azelac RU Serum for similar concerns. While both lines foster a balanced and radiant complexion through thoughtfully crafted routines, they differ in their heritage, core product types, and targeted skin profiles.

Shiseido Senka is a Japanese skincare brand founded in 2003 and owned by Bain Capital since 2026.

[corp.shiseido.com](https://corp.shiseido.com/jp/releimg/1918-j.pdf) [en.wikipedia.org](https://en.wikipedia.org/wiki/Shiseido)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Shiseido Senka and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgc4bea3dc0f).

### Popular Shiseido Senka vs Sesderma products

#### Shiseido Senka

- [Perfect Whip](https://lovi.care/skincare/it/p/shiseido-senka/perfect-whip/for/combination-skin) — High fit — [€13.30 at Amazon](https://www.amazon.it/dp/B0BYDLKG3Y?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/it/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€46.00 at Notino](https://www.notino.it/sesderma/azelac-ru-siero-depigmentante/p-514983/)

## Questions and answers

### Shiseido Senka or Sesderma: which is better?

Shiseido Senka is a better choice for fragrance-sensitive shoppers because the products on this page list no fragrance. Lovi rates Shiseido Senka High for all skin types, whereas Sesderma ranges from High to Low depending on the skin type.

### What is the difference between Shiseido Senka and Sesderma?

Shiseido Senka offers fragrance-free products on this page with High Lovi fit levels across all skin types, while Sesderma includes fragrance in its [serum](https://lovi.care/skincare/it/ingredients/serum) and shows varying fit levels from High to Low depending on the skin type.

### Which is more affordable, Shiseido Senka or Sesderma?

This page does not provide pricing or affordability information for either Shiseido Senka or Sesderma.

### Which causes fewer breakouts, Shiseido Senka or Sesderma?

Shiseido Senka is a better choice for breakout-prone skin because Lovi rates its Perfect Whip cleanser as a High fit for acne-prone skin, while Sesderma's Azelac RU Serum is rated as an Average fit. Additionally, every product on the Shiseido Senka page lists no fragrance, which helps reduce the likelihood of skin irritation.

### Which brand offers a cleanser, Shiseido Senka or Sesderma?

Shiseido Senka offers a cleanser, specifically the Perfect Whip, while Sesderma features a serum on this page.

### Do products from Shiseido Senka contain fragrance, unlike Sesderma's serum?

Shiseido Senka products on this page list no fragrance, whereas Sesderma's Azelac RU Serum contains fragrance.

### Which company is older, the one that founded Shiseido Senka in 2003 or Sesderma in 1989?

Sesderma is older, having been founded in Spain in 1989, whereas Shiseido Senka was founded later in Japan in 2003.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Myristic acid reduces skin inflammation and nociception](https://pubmed.ncbi.nlm.nih.gov/34811755/) Myristic acid · Journal of Food Biochemistry, 2022
- [The safety and efficacy of bacterial nanocellulose wound dressing incorporating sericin and polyhexamethylene biguanide: in vitro, in vivo and clinical studies](https://pubmed.ncbi.nlm.nih.gov/26796543/) Sericin · Archives of Dermatological Research, 2016
- [Design, preparation, and evaluation of liposomal gel formulations for treatment of acne: in vitro and in vivo studies](https://pubmed.ncbi.nlm.nih.gov/30442066/) Lauric acid · Drug Development and Industrial Pharmacy, 2019
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/33617668/) Citric acid · Journal of Cosmetic Dermatology, 2021
- [A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/32390309/) Lauric acid · Dermatologic Therapy, 2020
- [Synergistic approach for acne vulgaris treatment using glycerosomes loaded with lincomycin and lauric acid: Formulation, in silico, in vitro, LC-MS/MS skin deposition assay and in vivo evaluation](https://pubmed.ncbi.nlm.nih.gov/37805147/) Lauric acid · International Journal of Pharmaceutics, 2023
- [Anti-Inflammatory Activity of Babassu Oil and Development of a Microemulsion System for Topical Delivery](https://pubmed.ncbi.nlm.nih.gov/29430254/) Lauric acid · Evidence-based Complementary and Alternative Medicine, 2017
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

## The brands

- Japanese skincare: [Shiseido Senka](https://lovi.care/skincare/it/brands/shiseido-senka)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/it/brands/sesderma)

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- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/it/compare/la-roche-posay-vs-sesderma)
- [Dr. Althea vs Shiseido Senka](https://lovi.care/skincare/it/compare/dr-althea-vs-shiseido-senka)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/it/compare/dr-althea-vs-sesderma)
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- [Some By Mi vs Sesderma](https://lovi.care/skincare/it/compare/some-by-mi-vs-sesderma)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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