# Sesderma vs SKIN&CO

Page: https://lovi.care/skincare/it/compare/sesderma-vs-skin-and-co

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Sesderma and SKIN&CO are respected skincare brands offering expertly crafted formulas. Sesderma is beloved for its advanced [serums](https://lovi.care/skincare/it/ingredients/serum) and botanical [extracts](https://lovi.care/skincare/it/ingredients/extract), suiting sensitive, hyperpigmented, and aging skin best, whereas SKIN&CO is loved for its deeply nourishing moisturizers, suiting dry, normal, and combination skin best. The Spanish brand features standout products like the Azelac RU Serum for acne-prone skin, while the other brand delivers thoughtful care and features the Truffle Therapy Serum. Ultimately, both differ through their unique ingredient compositions and targeted approaches to refining skin texture.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Sesderma and SKIN&CO products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pga75077fb54).

### Popular Sesderma vs SKIN&CO products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/it/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€46.00 at Notino](https://www.notino.it/sesderma/azelac-ru-siero-depigmentante/p-514983/)

#### SKIN&CO

- [Truffle Therapy Serum](https://lovi.care/skincare/it/p/skin-and-co/truffle-therapy-serum/for/dry-skin) — Average fit

## Questions and answers

### Sesderma or SKIN&CO: which is better?

Sesderma offers a High Lovi fit for acne-prone skin and skin with dark spots with its Azelac RU [Serum](https://lovi.care/skincare/it/ingredients/serum), while SKIN&CO provides an Average fit across all skin types with its Truffle Therapy Serum.

### What is the difference between Sesderma and SKIN&CO?

Sesderma has a High fit for acne-prone skin and skin with dark spots with its Azelac RU Serum, whereas SKIN&CO offers Average fits across all skin types with its Truffle Therapy Serum. Both of the products on this page contain fragrance.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Which is more affordable, Sesderma or SKIN&CO?

The provided page facts do not contain pricing information, so it is not possible to determine whether Sesderma or SKIN&CO is more affordable.

### Which causes fewer breakouts, Sesderma or SKIN&CO?

For acne-prone skin, Sesderma offers a High fit with its Azelac RU Serum, whereas SKIN&CO provides an Average fit with Truffle Therapy Serum.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Which brand has been around longer, Sesderma or SKIN&CO?

Sesderma has been around longer, having been founded in Spain in 1989, whereas SKIN&CO was founded in 2008.

### Do Sesderma and SKIN&CO products contain fragrance?

Yes, both Sesderma and SKIN&CO include fragrance in the products on this page. Specifically, the Azelac RU Serum by Sesderma and the Truffle Therapy Serum by SKIN&CO both contain fragrance.

### Which skin types are best suited for Sesderma's Azelac RU Serum compared to SKIN&CO's Truffle Therapy Serum?

Sesderma's Azelac RU Serum has a High Lovi fit for acne-prone skin, skin with dark spots, and combination skin, whereas SKIN&CO's Truffle Therapy Serum achieves an Average fit across all listed skin types. Both products on this page contain fragrance.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/it/brands/sesderma)
- Skincare: [SKIN&CO](https://lovi.care/skincare/it/brands/skin-and-co)

## More comparisons

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- [SKIN1004 vs SKIN&CO](https://lovi.care/skincare/it/compare/skin1004-vs-skin-and-co)
- [Anua vs Sesderma](https://lovi.care/skincare/it/compare/anua-vs-sesderma)
- [Anua vs SKIN&CO](https://lovi.care/skincare/it/compare/anua-vs-skin-and-co)
- [Medicube vs Sesderma](https://lovi.care/skincare/it/compare/medicube-vs-sesderma)
- [Medicube vs SKIN&CO](https://lovi.care/skincare/it/compare/medicube-vs-skin-and-co)
- [The Ordinary vs Sesderma](https://lovi.care/skincare/it/compare/the-ordinary-vs-sesderma)
- [The Ordinary vs SKIN&CO](https://lovi.care/skincare/it/compare/the-ordinary-vs-skin-and-co)
- [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-sesderma)
- [Beauty of Joseon vs SKIN&CO](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-skin-and-co)
- [COSRX vs Sesderma](https://lovi.care/skincare/it/compare/cosrx-vs-sesderma)
- [COSRX vs SKIN&CO](https://lovi.care/skincare/it/compare/cosrx-vs-skin-and-co)
- [CeraVe vs Sesderma](https://lovi.care/skincare/it/compare/cerave-vs-sesderma)
- [CeraVe vs SKIN&CO](https://lovi.care/skincare/it/compare/cerave-vs-skin-and-co)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/it/compare/la-roche-posay-vs-sesderma)
- [La Roche-Posay vs SKIN&CO](https://lovi.care/skincare/it/compare/la-roche-posay-vs-skin-and-co)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/it/compare/dr-althea-vs-sesderma)
- [Dr. Althea vs SKIN&CO](https://lovi.care/skincare/it/compare/dr-althea-vs-skin-and-co)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/it/compare/some-by-mi-vs-sesderma)
- [Some By Mi vs SKIN&CO](https://lovi.care/skincare/it/compare/some-by-mi-vs-skin-and-co)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

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