# Sesderma vs Blume

Page: https://lovi.care/skincare/it/compare/sesderma-vs-blume

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Sesderma and Blume are distinct skincare brands with dedicated followings, representing Spanish and Canadian origins respectively. Sesderma offers advanced [serums](https://lovi.care/skincare/it/ingredients/serum) and meticulously engineered formulas featuring botanical [extracts](https://lovi.care/skincare/it/ingredients/extract) and active compounds that suit sensitive, hyperpigmented, and aging skin types best. Meanwhile, Blume provides nourishing moisturizers and thoughtful formulas that suit sensitive, acne-prone, and dry skin best. The Spanish brand excels in refining texture and promoting radiance with products like the Azelac RU Serum, whereas its Canadian counterpart supports a balanced complexion through daily offerings like the Meltdown Gel Cream.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

Blume is a Canadian skincare brand founded in 2018.

[beautymatter.com](https://beautymatter.com/articles/next50-2025-blume) [businessinsider.com](https://www.businessinsider.com/millennial-cofounders-feminine-care-startup-blume-raised-millions-one-month) [tracxn.com](https://tracxn.com/d/companies/blume/__jaX9OkWmricZDTbbibw7yJbRPVQYVtNZDJ0cH8e2j4s) [blume.com](https://www.blume.com/blogs/blume-university/blume-formerly-known-as-ellebox)

This page compares some of the most popular Sesderma and Blume products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgfd4447a7b1).

### Popular Sesderma vs Blume products

#### Blume

- [Meltdown Gel Cream](https://lovi.care/skincare/it/p/blume/meltdown-gel-cream/for/acne-prone-skin) — High fit

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/it/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€46.00 at Notino](https://www.notino.it/sesderma/azelac-ru-siero-depigmentante/p-514983/)

## Questions and answers

### Sesderma or Blume: which is better?

Blume is a better fit for sensitive skin with a High Lovi rating across all its fragrance-free products on this page, whereas Sesderma offers a High Lovi fit specifically for acne-prone skin and dark spots with its Azelac RU [Serum](https://lovi.care/skincare/it/ingredients/serum).

### What is the difference between Sesderma and Blume?

Blume is an independent Canadian brand offering fragrance-free products on this page like Meltdown Gel Cream, which has a High Lovi fit for acne-prone, oily, and dry skin. Sesderma is a Spanish brand owned by Grupo Sesderma whose Azelac RU Serum contains fragrance and has a High Lovi fit for acne-prone skin, skin with dark spots, and combination skin.

### Which is more affordable, Sesderma or Blume?

The page facts do not mention the prices of Sesderma or Blume products, so it is not possible to say which brand is more affordable.

### Which causes fewer breakouts, Sesderma or Blume?

Blume is a better choice for acne-prone skin because its Meltdown Gel Cream achieves a High Lovi fit for acne-prone, oily acne-prone, and oily skin, while Sesderma's Azelac RU Serum only reaches an Average fit for oily acne-prone skin.

### Between Sesderma and Blume, which brand offers fragrance-free products?

Blume offers fragrance-free products since every product on this page lists no fragrance, while Sesderma includes fragrance in its products on this page.

### How do the founding years and countries of origin compare between Sesderma and Blume?

Sesderma was founded in 1989 in Spain, whereas Blume was founded in 2018 in Canada.

### Which brand has higher Lovi fit levels for dry skin, Sesderma or Blume?

Blume has a higher Lovi fit level for dry skin than Sesderma, offering a High fit compared to Sesderma's Low fit.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract](https://pubmed.ncbi.nlm.nih.gov/27168678/) Centella asiatica extract · Indian Journal of Pharmaceutical Sciences, 2016
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramides · Scientific Reports, 2022
- [Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo](https://pubmed.ncbi.nlm.nih.gov/25381913/) Licorice root extract · Experimental Dermatology, 2015
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica extract · Molecules, 2023
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Standardized Terminalia chebula Fruit Extract: A Natural Ingredient That Provides Long-Lasting Antioxidant Protection and Reverses Visible Signs of Pollution-Induced Skin Damage](https://pubmed.ncbi.nlm.nih.gov/34557011/) Terminalia chebula fruit extract · Clinical, Cosmetic and Investigational Dermatology, 2021
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Terminalia chebula fruit extract · Health Science Reports, 2025

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/it/brands/sesderma)
- Canadian skincare: [Blume](https://lovi.care/skincare/it/brands/blume)

## More comparisons

- [SKIN1004 vs Sesderma](https://lovi.care/skincare/it/compare/skin1004-vs-sesderma)
- [SKIN1004 vs Blume](https://lovi.care/skincare/it/compare/skin1004-vs-blume)
- [Anua vs Sesderma](https://lovi.care/skincare/it/compare/anua-vs-sesderma)
- [Anua vs Blume](https://lovi.care/skincare/it/compare/anua-vs-blume)
- [Medicube vs Sesderma](https://lovi.care/skincare/it/compare/medicube-vs-sesderma)
- [Medicube vs Blume](https://lovi.care/skincare/it/compare/medicube-vs-blume)
- [The Ordinary vs Sesderma](https://lovi.care/skincare/it/compare/the-ordinary-vs-sesderma)
- [The Ordinary vs Blume](https://lovi.care/skincare/it/compare/the-ordinary-vs-blume)
- [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-sesderma)
- [Beauty of Joseon vs Blume](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-blume)
- [COSRX vs Sesderma](https://lovi.care/skincare/it/compare/cosrx-vs-sesderma)
- [COSRX vs Blume](https://lovi.care/skincare/it/compare/cosrx-vs-blume)
- [CeraVe vs Sesderma](https://lovi.care/skincare/it/compare/cerave-vs-sesderma)
- [CeraVe vs Blume](https://lovi.care/skincare/it/compare/cerave-vs-blume)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/it/compare/la-roche-posay-vs-sesderma)
- [La Roche-Posay vs Blume](https://lovi.care/skincare/it/compare/la-roche-posay-vs-blume)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/it/compare/dr-althea-vs-sesderma)
- [Dr. Althea vs Blume](https://lovi.care/skincare/it/compare/dr-althea-vs-blume)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/it/compare/some-by-mi-vs-sesderma)
- [Some By Mi vs Blume](https://lovi.care/skincare/it/compare/some-by-mi-vs-blume)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sesderma-vs-blume
- United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-blume
- Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-blume
- Germany: https://lovi.care/skincare/de/compare/sesderma-vs-blume
- France: https://lovi.care/skincare/fr/compare/sesderma-vs-blume
- Italy: https://lovi.care/skincare/it/compare/sesderma-vs-blume (this page)
- Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-blume
- Spain: https://lovi.care/skincare/es/compare/sesderma-vs-blume
- Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-blume
- Australia: https://lovi.care/skincare/au/compare/sesderma-vs-blume
- Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-blume
- Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-blume
- United Arab Emirates: https://lovi.care/skincare/ae/compare/sesderma-vs-blume