# Paula's Choice vs Mesoestetic

Page: https://lovi.care/skincare/it/compare/paula-s-choice-vs-mesoestetic

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Paula's Choice and Mesoestetic are established skincare brands offering distinct approaches to daily care. The American line, founded in 1995, features [serums](https://lovi.care/skincare/it/ingredients/serum), cleansers, moisturizers, and toners built around [hyaluronic acid](https://lovi.care/skincare/it/ingredients/hyaluronic-acid), [glycerin](https://lovi.care/skincare/it/ingredients/glycerin), and [vitamin C](https://lovi.care/skincare/it/ingredients/vitamin-c), making it best suited for oily and acne-prone skin. Meanwhile, the Spanish brand, founded in 1984, is beloved for targeted serums and meticulously crafted formulas that suit mature, sensitive, and uneven skin. Ultimately, the two differ in their core formulations, with the former emphasizing barrier-restoring glycerin while the latter delivers rigorous yet gentle nourishment.

Paula's Choice is an American skincare brand founded in 1995 and owned by Unilever since 2021.

[unilever.com](https://www.unilever.com/news/press-and-media/press-releases/2021/unilever-to-acquire-paulas-choice-skincare/) [tracxn.com](https://tracxn.com/d/companies/paulas-choice/__3NzlGcC2yhs-Z9XjkOCar6Dxe0DJgowfl0PAX9OD5s8)

Mesoestetic is a Spanish skincare brand founded in 1984 and owned by Mesoestetic Pharma Group, S.L..

[mesoestetic.com](https://www.mesoestetic.com/about-us) [tracxn.com](https://tracxn.com/d/companies/mesoestetic/__1eAnF7uALQzHII_So8HqZbHfSUJuilusj9hTisrG0tk)

This page compares some of the most popular Paula's Choice and Mesoestetic products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg42cb771ba1).

### Popular Paula's Choice vs Mesoestetic products

#### Paula's Choice

- [Skin Perfecting 2% BHA Liquid Exfoliant](https://lovi.care/skincare/it/p/paula-s-choice/skin-perfecting-2-bha-liquid-exfoliant/for/oily-skin) — Superior fit — [€14.00 at Amazon](https://www.amazon.it/dp/B07PQSRXR6?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [1% Retinol Treatment](https://lovi.care/skincare/it/p/paula-s-choice/1-retinol-treatment/for/dark-spots) — Superior fit — [€57.00 at Amazon](https://www.amazon.it/dp/B07P6M914G?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [10% Azelaic Acid Booster](https://lovi.care/skincare/it/p/paula-s-choice/10-azelaic-acid-booster/for/acne-prone-skin) — High fit — [€49.00 at Amazon](https://www.amazon.it/dp/B09S9R72XB?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [C15 Super Booster](https://lovi.care/skincare/it/p/paula-s-choice/c15-super-booster/for/mature-skin) — High fit — [€59.00 at Amazon](https://www.amazon.it/dp/B0H9975SCY?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/it/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — [€29.00 at Amazon](https://www.amazon.it/dp/B0D9Q99LKF?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [10% Niacinamide Booster](https://lovi.care/skincare/it/p/paula-s-choice/10-niacinamide-booster/for/dry-sensitive-skin) — Superior fit — [€57.00 at Amazon](https://www.amazon.it/dp/B07QCWTYJ2?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Weightless Body Treatment 2% BHA](https://lovi.care/skincare/it/p/paula-s-choice/weightless-body-treatment-2-bha/for/oily-acne-prone-skin) — Average fit
- [Skin Balancing Pore-Reducing Toner](https://lovi.care/skincare/it/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit

#### Mesoestetic

- [Cosmelan 2](https://lovi.care/skincare/it/p/mesoestetic/cosmelan-2/for/acne-prone-skin) — Average fit

### Paula's Choice vs Mesoestetic [serums](https://lovi.care/skincare/it/ingredients/serum) and treatments

#### Paula's Choice

- [1% Retinol Treatment](https://lovi.care/skincare/it/p/paula-s-choice/1-retinol-treatment/for/dark-spots) — Superior fit — [€57.00 at Amazon](https://www.amazon.it/dp/B07P6M914G?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [10% Azelaic Acid Booster](https://lovi.care/skincare/it/p/paula-s-choice/10-azelaic-acid-booster/for/acne-prone-skin) — High fit — [€49.00 at Amazon](https://www.amazon.it/dp/B09S9R72XB?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [C15 Super Booster](https://lovi.care/skincare/it/p/paula-s-choice/c15-super-booster/for/mature-skin) — High fit — [€59.00 at Amazon](https://www.amazon.it/dp/B0H9975SCY?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [10% Niacinamide Booster](https://lovi.care/skincare/it/p/paula-s-choice/10-niacinamide-booster/for/dry-sensitive-skin) — Superior fit — [€57.00 at Amazon](https://www.amazon.it/dp/B07QCWTYJ2?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Weightless Body Treatment 2% BHA](https://lovi.care/skincare/it/p/paula-s-choice/weightless-body-treatment-2-bha/for/oily-acne-prone-skin) — Average fit
- [25% Vitamin C + Glutathione Clinical Serum](https://lovi.care/skincare/it/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin) — High fit — [€73.00 at Amazon](https://www.amazon.it/dp/B0CZ4BKT3T?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Pro-Collagen Multi-Peptide Booster](https://lovi.care/skincare/it/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin) — Superior fit — [€65.00 at Amazon](https://www.amazon.it/dp/B0C5J46GVN?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [8% AHA Gel Exfoliant](https://lovi.care/skincare/it/p/paula-s-choice/8-aha-gel-exfoliant/for/oily-acne-prone-skin) — Superior fit — [€44.00 at Amazon](https://www.amazon.it/dp/B07V6Y81Q1?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [RESIST Intensive Wrinkle-Repair Retinol Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-intensive-wrinkle-repair-retinol-serum/for/acne-prone-skin) — Average fit — [€57.00 at Amazon](https://www.amazon.it/dp/B07P6M914G?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Clear Daily Skin Clearing Treatment](https://lovi.care/skincare/it/p/paula-s-choice/clear-daily-skin-clearing-treatment/for/acne-prone-skin) — Average fit
- [Discoloration Repair Serum](https://lovi.care/skincare/it/p/paula-s-choice/discoloration-repair-serum/for/dry-skin) — High fit — [€65.00 at Amazon](https://www.amazon.it/dp/B09H7KRDFR?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [PRO Retinaldehyde Dual-Retinoid Treatment](https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/acne-prone-skin) — Superior fit — [€75.00 at Amazon](https://www.amazon.it/dp/B0DCVTQ4XV?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Skin Perfecting 25% AHA + 2% BHA Exfoliant Peel](https://lovi.care/skincare/it/p/paula-s-choice/skin-perfecting-25-aha-2-bha-exfoliant-peel/for/dark-spots) — High fit — [€49.00 at Amazon](https://www.amazon.it/dp/B09R7K8LMP?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — [€57.00 at Amazon](https://www.amazon.it/dp/B07STB11MX?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Skin Perfecting 2% BHA Lotion Exfoliant](https://lovi.care/skincare/it/p/paula-s-choice/skin-perfecting-2-bha-lotion-exfoliant/for/oily-skin) — Superior fit — [€39.00 at Amazon](https://www.amazon.it/dp/B07TJRGDYC?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [RESIST Triple Active Total Repair Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-triple-active-total-repair-serum/for/mature-skin) — Superior fit
- [Niacinamide 20% Treatment](https://lovi.care/skincare/it/p/paula-s-choice/niacinamide-20-treatment/for/oily-skin) — Superior fit — [€63.00 at Amazon](https://www.amazon.it/dp/B08SW6VPJL?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Skin Perfecting 6% Mandelic Acid + 2% Lactic Acid Liquid Exfoliant](https://lovi.care/skincare/it/p/paula-s-choice/skin-perfecting-6-mandelic-acid-2-lactic-acid-liquid-exfoliant/for/dark-spots) — High fit — [€16.00 at Amazon](https://www.amazon.it/dp/B0D5BGLDVV?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)

#### Mesoestetic

- [Cosmelan 2](https://lovi.care/skincare/it/p/mesoestetic/cosmelan-2/for/acne-prone-skin) — Average fit

## Questions and answers

### Paula's Choice or Mesoestetic: which is better?

Paula's Choice offers a much wider selection of fragrance-free products on this page with better overall Lovi fit levels across skin types, whereas Mesoestetic features only a single product with lower ratings. Paula's Choice helps target concerns like aging and blemishes using proven ingredients like [retinol](https://lovi.care/skincare/it/ingredients/retinol) and [niacinamide](https://lovi.care/skincare/it/ingredients/niacinamide).

[The Journal of Investigative Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/10692106/) [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### What is the difference between Paula's Choice and Mesoestetic?

Paula's Choice offers a wide variety of fragrance-free products on this page with superior fit levels for oily, acne-prone, and mature skin, whereas Mesoestetic features a much narrower selection with an average or low fit across most skin types.

### Which is more affordable, Paula's Choice or Mesoestetic?

Reviewers note that Paula's Choice products on this page often come with a high price, but the provided page facts do not contain pricing information for Mesoestetic to make a direct comparison.

### When and where were Paula's Choice and Mesoestetic founded?

Paula's Choice was founded in 1995 in the United States, while Mesoestetic was founded in 1984 in Spain.

### Do any products from Paula's Choice or Mesoestetic contain fragrance?

Every product on the page from both Paula's Choice and Mesoestetic lists no fragrance in its ingredients.

### Which skin types do Paula's Choice routines fit best according to the page?

According to the page, Paula's Choice routines fit oily skin, acne-prone skin, and mature skin best.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Sodium hyaluronate · Drug Delivery, 2017
- [Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress](https://pubmed.ncbi.nlm.nih.gov/11181450/) Epigallocatechin gallate · Carcinogenesis, 2001
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments](https://pubmed.ncbi.nlm.nih.gov/21952107/) Rice bran oil · Journal of Nanobiotechnology, 2011
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol, Panthenol vitamin b5 · American Journal of Clinical Dermatology, 2002
- [Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes](https://pubmed.ncbi.nlm.nih.gov/23096708/) Epigallocatechin gallate · The Journal of Investigative Dermatology, 2013
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid, Tocopherol vitamin e, Tocopherol · Journal of Cosmetic Dermatology, 2020
- [A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation](https://pubmed.ncbi.nlm.nih.gov/18603326/) Ferulic acid · Journal of the American Academy of Dermatology, 2008
- [Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin](https://pubmed.ncbi.nlm.nih.gov/19146606/) Ferulic acid · Journal of Cosmetic Dermatology, 2008
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol, Bakuchiol · The British Journal of Dermatology, 2019
- [Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo](https://pubmed.ncbi.nlm.nih.gov/19186973/) Ascorbyl glucoside · Journal of Periodontology, 2009
- [Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women](https://pubmed.ncbi.nlm.nih.gov/25378941/) Glutathione · Clinical, Cosmetic and Investigational Dermatology, 2014
- [Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo](https://pubmed.ncbi.nlm.nih.gov/27279007/) Chamomilla recutita flower extract matricaria flower extract · International Journal of Molecular Medicine, 2016
- [Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects](https://pubmed.ncbi.nlm.nih.gov/26648450/) Ubiquinone · BioFactors, 2015
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Urea: a comprehensive review of the clinical literature](https://pubmed.ncbi.nlm.nih.gov/24314769/) Urea · Dermatology Online Journal, 2013
- [A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin](https://pubmed.ncbi.nlm.nih.gov/30822414/) Epigallocatechin gallate · The Journal of Investigative Dermatology, 2019
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramides · Scientific Reports, 2022
- [Topical benzoyl peroxide for acne](https://pubmed.ncbi.nlm.nih.gov/32175593/) Benzoyl peroxide · The Cochrane Database of Systematic Reviews, 2020
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ferulic acid, Tocopherol, Ascorbic acid, Tocopherol vitamin e · Journal of Cosmetic Dermatology, 2020
- [Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo](https://pubmed.ncbi.nlm.nih.gov/25381913/) Licorice root extract, Glycyrrhiza glabra root extract licorice root extract · Experimental Dermatology, 2015
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia oleifera leaf extract camellia sinensis leaf extract, Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [The clinical effect of glutathione on skin color and other related skin conditions: A systematic review](https://pubmed.ncbi.nlm.nih.gov/30895708/) Glutathione · Journal of Cosmetic Dermatology, 2019
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Benzoyl peroxide treatment decreases Cutibacterium acnes in shoulder surgery, from skin incision until wound closure](https://pubmed.ncbi.nlm.nih.gov/33545336/) Benzoyl peroxide · Journal of Shoulder and Elbow Surgery, 2021
- [Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial](https://pubmed.ncbi.nlm.nih.gov/19845667/) Acetyl glucosamine · The British Journal of Dermatology, 2010
- [Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine](https://pubmed.ncbi.nlm.nih.gov/17348991/) Acetyl glucosamine · Journal of Cosmetic Dermatology, 2007
- [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Benzoyl peroxide · American Journal of Clinical Dermatology, 2022
- [A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen](https://pubmed.ncbi.nlm.nih.gov/20374604/) Retinyl propionate · The British Journal of Dermatology, 2010
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol, Panthenol vitamin b5 · The Journal of Dermatological Treatment, 2017
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days](https://pubmed.ncbi.nlm.nih.gov/30924254/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2019
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin, Panthenol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Tetrahexyldecyl ascorbate · Photochemistry and Photobiology, 2021
- [Topical glutathione amino acid precursors protect skin against environmental and oxidative stress](https://pubmed.ncbi.nlm.nih.gov/38189670/) Glutathione · Journal of the European Academy of Dermatology and Venereology, 2024
- [An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects](https://pubmed.ncbi.nlm.nih.gov/32099438/) Blueberry fruit extract · Clinical, Cosmetic and Investigational Dermatology, 2020
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [In vivo skin irritation potential of a Castanea sativa (Chestnut) leaf extract, a putative natural antioxidant for topical application](https://pubmed.ncbi.nlm.nih.gov/18793273/) Chestnut leaf extract · Basic & Clinical Pharmacology & Toxicology, 2008
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols)](https://pubmed.ncbi.nlm.nih.gov/21917024/) Tocotrienols · Journal of the European Academy of Dermatology and Venereology, 2012
- [Tocotrienol-rich fraction attenuates UV-induced inflammaging: A bench to bedside study](https://pubmed.ncbi.nlm.nih.gov/28952200/) Tocotrienols · Journal of Cosmetic Dermatology, 2018
- [Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects](https://pubmed.ncbi.nlm.nih.gov/32129554/) Vitamin e · Journal of Cosmetic Dermatology, 2020
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment](https://pubmed.ncbi.nlm.nih.gov/19134126/) Sodium ascorbyl phosphate · International Journal of Cosmetic Science, 2009
- [Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol](https://pubmed.ncbi.nlm.nih.gov/27391637/) Hexylresorcinol · Journal of Drugs in Dermatology, 2016
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques](https://pubmed.ncbi.nlm.nih.gov/28385617/) Tetrahexyldecyl ascorbate · European Journal of Pharmaceutics and Biopharmaceutics, 2017
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Efficacy and safety of microencapsulated benzoyl peroxide and microencapsulated tretinoin for the treatment of acne vulgaris: Results from two phase 3 double-blind, randomized, vehicle-controlled studies](https://pubmed.ncbi.nlm.nih.gov/37356627/) Benzoyl peroxide · Journal of the American Academy of Dermatology, 2023
- [A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial](https://pubmed.ncbi.nlm.nih.gov/25914553/) Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 2015
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide](https://pubmed.ncbi.nlm.nih.gov/34958693/) Hexylresorcinol · International Journal of Cosmetic Science, 2022
- [Chemical peels for acne vulgaris: a systematic review of randomised controlled trials](https://pubmed.ncbi.nlm.nih.gov/29705755/) Mandelic acid · BMJ Open, 2018
- [Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations](https://pubmed.ncbi.nlm.nih.gov/35274433/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release](https://pubmed.ncbi.nlm.nih.gov/35929319/) Oenothera biennis oil · Biomaterials Advances, 2022
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia oleifera leaf extract camellia sinensis leaf extract, Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study](https://pubmed.ncbi.nlm.nih.gov/36729399/) Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023
- [Whitening effect of alpha-bisabolol in Asian women subjects](https://pubmed.ncbi.nlm.nih.gov/20642768/) Bisabolol · International Journal of Cosmetic Science, 2010
- [Is benzyl alcohol a significant contact sensitizer?](https://pubmed.ncbi.nlm.nih.gov/35080274/) Benzyl alcohol · Journal of the European Academy of Dermatology and Venereology, 2022
- [Inhibitory effects of shell of Camellia oleifera Abel extract on mushroom tyrosinase and human skin melanin](https://pubmed.ncbi.nlm.nih.gov/31033161/) Butylene glycol · Journal of Cosmetic Dermatology, 2019
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [Apple Extract (Malus sp.) and Rutin as Photochemopreventive Agents: Evaluation of Ultraviolet B-Induced Alterations on Skin Biopsies and Tissue-Engineered Skin](https://pubmed.ncbi.nlm.nih.gov/32242497/) Pyrus malus fruit extract · Rejuvenation Research, 2020
- [Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study](https://pubmed.ncbi.nlm.nih.gov/33128496/) Beta-glucan · Journal of Cosmetic Dermatology, 2021
- [Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers](https://pubmed.ncbi.nlm.nih.gov/27756097/) Sodium ascorbyl phosphate · Drug Research, 2017
- [Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement](https://pubmed.ncbi.nlm.nih.gov/30160014/) Adenosine · Journal of Cosmetic Dermatology, 2019
- [The impacts of sodium lauroyl sarcosinate in facial cleanser on facial skin microbiome and lipidome](https://pubmed.ncbi.nlm.nih.gov/37990616/) Sodium lauroyl sarcosinate · Journal of Cosmetic Dermatology, 2024
- [Nanostructured Lipid Carrier for Topical Application of N-Acetyl Glucosamine](https://pubmed.ncbi.nlm.nih.gov/28101465/) Acetyl glucosamine · Advanced Pharmaceutical Bulletin, 2016
- [Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids](https://pubmed.ncbi.nlm.nih.gov/12482041/) Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002
- [Stability, antioxidant activity, in vivo safety and efficacy of creams with standardized wild apple fruit extract: a comparison of conventional and biodegradable emulsifiers](https://pubmed.ncbi.nlm.nih.gov/31050807/) Pyrus malus fruit extract · International Journal of Cosmetic Science, 2019
- [Borage Oil Treated with Immobilized Lipase Inhibits Melanogenesis](https://pubmed.ncbi.nlm.nih.gov/33128473/) Borago officinalis oil, Borago officinalis seed oil · Lipids, 2020
- [Development, Characterization, and Clinical Investigation of a New Topical Emulsion System Containing a Castanea sativa Spiny Burs Active Extract](https://pubmed.ncbi.nlm.nih.gov/34683927/) Chestnut leaf extract · Pharmaceutics, 2021
- [Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects](https://pubmed.ncbi.nlm.nih.gov/39383579/) Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025
- [Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis](https://pubmed.ncbi.nlm.nih.gov/37763018/) Hydrolyzed yeast extract · Journal of Clinical Medicine, 2023
- [Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota](https://pubmed.ncbi.nlm.nih.gov/39598779/) Camellia oleifera leaf extract camellia sinensis leaf extract · Molecules, 2024
- [Novel beads made of alpha-cyclodextrin and oil for topical delivery of a lipophilic drug](https://pubmed.ncbi.nlm.nih.gov/17671830/) Glycine soja oil soybean oil · Pharmaceutical Research, 2008
- [Randomized prospective study of low-dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne tarda](https://pubmed.ncbi.nlm.nih.gov/35388606/) Mandelic acid · Journal of Cosmetic Dermatology, 2022
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol, Panthenol vitamin b5 · Journal of Cosmetic Dermatology, 2025
- [Standardized wild apple fruit extract as a bioactive agent in dermocosmetic products for efficacy skin hydration-In vitro and in vivo evaluation](https://pubmed.ncbi.nlm.nih.gov/35048513/) Pyrus malus fruit extract · Journal of Cosmetic Dermatology, 2022
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites](https://pubmed.ncbi.nlm.nih.gov/23438139/) Retinyl palmitate · Journal of Cosmetic Dermatology, 2013
- [TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection](https://pubmed.ncbi.nlm.nih.gov/36455708/) Avobenzone · European Journal of Pharmaceutical Sciences, 2023
- [Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance](https://pubmed.ncbi.nlm.nih.gov/36502500/) Hexylresorcinol · Archives of Dermatological Research, 2023
- [Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging](https://pubmed.ncbi.nlm.nih.gov/38525606/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2024
- [Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/42278371/) Adenosine · International Journal of Molecular Sciences, 2026
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females](https://pubmed.ncbi.nlm.nih.gov/27272084/) Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser: A prospective randomized vehicle-controlled parallel group study](https://pubmed.ncbi.nlm.nih.gov/35570397/) Beta-glucan · The Journal of Dermatology, 2022
- [Treatment of Stretch Marks Using a New Formulation Combining Nanofractional Radiofrequency Plus Magnetic Nanofractional Radiofrequency](https://pubmed.ncbi.nlm.nih.gov/37171578/) Beta-glucan · Dermatology and Therapy, 2023
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits](https://pubmed.ncbi.nlm.nih.gov/39964201/) Palmitoyl hexapeptide-12 · ACS Applied Bio Materials, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate vitamin e · Contemporary Clinical Trials Communications, 2021
- [Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos](https://pubmed.ncbi.nlm.nih.gov/39769217/) Ascorbyl glucoside · International Journal of Molecular Sciences, 2024
- [A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties](https://pubmed.ncbi.nlm.nih.gov/41562471/) Bakuchiol · Skin Research and Technology, 2026
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Octinoxate · Archives of Dermatological Research, 2024
- [Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling](https://pubmed.ncbi.nlm.nih.gov/35920724/) Portulaca oleracea extract purslane extract · Cutaneous and Ocular Toxicology, 2022
- [Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing](https://pubmed.ncbi.nlm.nih.gov/38685700/) Retinyl propionate · International Journal of Cosmetic Science, 2024
- [Retinyl propionate and climbazole combination demonstrates clinical improvement to the appearance of hyperpigmentation and deep wrinkling with minimal irritation](https://pubmed.ncbi.nlm.nih.gov/28733999/) Retinyl propionate · International Journal of Cosmetic Science, 2017
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study](https://pubmed.ncbi.nlm.nih.gov/42617898/) Sodium laureth sulfate · International Journal of Pharmaceutics, 2026
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter, Saccharide isomerate · Lasers in Medical Science, 2025
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025
- [Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin](https://pubmed.ncbi.nlm.nih.gov/41182319/) Portulaca oleracea extract purslane extract · Cutaneous and Ocular Toxicology, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study](https://pubmed.ncbi.nlm.nih.gov/41211697/) Saccharide isomerate · The Journal of Dermatological Treatment, 2025

## The brands

- American skincare: [Paula's Choice](https://lovi.care/skincare/it/brands/paula-s-choice)
- Spanish skincare: [Mesoestetic](https://lovi.care/skincare/it/brands/mesoestetic)

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- [COSRX vs Paula's Choice](https://lovi.care/skincare/it/compare/cosrx-vs-paula-s-choice)
- [COSRX vs Mesoestetic](https://lovi.care/skincare/it/compare/cosrx-vs-mesoestetic)
- [CeraVe vs Paula's Choice](https://lovi.care/skincare/it/compare/cerave-vs-paula-s-choice)
- [CeraVe vs Mesoestetic](https://lovi.care/skincare/it/compare/cerave-vs-mesoestetic)
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- [Some By Mi vs Mesoestetic](https://lovi.care/skincare/it/compare/some-by-mi-vs-mesoestetic)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/paula-s-choice-vs-mesoestetic
- United Kingdom: https://lovi.care/skincare/uk/compare/paula-s-choice-vs-mesoestetic
- Ireland: https://lovi.care/skincare/ie/compare/paula-s-choice-vs-mesoestetic
- Germany: https://lovi.care/skincare/de/compare/paula-s-choice-vs-mesoestetic
- France: https://lovi.care/skincare/fr/compare/paula-s-choice-vs-mesoestetic
- Italy: https://lovi.care/skincare/it/compare/paula-s-choice-vs-mesoestetic (this page)
- Netherlands: https://lovi.care/skincare/nl/compare/paula-s-choice-vs-mesoestetic
- Spain: https://lovi.care/skincare/es/compare/paula-s-choice-vs-mesoestetic
- Canada: https://lovi.care/skincare/ca/compare/paula-s-choice-vs-mesoestetic
- Australia: https://lovi.care/skincare/au/compare/paula-s-choice-vs-mesoestetic
- Singapore: https://lovi.care/skincare/sg/compare/paula-s-choice-vs-mesoestetic
- Saudi Arabia: https://lovi.care/skincare/sa/compare/paula-s-choice-vs-mesoestetic
- United Arab Emirates: https://lovi.care/skincare/ae/compare/paula-s-choice-vs-mesoestetic