# Medicube vs Hada Labo

Page: https://lovi.care/skincare/it/compare/medicube-vs-hada-labo

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Medicube and Hada Labo are celebrated Asian skincare lines, with the South Korean pioneer founded in 2016 by APR Corp. and its Japanese counterpart established in 2004 by Rohto Pharmaceutical Co., Ltd.. Skincare enthusiasts adore the Korean brand for thoughtfully formulated moisturizers, [serums](https://lovi.care/skincare/it/ingredients/serum), toners, and masks harnessing [niacinamide](https://lovi.care/skincare/it/ingredients/niacinamide), [collagen](https://lovi.care/skincare/it/ingredients/collagen), and [hyaluronic acid](https://lovi.care/skincare/it/ingredients/hyaluronic-acid), while fans cherish the Japanese creator for hydrating toners, gentle makeup removers, and nourishing moisturizers driven by advanced science. Both brands suit dry skin and acne-prone skin best to balance hydration, soothe irritation, and clarify without clogging pores. They differ primarily in their targeted concerns and active compounds, as the former utilizes peptides and specific gels for hyperpigmentation and aging signs, whereas the latter relies on expert formulations to restore moisture and support a healthy skin barrier.

Medicube is a Korean skincare brand founded in 2016 and owned by APR Corp..

[medicubereviews.co.uk](https://medicubereviews.co.uk/medicube/story/) [glossy.co](https://www.glossy.co/beauty/medicubes-founder-on-the-products-and-people-that-fueled-the-k-beauty-brands-booming-year/)

Hada Labo is a Japanese skincare brand founded in 2004 and owned by Rohto Pharmaceutical Co., Ltd..

[en.wikipedia.org](https://en.wikipedia.org/wiki/Hada_Labo) [hadalabosa.co.za](https://hadalabosa.co.za/about-hada-labo/) [hadalabotokyo.pl](https://www.hadalabotokyo.pl/en/the-world-of-hada-labo/brand-history/)

This page compares some of the most popular Medicube and Hada Labo products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pga908ed372e).

### Popular Medicube vs Hada Labo products

#### Hada Labo

- [Gokujyun Lotion](https://lovi.care/skincare/it/p/hada-labo/gokujyun-lotion/for/dry-skin) — Superior fit — [€41.70 at Amazon](https://www.amazon.it/dp/B0CSS816KJ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Gokujun Premium](https://lovi.care/skincare/it/p/hada-labo/gokujun-premium/for/dry-skin) — Superior fit
- [Shirojyun Premium Whitening Lotion](https://lovi.care/skincare/it/p/hada-labo/shirojyun-premium-whitening-lotion/for/dry-skin) — High fit — [€25.16 at Amazon](https://www.amazon.it/dp/B08WSCPL38?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Gokujyun Cleansing Oil](https://lovi.care/skincare/it/p/hada-labo/gokujyun-cleansing-oil/for/dry-skin) — Superior fit
- [Gokujyun Perfect Gel](https://lovi.care/skincare/it/p/hada-labo/gokujyun-perfect-gel/for/dry-skin) — High fit
- [Premium Whitening Lotion (Light)](https://lovi.care/skincare/it/p/hada-labo/premium-whitening-lotion-light/for/dry-sensitive-skin) — High fit — [€25.16 at Amazon](https://www.amazon.it/dp/B08WSCPL38?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)

#### Medicube

- [Zero Pore Pad](https://lovi.care/skincare/it/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [€17.15 at Amazon](https://www.amazon.it/dp/B09V7Z4TJG?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [PDRN Pink Peptide Serum](https://lovi.care/skincare/it/p/medicube/pdrn-pink-peptide-serum/for/mature-skin) — High fit — [€16.60 at Amazon](https://www.amazon.it/dp/B0DBF65JYY?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Collagen Jelly Cream](https://lovi.care/skincare/it/p/medicube/collagen-jelly-cream/for/mature-skin) — Superior fit — [€19.12 at Amazon](https://www.amazon.it/dp/B0CM2PPNMW?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Collagen Night Wrapping Mask](https://lovi.care/skincare/it/p/medicube/collagen-night-wrapping-mask/for/dry-skin) — High fit — [€17.15 at Amazon](https://www.amazon.it/dp/B0BRMYHMS5?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [PDRN Pink Collagen Gel Mask](https://lovi.care/skincare/it/p/medicube/pdrn-pink-collagen-gel-mask/for/dry-sensitive-skin) — High fit — [€16.08 at Amazon](https://www.amazon.it/dp/B0DGTMR754?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [DEEP VITA-C CAPSULE CREAM](https://lovi.care/skincare/it/p/medicube/deep-vita-c-capsule-cream/for/sensitive-skin) — Average fit — [€17.49 at Amazon](https://www.amazon.it/dp/B0D2Z3GGCY?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [TRIPLE COLLAGEN CREAM](https://lovi.care/skincare/it/p/medicube/triple-collagen-cream/for/mature-skin) — Average fit — [€28.99 at Amazon](https://www.amazon.it/dp/B0DLG3S62C?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Zero Foam Cleanser](https://lovi.care/skincare/it/p/medicube/zero-foam-cleanser/for/dry-skin) — Superior fit — [€14.50 at Amazon](https://www.amazon.it/dp/B09C1B7BH5?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)

## People Say

Medicube

Hada Labo

- Hydration and Moisture Mostly Mentioned Mostly Mentioned “skin drinks it up — Hada Labo Gokujyun Lotion” “Plumps fine lines — Hada Labo Gokujun Premium” “leaves skin soft, smooth, and hydrated — Hada Labo Shirojyun Premium Whitening Lotion” “skin feels bouncier and hydrated — Medicube PDRN Pink Peptide Serum”
- Convenient and Versatile Application Often Mentioned Mostly Mentioned “absorbs super quickly — Hada Labo Premium Whitening Lotion (Light)” “absorbs super quickly — Hada Labo Shirojyun Premium Whitening Lotion” “emulsifies beautifully — Hada Labo Gokujyun Cleansing Oil” “tweezers included are hygienic — Medicube Zero Pore Pad”
- Soothing and Gentle Formulation Often Mentioned Mostly Mentioned “never stings my sensitive skin — Hada Labo Gokujyun Lotion” “No fragrance/alcohol — Hada Labo Gokujun Premium” “calms my redness — Hada Labo Premium Whitening Lotion (Light)” “refreshing sensation — Medicube PDRN Pink Collagen Gel Mask”
- Smooth and Plump Skin Texture Mostly Mentioned Sometimes Noted “gives my skin a smooth, glass-like finish — Medicube Zero Pore Pad” “gave me instant glass skin — Medicube Collagen Jelly Cream” “woke up with glowing skin — Medicube Collagen Night Wrapping Mask” “Makes my skin plump and hydrating. — Hada Labo Gokujyun Perfect Gel”
- Brightening and Fading Spots Sometimes Noted Sometimes Noted “faded considerably — Hada Labo Shirojyun Premium Whitening Lotion” “faded my PIH considerably — Hada Labo Premium Whitening Lotion (Light)” “Dark spots go away faster — Medicube Deep Vita C Pad”
- Pores and Acne Control Often Mentioned Not noted “Pores drastically reduced — Medicube Zero Foam Cleanser” “Mochi-like foam — Medicube Zero Foam Cleanser” “Removes every trace of oil — Medicube Red Foam Cleanser”
- Sticky and Heavy Residue Often Mentioned Often Mentioned “hair sticks to my face — Medicube Collagen Jelly Cream” “feels way too sticky and tacky — Medicube DEEP VITA-C CAPSULE CREAM” “Tacky residue — Hada Labo Gokujun Premium” “Texture Sticky, sticky, sticky! If you have sensory issues, beware. — Hada Labo Gokujyun Perfect Gel”
- Breakouts and Skin Irritation Often Mentioned Often Mentioned “caused redness and sensitivity — Medicube Zero Pore Pad” “woke up with whiteheads — Medicube Collagen Night Wrapping Mask” “gave me tiny bumps — Hada Labo Gokujyun Lotion” “Closed comedones — Hada Labo Gokujun Premium”
- Other Performance Complaints Rarely Noted Often Mentioned “didn't notice any pore improvements — Medicube Zero Pore Pad” “Greasy in humidity — Hada Labo Gokujun Premium”

### Medicube vs Hada Labo routines for dry skin

#### Hada Labo-focused routine

- Cleanser: [CeraVe Hydrating Facial Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — [€9.19 at Amazon](https://www.amazon.it/dp/B07C5R51Q9?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Gokujyun Lotion](https://lovi.care/skincare/it/p/hada-labo/gokujyun-lotion/for/dry-skin) — Superior fit — [€41.70 at Amazon](https://www.amazon.it/dp/B0CSS816KJ?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Moisturizer: [Elizabeth Arden Advanced Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-skin) — Superior fit — [€53.50 at Amazon](https://www.amazon.it/dp/B09D2F2YF6?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [thinkbaby Safe Sunscreen SPF 50+](https://lovi.care/skincare/it/p/thinkbaby/safe-sunscreen-spf-50/for/dry-skin) — Superior fit — [€37.19 at Amazon](https://www.amazon.it/dp/B00JJZN1HG?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/it/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — [€15.90 at Amazon](https://www.amazon.it/dp/B084Q16G8D?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Serum or Treatment: [SKIN1004 Madagascar Centella Poremizing Fresh Ampoule](https://lovi.care/skincare/it/p/skin1004/madagascar-centella-poremizing-fresh-ampoule/for/dry-skin) — Superior fit — [€16.60 at Amazon](https://www.amazon.it/dp/B0B1JRGGLF?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Nourishing Mask: [MEDIHEAL Vita Essential Mask](https://lovi.care/skincare/it/p/mediheal/vita-essential-mask/for/dry-skin) — Superior fit — [€31.93 at Amazon](https://www.amazon.it/dp/B0BLXHYKTX?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week

#### Medicube-focused routine

- Cleanser: [Zero Foam Cleanser](https://lovi.care/skincare/it/p/medicube/zero-foam-cleanser/for/dry-skin) — Superior fit — [€14.50 at Amazon](https://www.amazon.it/dp/B09C1B7BH5?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/it/p/medicube/triple-collagen-toner/for/dry-skin) — High fit — [€15.90 at Amazon](https://www.amazon.it/dp/B085VS2J3T?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/it/p/medicube/age-r-booster-gel/for/dry-skin) — Superior fit — [€11.79 at Amazon](https://www.amazon.it/dp/B0DNPWYZMT?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [thinkbaby Safe Sunscreen SPF 50+](https://lovi.care/skincare/it/p/thinkbaby/safe-sunscreen-spf-50/for/dry-skin) — Superior fit — [€37.19 at Amazon](https://www.amazon.it/dp/B00JJZN1HG?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/it/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — [€15.90 at Amazon](https://www.amazon.it/dp/B084Q16G8D?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Serum or Treatment: [One Day Exosome Shot 2000](https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/dry-skin) — High fit — [€16.60 at Amazon](https://www.amazon.it/dp/B0D16L5F2M?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Nourishing Mask: [Deep Peptide Radiance Mask](https://lovi.care/skincare/it/p/medicube/deep-peptide-radiance-mask/for/dry-skin) — High fit — [€3.28 at Amazon](https://www.amazon.it/dp/B0HGBQSTDY?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 99% fit](https://lovi.care/skincare/it/skin/dry-skin)

### Medicube vs Hada Labo routines for oily skin

#### Hada Labo-focused routine

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/it/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — [€24.75 at Amazon](https://www.amazon.it/dp/B0CRSJ46YD?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Shirojyun Premium Whitening Lotion](https://lovi.care/skincare/it/p/hada-labo/shirojyun-premium-whitening-lotion/for/oily-skin) — Average fit — [€25.16 at Amazon](https://www.amazon.it/dp/B08WSCPL38?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion (with Birch Sap)](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — [€18.47 at Amazon](https://www.amazon.it/dp/B01CLTKI4A?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/it/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-skin) — Superior fit — [€40.49 at Amazon](https://www.amazon.it/dp/B094QD62C2?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/it/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/oily-skin) — Superior fit — [€40.00 at Amazon](https://www.amazon.it/dp/B0DNJKPSB8?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Pixi Glow Tonic](https://lovi.care/skincare/it/p/pixi/glow-tonic/for/oily-skin) — Superior fit — [€19.50 at Amazon](https://www.amazon.it/dp/B09SN5B88W?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [L'Oreal Paris Revitalift 12% Vitamin C + E + Salicylic Serum](https://lovi.care/skincare/it/p/l-oreal-paris/revitalift-12-vitamin-c-e-salicylic-serum/for/oily-skin) — Superior fit — [€14.21 at Amazon](https://www.amazon.it/dp/B0BKLWC84G?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/it/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [€49.00 at Amazon](https://www.amazon.it/dp/B0D1YJN279?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [VT Cosmetics Cica Purifying Mask](https://lovi.care/skincare/it/p/vt-cosmetics/cica-purifying-mask/for/oily-skin) — High fit — [€19.79 at Amazon](https://www.amazon.it/dp/B083X5R6VR?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week

#### Medicube-focused routine

- Cleanser: [Red Foam Cleanser](https://lovi.care/skincare/it/p/medicube/red-foam-cleanser/for/oily-skin) — High fit — [€14.50 at Amazon](https://www.amazon.it/dp/B073ZBXSJD?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/it/p/medicube/triple-collagen-toner/for/oily-skin) — High fit — [€15.90 at Amazon](https://www.amazon.it/dp/B085VS2J3T?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/it/p/medicube/age-r-booster-gel/for/oily-skin) — High fit — [€11.79 at Amazon](https://www.amazon.it/dp/B0DNPWYZMT?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/it/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-skin) — Superior fit — [€40.49 at Amazon](https://www.amazon.it/dp/B094QD62C2?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/it/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/oily-skin) — Superior fit — [€40.00 at Amazon](https://www.amazon.it/dp/B0DNJKPSB8?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Zero Pore Pad](https://lovi.care/skincare/it/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [€17.15 at Amazon](https://www.amazon.it/dp/B09V7Z4TJG?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/it/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [€49.00 at Amazon](https://www.amazon.it/dp/B0D1YJN279?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Zero Pore Blackhead Mud Mask](https://lovi.care/skincare/it/p/medicube/zero-pore-blackhead-mud-mask/for/oily-skin) — Average fit — [€13.00 at Amazon](https://www.amazon.it/dp/B0D1G7XF9X?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 95% fit](https://lovi.care/skincare/it/skin/oily-skin)

### Medicube vs Hada Labo routines for combination skin

#### Hada Labo-focused routine

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/it/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — [€13.50 at Amazon](https://www.amazon.it/dp/B07RY6Q6QM?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Premium Whitening Lotion (Light)](https://lovi.care/skincare/it/p/hada-labo/premium-whitening-lotion-light/for/combination-skin) — High fit — [€25.16 at Amazon](https://www.amazon.it/dp/B08WSCPL38?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion (with Birch Sap)](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — [€18.47 at Amazon](https://www.amazon.it/dp/B01CLTKI4A?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/it/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/combination-skin) — Superior fit — [€40.49 at Amazon](https://www.amazon.it/dp/B094QD62C2?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/it/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — [€40.00 at Amazon](https://www.amazon.it/dp/B0DNJKPSB8?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Medicube Zero Pore Pad 2.0](https://lovi.care/skincare/it/p/medicube/zero-pore-pad-2-0/for/combination-skin) — Superior fit — [€17.15 at Amazon](https://www.amazon.it/dp/B09V7Z4TJG?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [NEOGEN Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — [€37.99 at Amazon](https://www.amazon.it/dp/B0B8MVX1PS?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/it/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [€49.00 at Amazon](https://www.amazon.it/dp/B0D1YJN279?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [VT Cosmetics Cica Purifying Mask](https://lovi.care/skincare/it/p/vt-cosmetics/cica-purifying-mask/for/combination-skin) — High fit — [€19.79 at Amazon](https://www.amazon.it/dp/B083X5R6VR?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week

#### Medicube-focused routine

- Cleanser: [Red Foam Cleanser](https://lovi.care/skincare/it/p/medicube/red-foam-cleanser/for/combination-skin) — High fit — [€14.50 at Amazon](https://www.amazon.it/dp/B073ZBXSJD?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/it/p/medicube/triple-collagen-toner/for/combination-skin) — High fit — [€15.90 at Amazon](https://www.amazon.it/dp/B085VS2J3T?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/it/p/medicube/age-r-booster-gel/for/combination-skin) — High fit — [€11.79 at Amazon](https://www.amazon.it/dp/B0DNPWYZMT?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/it/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/combination-skin) — Superior fit — [€40.49 at Amazon](https://www.amazon.it/dp/B094QD62C2?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/it/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — [€40.00 at Amazon](https://www.amazon.it/dp/B0DNJKPSB8?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Zero Pore Pad](https://lovi.care/skincare/it/p/medicube/zero-pore-pad/for/combination-skin) — Superior fit — [€17.15 at Amazon](https://www.amazon.it/dp/B09V7Z4TJG?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/it/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [€49.00 at Amazon](https://www.amazon.it/dp/B0D1YJN279?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Zero Pore Blackhead Mud Mask](https://lovi.care/skincare/it/p/medicube/zero-pore-blackhead-mud-mask/for/combination-skin) — Average fit — [€13.00 at Amazon](https://www.amazon.it/dp/B0D1G7XF9X?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 95% fit](https://lovi.care/skincare/it/skin/combination-skin)

## Questions and answers

### Medicube or Hada Labo: which is better?

Hada Labo does better for hydration and gentle formulas, while Medicube is better for smooth skin texture, pores, and acne control. On this page, Hada Labo fits oily, combination, acne-prone, mature, and dark spot skin at a Superior level, while Medicube fits those types at a High level.

### What is the difference between Medicube and Hada Labo?

Medicube and Hada Labo both offer superior routines for dry skin, but Hada Labo is rated Superior for oily, combination, acne-prone, mature, and dark spot skin types where Medicube reaches High. Reviewers note that Hada Labo does better for hydration, gentle formulations, and brightening, while Medicube is favored for smooth skin texture, pores, and acne control. Furthermore, every Hada Labo product on this page lists no fragrance, whereas two Medicube products include it.

### Medicube or Hada Labo for dry skin?

Both Medicube and Hada Labo fit dry skin at a Superior level based on the routines on this page. Hada Labo does better for hydration and moisture, while Medicube delivers a smoother and plumper skin texture.

[Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/) [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Medicube or Hada Labo: which moisturizer is better?

Both Medicube and Hada Labo offer effective moisturizers, with Hada Labo generally performing better for hydration and moisture while Medicube excels in smooth and plump skin texture. Lovi rates the routine fit for dry skin as Superior for both brands. [Niacinamide](https://lovi.care/skincare/it/ingredients/niacinamide) helps reduce cutaneous pigmentation and melanosome transfer, and topical [hyaluronic acid](https://lovi.care/skincare/it/ingredients/hyaluronic-acid) benefits skin quality and signs of skin aging.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which is more affordable, Medicube or Hada Labo?

The provided page facts do not contain pricing information to determine whether Medicube or Hada Labo is more affordable.

### Medicube or Hada Labo: which performs better for hydration and moisture?

Hada Labo performs better for hydration and moisture, as review themes show it does better in this category. Hyaluronic acid helps provide deep hydration and moisturization.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Medicube or Hada Labo: which brand offers better options for pores and acne control?

Medicube offers better options for pores and acne control, outperforming Hada Labo in that category.

### Medicube or Hada Labo: which is better for targeting mature skin?

Medicube is better for targeting mature skin, as Lovi rates its routine fit for mature skin as High while Hada Labo also rates its routine fit for mature skin as High, and Medicube features active ingredients like [retinol](https://lovi.care/skincare/it/ingredients/retinol) and niacinamide that help stimulate [collagen](https://lovi.care/skincare/it/ingredients/collagen) accumulation and control skin aging.

[The Journal of Investigative Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/10692106/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Medicube or Hada Labo for oily skin?

For oily skin, Hada Labo achieves a Superior routine fit level while Medicube reaches a High routine fit level on this page. Hada Labo is also noted for doing better with hydration and moisture, while Medicube is noted for pores and acne control.

### Medicube or Hada Labo for acne-prone skin?

For acne-prone skin, both brands work well as Lovi rates Medicube High and Hada Labo Superior.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study](https://pubmed.ncbi.nlm.nih.gov/37377400/) Exosome cica · Journal of Cosmetic Dermatology, 2023
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo](https://pubmed.ncbi.nlm.nih.gov/12823436/) Vitamin c derivatives · Experimental Dermatology, 2003
- [Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin](https://pubmed.ncbi.nlm.nih.gov/28330776/) Aha · Journal of Dermatological Science, 2017
- [Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics](https://pubmed.ncbi.nlm.nih.gov/35223163/) Collagen, Water-soluble collagen · Dermatology Practical & Conceptual, 2022
- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005
- [Tea tree oil reduces histamine-induced skin inflammation](https://pubmed.ncbi.nlm.nih.gov/12452873/) Tree · The British Journal of Dermatology, 2002
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo](https://pubmed.ncbi.nlm.nih.gov/27279007/) Chamomilla recutita flower extract · International Journal of Molecular Medicine, 2016
- [Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract](https://pubmed.ncbi.nlm.nih.gov/27168678/) Centella asiatica extract, Madecassoside · Indian Journal of Pharmaceutical Sciences, 2016
- [Use of Collagen in Cosmetic Products](https://pubmed.ncbi.nlm.nih.gov/38534748/) Collagen, Water-soluble collagen · Current Issues in Molecular Biology, 2024
- [Effect of Camellia japonica oil on human type I procollagen production and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/17386986/) Camellia japonica flower extract · Journal of Ethnopharmacology, 2007
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramide · Scientific Reports, 2022
- [Preparation and characterization of a lecithin nanoemulsion as a topical delivery system](https://pubmed.ncbi.nlm.nih.gov/20652152/) Hydroxylated lecithin · Nanoscale Research Letters, 2009
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin](https://pubmed.ncbi.nlm.nih.gov/18503551/) Centella asiatica leaf extract · Experimental Dermatology, 2008
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32310680/) Madecassoside · Journal of Alternative and Complementary Medicine, 2020
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [Protective effects of Camellia japonica flower extract against urban air pollutants](https://pubmed.ncbi.nlm.nih.gov/30691451/) Camellia japonica flower extract · BMC Complementary and Alternative Medicine, 2019
- [Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging](https://pubmed.ncbi.nlm.nih.gov/28732847/) Bentonite · Carbohydrate Polymers, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28341613/) Dimethylmethoxy chromanol · European Journal of Pharmaceutical Sciences, 2017
- [Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study](https://pubmed.ncbi.nlm.nih.gov/30548170/) Glycolic acid · Journal of Cosmetic Dermatology, 2019
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [Hydrolyzed Collagen Induces an Anti-Inflammatory Response That Induces Proliferation of Skin Fibroblast and Keratinocytes](https://pubmed.ncbi.nlm.nih.gov/36501011/) Collagen extract · Nutrients, 2022
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Vitamin c derivatives · Photochemistry and Photobiology, 2021
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid, Gluconolactone · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica extract, Madecassoside, Centella asiatica leaf extract · Molecules, 2023
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine](https://pubmed.ncbi.nlm.nih.gov/34284096/) Sophora angustifolia root extract, Sophora flavescens root extract · European Journal of Pharmaceutical Sciences, 2021
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin](https://pubmed.ncbi.nlm.nih.gov/26805418/) Lifting peptide · Journal of the European Academy of Dermatology and Venereology, 2016
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies](https://pubmed.ncbi.nlm.nih.gov/37681127/) Alpha-arbutin · Heliyon, 2023
- [Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release](https://pubmed.ncbi.nlm.nih.gov/35929319/) Oenothera biennis flower extract · Biomaterials Advances, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin](https://pubmed.ncbi.nlm.nih.gov/22236139/) Magnesium ascorbyl phosphate · Photochemistry and Photobiology, 2012
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [New clinical approach in facial mild-moderate acne: Re-stabilization of skin microbiota balance with a topical biotechnological phytocomplex](https://pubmed.ncbi.nlm.nih.gov/39205505/) Succinic acid · Journal of Cosmetic Dermatology, 2024
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging](https://pubmed.ncbi.nlm.nih.gov/20883292/) Willow bark extract · Journal of Cosmetic Dermatology, 2010
- [A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/32390309/) Lauric acid · Dermatologic Therapy, 2020
- [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023
- [Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study](https://pubmed.ncbi.nlm.nih.gov/33128496/) Beta-glucan · Journal of Cosmetic Dermatology, 2021
- [Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement](https://pubmed.ncbi.nlm.nih.gov/30160014/) Adenosine · Journal of Cosmetic Dermatology, 2019
- [Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol](https://pubmed.ncbi.nlm.nih.gov/23752031/) Sorbitol · Journal of Cosmetic Science, 2013
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024
- [Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract](https://pubmed.ncbi.nlm.nih.gov/33410284/) Camellia japonica flower extract · FEBS Open Bio, 2021
- [Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects](https://pubmed.ncbi.nlm.nih.gov/39383579/) Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025
- [The anti-wrinkles properties of sodium acetylated hyaluronate](https://pubmed.ncbi.nlm.nih.gov/34708918/) Sodium acetylhyaluronate · Journal of Cosmetic Dermatology, 2022
- [Comparison of topical purslane & topical 0.1% triamcinolone acetonide in the management of oral lichen planus - a double blinded clinical trial](https://pubmed.ncbi.nlm.nih.gov/37726676/) Portulaca oleracea extract · BMC Oral Health, 2023
- [Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores](https://pubmed.ncbi.nlm.nih.gov/17598025/) Sodium cocoyl isethionate · Journal of Cosmetic Science, 2007
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate vitamin e · Arzneimittel-Forschung, 1998
- [Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins](https://pubmed.ncbi.nlm.nih.gov/17035721/) Grape seed extract · Skin Pharmacology and Physiology, 2007
- [Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract](https://pubmed.ncbi.nlm.nih.gov/35403355/) Grape seed extract · Journal of Cosmetic Dermatology, 2022
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays](https://pubmed.ncbi.nlm.nih.gov/34771112/) Propanediol · Molecules, 2021
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/27430380/) Diglycerin · Journal of Oleo Science, 2016
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides](https://pubmed.ncbi.nlm.nih.gov/36613524/) Glucosyl ceramide · International Journal of Molecular Sciences, 2022
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [Composition characterization and clinical efficacy study of a salmon egg extract](https://pubmed.ncbi.nlm.nih.gov/23738607/) Salmon egg extract · International Journal of Cosmetic Science, 2013
- [Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/42278371/) Adenosine · International Journal of Molecular Sciences, 2026
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate vitamin e · Scientific Reports, 2025
- [Ethanolamines permeate slowly across human skin ex vivo, but cause severe skin irritation at low concentrations](https://pubmed.ncbi.nlm.nih.gov/31435711/) Ethanolamine · Archives of Toxicology, 2019
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients](https://pubmed.ncbi.nlm.nih.gov/41628877/) 3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026
- [Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling](https://pubmed.ncbi.nlm.nih.gov/35920724/) Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2022
- [Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora](https://pubmed.ncbi.nlm.nih.gov/41516097/) Sodium dna, Pdrn polydeoxyribonucleotide · International Journal of Molecular Sciences, 2025
- [Polydeoxyribonucleotide-spermidine nanoparticles: Preparation, characterization, and verification of skin anti-aging efficacy](https://pubmed.ncbi.nlm.nih.gov/40840755/) Sodium dna · International Journal of Biological Macromolecules, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate vitamin e · Contemporary Clinical Trials Communications, 2021
- [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025
- [Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin](https://pubmed.ncbi.nlm.nih.gov/41182319/) Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2025
- [The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/41347526/) Bentonite · Journal of Cosmetic Dermatology, 2025
- [Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters](https://pubmed.ncbi.nlm.nih.gov/37357656/) Gluconolactone · Skin Research and Technology, 2023
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [Combined Effect of Silybin and Sodium Acetylated Hyaluronate on UV-Induced Photoaging](https://pubmed.ncbi.nlm.nih.gov/42728863/) Sodium acetylhyaluronate · Skin Research and Technology, 2026

## The brands

- Korean skincare: [Medicube](https://lovi.care/skincare/it/brands/medicube)
- Japanese skincare: [Hada Labo](https://lovi.care/skincare/it/brands/hada-labo)

## More comparisons

- [SKIN1004 vs Medicube](https://lovi.care/skincare/it/compare/skin1004-vs-medicube)
- [SKIN1004 vs Hada Labo](https://lovi.care/skincare/it/compare/skin1004-vs-hada-labo)
- [Anua vs Medicube](https://lovi.care/skincare/it/compare/anua-vs-medicube)
- [Anua vs Hada Labo](https://lovi.care/skincare/it/compare/anua-vs-hada-labo)
- [Medicube vs The Ordinary](https://lovi.care/skincare/it/compare/medicube-vs-the-ordinary)
- [Medicube vs Beauty of Joseon](https://lovi.care/skincare/it/compare/medicube-vs-beauty-of-joseon)
- [Medicube vs COSRX](https://lovi.care/skincare/it/compare/medicube-vs-cosrx)
- [Medicube vs CeraVe](https://lovi.care/skincare/it/compare/medicube-vs-cerave)
- [Medicube vs La Roche-Posay](https://lovi.care/skincare/it/compare/medicube-vs-la-roche-posay)
- [Medicube vs Dr. Althea](https://lovi.care/skincare/it/compare/medicube-vs-dr-althea)
- [Medicube vs Some By Mi](https://lovi.care/skincare/it/compare/medicube-vs-some-by-mi)
- [Medicube vs Torriden](https://lovi.care/skincare/it/compare/medicube-vs-torriden)
- [Medicube vs celimax](https://lovi.care/skincare/it/compare/medicube-vs-celimax)
- [Medicube vs Purito](https://lovi.care/skincare/it/compare/medicube-vs-purito)
- [Medicube vs Cetaphil](https://lovi.care/skincare/it/compare/medicube-vs-cetaphil)
- [Medicube vs Paula's Choice](https://lovi.care/skincare/it/compare/medicube-vs-paula-s-choice)
- [Medicube vs Neutrogena](https://lovi.care/skincare/it/compare/medicube-vs-neutrogena)
- [Medicube vs Kiehl's](https://lovi.care/skincare/it/compare/medicube-vs-kiehl-s)
- [Medicube vs Caudalie](https://lovi.care/skincare/it/compare/medicube-vs-caudalie)
- [Medicube vs Dermalogica](https://lovi.care/skincare/it/compare/medicube-vs-dermalogica)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/medicube-vs-hada-labo
- United Kingdom: https://lovi.care/skincare/uk/compare/medicube-vs-hada-labo
- Ireland: https://lovi.care/skincare/ie/compare/medicube-vs-hada-labo
- Germany: https://lovi.care/skincare/de/compare/medicube-vs-hada-labo
- France: https://lovi.care/skincare/fr/compare/medicube-vs-hada-labo
- Italy: https://lovi.care/skincare/it/compare/medicube-vs-hada-labo (this page)
- Netherlands: https://lovi.care/skincare/nl/compare/medicube-vs-hada-labo
- Spain: https://lovi.care/skincare/es/compare/medicube-vs-hada-labo
- Canada: https://lovi.care/skincare/ca/compare/medicube-vs-hada-labo
- Australia: https://lovi.care/skincare/au/compare/medicube-vs-hada-labo
- Singapore: https://lovi.care/skincare/sg/compare/medicube-vs-hada-labo
- Saudi Arabia: https://lovi.care/skincare/sa/compare/medicube-vs-hada-labo
- United Arab Emirates: https://lovi.care/skincare/ae/compare/medicube-vs-hada-labo