# ISDIN vs Sebamed

Page: https://lovi.care/skincare/it/compare/isdin-vs-sebamed

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

ISDIN and Sebamed are European skincare brands offering thoughtfully balanced formulas designed to support a healthy and balanced complexion. The Spanish brand is known for elegant moisturizers, advanced sunscreens, restorative [serums](https://lovi.care/skincare/it/ingredients/serum), and targeted eye products that suit dry and sensitive skin best, while the German brand is celebrated for thoughtful moisturizers and gentle cleansers that suit sensitive, reactive, and problematic skin. Although both provide dependable daily comfort and protection, ISDIN distinguishes itself through standout solutions like Fusion [Water](https://lovi.care/skincare/it/ingredients/water), Eryfotona Actinica, and K-Ox Eyes, whereas Sebamed maintains a steady focus on barrier health through its Facial Cleanser and Clear Face Care Gel.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

[puig.com](https://www.puig.com/en/newsroom/new-chapter-for-Isdin-Puig-to-assume-full-ownership/) [beautymatter.com](https://beautymatter.com/articles/puig-to-take-full-ownership-of-isdin-in-1-39-billion-deal) [uploads.puig.com](https://uploads.puig.com/uploads/Puig_NP_Sept_14_EN_fc21e2f47a.pdf)

Sebamed is a German skincare brand founded in 1967 and owned by Sebapharma GmbH & Co. KG.

[sebamed.ae](https://sebamed.ae/en/article/2/Sebapharma) [sebamed.com](https://sebamed.com/en/info/company/about-us/) [en.wikipedia.org](https://en.wikipedia.org/wiki/Sebamed) [de.wikipedia.org](https://de.wikipedia.org/wiki/Sebamed)

This page compares some of the most popular ISDIN and Sebamed products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgaa2c22823f).

### Popular ISDIN vs Sebamed products

#### Sebamed

- [Clear Face Care Gel](https://lovi.care/skincare/it/p/sebamed/clear-face-care-gel/for/oily-acne-prone-skin) — High fit — [€8.40 at Amazon](https://www.amazon.it/dp/B0GWMZBMSY?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Facial Cleanser](https://lovi.care/skincare/it/p/sebamed/facial-cleanser/for/combination-skin) — High fit

#### ISDIN

- [Eryfotona Actinica](https://lovi.care/skincare/it/p/isdin/eryfotona-actinica/for/mature-skin) — Superior fit — [€75.20 at Amazon](https://www.amazon.it/dp/B0H6FCL372?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Fusion Water](https://lovi.care/skincare/it/p/isdin/fusion-water/for/dry-sensitive-skin) — Superior fit — [€23.99 at Amazon](https://www.amazon.it/dp/B00Z72U6JQ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [K-Ox Eyes](https://lovi.care/skincare/it/p/isdin/k-ox-eyes/for/dry-skin) — High fit — [€41.50 at Amazon](https://www.amazon.it/dp/B01BMLQ4JQ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Hyaluronic Concentrate](https://lovi.care/skincare/it/p/isdin/hyaluronic-concentrate/for/sensitive-skin) — High fit
- [Hyaluronic Moisture](https://lovi.care/skincare/it/p/isdin/hyaluronic-moisture/for/dry-sensitive-skin) — Average fit
- [Flavo-C Serum](https://lovi.care/skincare/it/p/isdin/flavo-c-serum/for/sensitive-skin) — High fit — [€48.88 at Amazon](https://www.amazon.it/dp/B01BMLQ086?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Uradin Lotion 10](https://lovi.care/skincare/it/p/isdin/uradin-lotion-10/for/dry-skin) — High fit
- [Retinal Intense Serum](https://lovi.care/skincare/it/p/isdin/retinal-intense-serum/for/acne-prone-skin) — High fit — [€69.00 at Amazon](https://www.amazon.it/dp/B0BD9DK6SC?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### ISDIN or Sebamed: which is better?

ISDIN is the better fit for dry, sensitive, and mature skin, while Sebamed has only two products on this page with no specific brand-focused skin type fits. ISDIN offers a wide range of ultralight, makeup-friendly sunscreens, though shoppers often note its high price point.

### What is the difference between ISDIN and Sebamed?

ISDIN offers a larger variety of products on this page with specialized formulas for dry, sensitive, and mature skin, whereas Sebamed features only two fragrance-free options. Reviewers often mention ISDIN for its ultralight sunscreens, but note its high price point.

### ISDIN or Sebamed: which moisturizer is better?

ISDIN and Sebamed both offer moisturizers on this page, but they suit different needs since ISDIN has options like Hyaluronic Concentrate for sensitive and acne-prone skin, while Sebamed provides Clear Care Gel for oily and acne-prone skin. [Hyaluronic acid](https://lovi.care/skincare/it/ingredients/hyaluronic-acid) helps improve skin quality and signs of aging.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which is more affordable, ISDIN or Sebamed?

Reviews often mention a high price point for the products on this page from ISDIN. The page facts do not provide pricing information for Sebamed.

### Which causes fewer breakouts, ISDIN or Sebamed?

Sebamed products on this page are rated with an average or high fit for acne-prone skin, while ISDIN offers options like [Retinal](https://lovi.care/skincare/it/ingredients/retinal) Intense [Serum](https://lovi.care/skincare/it/ingredients/serum) that helps with acne-prone skin with a High Lovi fit. Both brands offer products that may help manage breakouts.

### Which brand was founded earlier, ISDIN or Sebamed?

Sebamed was founded earlier, in 1967 in Germany, while ISDIN was founded in 1975 in Spain.

### Do all Sebamed products list no fragrance in their ingredients?

Yes, every Sebamed product on this page lists no fragrance in its ingredients. In comparison, only 3 of 8 ISDIN products on this page list no fragrance.

### What skin types does ISDIN fit best according to its brand-focused routines?

According to its brand-focused routines, ISDIN fits dry skin, sensitive skin, and mature skin best. Lovi gives these skin types high to superior fit ratings across several of the products on this page.

## Research behind their key ingredients

- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Antioxidants · Drug Delivery, 2017
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Bakuchiol · The British Journal of Dermatology, 2019
- [The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction](https://pubmed.ncbi.nlm.nih.gov/27475700/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Antiaging efficacy of melatonin-based day and night creams: a randomized, split-face, assessor-blinded proof-of-concept trial](https://pubmed.ncbi.nlm.nih.gov/29416368/) Melatonin · Clinical, Cosmetic and Investigational Dermatology, 2018
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel bark extract · Phytochemistry, 2001
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol](https://pubmed.ncbi.nlm.nih.gov/23752031/) Sorbitol · Journal of Cosmetic Science, 2013
- [Comparison of methods for assessing photoprotection against ultraviolet A in vivo](https://pubmed.ncbi.nlm.nih.gov/3819071/) Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987
- [Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters](https://pubmed.ncbi.nlm.nih.gov/31437563/) Butyl methoxydibenzoylmethane · International Journal of Pharmaceutics, 2019
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters](https://pubmed.ncbi.nlm.nih.gov/40227214/) Octocrylene · Antioxidants, 2025
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection](https://pubmed.ncbi.nlm.nih.gov/36455708/) Butyl methoxydibenzoylmethane · European Journal of Pharmaceutical Sciences, 2023
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation](https://pubmed.ncbi.nlm.nih.gov/37074796/) Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Ethylhexyl salicylate · Archives of Dermatological Research, 2024
- [The clinical efficacy of a new emulsion for acne and conspicuous facial pore amelioration](https://pubmed.ncbi.nlm.nih.gov/38140770/) Lens esculenta seed extract · Journal of Cosmetic Dermatology, 2024
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · International Journal of Cosmetic Science, 2026
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025

## The brands

- Spanish skincare: [ISDIN](https://lovi.care/skincare/it/brands/isdin)
- German skincare: [Sebamed](https://lovi.care/skincare/it/brands/sebamed)

## More comparisons

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- [SKIN1004 vs Sebamed](https://lovi.care/skincare/it/compare/skin1004-vs-sebamed)
- [Anua vs ISDIN](https://lovi.care/skincare/it/compare/anua-vs-isdin)
- [Anua vs Sebamed](https://lovi.care/skincare/it/compare/anua-vs-sebamed)
- [Medicube vs ISDIN](https://lovi.care/skincare/it/compare/medicube-vs-isdin)
- [Medicube vs Sebamed](https://lovi.care/skincare/it/compare/medicube-vs-sebamed)
- [The Ordinary vs ISDIN](https://lovi.care/skincare/it/compare/the-ordinary-vs-isdin)
- [The Ordinary vs Sebamed](https://lovi.care/skincare/it/compare/the-ordinary-vs-sebamed)
- [Beauty of Joseon vs ISDIN](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-isdin)
- [Beauty of Joseon vs Sebamed](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-sebamed)
- [COSRX vs ISDIN](https://lovi.care/skincare/it/compare/cosrx-vs-isdin)
- [COSRX vs Sebamed](https://lovi.care/skincare/it/compare/cosrx-vs-sebamed)
- [CeraVe vs ISDIN](https://lovi.care/skincare/it/compare/cerave-vs-isdin)
- [CeraVe vs Sebamed](https://lovi.care/skincare/it/compare/cerave-vs-sebamed)
- [La Roche-Posay vs ISDIN](https://lovi.care/skincare/it/compare/la-roche-posay-vs-isdin)
- [La Roche-Posay vs Sebamed](https://lovi.care/skincare/it/compare/la-roche-posay-vs-sebamed)
- [Dr. Althea vs ISDIN](https://lovi.care/skincare/it/compare/dr-althea-vs-isdin)
- [Dr. Althea vs Sebamed](https://lovi.care/skincare/it/compare/dr-althea-vs-sebamed)
- [Some By Mi vs ISDIN](https://lovi.care/skincare/it/compare/some-by-mi-vs-isdin)
- [Some By Mi vs Sebamed](https://lovi.care/skincare/it/compare/some-by-mi-vs-sebamed)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/isdin-vs-sebamed
- United Kingdom: https://lovi.care/skincare/uk/compare/isdin-vs-sebamed
- Ireland: https://lovi.care/skincare/ie/compare/isdin-vs-sebamed
- Germany: https://lovi.care/skincare/de/compare/isdin-vs-sebamed
- France: https://lovi.care/skincare/fr/compare/isdin-vs-sebamed
- Italy: https://lovi.care/skincare/it/compare/isdin-vs-sebamed (this page)
- Netherlands: https://lovi.care/skincare/nl/compare/isdin-vs-sebamed
- Spain: https://lovi.care/skincare/es/compare/isdin-vs-sebamed
- Canada: https://lovi.care/skincare/ca/compare/isdin-vs-sebamed
- Australia: https://lovi.care/skincare/au/compare/isdin-vs-sebamed
- Singapore: https://lovi.care/skincare/sg/compare/isdin-vs-sebamed
- Saudi Arabia: https://lovi.care/skincare/sa/compare/isdin-vs-sebamed
- United Arab Emirates: https://lovi.care/skincare/ae/compare/isdin-vs-sebamed