# ISDIN vs Galderma

Page: https://lovi.care/skincare/it/compare/isdin-vs-galderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

ISDIN and Galderma are established European skincare companies offering distinct formulations for various dermatological needs. The Spanish brand is known for elegant moisturizers, advanced sunscreens, restorative [serums](https://lovi.care/skincare/it/ingredients/serum), and targeted eye products featuring thoughtfully balanced formulas, suiting dry and sensitive skin best with reliable daily support. Meanwhile, the Swiss brand focuses entirely on specialized serums, including top-rated options for acne-prone skin, dark spots, and mature concerns. While the former emphasizes gentle daily comfort and dependable protection across a broad spectrum of everyday remedies, the latter provides targeted clinical strengths to address specific complexion challenges.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

[puig.com](https://www.puig.com/en/newsroom/new-chapter-for-Isdin-Puig-to-assume-full-ownership/) [beautymatter.com](https://beautymatter.com/articles/puig-to-take-full-ownership-of-isdin-in-1-39-billion-deal) [uploads.puig.com](https://uploads.puig.com/uploads/Puig_NP_Sept_14_EN_fc21e2f47a.pdf)

Galderma is a Swiss skincare brand founded in 1981 and owned by Galderma Group AG.

[en.wikipedia.org](https://en.wikipedia.org/wiki/Galderma)

This page compares some of the most popular ISDIN and Galderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg1543aff547).

### Popular ISDIN vs Galderma products

#### Galderma

- [Epiduo Gel](https://lovi.care/skincare/it/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit
- [Benzac AC 5](https://lovi.care/skincare/it/p/galderma/benzac-ac-5/for/oily-acne-prone-skin) — High fit
- [Benzac AC Mild Strength 2.5% Acne Gel](https://lovi.care/skincare/it/p/galderma/benzac-ac-mild-strength-2-5-acne-gel/for/oily-acne-prone-skin) — High fit

#### ISDIN

- [Eryfotona Actinica](https://lovi.care/skincare/it/p/isdin/eryfotona-actinica/for/mature-skin) — Superior fit — [€75.20 at Amazon](https://www.amazon.it/dp/B0H6FCL372?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Fusion Water](https://lovi.care/skincare/it/p/isdin/fusion-water/for/dry-sensitive-skin) — Superior fit — [€23.99 at Amazon](https://www.amazon.it/dp/B00Z72U6JQ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [K-Ox Eyes](https://lovi.care/skincare/it/p/isdin/k-ox-eyes/for/dry-skin) — High fit — [€41.50 at Amazon](https://www.amazon.it/dp/B01BMLQ4JQ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Hyaluronic Concentrate](https://lovi.care/skincare/it/p/isdin/hyaluronic-concentrate/for/sensitive-skin) — High fit
- [Hyaluronic Moisture](https://lovi.care/skincare/it/p/isdin/hyaluronic-moisture/for/dry-sensitive-skin) — Average fit
- [Flavo-C Serum](https://lovi.care/skincare/it/p/isdin/flavo-c-serum/for/sensitive-skin) — High fit — [€48.88 at Amazon](https://www.amazon.it/dp/B01BMLQ086?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Uradin Lotion 10](https://lovi.care/skincare/it/p/isdin/uradin-lotion-10/for/dry-skin) — High fit
- [Retinal Intense Serum](https://lovi.care/skincare/it/p/isdin/retinal-intense-serum/for/acne-prone-skin) — High fit — [€69.00 at Amazon](https://www.amazon.it/dp/B0BD9DK6SC?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)

## People Say

ISDIN

Galderma

- Acne clearance and prevention Not noted Mostly Mentioned “cleared up my skin — Galderma Benzac AC Mild Strength 2.5% Acne Gel” “cystic acne gone — Galderma Epiduo Gel” “stops new pimples — Galderma Epiduo Gel”
- Lightweight and fluid texture Mostly Mentioned Not noted “absorbs instantly — ISDIN Eryfotona Actinica” “ultra-light fluid product, which makes it super easy to apply — ISDIN Fusion Water” “Lightweight formula absorbs fast — ISDIN Hyaluronic Concentrate”
- Hydration and plumping Mostly Mentioned Not noted “Improved moisture and texture — ISDIN Hyaluronic Moisture” “skin looks smooth and healthy — ISDIN K-Ox Eyes” “Skin feels intensely hydrated — ISDIN Hyaluronic Concentrate”
- Makeup compatibility and finish Often Mentioned Not noted “doesn't leave you white as a ghost — ISDIN Fusion Water” “acts like a primer — ISDIN Eryfotona Actinica” “dries down matte — ISDIN Eryfotona Actinica”
- Skin tolerance and sensitivity Often Mentioned Not noted “Sensitive/reactive skin tolerates — ISDIN Hyaluronic Moisture” “no excessive exfoliation — ISDIN Retinal Intense Serum” “doesn't sting eyes — ISDIN Eryfotona Actinica”
- Initial irritation and side effects Rarely Noted Mostly Mentioned “I think the serum is too strong for my face as it has burned and left very rough and a peeling face. — ISDIN Flavo-C Serum” “slight peeling — ISDIN Retinal Intense Serum” “face on fire — Galderma Epiduo Gel”
- Fabric bleaching Not noted Mostly Mentioned “bleached my towel — Galderma Benzac AC 5”
- Price and value concerns Often Mentioned Not noted “very expensive — ISDIN Eryfotona Actinica”
- Fragrance and scent issues Often Mentioned Not noted “smell is overpowering — ISDIN Eryfotona Actinica”

## Questions and answers

### ISDIN or Galderma: which is better?

ISDIN does better for hydration, texture, and sensitive skin, while Galderma stands out for acne clearance.

### What is the difference between ISDIN and Galderma?

ISDIN focuses on lightweight sunscreens and moisturizers with good skin tolerance, whereas Galderma specializes in effective acne-clearing [serums](https://lovi.care/skincare/it/ingredients/serum) that may cause severe dryness and irritation. The products on this page from ISDIN fit dry, sensitive, and mature skin best, while Galderma has no fragrance across its line.

### Which is more affordable, ISDIN or Galderma?

Galderma is known for price and value concerns on this page, whereas ISDIN faces high price point mentions. Review themes indicate price and value concerns are tied specifically to Galderma.

### Which causes fewer breakouts, ISDIN or Galderma?

Galderma is better for acne clearance and prevention, offering effective acne-clearing serums on this page. However, ISDIN products on this page help provide lightweight hydration and are generally well-tolerated by sensitive skin.

[The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/)

### Which brand has more products containing added fragrance, ISDIN or Galderma?

ISDIN has more products containing added fragrance, with five of its eight products listing fragrance, whereas every product on the Galderma page lists no fragrance.

### Which brand offers better skin tolerance and sensitivity according to the review themes?

ISDIN does better than Galderma for skin tolerance and sensitivity. Reviewers often mention side effects like severe irritation and peeling with Galderma, whereas ISDIN is recognized for skin-friendly sunscreens.

### Which company was founded first, ISDIN or Galderma?

ISDIN was founded in 1975, making it older than Galderma, which was founded in 1981.

## Research behind their key ingredients

- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Antioxidants · Drug Delivery, 2017
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate, Hyaluronic acid · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Bakuchiol · The British Journal of Dermatology, 2019
- [Topical benzoyl peroxide for acne](https://pubmed.ncbi.nlm.nih.gov/32175593/) Benzoyl peroxide, Benzoyl peroxide 25mg g · The Cochrane Database of Systematic Reviews, 2020
- [Antiaging efficacy of melatonin-based day and night creams: a randomized, split-face, assessor-blinded proof-of-concept trial](https://pubmed.ncbi.nlm.nih.gov/29416368/) Melatonin · Clinical, Cosmetic and Investigational Dermatology, 2018
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison](https://pubmed.ncbi.nlm.nih.gov/29549588/) Adapalene · American Journal of Clinical Dermatology, 2018
- [Benzoyl peroxide treatment decreases Cutibacterium acnes in shoulder surgery, from skin incision until wound closure](https://pubmed.ncbi.nlm.nih.gov/33545336/) Benzoyl peroxide, Benzoyl peroxide 25mg g · Journal of Shoulder and Elbow Surgery, 2021
- [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Benzoyl peroxide, Benzoyl peroxide 25mg g · American Journal of Clinical Dermatology, 2022
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Adapalene · Archives of Dermatological Research, 2022
- [Development of Multifunctional Cosmetic Cream Using Bioactive Materials from Streptomyces sp. T65 with Synthesized Mesoporous Silica Particles SBA-15](https://pubmed.ncbi.nlm.nih.gov/32224894/) Silicon dioxide · Antioxidants, 2020
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection](https://pubmed.ncbi.nlm.nih.gov/32395645/) Silicon dioxide · Heliyon, 2020
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials](https://pubmed.ncbi.nlm.nih.gov/37656094/) Adapalene · Journal of the American Academy of Dermatology, 2023
- [Efficacy and safety of microencapsulated benzoyl peroxide and microencapsulated tretinoin for the treatment of acne vulgaris: Results from two phase 3 double-blind, randomized, vehicle-controlled studies](https://pubmed.ncbi.nlm.nih.gov/37356627/) Benzoyl peroxide, Benzoyl peroxide 25mg g · Journal of the American Academy of Dermatology, 2023
- [Semi-Solid Dosage Forms Containing Pranoprofen-Loaded NLC as Topical Therapy for Local Inflammation: In Vitro, Ex Vivo and In Vivo Evaluation](https://pubmed.ncbi.nlm.nih.gov/37367119/) Carbomer 940 · Gels, 2023
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Comparison of methods for assessing photoprotection against ultraviolet A in vivo](https://pubmed.ncbi.nlm.nih.gov/3819071/) Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987
- [Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters](https://pubmed.ncbi.nlm.nih.gov/31437563/) Butyl methoxydibenzoylmethane · International Journal of Pharmaceutics, 2019
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters](https://pubmed.ncbi.nlm.nih.gov/40227214/) Octocrylene · Antioxidants, 2025
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection](https://pubmed.ncbi.nlm.nih.gov/36455708/) Butyl methoxydibenzoylmethane · European Journal of Pharmaceutical Sciences, 2023
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation](https://pubmed.ncbi.nlm.nih.gov/37074796/) Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Ethylhexyl salicylate · Archives of Dermatological Research, 2024
- [The clinical efficacy of a new emulsion for acne and conspicuous facial pore amelioration](https://pubmed.ncbi.nlm.nih.gov/38140770/) Lens esculenta seed extract · Journal of Cosmetic Dermatology, 2024
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · International Journal of Cosmetic Science, 2026
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025

## The brands

- Spanish skincare: [ISDIN](https://lovi.care/skincare/it/brands/isdin)
- Swiss skincare: [Galderma](https://lovi.care/skincare/it/brands/galderma)

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- [CeraVe vs ISDIN](https://lovi.care/skincare/it/compare/cerave-vs-isdin)
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- [La Roche-Posay vs ISDIN](https://lovi.care/skincare/it/compare/la-roche-posay-vs-isdin)
- [La Roche-Posay vs Galderma](https://lovi.care/skincare/it/compare/la-roche-posay-vs-galderma)
- [Dr. Althea vs ISDIN](https://lovi.care/skincare/it/compare/dr-althea-vs-isdin)
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- [Some By Mi vs Galderma](https://lovi.care/skincare/it/compare/some-by-mi-vs-galderma)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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