# FANCL vs Mesoestetic

Page: https://lovi.care/skincare/it/compare/fancl-vs-mesoestetic

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

FANCL and Mesoestetic are skincare brands, founded in Japan in 1980 and Spain in 1984 respectively, that offer pure, effective formulas. FANCL is loved for its thoughtful makeup removers and gentle exfoliants, while Mesoestetic is beloved for its targeted [serums](https://lovi.care/skincare/it/ingredients/serum). The Japanese brand suits sensitive, dry, and normal skin types best with options like the Facial Washing Powder and Mild Cleansing Oil, whereas the Spanish brand suits mature, sensitive, and uneven skin best through rigorous compositions like Cosmelan 2. They differ primarily in their origins and specific treatments, though both deliver balanced nourishment and reliable daily care.

FANCL is a Japanese skincare brand founded in 1980 and owned by Kirin Holdings Company, Limited since 2024.

[fancl.jp](https://www.fancl.jp/en/about/outline/index.html) [en.wikipedia.org](https://en.wikipedia.org/wiki/FANCL_Corporation) [pitchbook.com](https://pitchbook.com/profiles/company/40398-22)

Mesoestetic is a Spanish skincare brand founded in 1984 and owned by Mesoestetic Pharma Group, S.L..

[mesoestetic.com](https://www.mesoestetic.com/about-us) [tracxn.com](https://tracxn.com/d/companies/mesoestetic/__1eAnF7uALQzHII_So8HqZbHfSUJuilusj9hTisrG0tk)

This page compares some of the most popular FANCL and Mesoestetic products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg6294a359ee).

### Popular FANCL vs Mesoestetic products

#### FANCL

- [Mild Cleansing Oil](https://lovi.care/skincare/it/p/fancl/mild-cleansing-oil/for/dry-sensitive-skin) — Superior fit — [€54.68 at Amazon](https://www.amazon.it/dp/B0773Q4M66?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Facial Washing Powder](https://lovi.care/skincare/it/p/fancl/facial-washing-powder/for/sensitive-skin) — Superior fit — [€19.30 at Amazon](https://www.amazon.it/dp/B01KTJXVI4?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)

#### Mesoestetic

- [Cosmelan 2](https://lovi.care/skincare/it/p/mesoestetic/cosmelan-2/for/acne-prone-skin) — Average fit

## Questions and answers

### FANCL or Mesoestetic: which is better?

FANCL is the better fit for most users, earning Superior Lovi ratings for its Facial Washing Powder across sensitive, dry, and oily skin types, while Mesoestetic's Cosmelan 2 ranks lower for sensitive skin.

### What is the difference between FANCL and Mesoestetic?

FANCL features products on this page that achieve a Superior fit for sensitive, dry sensitive, and oily skin types, whereas Mesoestetic tops out at an Average fit for those same skin types. Additionally, every product listed for both FANCL and Mesoestetic contains no fragrance in its ingredients.

### Which is more affordable, FANCL or Mesoestetic?

Neither FANCL nor Mesoestetic displays pricing or affordability information for the products on this page.

### Which causes fewer breakouts, FANCL or Mesoestetic?

For acne-prone skin, Lovi rates FANCL products on this page at High to Average fit, while Mesoestetic Cosmelan 2 is an Average fit. Both brands list no fragrance in their products on this page.

### In which countries were FANCL and Mesoestetic founded?

FANCL was founded in Japan, while Mesoestetic was founded in Spain.

### Do either FANCL or Mesoestetic products contain fragrance?

No, every product on this page for both FANCL and Mesoestetic lists no fragrance in its ingredients.

### How does the Lovi fit level of FANCL Mild Cleansing Oil compare for dry skin versus oily skin?

For dry skin, Lovi rates FANCL Mild Cleansing Oil as Superior, whereas for oily skin it is rated Average.

## Research behind their key ingredients

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol, Tocopherol vitamin e · Journal of Cosmetic Dermatology, 2020
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Tocopherol, Tocopherol vitamin e · Journal of Cosmetic Dermatology, 2020
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol](https://pubmed.ncbi.nlm.nih.gov/23752031/) Sorbitol · Journal of Cosmetic Science, 2013
- [Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores](https://pubmed.ncbi.nlm.nih.gov/17598025/) Sodium cocoyl isethionate · Journal of Cosmetic Science, 2007

## The brands

- Japanese skincare: [FANCL](https://lovi.care/skincare/it/brands/fancl)
- Spanish skincare: [Mesoestetic](https://lovi.care/skincare/it/brands/mesoestetic)

## More comparisons

- [SKIN1004 vs FANCL](https://lovi.care/skincare/it/compare/skin1004-vs-fancl)
- [SKIN1004 vs Mesoestetic](https://lovi.care/skincare/it/compare/skin1004-vs-mesoestetic)
- [Anua vs FANCL](https://lovi.care/skincare/it/compare/anua-vs-fancl)
- [Anua vs Mesoestetic](https://lovi.care/skincare/it/compare/anua-vs-mesoestetic)
- [Medicube vs FANCL](https://lovi.care/skincare/it/compare/medicube-vs-fancl)
- [Medicube vs Mesoestetic](https://lovi.care/skincare/it/compare/medicube-vs-mesoestetic)
- [The Ordinary vs FANCL](https://lovi.care/skincare/it/compare/the-ordinary-vs-fancl)
- [The Ordinary vs Mesoestetic](https://lovi.care/skincare/it/compare/the-ordinary-vs-mesoestetic)
- [Beauty of Joseon vs FANCL](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-fancl)
- [Beauty of Joseon vs Mesoestetic](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-mesoestetic)
- [COSRX vs FANCL](https://lovi.care/skincare/it/compare/cosrx-vs-fancl)
- [COSRX vs Mesoestetic](https://lovi.care/skincare/it/compare/cosrx-vs-mesoestetic)
- [CeraVe vs FANCL](https://lovi.care/skincare/it/compare/cerave-vs-fancl)
- [CeraVe vs Mesoestetic](https://lovi.care/skincare/it/compare/cerave-vs-mesoestetic)
- [La Roche-Posay vs FANCL](https://lovi.care/skincare/it/compare/la-roche-posay-vs-fancl)
- [La Roche-Posay vs Mesoestetic](https://lovi.care/skincare/it/compare/la-roche-posay-vs-mesoestetic)
- [Dr. Althea vs FANCL](https://lovi.care/skincare/it/compare/dr-althea-vs-fancl)
- [Dr. Althea vs Mesoestetic](https://lovi.care/skincare/it/compare/dr-althea-vs-mesoestetic)
- [Some By Mi vs FANCL](https://lovi.care/skincare/it/compare/some-by-mi-vs-fancl)
- [Some By Mi vs Mesoestetic](https://lovi.care/skincare/it/compare/some-by-mi-vs-mesoestetic)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

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- Spain: https://lovi.care/skincare/es/compare/fancl-vs-mesoestetic
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