# Clinique vs Shiseido

Page: https://lovi.care/skincare/it/compare/clinique-vs-shiseido

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Clinique and Shiseido are respected skincare brands from America and Japan respectively, each offering thoughtful arrays of moisturizers, [serums](https://lovi.care/skincare/it/ingredients/serum), and cleansers. The American brand is known for incorporating hydrating [hyaluronic acid](https://lovi.care/skincare/it/ingredients/hyaluronic-acid), nourishing [glycerin](https://lovi.care/skincare/it/ingredients/glycerin), and invigorating [caffeine](https://lovi.care/skincare/it/ingredients/caffeine) to suit dry sensitive skin and oily skin best, while the Japanese brand relies on nourishing glycerin to suit mature skin and skin with dark spots best. While the former features standout items like the Clarifying Do-Over Peel, the for Men Oil-Free Moisturizer, and the Smart Clinical Repair Lifting Face + Neck Cream, the latter offers the Treatment Softener, the Benefiance Wrinkle Smoothing Day Cream, and the Essential Energy Hydrating Cream. Ultimately, both differ primarily in their founding heritage, targeted skin types, and unique ingredient synergies.

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

[en.wikipedia.org](https://en.wikipedia.org/wiki/Clinique) [elcompanies.com](https://www.elcompanies.com/en/who-we-are/our-heritage) [businesswire.com](https://www.businesswire.com/news/home/20261019083802/en/The-Este-Lauder-Companies-Appoints-Krista-Lee-Berger-Senior-Vice-President-Global-Marketing-Clinique) [glossy.co](https://www.glossy.co/beauty/glossy-pop-newsletter-clinique-launches-first-ever-creator-led-campaign/)

Shiseido is a Japanese skincare brand founded in 1872 and owned by Shiseido Company, Limited.

[corp.shiseido.com](https://corp.shiseido.com/en/company/info/) [en.wikipedia.org](https://en.wikipedia.org/wiki/Shiseido) [marketscreener.com](https://www.marketscreener.com/quote/stock/SHISEIDO-COMPANY-LIMITED-6492328/news/Shiseido-Company-Limited-Announces-CEO-Changes-Effective-January-1-2025-47501230/)

This page compares some of the most popular Clinique and Shiseido products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg7d9b6193c2).

### Popular Clinique vs Shiseido products

#### Clinique

- [moisture surge](https://lovi.care/skincare/it/p/clinique/moisture-surge/for/sensitive-skin) — High fit
- [Take The Day Off Cleansing Balm](https://lovi.care/skincare/it/p/clinique/take-the-day-off-cleansing-balm/for/dry-skin) — Average fit — [€27.37 at Amazon](https://www.amazon.it/dp/B07D5C86RX?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Dramatically Different Moisturizing Lotion+](https://lovi.care/skincare/it/p/clinique/dramatically-different-moisturizing-lotion/for/dry-skin) — Average fit — [€31.36 at Amazon](https://www.amazon.it/dp/B00CVZ3NJ2?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [All About Eyes](https://lovi.care/skincare/it/p/clinique/all-about-eyes/for/dry-skin) — High fit — [€35.99 at Amazon](https://www.amazon.it/dp/B001IZ0ZFQ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Dramatically Different Moisturizing Gel](https://lovi.care/skincare/it/p/clinique/dramatically-different-moisturizing-gel/for/oily-skin) — High fit — [€32.99 at Amazon](https://www.amazon.it/dp/B003JRI3OG?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [€88.99 at Amazon](https://www.amazon.it/dp/B09FG8TJDD?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Moisture Surge Overnight Mask](https://lovi.care/skincare/it/p/clinique/moisture-surge-overnight-mask/for/dry-skin) — High fit — [€29.39 at Amazon](https://www.amazon.it/dp/B00HSZRQQQ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Clarifying Lotion 2](https://lovi.care/skincare/it/p/clinique/clarifying-lotion-2/for/oily-acne-prone-skin) — Average fit — [€32.00 at Amazon](https://www.amazon.it/dp/B000H74MNW?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)

#### Shiseido

- [Benefiance Wrinkle Smoothing Eye Cream](https://lovi.care/skincare/it/p/shiseido/benefiance-wrinkle-smoothing-eye-cream/for/mature-skin) — High fit — [€59.95 at Amazon](https://www.amazon.it/dp/B0C9RXV1VY?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Ultimune Power Infusing Concentrate](https://lovi.care/skincare/it/p/shiseido/ultimune-power-infusing-concentrate/for/sensitive-skin) — Average fit — [€140.71 at Amazon](https://www.amazon.it/dp/B09MKR9HXR?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [VITAL PERFECTION](https://lovi.care/skincare/it/p/shiseido/vital-perfection/for/mature-skin) — Average fit — [€55.99 at Amazon](https://www.amazon.it/dp/B0FFNGPX46?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Clarifying Cleansing Foam](https://lovi.care/skincare/it/p/shiseido/clarifying-cleansing-foam/for/mature-skin) — Average fit — [€39.99 at Amazon](https://www.amazon.it/dp/B0H4NPLD9T?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Essential Energy Hydrating Cream](https://lovi.care/skincare/it/p/shiseido/essential-energy-hydrating-cream/for/mature-skin) — Superior fit — [€44.82 at Amazon](https://www.amazon.it/dp/B09SBSPXTY?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- [Activating Essence](https://lovi.care/skincare/it/p/shiseido/activating-essence/for/dry-skin) — High fit
- [FUTURE SOLUTION LX](https://lovi.care/skincare/it/p/shiseido/future-solution-lx/for/sensitive-skin) — High fit
- [Bio-Performance Advanced Super Revitalizing Cream](https://lovi.care/skincare/it/p/shiseido/bio-performance-advanced-super-revitalizing-cream/for/dry-skin) — Warning fit — [€99.99 at Amazon](https://www.amazon.it/dp/B0H275MK21?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)

## People Say

Clinique

Shiseido

- Hydration and Moisture Often Mentioned Mostly Mentioned “Immediate sensation of comfort — Shiseido Benefiance Wrinkle Smoothing Eye Cream” “skin feels plump, soft and nourished, eliminates dryness, bouncy feel — Shiseido VITAL PERFECTION” “Skin feels more hydrated — Shiseido Activating Essence” “Keeps my dry patches at bay all day — Clinique Dramatically Different Moisturizing Lotion+”
- Lightweight and Fast Absorbing Mostly Mentioned Often Mentioned “sinks in immediately — Clinique moisture surge” “sinks in instantly — Clinique Dramatically Different Moisturizing Gel” “Lightweight, silky, non-sticky, sinks in instantly. — Shiseido Ultimune Power Infusing Concentrate” “Airy-soft texture — Shiseido Essential Energy Hydrating Cream”
- Texture and Softness Often Mentioned Mostly Mentioned “silky smooth, rich but non-greasy, absorbs quickly, melts into skin — Shiseido VITAL PERFECTION” “foams into a rich cloud — Shiseido Clarifying Cleansing Foam” “Velvety, rich cream texture — Shiseido Benefiance Wrinkle Smoothing Eye Cream” “skin feels silky smooth — Clinique Smart Clinical Repair Wrinkle Correcting Serum”
- Gentle and Non-Irritating Mostly Mentioned Rarely Noted “never irritated my eyes — Clinique All About Eyes” “No strong scent — Clinique Take The Day Off Cleansing Balm” “No stinging eyes — Clinique Take The Day Off Cleansing Balm” “No irritation — Shiseido Essential Energy Hydrating Cream”
- Makeup Compatibility and Base Often Mentioned Rarely Noted “Melts waterproof mascara — Clinique Take The Day Off Cleansing Balm” “foundation glides on — Clinique moisture surge” “holds concealer in place — Clinique All About Eyes” “Great base for makeup — Shiseido Essential Energy Hydrating Cream”
- Brightening and Radiance Rarely Noted Often Mentioned “Skin looks brighter, more radiant, and "glowy." — Shiseido Ultimune Power Infusing Concentrate” “faded pimple marks — Shiseido White Lucent Brightening Gel Cream” “Eyes look more awake — Shiseido Benefiance Wrinkle Smoothing Eye Cream” “wake up glowing — Clinique Moisture Surge Overnight Mask”
- High Price Point Often Mentioned Mostly Mentioned “jar is too small for the cost — Clinique moisture surge” “quite pricey — Clinique Smart Clinical Repair Wrinkle Correcting Serum” “Expensive for cleanser — Clinique Take The Day Off Cleansing Balm” “Very expensive for the size — Shiseido Benefiance Wrinkle Smoothing Eye Cream”
- Unpleasant or Strong Scent Sometimes Noted Often Mentioned “Smells like nail polish remover — Clinique Clarifying Lotion 2” “Smells like old oil — Clinique Take The Day Off Cleansing Balm” “Has a weird plastic-like smell — Clinique Dramatically Different Moisturizing Lotion+” “old lady smell — Shiseido Eudermine Revitalizing Essence”
- Insufficient Hydration or Dryness Often Mentioned Rarely Noted “Not enough for winter — Shiseido Essential Energy Hydrating Cream” “left my skin squeaky dry — Shiseido Clarifying Cleansing Foam” “skin felt tight — Clinique Dramatically Different Moisturizing Gel”
- Skin Irritation and Sensitivity Sometimes Noted Sometimes Noted “Blurry vision after use — Clinique Take The Day Off Cleansing Balm” “Face stung and became red — Clinique Clarifying Lotion 2” “increase your skin's sun sensitivity — Clinique Smart Clinical Repair Wrinkle Correcting Serum” “Caused some irritation — Shiseido Bio-Performance Advanced Super Revitalizing Cream”

### Clinique vs Shiseido routines for dry skin

#### Shiseido-focused routine

- Cleanser: [Clarifying Cleansing Foam](https://lovi.care/skincare/it/p/shiseido/clarifying-cleansing-foam/for/dry-skin) — Caution fit — [€39.99 at Amazon](https://www.amazon.it/dp/B0H4NPLD9T?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — [€15.16 at Amazon](https://www.amazon.it/dp/B08Q6WZ6J1?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Moisturizer: [Essential Energy Hydrating Cream](https://lovi.care/skincare/it/p/shiseido/essential-energy-hydrating-cream/for/dry-skin) — High fit — [€44.82 at Amazon](https://www.amazon.it/dp/B09SBSPXTY?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [thinkbaby Safe Sunscreen SPF 50+](https://lovi.care/skincare/it/p/thinkbaby/safe-sunscreen-spf-50/for/dry-skin) — Superior fit — [€37.19 at Amazon](https://www.amazon.it/dp/B00JJZN1HG?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/it/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — [€15.90 at Amazon](https://www.amazon.it/dp/B084Q16G8D?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Serum or Treatment: [Ultimune Power Infusing Concentrate](https://lovi.care/skincare/it/p/shiseido/ultimune-power-infusing-concentrate/for/dry-skin) — Low fit — [€140.71 at Amazon](https://www.amazon.it/dp/B09MKR9HXR?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Nourishing Mask: [MEDIHEAL Vita Essential Mask](https://lovi.care/skincare/it/p/mediheal/vita-essential-mask/for/dry-skin) — Superior fit — [€31.93 at Amazon](https://www.amazon.it/dp/B0BLXHYKTX?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week

#### Clinique-focused routine

- Cleanser: [all about clean](https://lovi.care/skincare/it/p/clinique/all-about-clean/for/dry-skin) — Warning fit — [€34.00 at Amazon](https://www.amazon.it/dp/B002RBTB8C?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — [€15.16 at Amazon](https://www.amazon.it/dp/B08Q6WZ6J1?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Moisturizer: [Smart Clinical Repair Lifting Face + Neck Cream](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-lifting-face-neck-cream/for/dry-skin) — High fit — [€77.00 at Amazon](https://www.amazon.it/dp/B0CHXGY211?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [thinkbaby Safe Sunscreen SPF 50+](https://lovi.care/skincare/it/p/thinkbaby/safe-sunscreen-spf-50/for/dry-skin) — Superior fit — [€37.19 at Amazon](https://www.amazon.it/dp/B00JJZN1HG?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Take The Day Off Cleansing Balm](https://lovi.care/skincare/it/p/clinique/take-the-day-off-cleansing-balm/for/dry-skin) — Average fit — [€27.37 at Amazon](https://www.amazon.it/dp/B07D5C86RX?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Serum or Treatment: [Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/dry-skin) — Average fit — [€88.99 at Amazon](https://www.amazon.it/dp/B09FG8TJDD?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Nourishing Mask: [Moisture Surge Overnight Mask](https://lovi.care/skincare/it/p/clinique/moisture-surge-overnight-mask/for/dry-skin) — High fit — [€29.39 at Amazon](https://www.amazon.it/dp/B00HSZRQQQ?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 99% fit](https://lovi.care/skincare/it/skin/dry-skin)

### Clinique vs Shiseido routines for oily skin

#### Shiseido-focused routine

- Cleanser: [Deep Cleansing Foam](https://lovi.care/skincare/it/p/shiseido/deep-cleansing-foam/for/oily-skin) — High fit — [€49.95 at Amazon](https://www.amazon.it/dp/B0HD8DFZ9M?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/oily-skin) — Superior fit — [€103.91 at Amazon](https://www.amazon.it/dp/B0CY5LW9DY?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Essential Energy Hydrating Cream](https://lovi.care/skincare/it/p/shiseido/essential-energy-hydrating-cream/for/oily-skin) — Average fit — [€44.82 at Amazon](https://www.amazon.it/dp/B09SBSPXTY?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/it/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-skin) — Superior fit — [€40.49 at Amazon](https://www.amazon.it/dp/B094QD62C2?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/it/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/oily-skin) — Superior fit — [€40.00 at Amazon](https://www.amazon.it/dp/B0DNJKPSB8?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Pixi Glow Tonic](https://lovi.care/skincare/it/p/pixi/glow-tonic/for/oily-skin) — Superior fit — [€19.50 at Amazon](https://www.amazon.it/dp/B09SN5B88W?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Ultimune Power Infusing Concentrate](https://lovi.care/skincare/it/p/shiseido/ultimune-power-infusing-concentrate/for/oily-skin) — Average fit — [€140.71 at Amazon](https://www.amazon.it/dp/B09MKR9HXR?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/it/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [€49.00 at Amazon](https://www.amazon.it/dp/B0D1YJN279?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [VT Cosmetics Cica Purifying Mask](https://lovi.care/skincare/it/p/vt-cosmetics/cica-purifying-mask/for/oily-skin) — High fit — [€19.79 at Amazon](https://www.amazon.it/dp/B083X5R6VR?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week

#### Clinique-focused routine

- Cleanser: [Redness Solutions Soothing Cleanser](https://lovi.care/skincare/it/p/clinique/redness-solutions-soothing-cleanser/for/oily-skin) — Average fit — [€31.05 at Lookfantastic](https://www.lookfantastic.it/p/clinique-clinique-redness-solutionssoothing-cleanser-for-unisex-0/11144770/) — Morning · Evening · Once a week
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/oily-skin) — Superior fit — [€103.91 at Amazon](https://www.amazon.it/dp/B0CY5LW9DY?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Dramatically Different Moisturizing Gel](https://lovi.care/skincare/it/p/clinique/dramatically-different-moisturizing-gel/for/oily-skin) — High fit — [€32.99 at Amazon](https://www.amazon.it/dp/B003JRI3OG?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/it/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-skin) — Superior fit — [€40.49 at Amazon](https://www.amazon.it/dp/B094QD62C2?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Take The Day Off Cleansing Balm](https://lovi.care/skincare/it/p/clinique/take-the-day-off-cleansing-balm/for/oily-skin) — Low fit — [€27.37 at Amazon](https://www.amazon.it/dp/B07D5C86RX?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Clarifying Lotion 2](https://lovi.care/skincare/it/p/clinique/clarifying-lotion-2/for/oily-skin) — Average fit — [€32.00 at Amazon](https://www.amazon.it/dp/B000H74MNW?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/oily-skin) — Average fit — [€88.99 at Amazon](https://www.amazon.it/dp/B09FG8TJDD?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/it/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [€49.00 at Amazon](https://www.amazon.it/dp/B0D1YJN279?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [VT Cosmetics Cica Purifying Mask](https://lovi.care/skincare/it/p/vt-cosmetics/cica-purifying-mask/for/oily-skin) — High fit — [€19.79 at Amazon](https://www.amazon.it/dp/B083X5R6VR?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 95% fit](https://lovi.care/skincare/it/skin/oily-skin)

### Clinique vs Shiseido routines for combination skin

#### Shiseido-focused routine

- Cleanser: [Deep Cleansing Foam](https://lovi.care/skincare/it/p/shiseido/deep-cleansing-foam/for/combination-skin) — High fit — [€49.95 at Amazon](https://www.amazon.it/dp/B0HD8DFZ9M?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/combination-skin) — Superior fit — [€103.91 at Amazon](https://www.amazon.it/dp/B0CY5LW9DY?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Essential Energy Hydrating Cream](https://lovi.care/skincare/it/p/shiseido/essential-energy-hydrating-cream/for/combination-skin) — Average fit — [€44.82 at Amazon](https://www.amazon.it/dp/B09SBSPXTY?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/it/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/combination-skin) — Superior fit — [€40.49 at Amazon](https://www.amazon.it/dp/B094QD62C2?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/it/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — [€40.00 at Amazon](https://www.amazon.it/dp/B0DNJKPSB8?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Medicube Zero Pore Pad 2.0](https://lovi.care/skincare/it/p/medicube/zero-pore-pad-2-0/for/combination-skin) — Superior fit — [€17.15 at Amazon](https://www.amazon.it/dp/B09V7Z4TJG?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Ultimune Power Infusing Concentrate](https://lovi.care/skincare/it/p/shiseido/ultimune-power-infusing-concentrate/for/combination-skin) — Average fit — [€140.71 at Amazon](https://www.amazon.it/dp/B09MKR9HXR?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/it/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [€49.00 at Amazon](https://www.amazon.it/dp/B0D1YJN279?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [VT Cosmetics Cica Purifying Mask](https://lovi.care/skincare/it/p/vt-cosmetics/cica-purifying-mask/for/combination-skin) — High fit — [€19.79 at Amazon](https://www.amazon.it/dp/B083X5R6VR?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week

#### Clinique-focused routine

- Cleanser: [all about clean](https://lovi.care/skincare/it/p/clinique/all-about-clean/for/combination-skin) — Low fit — [€34.00 at Amazon](https://www.amazon.it/dp/B002RBTB8C?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/combination-skin) — Superior fit — [€103.91 at Amazon](https://www.amazon.it/dp/B0CY5LW9DY?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Dramatically Different Moisturizing Gel](https://lovi.care/skincare/it/p/clinique/dramatically-different-moisturizing-gel/for/combination-skin) — Average fit — [€32.99 at Amazon](https://www.amazon.it/dp/B003JRI3OG?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/it/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/combination-skin) — Superior fit — [€40.49 at Amazon](https://www.amazon.it/dp/B094QD62C2?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Take The Day Off Cleansing Balm](https://lovi.care/skincare/it/p/clinique/take-the-day-off-cleansing-balm/for/combination-skin) — Low fit — [€27.37 at Amazon](https://www.amazon.it/dp/B07D5C86RX?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Clarifying Lotion 2](https://lovi.care/skincare/it/p/clinique/clarifying-lotion-2/for/combination-skin) — Average fit — [€32.00 at Amazon](https://www.amazon.it/dp/B000H74MNW?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin) — Average fit — [€88.99 at Amazon](https://www.amazon.it/dp/B09FG8TJDD?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/it/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [€49.00 at Amazon](https://www.amazon.it/dp/B0D1YJN279?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [VT Cosmetics Cica Purifying Mask](https://lovi.care/skincare/it/p/vt-cosmetics/cica-purifying-mask/for/combination-skin) — High fit — [€19.79 at Amazon](https://www.amazon.it/dp/B083X5R6VR?tag=lovi-care-web-routine0a-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 95% fit](https://lovi.care/skincare/it/skin/combination-skin)

## Questions and answers

### Clinique or Shiseido: which is better?

Shiseido is often better for deep hydration and radiance, while Clinique is typically better for gentle, fragrance-free care. Shiseido achieves high routine fit levels for dry, combination, and sensitive skin on this page, whereas Clinique is well-liked for its lightweight moisturizers and makeup removers.

### What is the difference between Clinique and Shiseido?

Clinique is known for its fragrance-free formulas and gentleness, while Shiseido offers deeper hydration and luxurious textures.

### Clinique or Shiseido for dry skin?

For dry skin, Shiseido is the better choice as it achieves a High routine fit compared to Clinique's Average rating. The products on this page help deliver deep hydration, though Shiseido formulations frequently feature added fragrance.

### Clinique or Shiseido: which cleanser is better?

Clinique is better for gentle cleansers, while Shiseido is better for deep-cleansing and efficient cleansers based on reviewer feedback. Clinique cleansers on this page are completely fragrance-free, whereas most Shiseido cleansers contain fragrance.

### Which is more affordable, Clinique or Shiseido?

Reviewers note that Clinique has a high price point, while Shiseido is also frequently noted for its high price point.

### Clinique or Shiseido for fragrance-free options?

Clinique is better for fragrance-free options because every product on the products on this page lists no fragrance in its ingredients. In contrast, only 5 of 20 products on this page for Shiseido list no fragrance.

### Clinique or Shiseido for oily skin?

Both Clinique and Shiseido offer products on this page that achieve a High Lovi fit level for oily skin. Reviewers note that Clinique provides effective oil-controlling moisturizers, while Shiseido delivers deep hydration and cleansing.

### Clinique or Shiseido: which moisturizer is better?

Both Clinique and Shiseido offer great moisturizers, with Shiseido generally providing deeper hydration and luxurious textures while Clinique focuses on gentle, fragrance-free formulas. For dry skin, the products on this page show that Shiseido achieves a High routine fit level compared to Clinique's Average fit level.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Clinique or Shiseido for sensitive skin?

For sensitive skin, Shiseido is the better choice because Lovi rates its brand-focused routine fit as High compared to Clinique's Average fit level. While Clinique products on this page list no fragrance, Shiseido products on this page offer deep hydration and luxurious textures.

### Clinique or Shiseido for acne-prone skin?

For acne-prone skin, Shiseido is the better choice because Lovi rates its brand-focused routine fit as High compared to Clinique's Average fit. Shiseido's products on this page help provide deep cleansing and efficient care, though reviewers sometimes note a strong fragrance.

### Clinique or Shiseido for mature skin?

Both Clinique and Shiseido offer products on this page that are well-suited for mature skin. Lovi rates the routine fit for mature skin as High for both brands.

### Clinique or Shiseido for skin with dark spots?

Shiseido is a better fit for skin with dark spots, as the products on this page achieve a high routine fit compared to Clinique's average fit. Shiseido's selection includes specialized brightening moisturizers and essences that help improve radiance.

## Research behind their key ingredients

- [Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology](https://pubmed.ncbi.nlm.nih.gov/19169201/) Squalene · Molecules, 2009
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Caffeine's mechanisms of action and its cosmetic use](https://pubmed.ncbi.nlm.nih.gov/23075568/) Caffeine · Skin Pharmacology and Physiology, 2013
- [Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/16778793/) Squalane · The Journal of Investigative Dermatology, 2006
- [Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin](https://pubmed.ncbi.nlm.nih.gov/28330776/) Micro-acid complex · Journal of Dermatological Science, 2017
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Psychophysical study of the effects of topical application of menthol in healthy volunteers](https://pubmed.ncbi.nlm.nih.gov/16527405/) Menthol · Pain, 2006
- [Protecting skin photoaging by NF-kappaB inhibitor](https://pubmed.ncbi.nlm.nih.gov/20540695/) Magnolia officinalis bark extract · Current Drug Metabolism, 2010
- [Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo](https://pubmed.ncbi.nlm.nih.gov/19186973/) Ascorbyl glucoside · Journal of Periodontology, 2009
- [Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/25607790/) Scutellaria baicalensis root extract · Journal of Drugs in Dermatology, 2014
- [Ethanol extracts of Sanguisorba officinalis L. suppress TNF-α/IFN-γ-induced pro-inflammatory chemokine production in HaCaT cells](https://pubmed.ncbi.nlm.nih.gov/26655409/) Sanguisorba officinalis root extract · Phytomedicine, 2015
- [Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/18007579/) Sodium lauryl sulfate · The Journal of Investigative Dermatology, 2008
- [Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling](https://pubmed.ncbi.nlm.nih.gov/16890388/) Panax ginseng root extract · Journal of Ethnopharmacology, 2007
- [Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin](https://pubmed.ncbi.nlm.nih.gov/33037252/) Squalane · Scientific Reports, 2020
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf water, Aloe barbadensis · Clinical Pharmacology, 2018
- [Urea: a comprehensive review of the clinical literature](https://pubmed.ncbi.nlm.nih.gov/24314769/) Urea · Dermatology Online Journal, 2013
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Effect of 30% Supramolecular Salicylic Acid Peel on Skin Microbiota and Inflammation in Patients with Moderate-to-Severe Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/36350527/) Micro-acid complex · Dermatology and Therapy, 2023
- [Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy](https://pubmed.ncbi.nlm.nih.gov/36985709/) Polygonum cuspidatum root extract · Molecules, 2023
- [Role of Resveratrol in Regulating Cutaneous Functions](https://pubmed.ncbi.nlm.nih.gov/32382280/) Polygonum cuspidatum root extract · Evidence-based Complementary and Alternative Medicine, 2020
- [A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia](https://pubmed.ncbi.nlm.nih.gov/23963768/) Menthol · European Journal of Pain, 2014
- [Design, preparation, and evaluation of liposomal gel formulations for treatment of acne: in vitro and in vivo studies](https://pubmed.ncbi.nlm.nih.gov/30442066/) Lauric acid · Drug Development and Industrial Pharmacy, 2019
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [In vitro antioxidant, collagenase inhibition, and in vivo anti-wrinkle effects of combined formulation containing Punica granatum, Ginkgo biloba, Ficus carica, and Morus alba fruits extract](https://pubmed.ncbi.nlm.nih.gov/26203268/) Ginkgo biloba leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2015
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB](https://pubmed.ncbi.nlm.nih.gov/17346696/) Magnolia officinalis bark extract · European Journal of Pharmacology, 2007
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant](https://pubmed.ncbi.nlm.nih.gov/31130869/) Caffeine · Frontiers in Physiology, 2019
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel leaf extract · Phytochemistry, 2001
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of Probiotic Supplements and Topical Applications in the Treatment of Acne: A Scoping Review of Current Results](https://pubmed.ncbi.nlm.nih.gov/39810881/) Probiotic technology · Journal of Experimental Pharmacology, 2025
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid, Micro-acid complex · Journal of Cosmetic Dermatology, 2024
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2015
- [Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy](https://pubmed.ncbi.nlm.nih.gov/33804924/) Sodium lauryl sulfate · Pharmaceutics, 2021
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)](https://pubmed.ncbi.nlm.nih.gov/11278060/) Sodium laureth sulfate · Food and Chemical Toxicology, 2001
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [A novel model of inflammatory pain in human skin involving topical application of sodium lauryl sulfate](https://pubmed.ncbi.nlm.nih.gov/20358390/) Sodium lauryl sulfate · Inflammation Research, 2010
- [Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane](https://pubmed.ncbi.nlm.nih.gov/22247236/) Cyclopentasiloxane · International Journal of Toxicology, 2011
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Whitening effect of alpha-bisabolol in Asian women subjects](https://pubmed.ncbi.nlm.nih.gov/20642768/) Bisabolol · International Journal of Cosmetic Science, 2010
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023
- [Understanding Solar Skin Elastosis-Cause and Treatment](https://pubmed.ncbi.nlm.nih.gov/30052192/) Witch hazel extract · Journal of Cosmetic Science, 2018
- [In vivo and in vitro evaluation of octyl methoxycinnamate liposomes](https://pubmed.ncbi.nlm.nih.gov/24376350/) Ethylhexyl methoxycinnamate · International Journal of Nanomedicine, 2013
- [A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/32390309/) Lauric acid · Dermatologic Therapy, 2020
- [Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast](https://pubmed.ncbi.nlm.nih.gov/40363772/) Squalane · Molecules, 2025
- [Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration](https://pubmed.ncbi.nlm.nih.gov/38611819/) Betaine · Molecules, 2024
- [Microbicidal activity of tripotassium phosphate and fatty acids toward spoilage and pathogenic bacteria associated with poultry](https://pubmed.ncbi.nlm.nih.gov/16013388/) Myristic acid · Journal of Food Protection, 2005
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 2-o-ethyl ascorbic acid · Polymers, 2023
- [Synergistic approach for acne vulgaris treatment using glycerosomes loaded with lincomycin and lauric acid: Formulation, in silico, in vitro, LC-MS/MS skin deposition assay and in vivo evaluation](https://pubmed.ncbi.nlm.nih.gov/37805147/) Lauric acid · International Journal of Pharmaceutics, 2023
- [Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota](https://pubmed.ncbi.nlm.nih.gov/39598779/) Camellia sinensis leaf extract · Molecules, 2024
- [Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis](https://pubmed.ncbi.nlm.nih.gov/37763018/) Yeast extract · Journal of Clinical Medicine, 2023
- [Effect of hydroxypropyl-β-cyclodextrin in fluid and semi-solid submicron emulsions on physiological skin parameters during regular in vivo application](https://pubmed.ncbi.nlm.nih.gov/33236374/) Cyclodextrin · International Journal of Cosmetic Science, 2021
- [Formulation of Ascorbic Acid and Betaine-based Therapeutic Deep Eutectic System for Enhanced Transdermal Delivery of Ascorbic Acid](https://pubmed.ncbi.nlm.nih.gov/38794349/) Betaine · Pharmaceutics, 2024
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles](https://pubmed.ncbi.nlm.nih.gov/32783330/) Dimethoxytolyl propylresorcinol · Journal of Cosmetic Dermatology, 2021
- [Synergistic action of a triple peptide complex on an essential extra-cellular matrix protein exhibits significant anti-aging benefits](https://pubmed.ncbi.nlm.nih.gov/20618556/) Multi-peptides · Journal of Cosmetic Dermatology, 2010
- [Algae extract protection effect on oxidized protein level in human stratum corneum](https://pubmed.ncbi.nlm.nih.gov/15247018/) Algae extract · Annals of the New York Academy of Sciences, 2004
- [Anatomical site differences of sodium lauryl sulfate-induced irritation: randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/30637727/) Sodium lauryl sulfate · The British Journal of Dermatology, 2019
- [A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants](https://pubmed.ncbi.nlm.nih.gov/16439809/) Dimethicone · Ostomy/wound Management, 2005
- [The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively](https://pubmed.ncbi.nlm.nih.gov/12535284/) Betaine · Skin Research and Technology, 2003
- [Skin recovery by Lavandula angustifolia leaf callus extract: Redox control of Nrf2 signaling](https://pubmed.ncbi.nlm.nih.gov/40345503/) Lavandula angustifolia oil lavender oil · Free Radical Biology & Medicine, 2025
- [Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects](https://pubmed.ncbi.nlm.nih.gov/38336313/) Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024
- [Amended safety assessment of Sesamum indicum (sesame) seed oil, hydrogenated sesame seed oil, Sesamum indicum (sesame) oil unsaponifiables, and sodium sesameseedate](https://pubmed.ncbi.nlm.nih.gov/21772026/) Sesamum indicum oil · International Journal of Toxicology, 2011
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol](https://pubmed.ncbi.nlm.nih.gov/19514921/) Caprylyl glycol · Cutaneous and Ocular Toxicology, 2009
- [Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/27430380/) Diglycerin · Journal of Oleo Science, 2016
- [Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation](https://pubmed.ncbi.nlm.nih.gov/37074796/) Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023
- [Combining Topical and Oral Botanicals for Skin Redness, Pigmentation, Sleep, and Mood: A Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/36431167/) Theanine · Journal of Clinical Medicine, 2022
- [Antioxidant and membrane-protective effects of the 3-O-ethyl ascorbic acid-cannabigerol system on UVB-irradiated human keratinocytes](https://pubmed.ncbi.nlm.nih.gov/39778604/) 2-o-ethyl ascorbic acid · Free Radical Biology & Medicine, 2025
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females](https://pubmed.ncbi.nlm.nih.gov/27272084/) Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Evaulation of irritation potential of surfactant mixtures](https://pubmed.ncbi.nlm.nih.gov/18503452/) Sodium laureth sulfate · International Journal of Cosmetic Science, 1999
- [Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome](https://pubmed.ncbi.nlm.nih.gov/37767337/) Lactobacillus ferment · Clinical, Cosmetic and Investigational Dermatology, 2023
- [Transdermal Delivery of Baicalin Based on Bio-Vesicles and Its Efficacy in Antiaging of the Skin](https://pubmed.ncbi.nlm.nih.gov/39946269/) Scutellaria baicalensis root extract · Journal of Cosmetic Dermatology, 2025
- [Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes](https://pubmed.ncbi.nlm.nih.gov/28447741/) Artemisia princeps leaf extract · Molecular Medicine Reports, 2017
- [Liposomal formulation of a vitamin C derivative: a promising strategy to increase skin permeability](https://pubmed.ncbi.nlm.nih.gov/39985147/) 2-o-ethyl ascorbic acid · Journal of Liposome Research, 2025
- [Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients](https://pubmed.ncbi.nlm.nih.gov/41628877/) 2-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025
- [Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos](https://pubmed.ncbi.nlm.nih.gov/39769217/) Ascorbyl glucoside · International Journal of Molecular Sciences, 2024
- [Impact of Hydrocolloid Dressing and Moisturizing Cream as Facial Skin Protectants Among Health Care Workers](https://pubmed.ncbi.nlm.nih.gov/38771104/) Dimethicone · Military Medicine, 2024
- [Potassium 4-Methoxysalicylate (4MSK) Exerts a Skin Lightening Effect by Acting on Melanocytes and Keratinocytes](https://pubmed.ncbi.nlm.nih.gov/40071590/) Potassium methoxysalicylate · Journal of Cosmetic Dermatology, 2025
- [New Chalcone-Derived Molecule for the Topical Regulation of Hyperpigmentation and Skin Aging](https://pubmed.ncbi.nlm.nih.gov/39598529/) Angelica keiskei leaf extract · Pharmaceutics, 2024
- [Mitigation of ultraviolet-induced erythema and inflammation by para-hydroxycinnamic acid in human skin](https://pubmed.ncbi.nlm.nih.gov/39138602/) Ethylhexyl methoxycinnamate · International Journal of Cosmetic Science, 2025
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Ethylhexyl methoxycinnamate, Octocrylene · Archives of Dermatological Research, 2024
- [The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies](https://pubmed.ncbi.nlm.nih.gov/41668671/) Laminaria digitata extract · International Journal of Cosmetic Science, 2026
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter, Shea butter · Lasers in Medical Science, 2025
- [Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42147661/) Ascorbyl glucoside · Cureus, 2026
- [Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study](https://pubmed.ncbi.nlm.nih.gov/42617898/) Sodium laureth sulfate · International Journal of Pharmaceutics, 2026
- [Simmondsia chinensis (jojoba) cake fermentation: A new, sustainable technology for advanced skin and scalp care ingredients](https://pubmed.ncbi.nlm.nih.gov/42698229/) Lactobacillus ferment · International Journal of Cosmetic Science, 2026
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1 · International Journal of Cosmetic Science, 2026
- [Efficacy of anti-sebum moisturizing cream containing 2% l-carnitine and 5% epigallocatechin gallate in seborrhea: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/37194909/) Uji green tea extract · Journal of Cosmetic Dermatology, 2023
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Homosalate · Journal of Drugs in Dermatology, 2025

## The brands

- American skincare: [Clinique](https://lovi.care/skincare/it/brands/clinique)
- Japanese skincare: [Shiseido](https://lovi.care/skincare/it/brands/shiseido)

## More comparisons

- [SKIN1004 vs Clinique](https://lovi.care/skincare/it/compare/skin1004-vs-clinique)
- [SKIN1004 vs Shiseido](https://lovi.care/skincare/it/compare/skin1004-vs-shiseido)
- [Anua vs Clinique](https://lovi.care/skincare/it/compare/anua-vs-clinique)
- [Anua vs Shiseido](https://lovi.care/skincare/it/compare/anua-vs-shiseido)
- [Medicube vs Clinique](https://lovi.care/skincare/it/compare/medicube-vs-clinique)
- [Medicube vs Shiseido](https://lovi.care/skincare/it/compare/medicube-vs-shiseido)
- [The Ordinary vs Clinique](https://lovi.care/skincare/it/compare/the-ordinary-vs-clinique)
- [The Ordinary vs Shiseido](https://lovi.care/skincare/it/compare/the-ordinary-vs-shiseido)
- [Beauty of Joseon vs Clinique](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-clinique)
- [Beauty of Joseon vs Shiseido](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-shiseido)
- [COSRX vs Clinique](https://lovi.care/skincare/it/compare/cosrx-vs-clinique)
- [COSRX vs Shiseido](https://lovi.care/skincare/it/compare/cosrx-vs-shiseido)
- [CeraVe vs Clinique](https://lovi.care/skincare/it/compare/cerave-vs-clinique)
- [CeraVe vs Shiseido](https://lovi.care/skincare/it/compare/cerave-vs-shiseido)
- [La Roche-Posay vs Clinique](https://lovi.care/skincare/it/compare/la-roche-posay-vs-clinique)
- [La Roche-Posay vs Shiseido](https://lovi.care/skincare/it/compare/la-roche-posay-vs-shiseido)
- [Dr. Althea vs Clinique](https://lovi.care/skincare/it/compare/dr-althea-vs-clinique)
- [Dr. Althea vs Shiseido](https://lovi.care/skincare/it/compare/dr-althea-vs-shiseido)
- [Some By Mi vs Clinique](https://lovi.care/skincare/it/compare/some-by-mi-vs-clinique)
- [Some By Mi vs Shiseido](https://lovi.care/skincare/it/compare/some-by-mi-vs-shiseido)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/clinique-vs-shiseido
- United Kingdom: https://lovi.care/skincare/uk/compare/clinique-vs-shiseido
- Ireland: https://lovi.care/skincare/ie/compare/clinique-vs-shiseido
- Germany: https://lovi.care/skincare/de/compare/clinique-vs-shiseido
- France: https://lovi.care/skincare/fr/compare/clinique-vs-shiseido
- Italy: https://lovi.care/skincare/it/compare/clinique-vs-shiseido (this page)
- Netherlands: https://lovi.care/skincare/nl/compare/clinique-vs-shiseido
- Spain: https://lovi.care/skincare/es/compare/clinique-vs-shiseido
- Canada: https://lovi.care/skincare/ca/compare/clinique-vs-shiseido
- Australia: https://lovi.care/skincare/au/compare/clinique-vs-shiseido
- Singapore: https://lovi.care/skincare/sg/compare/clinique-vs-shiseido
- Saudi Arabia: https://lovi.care/skincare/sa/compare/clinique-vs-shiseido
- United Arab Emirates: https://lovi.care/skincare/ae/compare/clinique-vs-shiseido