# Bayer vs Sesderma

Page: https://lovi.care/skincare/it/compare/bayer-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Bayer is a German skincare brand founded in 1863 and owned by Bayer AG.

[en.wikipedia.org](https://en.wikipedia.org/wiki/Bayer) [de.wikipedia.org](https://de.wikipedia.org/wiki/Bayer_AG) [forbes.com](https://www.forbes.com/companies/bayer/) [prnewswire.com](https://www.prnewswire.com/news-releases/wellspring-consumer-healthcare-acquires-iconic-otc-skin-care-brands-from-bayer-301789173.html)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Bayer and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgf3d099c7b4).

### Popular Bayer vs Sesderma products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/it/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€46.00 at Notino](https://www.notino.it/sesderma/azelac-ru-siero-depigmentante/p-514983/)

#### Bayer

- [Skinoren Cream 20%](https://lovi.care/skincare/it/p/bayer/skinoren-cream-20/for/oily-skin) — High fit

### Bayer vs Sesderma [serums](https://lovi.care/skincare/it/ingredients/serum) and treatments

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/it/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€46.00 at Notino](https://www.notino.it/sesderma/azelac-ru-siero-depigmentante/p-514983/)

#### Bayer

- [Skinoren Cream 20%](https://lovi.care/skincare/it/p/bayer/skinoren-cream-20/for/oily-skin) — High fit

## Questions and answers

### Which is more affordable, Bayer or Sesderma?

The provided page facts do not contain pricing information for either Bayer or Sesderma, so it is not possible to determine which brand is more affordable.

### Which brand was founded earlier, Bayer or Sesderma?

Bayer was founded earlier than Sesderma, as Bayer started in Germany in 1863 while Sesderma was founded in Spain in 1989.

### Do the skincare products from Bayer or Sesderma contain fragrance?

Bayer products on this page list no fragrance in their ingredients, whereas the Azelac RU [Serum](https://lovi.care/skincare/it/ingredients/serum) from Sesderma contains fragrance.

### Which countries are Bayer and Sesderma originally from?

Bayer was originally founded in Germany, while Sesderma originated in Spain.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study](https://pubmed.ncbi.nlm.nih.gov/36729399/) Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

## The brands

- German skincare: [Bayer](https://lovi.care/skincare/it/brands/bayer)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/it/brands/sesderma)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/bayer-vs-sesderma
- United Kingdom: https://lovi.care/skincare/uk/compare/bayer-vs-sesderma
- Ireland: https://lovi.care/skincare/ie/compare/bayer-vs-sesderma
- Germany: https://lovi.care/skincare/de/compare/bayer-vs-sesderma
- France: https://lovi.care/skincare/fr/compare/bayer-vs-sesderma
- Italy: https://lovi.care/skincare/it/compare/bayer-vs-sesderma (this page)
- Netherlands: https://lovi.care/skincare/nl/compare/bayer-vs-sesderma
- Spain: https://lovi.care/skincare/es/compare/bayer-vs-sesderma
- Canada: https://lovi.care/skincare/ca/compare/bayer-vs-sesderma
- Australia: https://lovi.care/skincare/au/compare/bayer-vs-sesderma
- Singapore: https://lovi.care/skincare/sg/compare/bayer-vs-sesderma
- Saudi Arabia: https://lovi.care/skincare/sa/compare/bayer-vs-sesderma
- United Arab Emirates: https://lovi.care/skincare/ae/compare/bayer-vs-sesderma