# Azclear vs Sesderma Page: https://lovi.care/skincare/it/compare/azclear-vs-sesderma The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy. Azclear and Sesderma are carefully balanced skincare lines known for their advanced [serums](https://lovi.care/skincare/it/ingredients/serum), soothing formulas, and targeted active ingredients. Azclear suits sensitive, acne-prone, and reactive skin types best, featuring its Medicated Lotion, while Sesderma suits sensitive, hyperpigmented, and aging skin types best, featuring its Azelac RU Serum. Both brands offer thoughtful formulations that work to gently nurture and balance the complexion, but they differ in their specific botanical [extracts](https://lovi.care/skincare/it/ingredients/extract) and active compounds designed to refine skin texture and promote radiance. Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026. [skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html) This page compares some of the most popular Azclear and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgd57adb4cec). ### Popular Azclear vs Sesderma products #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/it/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€46.00 at Notino](https://www.notino.it/sesderma/azelac-ru-siero-depigmentante/p-514983/) #### Azclear - [Medicated Lotion](https://lovi.care/skincare/it/p/azclear/medicated-lotion/for/oily-acne-prone-skin) — High fit ### Azclear vs Sesderma [serums](https://lovi.care/skincare/it/ingredients/serum) and treatments #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/it/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€46.00 at Notino](https://www.notino.it/sesderma/azelac-ru-siero-depigmentante/p-514983/) #### Azclear - [Medicated Lotion](https://lovi.care/skincare/it/p/azclear/medicated-lotion/for/oily-acne-prone-skin) — High fit ## Questions and answers ### Azclear or Sesderma: which is better? Azclear Medicated Lotion has a High fit for oily acne-prone skin, while Sesderma Azelac RU [Serum](https://lovi.care/skincare/it/ingredients/serum) has a High fit for acne-prone skin, skin with dark spots, and combination skin. Azclear lists no fragrance in its ingredients, whereas Sesderma includes fragrance in its serum. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### What is the difference between Azclear and Sesderma? Azclear products on this page have no fragrance, whereas the Sesderma product includes fragrance. For oily acne-prone skin, Azclear achieves a High Lovi fit level while Sesderma has an Average fit level. ### Which is more affordable, Azclear or Sesderma? The provided page facts do not contain pricing information, so it is not possible to determine whether Azclear or Sesderma is more affordable based on this page. ### Which causes fewer breakouts, Azclear or Sesderma? Azclear Medicated Lotion achieves a High Lovi fit for oily acne-prone skin, while Sesderma Azelac RU Serum reaches a High fit for acne-prone skin. Both brands on this page help manage breakouts. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### When were Azclear and Sesderma founded, and who owns them? Azclear was founded in 2010 and is owned by Ego Pharmaceuticals, while Sesderma was founded in 1989 in Spain and is owned by Grupo Sesderma since 2026. ### Do Azclear products contain fragrance compared to Sesderma products? Every product on this page by Azclear lists no fragrance in its ingredients, whereas the Azelac RU Serum by Sesderma includes fragrance. ### Which brand offers a serum better suited for skin with dark spots? For skin with dark spots, Sesderma offers a better-suited serum because its Azelac RU Serum has a High Lovi fit level compared to the Average fit of Azclear Medicated Lotion. Additionally, Azclear lists no fragrance in its products, while Sesderma includes fragrance in its serum. ## Research behind their key ingredients - [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000 - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007 - [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004 - [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017 - [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007 - [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017 - [Inhibition of TRPV1 prevented skin irritancy induced by phenoxyethanol. A preliminary in vitro and in vivo study](https://pubmed.ncbi.nlm.nih.gov/27168163/) Phenoxyethanol · International Journal of Cosmetic Science, 2017 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study](https://pubmed.ncbi.nlm.nih.gov/36729399/) Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023 - [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998 - [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025 - [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021 - [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024 ## The brands - Skincare: [Azclear](https://lovi.care/skincare/it/brands/azclear) - Spanish skincare: [Sesderma](https://lovi.care/skincare/it/brands/sesderma) ## More comparisons - [SKIN1004 vs Azclear](https://lovi.care/skincare/it/compare/skin1004-vs-azclear) - [SKIN1004 vs Sesderma](https://lovi.care/skincare/it/compare/skin1004-vs-sesderma) - [Anua vs Azclear](https://lovi.care/skincare/it/compare/anua-vs-azclear) - [Anua vs Sesderma](https://lovi.care/skincare/it/compare/anua-vs-sesderma) - [Medicube vs Azclear](https://lovi.care/skincare/it/compare/medicube-vs-azclear) - [Medicube vs Sesderma](https://lovi.care/skincare/it/compare/medicube-vs-sesderma) - [The Ordinary vs Azclear](https://lovi.care/skincare/it/compare/the-ordinary-vs-azclear) - [The Ordinary vs Sesderma](https://lovi.care/skincare/it/compare/the-ordinary-vs-sesderma) - [Beauty of Joseon vs Azclear](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-azclear) - [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/it/compare/beauty-of-joseon-vs-sesderma) - [COSRX vs Azclear](https://lovi.care/skincare/it/compare/cosrx-vs-azclear) - [COSRX vs Sesderma](https://lovi.care/skincare/it/compare/cosrx-vs-sesderma) - [CeraVe vs Azclear](https://lovi.care/skincare/it/compare/cerave-vs-azclear) - [CeraVe vs Sesderma](https://lovi.care/skincare/it/compare/cerave-vs-sesderma) - [La Roche-Posay vs Azclear](https://lovi.care/skincare/it/compare/la-roche-posay-vs-azclear) - [La Roche-Posay vs Sesderma](https://lovi.care/skincare/it/compare/la-roche-posay-vs-sesderma) - [Dr. Althea vs Azclear](https://lovi.care/skincare/it/compare/dr-althea-vs-azclear) - [Dr. Althea vs Sesderma](https://lovi.care/skincare/it/compare/dr-althea-vs-sesderma) - [Some By Mi vs Azclear](https://lovi.care/skincare/it/compare/some-by-mi-vs-azclear) - [Some By Mi vs Sesderma](https://lovi.care/skincare/it/compare/some-by-mi-vs-sesderma) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/azclear-vs-sesderma - United Kingdom: https://lovi.care/skincare/uk/compare/azclear-vs-sesderma - Ireland: https://lovi.care/skincare/ie/compare/azclear-vs-sesderma - Germany: https://lovi.care/skincare/de/compare/azclear-vs-sesderma - France: https://lovi.care/skincare/fr/compare/azclear-vs-sesderma - Italy: https://lovi.care/skincare/it/compare/azclear-vs-sesderma (this page) - Netherlands: https://lovi.care/skincare/nl/compare/azclear-vs-sesderma - Spain: https://lovi.care/skincare/es/compare/azclear-vs-sesderma - Canada: https://lovi.care/skincare/ca/compare/azclear-vs-sesderma - Australia: https://lovi.care/skincare/au/compare/azclear-vs-sesderma - Singapore: https://lovi.care/skincare/sg/compare/azclear-vs-sesderma - Saudi Arabia: https://lovi.care/skincare/sa/compare/azclear-vs-sesderma - United Arab Emirates: https://lovi.care/skincare/ae/compare/azclear-vs-sesderma