# Phytosphingosine and palmitoyl tripeptide-1

Page: https://lovi.care/skincare/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Work well together

Use them together in the same routine, applying the lipid component first followed by the peptide cream, because lipids help skin absorb peptides better. They work together to strengthen the skin barrier and improve moisture, giving you smoother, firmer skin. If your skin feels sensitive, you can apply them on alternate nights or switch to a gentler formula.

- [All about phytosphingosine](https://lovi.care/skincare/ingredients/phytosphingosine)
- [All about palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/palmitoyl-tripeptide-1)

### [Phytosphingosine](https://lovi.care/skincare/ingredients/phytosphingosine) products

- [CeraVe Hydrating Facial Cleanser](https://lovi.care/skincare/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — [$16.97 at Amazon](https://www.amazon.com/dp/B07RL88DD2?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — [$13.62 at Amazon](https://www.amazon.com/dp/B00365DABC?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Aestura Atobarrier 365 Cream](https://lovi.care/skincare/p/aestura/atobarrier-365-cream/for/dry-skin) — High fit — [$32.00 at Amazon](https://www.amazon.com/dp/B09YDCCJBJ?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Cetaphil Ceramide Serum](https://lovi.care/skincare/p/cetaphil/ceramide-serum/for/acne-prone-skin) — Superior fit — [$13.99 at Amazon](https://www.amazon.com/dp/B0CZD72G5W?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Bioderma Atoderm Intensive Eye](https://lovi.care/skincare/p/bioderma/atoderm-intensive-eye/for/acne-prone-skin) — High fit
- [Obagi Rebalance Skin Barrier Recovery Cream](https://lovi.care/skincare/p/obagi/rebalance-skin-barrier-recovery-cream/for/dry-sensitive-skin) — High fit
- [Elizabeth Arden Advanced Ceramide Capsules Daily Youth Restoring Serum](https://lovi.care/skincare/p/elizabeth-arden/advanced-ceramide-capsules-daily-youth-restoring-serum/for/oily-skin) — High fit — [$130.00 at Amazon](https://www.amazon.com/dp/B0H4WF9SG1?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

### [Palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/palmitoyl-tripeptide-1) products

- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [$32.00 at Amazon](https://www.amazon.com/dp/B0C9DXGXZ3?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [$19.90 at Amazon](https://www.amazon.com/dp/B0BLHW7JZM?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Medik8 Liquid Peptides](https://lovi.care/skincare/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [$95.00 at Amazon](https://www.amazon.com/dp/B0DT1LYVZ6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Shiseido Benefiance Wrinkle Smoothing Eye Cream](https://lovi.care/skincare/p/shiseido/benefiance-wrinkle-smoothing-eye-cream/for/mature-skin) — High fit — [$68.00 at Amazon](https://www.amazon.com/dp/B0C9RXV1VY?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [$109.00 at Amazon](https://www.amazon.com/dp/B09FG8TJDD?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Alastin Skincare Regenerating Skin Nectar](https://lovi.care/skincare/p/alastin-skincare/regenerating-skin-nectar/for/mature-skin) — Superior fit
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/p/the-ordinary/matrixyl-10-ha/for/dry-skin) — Superior fit — [$10.90 at Amazon](https://www.amazon.com/dp/B071J1PBQ6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [ZO Skin Health Daily Power Defense](https://lovi.care/skincare/p/zo-skin-health/daily-power-defense/for/oily-skin) — High fit — [$127.07 at Amazon](https://www.amazon.com/dp/B0GPCPVXB3?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit
- [Alastin Ultra Nourishing Moisturizer](https://lovi.care/skincare/p/alastin/ultra-nourishing-moisturizer/for/dry-skin) — Superior fit
- [DRMTLGY Needle-less Serum](https://lovi.care/skincare/p/drmtlgy/needle-less-serum/for/dry-skin) — Superior fit — [$69.00 at Amazon](https://www.amazon.com/dp/B0FQKWFFQ6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Valmont Prime Renewing Pack](https://lovi.care/skincare/p/valmont/prime-renewing-pack/for/mature-skin) — High fit

## Questions and answers

### Can you use phytosphingosine and palmitoyl tripeptide-1 together?

Yes, you can use [phytosphingosine](https://lovi.care/skincare/ingredients/phytosphingosine) and [palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/palmitoyl-tripeptide-1) together because they work well to support skin barrier repair and reinforce skin structure. Lovi rates their compatibility as Superior.

[Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/)

### Which goes first, phytosphingosine or palmitoyl tripeptide-1?

Phytosphingosine and palmitoyl tripeptide-1 work well together to enhance skin barrier repair and support skin structure. You can combine them in your routine to improve absorption and reinforce the skin barrier.

[Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/)

### Are phytosphingosine and palmitoyl tripeptide-1 good for sensitive skin?

Yes, phytosphingosine and palmitoyl tripeptide-1 work well together to benefit barrier-impaired and dry skin. Combining them helps improve skin structure, enhances barrier repair, and supports moisture retention.

[Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/)

## Research on phytosphingosine and palmitoyl tripeptide-1

- [Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/18489348/) Phytosphingosine · International Journal of Cosmetic Science, 2007
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2015
- [Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids](https://pubmed.ncbi.nlm.nih.gov/12482041/) Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002
- [Salicyloyl-phytosphingosine: a novel agent for the repair of photoaged skin](https://pubmed.ncbi.nlm.nih.gov/18489360/) Phytosphingosine · International Journal of Cosmetic Science, 2007
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tripeptide-1 · International Journal of Cosmetic Science, 2026

## Other combinations

- Keep them apart: [Adapalene and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/adapalene-and-palmitoyl-tripeptide-1)
- Keep them apart: [Granactive retinoid and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/granactive-retinoid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Hydroxypinacolone retinoate and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-tripeptide-1)
- Keep them apart: [Pro-retinol and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/pro-retinol-and-palmitoyl-tripeptide-1)
- Keep them apart: [Retinal and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/retinal-and-palmitoyl-tripeptide-1)
- Keep them apart: [Retinoid blend and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/retinoid-blend-and-palmitoyl-tripeptide-1)
- Depends on the strength: [Retinol and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/retinol-and-palmitoyl-tripeptide-1)
- Keep them apart: [Tretinoin and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/tretinoin-and-palmitoyl-tripeptide-1)
- Keep them apart: [Vitamin A and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/vitamin-a-and-palmitoyl-tripeptide-1)
- Work well together: [Liposome and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/liposome-and-palmitoyl-tripeptide-1)
- Work well together: [Microcapsule and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/microcapsule-and-palmitoyl-tripeptide-1)
- Depends on the strength: [Vitamin C and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/vitamin-c-and-palmitoyl-tripeptide-1)
- Work well together: [Betaine and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/betaine-and-palmitoyl-tripeptide-1)
- Work well together: [Glycerin and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/glycerin-and-palmitoyl-tripeptide-1)
- Work well together: [Hyaluronic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/hyaluronic-acid-and-palmitoyl-tripeptide-1)
- Depends on the strength: [Niacinamide and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/niacinamide-and-palmitoyl-tripeptide-1)
- Work well together: [Panthenol and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/panthenol-and-palmitoyl-tripeptide-1)
- Work well together: [Bakuchiol and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/bakuchiol-and-palmitoyl-tripeptide-1)
- Work well together: [Arginine and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/arginine-and-palmitoyl-tripeptide-1)
- Work well together: [GABA and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/gaba-and-palmitoyl-tripeptide-1)
- Work well together: [Silk amino acids and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/silk-amino-acids-and-palmitoyl-tripeptide-1)
- Work well together: [Taurine and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/taurine-and-palmitoyl-tripeptide-1)
- Work well together: [Palmitoyl tripeptide-1 and theanine](https://lovi.care/skincare/ingredients/palmitoyl-tripeptide-1-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-palmitoyl-tripeptide-1)
- Keep them apart: [Citric acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/citric-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Glycolic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/glycolic-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Lactic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/lactic-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Mandelic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/mandelic-acid-and-palmitoyl-tripeptide-1)
- Work well together: [Coenzyme Q10 and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/coenzyme-q10-and-palmitoyl-tripeptide-1)
- Work well together: [Green tea and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/green-tea-and-palmitoyl-tripeptide-1)
- Work well together: [Vitamin E and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/vitamin-e-and-palmitoyl-tripeptide-1)
- Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-phytosphingosine)
- Work well together: [Bio-placenta peptides and phytosphingosine](https://lovi.care/skincare/ingredients/bio-placenta-peptides-and-phytosphingosine)
- Work well together: [Collagen peptide and phytosphingosine](https://lovi.care/skincare/ingredients/collagen-peptide-and-phytosphingosine)
- Work well together: [Phytosphingosine and copper peptide](https://lovi.care/skincare/ingredients/phytosphingosine-and-copper-peptide)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4)
- Work well together: [Beta-sitosterol and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/beta-sitosterol-and-palmitoyl-tripeptide-1)
- Work well together: [Ceramide-building complex and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/ceramide-building-complex-and-palmitoyl-tripeptide-1)
- Work well together: [Cholesterol and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/cholesterol-and-palmitoyl-tripeptide-1)
- Work well together: [Phytosterol and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/phytosterol-and-palmitoyl-tripeptide-1)
- Work well together: [Squalene and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/squalene-and-palmitoyl-tripeptide-1)
- Work well together: [Tri-ceramide complex and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/tri-ceramide-complex-and-palmitoyl-tripeptide-1)
- Work well together: [Phytosphingosine and peptide-rich plasma](https://lovi.care/skincare/ingredients/phytosphingosine-and-peptide-rich-plasma)
- Work well together: [Phytosphingosine and triple peptide blend](https://lovi.care/skincare/ingredients/phytosphingosine-and-triple-peptide-blend)
- Keep them apart: [Salicylic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/salicylic-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Baking soda and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/baking-soda-and-palmitoyl-tripeptide-1)
- Keep them apart: [Bleach and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/bleach-and-palmitoyl-tripeptide-1)
- Keep them apart: [Potassium hydroxide and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/potassium-hydroxide-and-palmitoyl-tripeptide-1)
- Keep them apart: [Behenyl alcohol and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/behenyl-alcohol-and-palmitoyl-tripeptide-1)
- Keep them apart: [Isopropyl alcohol and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/isopropyl-alcohol-and-palmitoyl-tripeptide-1)
- Keep them apart: [Polyvinyl alcohol and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/polyvinyl-alcohol-and-palmitoyl-tripeptide-1)
- Keep them apart: [Copper and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/copper-and-palmitoyl-tripeptide-1)
- Keep them apart: [Benzoyl peroxide and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-palmitoyl-tripeptide-1)
- Keep them apart: [Magnesium and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/magnesium-and-palmitoyl-tripeptide-1)
- Keep them apart: [Zinc and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/zinc-and-palmitoyl-tripeptide-1)
- Keep them apart: [Zinc sulfate and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/zinc-sulfate-and-palmitoyl-tripeptide-1)
- Keep them apart: [Azelaic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/azelaic-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Protease and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/protease-and-palmitoyl-tripeptide-1)
- Keep them apart: [Superoxide dismutase and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/superoxide-dismutase-and-palmitoyl-tripeptide-1)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1 (this page)
- United Kingdom: https://lovi.care/skincare/uk/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1
- Ireland: https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1
- Germany: https://lovi.care/skincare/de/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1
- France: https://lovi.care/skincare/fr/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1
- Italy: https://lovi.care/skincare/it/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1
- Netherlands: https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1
- Spain: https://lovi.care/skincare/es/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1
- Canada: https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1
- Australia: https://lovi.care/skincare/au/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1
- Singapore: https://lovi.care/skincare/sg/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1