# Niacinamide and hexapeptide

Page: https://lovi.care/skincare/ingredients/niacinamide-and-hexapeptide

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Depends on the strength

Use them together in the same routine, because [niacinamide](https://lovi.care/skincare/ingredients/niacinamide) helps strengthen the skin while the peptide supports anti-aging and firmness. Niacinamide boosts your skin barrier and pairs safely with [hexapeptides](https://lovi.care/skincare/ingredients/hexapeptide) to improve overall skin health and texture without any clashing. If you have sensitive skin, you can use a gentler strength or apply them a few minutes apart.

- [All about niacinamide](https://lovi.care/skincare/ingredients/niacinamide)
- [All about hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide)

### [Niacinamide](https://lovi.care/skincare/ingredients/niacinamide) products

- [La Roche-Posay Toleriane Double Repair Face Moisturizer](https://lovi.care/skincare/p/la-roche-posay/toleriane-double-repair-face-moisturizer/for/oily-acne-prone-skin) — High fit — [$24.99 at Amazon](https://www.amazon.com/dp/B01N9SPQHQ?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — [$15.97 at Amazon](https://www.amazon.com/dp/B01N1LL62W?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Cetaphil Gentle Skin Cleanser](https://lovi.care/skincare/p/cetaphil/gentle-skin-cleanser/for/dry-skin) — Superior fit — [$13.44 at Amazon](https://www.amazon.com/dp/B099N3NM61?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [La Roche-Posay Toleriane Hydrating Gentle Cleanser](https://lovi.care/skincare/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — [$19.99 at Amazon](https://www.amazon.com/dp/B01N7T7JKJ?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Dr. Althea 345 Relief Cream](https://lovi.care/skincare/p/dr-althea/345-relief-cream/for/acne-prone-skin) — Superior fit — [$27.00 at Amazon](https://www.amazon.com/dp/B0FKGJYFC8?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Biodance Bio-Collagen Real Deep Mask](https://lovi.care/skincare/p/biodance/bio-collagen-real-deep-mask/for/mature-skin) — Superior fit — [$19.00 at Amazon](https://www.amazon.com/dp/B0B2RM68G2?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Olay Regenerist Micro-Sculpting Cream](https://lovi.care/skincare/p/olay/regenerist-micro-sculpting-cream/for/mature-skin) — Superior fit — [$23.54 at Amazon](https://www.amazon.com/dp/B007M81B4M?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [CeraVe Resurfacing Retinol Serum](https://lovi.care/skincare/p/cerave/resurfacing-retinol-serum/for/dark-spots) — High fit — [$16.44 at Amazon](https://www.amazon.com/dp/B07VWSN95S?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — [$13.62 at Amazon](https://www.amazon.com/dp/B00365DABC?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Medicube PDRN Pink Peptide Serum](https://lovi.care/skincare/p/medicube/pdrn-pink-peptide-serum/for/mature-skin) — High fit — [$18.90 at Amazon](https://www.amazon.com/dp/B0DBF65JYY?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [CeraVe Renewing SA Cleanser](https://lovi.care/skincare/p/cerave/renewing-sa-cleanser/for/oily-acne-prone-skin) — High fit — [$12.37 at Amazon](https://www.amazon.com/dp/B00U1YCRD8?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Medicube Collagen Jelly Cream](https://lovi.care/skincare/p/medicube/collagen-jelly-cream/for/mature-skin) — Superior fit — [$14.90 at Amazon](https://www.amazon.com/dp/B0DGPSZVW3?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use niacinamide and hexapeptide together?

Yes, you can use [niacinamide](https://lovi.care/skincare/ingredients/niacinamide) and [hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) together depending on the strength, and they are beneficial when paired with [panthenol](https://lovi.care/skincare/ingredients/panthenol) to strengthen the skin barrier and complement regeneration. You can find both ingredients combined in SkinCeuticals P-TOX. This combination helps reduce the progression of skin aging while being well tolerated.

[Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/) [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which goes first, niacinamide or hexapeptide?

Niacinamide and hexapeptides can be used together depending on the strength, and products like SkinCeuticals P-TOX combine them effectively. Niacinamide strengthens the skin barrier and boosts ceramide synthesis to complement peptide regeneration.

### Are niacinamide and hexapeptide good for sensitive skin?

Yes, niacinamide and hexapeptide are good for sensitive skin because they help strengthen the skin barrier and complement peptide regeneration. They are ideal in anti-aging, barrier repair, or post-procedure products like SkinCeuticals P-TOX when using the right strength.

## Research on niacinamide and hexapeptide

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019

## Other combinations

- Depends on the strength: [Retinol and niacinamide](https://lovi.care/skincare/ingredients/retinol-and-niacinamide)
- Depends on the strength: [AHA blend glycolic and citric acids and niacinamide](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-niacinamide)
- Depends on the strength: [Niacinamide and citric acid](https://lovi.care/skincare/ingredients/niacinamide-and-citric-acid)
- Depends on the strength: [Glycolic acid and niacinamide](https://lovi.care/skincare/ingredients/glycolic-acid-and-niacinamide)
- Depends on the strength: [Niacinamide and lactic acid](https://lovi.care/skincare/ingredients/niacinamide-and-lactic-acid)
- Depends on the strength: [Niacinamide and mandelic acid](https://lovi.care/skincare/ingredients/niacinamide-and-mandelic-acid)
- Depends on the strength: [Niacinamide and salicylic acid](https://lovi.care/skincare/ingredients/niacinamide-and-salicylic-acid)
- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/ingredients/hexapeptide-and-granactive-retinoid)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/ingredients/hexapeptide-and-pro-retinol)
- Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/ingredients/hexapeptide-and-retinal)
- Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/ingredients/hexapeptide-and-retinoid-blend)
- Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/ingredients/retinol-and-hexapeptide)
- Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/ingredients/tretinoin-and-hexapeptide)
- Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/ingredients/hexapeptide-and-vitamin-a)
- Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/ingredients/hexapeptide-and-liposome)
- Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/ingredients/hexapeptide-and-microcapsule)
- Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/ingredients/vitamin-c-and-hexapeptide)
- Depends on the strength: [Niacinamide and gluconolactone](https://lovi.care/skincare/ingredients/niacinamide-and-gluconolactone)
- Depends on the strength: [Niacinamide and lactobionic acid](https://lovi.care/skincare/ingredients/niacinamide-and-lactobionic-acid)
- Work well together: [Niacinamide and cholesterol](https://lovi.care/skincare/ingredients/niacinamide-and-cholesterol)
- Work well together: [Niacinamide and lauric acid](https://lovi.care/skincare/ingredients/niacinamide-and-lauric-acid)
- Work well together: [Niacinamide and linoleic acid](https://lovi.care/skincare/ingredients/niacinamide-and-linoleic-acid)
- Work well together: [Niacinamide and tri-ceramide complex](https://lovi.care/skincare/ingredients/niacinamide-and-tri-ceramide-complex)
- Depends on the strength: [Adapalene and niacinamide](https://lovi.care/skincare/ingredients/adapalene-and-niacinamide)
- Depends on the strength: [Niacinamide and granactive retinoid](https://lovi.care/skincare/ingredients/niacinamide-and-granactive-retinoid)
- Depends on the strength: [Niacinamide and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/niacinamide-and-hydroxypinacolone-retinoate)
- Depends on the strength: [Niacinamide and pro-retinol](https://lovi.care/skincare/ingredients/niacinamide-and-pro-retinol)
- Depends on the strength: [Niacinamide and retinal](https://lovi.care/skincare/ingredients/niacinamide-and-retinal)
- Depends on the strength: [Niacinamide and retinoid blend](https://lovi.care/skincare/ingredients/niacinamide-and-retinoid-blend)
- Depends on the strength: [Niacinamide and tretinoin](https://lovi.care/skincare/ingredients/niacinamide-and-tretinoin)
- Depends on the strength: [Niacinamide and vitamin A](https://lovi.care/skincare/ingredients/niacinamide-and-vitamin-a)
- Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/ingredients/hexapeptide-and-betaine)
- Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/ingredients/glycerin-and-hexapeptide)
- Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/niacinamide-and-acetyl-hexapeptide-3)
- Depends on the strength: [Niacinamide and bio-placenta peptides](https://lovi.care/skincare/ingredients/niacinamide-and-bio-placenta-peptides)
- Depends on the strength: [Niacinamide and collagen peptide](https://lovi.care/skincare/ingredients/niacinamide-and-collagen-peptide)
- Depends on the strength: [Niacinamide and copper peptide](https://lovi.care/skincare/ingredients/niacinamide-and-copper-peptide)
- Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/ingredients/panthenol-and-hexapeptide)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/ingredients/niacinamide-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/ingredients/niacinamide-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Niacinamide and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/niacinamide-and-palmitoyl-tripeptide-1)
- Depends on the strength: [Niacinamide and peptide-rich plasma](https://lovi.care/skincare/ingredients/niacinamide-and-peptide-rich-plasma)
- Depends on the strength: [Niacinamide and triple peptide blend](https://lovi.care/skincare/ingredients/niacinamide-and-triple-peptide-blend)
- Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/ingredients/bakuchiol-and-hexapeptide)
- Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/ingredients/hexapeptide-and-arginine)
- Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/ingredients/hexapeptide-and-gaba)
- Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/ingredients/hexapeptide-and-silk-amino-acids)
- Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/ingredients/hexapeptide-and-taurine)
- Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/ingredients/hexapeptide-and-theanine)
- Work well together: [Niacinamide and hyaluronic acid](https://lovi.care/skincare/ingredients/niacinamide-and-hyaluronic-acid)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide)
- Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/ingredients/hexapeptide-and-citric-acid)
- Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/ingredients/glycolic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/ingredients/coenzyme-q10-and-hexapeptide)
- Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/ingredients/green-tea-and-hexapeptide)
- Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/ingredients/vitamin-e-and-hexapeptide)
- Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/ingredients/hexapeptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/ingredients/ceramide-building-complex-and-hexapeptide)
- Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/ingredients/hexapeptide-and-cholesterol)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/ingredients/hexapeptide-and-phytosterol)
- Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/ingredients/hexapeptide-and-squalene)
- Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/ingredients/hexapeptide-and-tri-ceramide-complex)
- Work well together: [Niacinamide and bakuchiol](https://lovi.care/skincare/ingredients/niacinamide-and-bakuchiol)
- Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/ingredients/salicylic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/ingredients/hexapeptide-and-bleach)
- Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/ingredients/hexapeptide-and-potassium-hydroxide)
- Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-isopropyl-alcohol)
- Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-polyvinyl-alcohol)
- Work well together: [Niacinamide and zinc](https://lovi.care/skincare/ingredients/niacinamide-and-zinc)
- Work well together: [Niacinamide and zinc gluconate](https://lovi.care/skincare/ingredients/niacinamide-and-zinc-gluconate)
- Work well together: [Niacinamide and zinc oxide](https://lovi.care/skincare/ingredients/niacinamide-and-zinc-oxide)
- Work well together: [Niacinamide and zinc sulfate](https://lovi.care/skincare/ingredients/niacinamide-and-zinc-sulfate)
- Work well together: [Benzoyl peroxide and niacinamide](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-niacinamide)
- Keep them apart: [Niacinamide and lipohydroxy acid](https://lovi.care/skincare/ingredients/niacinamide-and-lipohydroxy-acid)
- Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/ingredients/hexapeptide-and-copper)
- Work well together: [Ferulic acid and niacinamide](https://lovi.care/skincare/ingredients/ferulic-acid-and-niacinamide)
- Work well together: [Green tea and niacinamide](https://lovi.care/skincare/ingredients/green-tea-and-niacinamide)
- Work well together: [Niacinamide and vitamin E](https://lovi.care/skincare/ingredients/niacinamide-and-vitamin-e)
- Keep them apart: [Niacinamide and isopropyl alcohol](https://lovi.care/skincare/ingredients/niacinamide-and-isopropyl-alcohol)
- Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/ingredients/hexapeptide-and-magnesium)
- Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/ingredients/hexapeptide-and-zinc)
- Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/ingredients/hexapeptide-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-hexapeptide)
- Work well together: [Niacinamide and ascorbyl glucoside](https://lovi.care/skincare/ingredients/niacinamide-and-ascorbyl-glucoside)
- Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/ingredients/azelaic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/ingredients/hexapeptide-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/niacinamide-and-hexapeptide (this page)
- United Kingdom: https://lovi.care/skincare/uk/ingredients/niacinamide-and-hexapeptide
- Ireland: https://lovi.care/skincare/ie/ingredients/niacinamide-and-hexapeptide
- Germany: https://lovi.care/skincare/de/ingredients/niacinamide-and-hexapeptide
- France: https://lovi.care/skincare/fr/ingredients/niacinamide-and-hexapeptide
- Italy: https://lovi.care/skincare/it/ingredients/niacinamide-and-hexapeptide
- Netherlands: https://lovi.care/skincare/nl/ingredients/niacinamide-and-hexapeptide
- Spain: https://lovi.care/skincare/es/ingredients/niacinamide-and-hexapeptide
- Canada: https://lovi.care/skincare/ca/ingredients/niacinamide-and-hexapeptide
- Australia: https://lovi.care/skincare/au/ingredients/niacinamide-and-hexapeptide
- Singapore: https://lovi.care/skincare/sg/ingredients/niacinamide-and-hexapeptide
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/niacinamide-and-hexapeptide
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/niacinamide-and-hexapeptide