# Niacinamide and hexapeptide-9

Page: https://lovi.care/skincare/ingredients/niacinamide-and-hexapeptide-9

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Depends on the strength

Use them together in the same routine, applying [niacinamide](https://lovi.care/skincare/ingredients/niacinamide) first and [hexapeptide-9](https://lovi.care/skincare/ingredients/hexapeptide-9) right after, because they boost each other's skin benefits. Niacinamide helps your skin absorb the peptide better while strengthening your moisture barrier, leading to smoother, younger-looking skin. You can use them both daily without changes, or space them out if your skin feels sensitive.

- [All about niacinamide](https://lovi.care/skincare/ingredients/niacinamide)
- [All about hexapeptide-9](https://lovi.care/skincare/ingredients/hexapeptide-9)

### [Niacinamide](https://lovi.care/skincare/ingredients/niacinamide) products

- [La Roche-Posay Toleriane Double Repair Face Moisturizer](https://lovi.care/skincare/p/la-roche-posay/toleriane-double-repair-face-moisturizer/for/oily-acne-prone-skin) — High fit — [$24.99 at Amazon](https://www.amazon.com/dp/B01N9SPQHQ?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — [$15.97 at Amazon](https://www.amazon.com/dp/B01N1LL62W?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Cetaphil Gentle Skin Cleanser](https://lovi.care/skincare/p/cetaphil/gentle-skin-cleanser/for/dry-skin) — Superior fit — [$13.44 at Amazon](https://www.amazon.com/dp/B099N3NM61?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [La Roche-Posay Toleriane Hydrating Gentle Cleanser](https://lovi.care/skincare/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — [$19.99 at Amazon](https://www.amazon.com/dp/B01N7T7JKJ?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Dr. Althea 345 Relief Cream](https://lovi.care/skincare/p/dr-althea/345-relief-cream/for/acne-prone-skin) — Superior fit — [$27.00 at Amazon](https://www.amazon.com/dp/B0FKGJYFC8?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Biodance Bio-Collagen Real Deep Mask](https://lovi.care/skincare/p/biodance/bio-collagen-real-deep-mask/for/mature-skin) — Superior fit — [$19.00 at Amazon](https://www.amazon.com/dp/B0B2RM68G2?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Olay Regenerist Micro-Sculpting Cream](https://lovi.care/skincare/p/olay/regenerist-micro-sculpting-cream/for/mature-skin) — Superior fit — [$23.54 at Amazon](https://www.amazon.com/dp/B007M81B4M?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [CeraVe Resurfacing Retinol Serum](https://lovi.care/skincare/p/cerave/resurfacing-retinol-serum/for/dark-spots) — High fit — [$16.44 at Amazon](https://www.amazon.com/dp/B07VWSN95S?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — [$13.62 at Amazon](https://www.amazon.com/dp/B00365DABC?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Medicube PDRN Pink Peptide Serum](https://lovi.care/skincare/p/medicube/pdrn-pink-peptide-serum/for/mature-skin) — High fit — [$18.90 at Amazon](https://www.amazon.com/dp/B0DBF65JYY?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [CeraVe Renewing SA Cleanser](https://lovi.care/skincare/p/cerave/renewing-sa-cleanser/for/oily-acne-prone-skin) — High fit — [$12.37 at Amazon](https://www.amazon.com/dp/B00U1YCRD8?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Medicube Collagen Jelly Cream](https://lovi.care/skincare/p/medicube/collagen-jelly-cream/for/mature-skin) — Superior fit — [$14.90 at Amazon](https://www.amazon.com/dp/B0DGPSZVW3?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

### [Hexapeptide-9](https://lovi.care/skincare/ingredients/hexapeptide-9) products

- [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [$153.00 at Amazon](https://www.amazon.com/dp/B00175YVOS?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit
- [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [$19.44 at Amazon](https://www.amazon.com/dp/B095YHYF33?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use niacinamide and hexapeptide-9 together?

Yes, you can use [niacinamide](https://lovi.care/skincare/ingredients/niacinamide) and [hexapeptide-9](https://lovi.care/skincare/ingredients/hexapeptide-9) together depending on the strength, as they help strengthen the skin barrier, support dermal remodeling, and reduce irritation. This combination is ideal in anti-aging, barrier repair, or restorative care routines.

[Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/)

### Which goes first, niacinamide or hexapeptide-9?

Niacinamide and hexapeptide-9 depend on product strength and can be used together in anti-aging routines to strengthen the skin barrier and support dermal remodeling.

[Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/) [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/)

### Are niacinamide and hexapeptide-9 good for sensitive skin?

Yes, niacinamide and hexapeptide-9 are generally good for sensitive skin depending on the strength, as niacinamide helps boost ceramide synthesis while the combination supports dermal remodeling and reduces irritation.

## Research on niacinamide and hexapeptide-9

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Depends on the strength: [Retinol and niacinamide](https://lovi.care/skincare/ingredients/retinol-and-niacinamide)
- Depends on the strength: [AHA blend glycolic and citric acids and niacinamide](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-niacinamide)
- Depends on the strength: [Niacinamide and citric acid](https://lovi.care/skincare/ingredients/niacinamide-and-citric-acid)
- Depends on the strength: [Glycolic acid and niacinamide](https://lovi.care/skincare/ingredients/glycolic-acid-and-niacinamide)
- Depends on the strength: [Niacinamide and lactic acid](https://lovi.care/skincare/ingredients/niacinamide-and-lactic-acid)
- Depends on the strength: [Niacinamide and mandelic acid](https://lovi.care/skincare/ingredients/niacinamide-and-mandelic-acid)
- Depends on the strength: [Niacinamide and salicylic acid](https://lovi.care/skincare/ingredients/niacinamide-and-salicylic-acid)
- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/ingredients/granactive-retinoid-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/ingredients/retinoid-blend-and-hexapeptide-9)
- Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/ingredients/retinol-and-hexapeptide-9)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/ingredients/vitamin-a-and-hexapeptide-9)
- Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/ingredients/liposome-and-hexapeptide-9)
- Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/ingredients/microcapsule-and-hexapeptide-9)
- Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/ingredients/vitamin-c-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and gluconolactone](https://lovi.care/skincare/ingredients/niacinamide-and-gluconolactone)
- Depends on the strength: [Niacinamide and lactobionic acid](https://lovi.care/skincare/ingredients/niacinamide-and-lactobionic-acid)
- Work well together: [Niacinamide and cholesterol](https://lovi.care/skincare/ingredients/niacinamide-and-cholesterol)
- Work well together: [Niacinamide and lauric acid](https://lovi.care/skincare/ingredients/niacinamide-and-lauric-acid)
- Work well together: [Niacinamide and linoleic acid](https://lovi.care/skincare/ingredients/niacinamide-and-linoleic-acid)
- Work well together: [Niacinamide and tri-ceramide complex](https://lovi.care/skincare/ingredients/niacinamide-and-tri-ceramide-complex)
- Depends on the strength: [Adapalene and niacinamide](https://lovi.care/skincare/ingredients/adapalene-and-niacinamide)
- Depends on the strength: [Niacinamide and granactive retinoid](https://lovi.care/skincare/ingredients/niacinamide-and-granactive-retinoid)
- Depends on the strength: [Niacinamide and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/niacinamide-and-hydroxypinacolone-retinoate)
- Depends on the strength: [Niacinamide and pro-retinol](https://lovi.care/skincare/ingredients/niacinamide-and-pro-retinol)
- Depends on the strength: [Niacinamide and retinal](https://lovi.care/skincare/ingredients/niacinamide-and-retinal)
- Depends on the strength: [Niacinamide and retinoid blend](https://lovi.care/skincare/ingredients/niacinamide-and-retinoid-blend)
- Depends on the strength: [Niacinamide and tretinoin](https://lovi.care/skincare/ingredients/niacinamide-and-tretinoin)
- Depends on the strength: [Niacinamide and vitamin A](https://lovi.care/skincare/ingredients/niacinamide-and-vitamin-a)
- Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/ingredients/betaine-and-hexapeptide-9)
- Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/ingredients/glycerin-and-hexapeptide-9)
- Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/ingredients/hyaluronic-acid-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/niacinamide-and-acetyl-hexapeptide-3)
- Depends on the strength: [Niacinamide and bio-placenta peptides](https://lovi.care/skincare/ingredients/niacinamide-and-bio-placenta-peptides)
- Depends on the strength: [Niacinamide and collagen peptide](https://lovi.care/skincare/ingredients/niacinamide-and-collagen-peptide)
- Depends on the strength: [Niacinamide and copper peptide](https://lovi.care/skincare/ingredients/niacinamide-and-copper-peptide)
- Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/ingredients/niacinamide-and-hexapeptide)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/ingredients/panthenol-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/ingredients/niacinamide-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Niacinamide and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/niacinamide-and-palmitoyl-tripeptide-1)
- Depends on the strength: [Niacinamide and peptide-rich plasma](https://lovi.care/skincare/ingredients/niacinamide-and-peptide-rich-plasma)
- Depends on the strength: [Niacinamide and triple peptide blend](https://lovi.care/skincare/ingredients/niacinamide-and-triple-peptide-blend)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/ingredients/arginine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/ingredients/hexapeptide-9-and-gaba)
- Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/ingredients/silk-amino-acids-and-hexapeptide-9)
- Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/ingredients/taurine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/ingredients/hexapeptide-9-and-theanine)
- Work well together: [Niacinamide and hyaluronic acid](https://lovi.care/skincare/ingredients/niacinamide-and-hyaluronic-acid)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9)
- Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/ingredients/citric-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/ingredients/mandelic-acid-and-hexapeptide-9)
- Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/ingredients/coenzyme-q10-and-hexapeptide-9)
- Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/ingredients/green-tea-and-hexapeptide-9)
- Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/ingredients/vitamin-e-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/ingredients/ceramide-building-complex-and-hexapeptide-9)
- Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/ingredients/cholesterol-and-hexapeptide-9)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/ingredients/phytosterol-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/ingredients/hexapeptide-9-and-squalene)
- Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/ingredients/hexapeptide-9-and-tri-ceramide-complex)
- Work well together: [Niacinamide and bakuchiol](https://lovi.care/skincare/ingredients/niacinamide-and-bakuchiol)
- Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/ingredients/salicylic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/ingredients/hexapeptide-9-and-baking-soda)
- Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/ingredients/bleach-and-hexapeptide-9)
- Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/ingredients/potassium-hydroxide-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-9-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-9-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/ingredients/polyvinyl-alcohol-and-hexapeptide-9)
- Work well together: [Niacinamide and zinc](https://lovi.care/skincare/ingredients/niacinamide-and-zinc)
- Work well together: [Niacinamide and zinc gluconate](https://lovi.care/skincare/ingredients/niacinamide-and-zinc-gluconate)
- Work well together: [Niacinamide and zinc oxide](https://lovi.care/skincare/ingredients/niacinamide-and-zinc-oxide)
- Work well together: [Niacinamide and zinc sulfate](https://lovi.care/skincare/ingredients/niacinamide-and-zinc-sulfate)
- Work well together: [Benzoyl peroxide and niacinamide](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-niacinamide)
- Keep them apart: [Niacinamide and lipohydroxy acid](https://lovi.care/skincare/ingredients/niacinamide-and-lipohydroxy-acid)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/ingredients/copper-and-hexapeptide-9)
- Work well together: [Ferulic acid and niacinamide](https://lovi.care/skincare/ingredients/ferulic-acid-and-niacinamide)
- Work well together: [Green tea and niacinamide](https://lovi.care/skincare/ingredients/green-tea-and-niacinamide)
- Work well together: [Niacinamide and vitamin E](https://lovi.care/skincare/ingredients/niacinamide-and-vitamin-e)
- Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-hexapeptide-9)
- Keep them apart: [Niacinamide and isopropyl alcohol](https://lovi.care/skincare/ingredients/niacinamide-and-isopropyl-alcohol)
- Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/ingredients/magnesium-and-hexapeptide-9)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/ingredients/zinc-sulfate-and-hexapeptide-9)
- Work well together: [Niacinamide and ascorbyl glucoside](https://lovi.care/skincare/ingredients/niacinamide-and-ascorbyl-glucoside)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/ingredients/azelaic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/ingredients/superoxide-dismutase-and-hexapeptide-9)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/niacinamide-and-hexapeptide-9 (this page)
- United Kingdom: https://lovi.care/skincare/uk/ingredients/niacinamide-and-hexapeptide-9
- Ireland: https://lovi.care/skincare/ie/ingredients/niacinamide-and-hexapeptide-9
- Germany: https://lovi.care/skincare/de/ingredients/niacinamide-and-hexapeptide-9
- France: https://lovi.care/skincare/fr/ingredients/niacinamide-and-hexapeptide-9
- Italy: https://lovi.care/skincare/it/ingredients/niacinamide-and-hexapeptide-9
- Netherlands: https://lovi.care/skincare/nl/ingredients/niacinamide-and-hexapeptide-9
- Spain: https://lovi.care/skincare/es/ingredients/niacinamide-and-hexapeptide-9
- Canada: https://lovi.care/skincare/ca/ingredients/niacinamide-and-hexapeptide-9
- Australia: https://lovi.care/skincare/au/ingredients/niacinamide-and-hexapeptide-9
- Singapore: https://lovi.care/skincare/sg/ingredients/niacinamide-and-hexapeptide-9
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/niacinamide-and-hexapeptide-9
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/niacinamide-and-hexapeptide-9