# Hexapeptide and zinc

Page: https://lovi.care/skincare/ingredients/hexapeptide-and-zinc

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Keep them apart

Use them at different times of day, applying the peptide first and the [zinc](https://lovi.care/skincare/ingredients/zinc) later, because mixing them makes the peptide less effective. Zinc can bind to [hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) and stop it from working properly on the skin. The shopper can separate them into morning and evening routines to get the best results from both.

- [All about hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide)
- [All about zinc](https://lovi.care/skincare/ingredients/zinc)

### [Hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) products

- [SkinCeuticals P-TOX](https://lovi.care/skincare/p/skinceuticals/p-tox/for/mature-skin) — High fit

### [Zinc](https://lovi.care/skincare/ingredients/zinc) products

- [BYOMA Clarifying Serum](https://lovi.care/skincare/p/byoma/clarifying-serum/for/dry-skin) — High fit — [$15.99 at Amazon](https://www.amazon.com/dp/B0C7C8BZLM?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Minimalist Vitamin B5 10% Moisturizer](https://lovi.care/skincare/p/minimalist/vitamin-b5-10-moisturizer/for/mature-skin) — High fit — [$7.99 at Amazon](https://www.amazon.com/dp/B09Q3MWP2S?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Sunday Riley Saturn Sulfur Spot Treatment Mask](https://lovi.care/skincare/p/sunday-riley/saturn-sulfur-spot-treatment-mask/for/oily-acne-prone-skin) — Superior fit

## Questions and answers

### Can you use hexapeptide and zinc together?

No, you should keep [hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) and [zinc](https://lovi.care/skincare/ingredients/zinc) apart in your routine. They may [complex](https://lovi.care/skincare/ingredients/complex) together and reduce biological activity.

### Which goes first, hexapeptide or zinc?

Keep hexapeptide and zinc apart in your routine because unchelated metal ions may complex with peptides and reduce their biological activity.

### Are hexapeptide and zinc good for sensitive skin?

Keep hexapeptide and zinc apart in your routine, as combining them may reduce their biological activity. Unchelated metal ions should not be used with peptides at the same time.

## Research on hexapeptide and zinc

- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013
- [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc · Journal of Controlled Release, 2025
- [Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32983333/) Zinc · The Journal of Clinical and Aesthetic Dermatology, 2020
- [Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study](https://pubmed.ncbi.nlm.nih.gov/36698447/) Zinc · Clinical, Cosmetic and Investigational Dermatology, 2023
- [Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study](https://pubmed.ncbi.nlm.nih.gov/41487026/) Zinc · Journal of Cosmetic Dermatology, 2026

## Other combinations

- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/ingredients/hexapeptide-and-granactive-retinoid)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/ingredients/hexapeptide-and-pro-retinol)
- Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/ingredients/hexapeptide-and-retinal)
- Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/ingredients/hexapeptide-and-retinoid-blend)
- Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/ingredients/retinol-and-hexapeptide)
- Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/ingredients/tretinoin-and-hexapeptide)
- Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/ingredients/hexapeptide-and-vitamin-a)
- Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/ingredients/hexapeptide-and-liposome)
- Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/ingredients/hexapeptide-and-microcapsule)
- Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/ingredients/vitamin-c-and-hexapeptide)
- Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/ingredients/hexapeptide-and-betaine)
- Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/ingredients/glycerin-and-hexapeptide)
- Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-hyaluronic-acid)
- Depends on the strength: [Salicylic acid and zinc](https://lovi.care/skincare/ingredients/salicylic-acid-and-zinc)
- Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/ingredients/niacinamide-and-hexapeptide)
- Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/ingredients/panthenol-and-hexapeptide)
- Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/ingredients/bakuchiol-and-hexapeptide)
- Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/ingredients/hexapeptide-and-arginine)
- Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/ingredients/hexapeptide-and-gaba)
- Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/ingredients/hexapeptide-and-silk-amino-acids)
- Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/ingredients/hexapeptide-and-taurine)
- Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/ingredients/hexapeptide-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide)
- Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/ingredients/hexapeptide-and-citric-acid)
- Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/ingredients/glycolic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/ingredients/coenzyme-q10-and-hexapeptide)
- Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/ingredients/green-tea-and-hexapeptide)
- Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/ingredients/vitamin-e-and-hexapeptide)
- Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/ingredients/hexapeptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/ingredients/ceramide-building-complex-and-hexapeptide)
- Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/ingredients/hexapeptide-and-cholesterol)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/ingredients/hexapeptide-and-phytosterol)
- Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/ingredients/hexapeptide-and-squalene)
- Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/ingredients/hexapeptide-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/ingredients/salicylic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/ingredients/hexapeptide-and-bleach)
- Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/ingredients/hexapeptide-and-potassium-hydroxide)
- Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-isopropyl-alcohol)
- Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-polyvinyl-alcohol)
- Work well together: [Niacinamide and zinc](https://lovi.care/skincare/ingredients/niacinamide-and-zinc)
- Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/ingredients/hexapeptide-and-copper)
- Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-zinc)
- Keep them apart: [Bio-placenta peptides and zinc](https://lovi.care/skincare/ingredients/bio-placenta-peptides-and-zinc)
- Keep them apart: [Zinc and collagen peptide](https://lovi.care/skincare/ingredients/zinc-and-collagen-peptide)
- Keep them apart: [Zinc and copper peptide](https://lovi.care/skincare/ingredients/zinc-and-copper-peptide)
- Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/ingredients/hexapeptide-and-magnesium)
- Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/ingredients/hexapeptide-and-zinc-sulfate)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Zinc and palmitoyl pentapeptide-4](https://lovi.care/skincare/ingredients/zinc-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/zinc-and-palmitoyl-tripeptide-1)
- Keep them apart: [Zinc and peptide-rich plasma](https://lovi.care/skincare/ingredients/zinc-and-peptide-rich-plasma)
- Keep them apart: [Zinc and triple peptide blend](https://lovi.care/skincare/ingredients/zinc-and-triple-peptide-blend)
- Work well together: [Benzoyl peroxide and zinc](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-zinc)
- Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-hexapeptide)
- Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/ingredients/azelaic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/ingredients/hexapeptide-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/hexapeptide-and-zinc (this page)
- United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-zinc
- Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-zinc
- Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-zinc
- France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-zinc
- Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-zinc
- Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-zinc
- Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-zinc
- Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-zinc
- Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-zinc
- Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-zinc
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-zinc
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-zinc